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Treatment of Acute Myeloid Leukemia in Germany

Due to the difficulties associated with the organization of treatment in Turkey, Switzerland, South Korea and India, we are not currently processing requests to these regions.

If you are interested in treatment in Germany, please leave a request and our specialists will contact you as soon as possible.

 

Cost for treatment

Acute Myeloid Leukemia (AML) Diagnosis
12799.15
Allogeneic bone marrow transplantation in acute myeloid leukemia
140710.9
Consolidation treatment of acute myeloid leukemia
64084.2

University Hospital Mannheim

9.8/10
location_onGermany, Mannheim

Department of Hematology and Oncology

According to the reputable Focus magazine, the University Hospital Mannheim ranks among the top medical institutions of Germany, which is an undeniable confirmation of the impeccable medical care and excellent reputation of the hospital! The hospital is a high-tech modern medical institution, which provides accurate diagnosis an
Acute Myeloid Leukemia (AML) Diagnosis
19083.9
Allogeneic bone marrow transplantation in acute myeloid leukemia
300738.45
Consolidation treatment of acute myeloid leukemia
99419

University Hospital Ulm

8.7/10
location_onGermany, Ulm

Department of Hematology, Oncology, Palliative Care, Rheumatology and Infectology

The University Hospital Ulm started its activities 35 years ago and during this time it has become one of the most prestigious medical institutions in Europe. The hospital is famous for its numerous discoveries and the world-class achievements in medicine and pharmaceuticals. The medical facility has 29 specialized departments a
Acute Myeloid Leukemia (AML) Diagnosis
21435.8
Allogeneic bone marrow transplantation in acute myeloid leukemia
387080.15
Consolidation treatment of acute myeloid leukemia
97606.5

University Hospital Freiburg

9.7/10
location_onGermany, Freibung

Department of Hematology and Oncology

The University Hospital Freiburg is famous for its rich history and is one of the oldest and most prestigious medical facilities in Germany (one of the three best medical institutions in the country). The hospital was based on the Faculty of Medicine of the Albert Ludwig University of Freiburg, which celebrated its 550th anniver
Acute Myeloid Leukemia (AML) Diagnosis
22424.7
Allogeneic bone marrow transplantation in acute myeloid leukemia
415882.95
Consolidation treatment of acute myeloid leukemia
122260.85

University Hospital Heidelberg

9.8/10
location_onGermany, Heidelberg

Department of Hematology, Oncology, Adult and Pediatric Rheumatology

According to Focus magazine, the University Hospital Heidelberg ranks among the top five hospitals in Germany! The hospital is one of the most advanced and reputable medical institutions not only in Germany, but throughout Europe. There are more than 43 specialized departments and 13 medical institutes, which cover all fields of
Acute Myeloid Leukemia (AML) Diagnosis
0
Allogeneic bone marrow transplantation in acute myeloid leukemia
0
Consolidation treatment of acute myeloid leukemia
0

University Hospital Frankfurt am Main

10/10
location_onGermany, Frankfurt am Main

Department of Hematology, Oncology, Hemostaseology, Rheumatology and Infectology

According to the reputable Focus magazine, the University Hospital Frankfurt am Main ranks among the top German medical facilities! The hospital was founded in 1914 and today is a well-known German medical facility, which combines rich traditions and scientific innovations. A medical team of more than 6,500 employees cares about
Acute Myeloid Leukemia (AML) Diagnosis
20236.65
Allogeneic bone marrow transplantation in acute myeloid leukemia
358680.45
Consolidation treatment of acute myeloid leukemia
106787.9

University Hospital RWTH Aachen

8.7/10
location_onGermany, Aachen

Department of Oncology and Hematology

According to the prestigious Focus magazine, the University Hospital RWTH Aachen ranks among the top German hospitals! As a maximum care university medical facility, the hospital guarantees patients first-class medical services combined with a respectful and human attitude. The hospital integrates all the modern options for the
Acute Myeloid Leukemia (AML) Diagnosis
22514.6
Allogeneic bone marrow transplantation in acute myeloid leukemia
415239.15
Consolidation treatment of acute myeloid leukemia
122256.5

University Hospital Würzburg

9.2/10
location_onGermany, Würzburg

Department of Gastroenterology, Hematology, Oncology, Hepatology, Infectology, Rheumatology and Clinical Immunology

According to the Focus magazine in 2019, the University Hospital Würzburg ranks among the top national German hospitals! The hospital is one of the oldest medical facilities in Germany. The centuries-old traditions of first-class treatment are combined with the very latest achievements of modern evidence-based medicine and
Acute Myeloid Leukemia (AML) Diagnosis
19096.95
Allogeneic bone marrow transplantation in acute myeloid leukemia
329815.3
Consolidation treatment of acute myeloid leukemia
99475.55

University Hospital Erlangen

9.1/10
location_onGermany, Erlangen

Department of Hematology and Oncology

According to the Focus magazine, University Hospital Erlangen ranks among the best medical facilities in Germany! The hospital is one of the leading healthcare facilities in Bavaria and offers top-class medical care distinguished by the close intertwining of clinical activities with research and training of medical students. The
Acute Myeloid Leukemia (AML) Diagnosis
21498.15
Allogeneic bone marrow transplantation in acute myeloid leukemia
387326.65
Consolidation treatment of acute myeloid leukemia
97953.05

University Hospital Halle (Saale)

9.6/10
location_onGermany, Halle

Department of Hematology and Oncology

According to the prestigious Focus magazine, the University Hospital Halle (Saale) ranks among the top German medical facilities! The history of the hospital has more than 300 years, and during this time it managed to earn an excellent reputation not only in Germany, but throughout the world. The hospital positions itself as a s
Acute Myeloid Leukemia (AML) Diagnosis
19195.55
Allogeneic bone marrow transplantation in acute myeloid leukemia
329323.75
Consolidation treatment of acute myeloid leukemia
99294.3

University Hospital Hamburg-Eppendorf

9.2/10
location_onGermany, Hamburg

Department of Hematology, Oncology and Pulmonology

According to the Focus magazine, the University Hospital Hamburg-Eppendorf ranks among the top ten hospitals in Germany! Since its foundation in 1889, the hospital has taken a leading position in the European medical arena and still occupies it until today. A highly competent medical team of more than 11,000 employees takes care
Acute Myeloid Leukemia (AML) Diagnosis
18875.1
Allogeneic bone marrow transplantation in acute myeloid leukemia
329442.65
Consolidation treatment of acute myeloid leukemia
99619.1

Charite University Hospital Berlin

9/10
location_onGermany, Berlin

Charité Comprehensive Cancer Center

According to the authoritative Focus magazine, the Charite University Hospital Berlin occupies the first place in the rating of the top German medical facilities! The hospital is one of the largest and leading university medical complexes in Europe. The hospital in Germany provides modern diagnostics and treatment of patients, a
Acute Myeloid Leukemia (AML) Diagnosis
18792.45
Allogeneic bone marrow transplantation in acute myeloid leukemia
329512.25
Consolidation treatment of acute myeloid leukemia
99503.1

University Hospital Bonn

9.2/10
location_onGermany, Bonn

Department of Oncology, Hematology, Rheumatology and Immunoncology

According to the authoritative Focus magazine, the University Hospital Bonn ranks among the top ten medical facilities in Germany! The hospital was opened on January 1, 2001, although in fact it inherits the medical facility, which operated at the Faculty of Medicine of the University of Bonn. The hospital in Germany combin
Acute Myeloid Leukemia (AML) Diagnosis
22547.95
Allogeneic bone marrow transplantation in acute myeloid leukemia
415420.4
Consolidation treatment of acute myeloid leukemia
122278.25

University Hospital Giessen UKGM

9.5/10
location_onGermany, Giessen

Department of Oncology, Hematology and Palliative Care

The University Hospital Giessen UKGM positions itself as an ultramodern medical facility with outstanding quality of medical care. The hospital presents almost all areas of medicine, ranging from ophthalmology to traumatology and dentistry. The priorities of the hospital’s activities include surgery, neurosurgery, oncology
Acute Myeloid Leukemia (AML) Diagnosis
18815.65
Allogeneic bone marrow transplantation in acute myeloid leukemia
329502.1
Consolidation treatment of acute myeloid leukemia
99307.35

University Hospital of Ludwig Maximilian University of Munich

10/10
location_onGermany, Munich

Department of Oncology and Hematology

According to the Focus magazine, the University Hospital of Ludwig Maximilian University of Munich is regularly ranked among the best medical institutions in Germany! The hospital is the largest multidisciplinary medical facility, as well as a leading research and training center in Germany and Europe. The hospital is proud of i
Acute Myeloid Leukemia (AML) Diagnosis
22320.3
Allogeneic bone marrow transplantation in acute myeloid leukemia
415901.8
Consolidation treatment of acute myeloid leukemia
104044.5

University Hospital Marburg UKGM

8.6/10
location_onGermany, Marburg

Department of Hematology, Oncology and Immunology

The University Hospital Marburg UKGM offers patients modern diagnostics and comprehensive therapy at the international level. As a maximum care hospital, the medical facility specializes in all fields of modern medicine ranging from ophthalmology to traumatology and dentistry. The main areas of specialization of the hospital are
Acute Myeloid Leukemia (AML) Diagnosis
18835.95
Allogeneic bone marrow transplantation in acute myeloid leukemia
329632.6
Consolidation treatment of acute myeloid leukemia
99256.6

University Hospital Muenster

9.8/10
location_onGermany, Muenster

Department of Hematology, Hemostaseology, Oncology and Pulmonology

According to the Focus magazine, the University Hospital Muenster ranks among the top German hospitals! The hospital belongs to the most prestigious medical institutions in Germany. The hospital is distinguished by a high professionalism of its doctors, state-of-the-art technological equipment and the availability of the most ad
Acute Myeloid Leukemia (AML) Diagnosis
19024.45
Allogeneic bone marrow transplantation in acute myeloid leukemia
330045.85
Consolidation treatment of acute myeloid leukemia
99532.1
| from Booking Health GmbH

Content

  1. Standard treatment
  2. Induction
  3. Consolidation
  4. Selection of treatment methods
  5. Treatment in Germany with Booking Health

 

Myeloblastic acute leukemia is the most common malignant disease of the hematopoietic system. In general, it is rare and its occurrence is about 1% of all cancer cases. The disease rarely develops before the age of 45 years. Most patients are over the age of 60 at the time of diagnosis. Myeloblastic leukemia is rare in children.

Acute myeloid leukemia (AML) is a cancer of the myeloid blood cells.

Depending on the disease stage, treatment of AML includes chemo- and targeted therapy, CAR T-cell therapy, bone marrow transplant.

Price for induction chemotherapy starts at €22,027. Cost of consolidation treatment starts at €44,196. Cost of treatment with CAR T-cell therapy starts at €81,970. You can find other prices on our website.

The best hospitals treatment of leukemia in Germany are:

  • University Hospital Rechts der Isar Munich
  • University Hospital of Ludwig Maximilian University of Munich
  • University Hospital Frankfurt am Main
  • Helios Hospital Berlin-Buch
  • Clinic of Advanced Biological Medicine Frankfurt am Main

Standard treatment

 

Depending on the age of the patient and the specificities of the disease, the treatment regimen for acute myelogenous leukemia can vary significantly. A standard therapy includes 2 stages. The basis of treatment is chemotherapy.

  1. Induction. The goal of the treatment is to achieve a remission – reduction of the number of myeloblasts in the bone marrow to less than 5%, which is normal.
  2. Consolidation. This is the maintenance of remission as long as possible.

Chemotherapy is started as early as possible because the symptoms of the disease progress rapidly. Hematologists may change the treatment regimen from time to time in order to avoid resistance to the treatment. They often do this prior to the onset of signs of ineffectiveness of chemotherapy.

At the time of detection of the disease, the patients often have signs of leukostasis. This condition occurs due to the accumulation of a large number of myeloblasts in small vessels. They clog them, thereby disrupting the blood supply to vital organs, most often to the brain. To eliminate leukostasis, leukapheresis is performed. This is a procedure, in which blood goes through a device, which removes excess leukocytes.

Induction

 

An intensive chemotherapy is indicated for patients under 60 years old, but it is poorly tolerated by the elderly. The doses, regimens and the choice of drugs depend on the type of myeloid leukemia, which is determined by the results of red bone marrow examination. Of greatest importance are cytogenetic analyses, which determine chromosomal changes in abnormal cells, and molecular diagnostics, which determine changes in genes (DNA nucleotide sequences).

As a rule, the patient is prescribed two drugs. Sometimes, three medicines can be required at once. This increases the likelihood of achieving remission.

In rare cases, the introduction of drugs using lumbar puncture is required. This is necessary, if acute myeloid leukemia has spread to the central nervous system.

In parallel, maintenance therapy is carried out for the elimination of symptoms and complications. The patient may need the following measures:

  • Blood transfusion.
  • Antibiotics for bacterial infection suppression (in case of myeloid leukemia, immunity becomes weak).
  • Growth factors, which stimulate the maturation of normal blood cells.
  • Fluid volume replacement (infusion therapy) in blood loss.

In a week, the doctors perform the second biopsy of the red bone marrow. Most patients have remission after the first course of treatment. If it does not happen, other treatment options suggest:

  • Second course of chemotherapy with a change in the regimen.
  • Stem cell transplantation (bone marrow transplantation).

Should the positive result be achieved, the treatment will not be completed. The patient requires maintenance therapy or otherwise the relapse may occur within a few months.

Consolidation

 

The next stage of treatment is maintenance therapy. It is aimed at the destruction of all remaining malignant cells. If the specialists fail to achieve it, at least they can prolong life expectancy of the patient.

Here are some of the consolidation options for patients under 60 years old:

  • Several cycles of chemotherapy.
  • Allogeneic (from the donor) stem cell transplantation.
  • Autologous stem cell transplantation.

Stem cell transplantation offers a better chance of recovery in comparison with chemotherapy. However, this type of therapy increases the risk of complications, including the fatal ones.

The following consolidation options are provided for patients after 60 years old or debilitated patients with concomitant somatic pathologies:

  • High doses of one drug.
  • Low doses, the use of a combination of 2 drugs.
  • Mini stem cell transplantation (transplantation of material without complete destruction of the patient's own bone marrow).

If the doctor concludes that the transplantation is impractical or the patient refuses it, chemotherapy may be complemented with targeted therapy. It also helps to reduce chemotherapy doses and improve treatment tolerance.

Selection of treatment methods

 

There can be used different therapy regimens. The doses of chemotherapy drugs may be higher or lower. Additionally, targeted therapy may or may not be applied. The stem cell transplantation can sometimes be performed as well.  If it is indicated, different treatment options are possible (donor or patient’s own stem cells, mini-transplantation).

The decision on the most effective treatment is made based on the analysis of the following data:

  • How quickly the remission was achieved. If the first cycle of chemotherapy decreased the number of blast cells in the bone marrow to less than 5%, this is a good prognostic sign. The patient is recommended for stem cell transplantation in order to try to completely cure the disease.
  • Whether the compatible donors are available. The bone marrow transplant from a brother, sister or another person with good compatibility improves the results of the procedure. The allogeneic transplantation is more effective than autologous, but at the same time it is more dangerous. It is used mainly in young patients.
  • Whether any unaffected regions of the red bone marrow are presented. The autologous transplantation can also be effective, if it is possible to obtain samples, which are not affected by the malignant process. To destroy the remaining cancer cells, the bone marrow is processed in a laboratory.
  • Adverse prognostic factors. Their presence and quantity are taken into account. These can be particular gene and chromosomal abnormalities, the excessively high initial levels of myeloblasts in the blood, the relapse of the disease, its spread to the central nervous system. With a large number of adverse factors, more aggressive treatment may be required, while in a favorable prognosis and prolonged absence of the relapse, the doctor may recommend to delay stem cell transplantation and observe the further course of the disease. Perhaps it can be cured by means of chemotherapy.
  • Patient's age and state of health. These may be a limitation for more effective therapeutic approaches when high doses of chemotherapy are applied and stem cell transplantation is performed.
  • The patient's requests. The opinion of the patient is always taken into account. The most effective treatment methods are the most risky and uncomfortable at the same time, and moreover, rather expensive. Some patients do not want to undergo aggressive therapy, thereby limiting themselves to maintenance therapy for the elimination of symptoms and the use of low doses of chemotherapy drugs, which can delay the relapse of the disease.

Treatment in Germany with Booking Health

 

If you want to undergo the diagnosis of acute myeloid leukemia in Germany and the treatment of this disease by leading hematologists in the world, you should use the services of the specialists of the Booking Health company. We offer the following benefits:

  • Selection of the best German clinic with a well-equipped Department of Hematology and Oncology, which specializes in the treatment of acute myeloid leukemia and achieves outstanding results in this medical field.
  • Your financial expenses will be reduced. The discount reaches up to 50% due to the lack of overpricing and additional coefficients for foreign patients.
  • Booking an appointment on the most suitable dates for you.
  • Preparation of the program, taking into account previously performed examinations.
  • Establishment of communication with the hematologist.
  • Monitoring of the program at all its stages.
  • Control of invoices and return of unspent funds.
  • Buying and forwarding of medicines.
  • Organization of additional diagnosis of acute myeloid leukemia in Germany, treatment or rehabilitation.
  • Communication with the German clinic upon treatment completion.

The Booking Health company will provide you with top-class services. We will book a hotel for you, meet you at the German airport and take you to the clinic.

Authors: Dr. Vadim ZhiliukDr. Sergey Pashchenko




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