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Acute Myeloid Leukemia (AML) — CAR T-cell Therapy: treatment in the Best Hospitals of Germany

University Hospital Ulm

8.7/10
location_onGermany, Ulm

Department of Hematology, Oncology, Palliative Care, Rheumatology and Infectology

The Department of Hematology, Oncology, Palliative Care, Rheumatology and Infectology offers the full range of services in these fields. It provides the accurate diagnostics and effective treatment of oncological diseases, benign and malignant blood pathologies, rheumatic and infectious diseases. A separate focus of the department is palliative care aimed at relieving pain and improving the quality of life of the terminally ill patients. The doctors of the department have unique clinical skills and rich experience, which contributes to high treatment success rates.

University Hospital Freiburg

9.7/10
location_onGermany, Freibung

Department of Hematology and Oncology

The Department of Hematology and Oncology offers the full range of diagnostics and treatment of blood diseases, coagulation disorders, oncological diseases and related pathological conditions. The treatment is provided both on an outpatient and inpatient basis. The patient is offered a comprehensive treatment, including intensive care to eliminate side effects associated with the tumor and therapy, development of individual recommendations on nutrition, physiotherapeutic measures and psycho-oncological care.

University Hospital Frankfurt am Main

10/10
location_onGermany, Frankfurt am Main

Department of Hematology, Oncology, Hemostaseology, Rheumatology and Infectology

The Department of Hematology, Oncology, Hemostaseology, Rheumatology and Infectology offers the full range of medical services in the fields of its specialization. The department specializes in the diagnostics and treatment of all diseases of the hematopoietic system, systemic treatment of solid tumors, infectious diseases, including outpatient admission of patients with HIV, blood clotting disorders, as well as the entire clinical and morphological group of rheumatic diseases. The department is actively engaged in research activities and regularly implements the latest medical developments into clinical practice, thereby providing treatment in accordance with the most advanced scientific achievements.

University Hospital Heidelberg

9.8/10
location_onGermany, Heidelberg

Department of Hematology, Oncology, Adult and Pediatric Rheumatology

The Department of Hematology, Oncology, Adult and Pediatric Rheumatology offers the full range of modern diagnostics and treatment of malignant diseases, rheumatic pathologies, including particularly complex clinical cases in these fields. In addition, the department's doctors specialize in stem cell transplantation and occupy leading positions in this field at the international level. The medical team of the department makes every effort to guarantee each patient an individual, first-class treatment, based on the very latest achievements of modern medicine and human respect, understanding of the needs of each patient.

University Hospital Würzburg

9.2/10
location_onGermany, Würzburg

Department of Gastroenterology, Hematology, Oncology, Hepatology, Infectology, Rheumatology and Clinical Immunology

The Department of Gastroenterology, Hematology, Oncology, Hepatology, Infectology, Rheumatology and Clinical Immunology offers the full range of diagnostics and treatment in these fields. The department specializes in the treatment of benign and malignant diseases of the digestive system, liver and bile ducts, the hematopoietic system, etc. Much attention is paid to the interdisciplinary cooperation (Cancer Center Mainfranken, etc.).

University Hospital RWTH Aachen

8.7/10
location_onGermany, Aachen

Department of Oncology and Hematology

The Department of Oncology and Hematology offers accurate diagnostics and effective treatment of benign and malignant blood diseases, as well as solid tumors. The department's specialists are proud of the excellent results in the field of bone marrow transplantation, which is among the department’s priority focuses. The department has 61 beds. Medical care is carried out both on an outpatient and inpatient basis.

University Hospital Erlangen

9.1/10
location_onGermany, Erlangen

Department of Hematology and Oncology

The Department of Hematology and Oncology provides diagnostics and comprehensive treatment of diseases of the hematopoietic system, as well as solid tumors of various organs. Hematologists most often deal with the treatment of acute and chronic leukemias, malignant lymphomas, myelodysplastic syndromes, plasmacytomas and other pathologies. Chemotherapy is usually first-line therapy. The department's specialists also successfully perform bone marrow transplantation. In the field of oncology, the department provides effective treatment of various tumors of the gastrointestinal tract, endocrine glands, female and male reproductive system, skin cancer, soft tissue and bone sarcomas, head and neck malignancies, etc. The patients suffering from cancer are offered classical (chemotherapy, immunotherapy, hormone therapy) and innovative (immunotherapy, CAR T-cell therapy) treatment methods. Surgical resection of solid tumors is performed by specialized surgeons. The treatment regimen is developed individually for each patient at the tumor board, which plays an important role in achieving a successful treatment result.

University Hospital Halle (Saale)

9.6/10
location_onGermany, Halle

Department of Hematology and Oncology

According to the Focus magazine, the Department of Hematology and Oncology ranks among the top German medical facilities specializing in bowel cancer treatment! The department offers the full range of specialized diagnostics, treatment and follow-up care for patients with oncological diseases and blood diseases. The department's doctors have in their arsenal many innovative effective methods to fight against cancer. In addition, a number of clinical trials are carried out here in order to develop the very latest targeted drugs, immunotherapy drugs, etc. All the department's specialists regularly undergo advanced training courses, which help them to keep abreast of innovations in medicine and to guarantee the best therapy result for patients.

University Hospital Hamburg-Eppendorf

9.2/10
location_onGermany, Hamburg

Department of Hematology, Oncology and Pulmonology

According to the Focus magazine, the Department of Hematology, Oncology and Pulmonology ranks among the top medical facilities in Germany specializing in bowel cancer treatment! The department offers the full range of modern diagnostics and treatment of solid tumors, benign and malignant blood and hematopoietic system diseases, including bleeding disorders, as well as pathologies of the lungs and other organs of the respiratory system. The offer is complemented by effective palliative care. All physicians of the department are highly qualified experts in their area of specialization and apply theoretical knowledge and clinical experience to ensure an optimal therapy result.

University Hospital Bonn

9.2/10
location_onGermany, Bonn

Department of Oncology, Hematology, Rheumatology and Immunoncology

The Department of Oncology, Hematology, Rheumatology and Immunoncology offers the full range of diagnostics and treatment of solid tumors, benign and malignant diseases of blood and bone marrow, rheumatic pathologies. The priority purpose of each employee in the department is to provide patients with an optimal medical care, based on the use of the very latest treatment methods. The department's specialists are distinguished by their high professionalism and colossal experience in the treatment of extremely complex clinical cases.

University Hospital of Ludwig Maximilian University of Munich

10/10
location_onGermany, Munich

Department of Oncology, Hematology and Bone Marrow Transplantation

The Department of Oncology, Hematology and Bone Marrow Transplantation provides the full range of diagnostic and therapeutic services to patients with malignant solid tumors, and benign and malignant blood pathologies. Of particular interest is the treatment of patients with acute leukemia, lymphomas, multiple myeloma, sarcomas, gastrointestinal cancer, lung cancer, breast cancer, and rare malignant tumors. The department is part of the Comprehensive Cancer Center Munich, thanks to which doctors from related specialties are involved in the therapeutic process. All modern diagnostic methods and therapeutic procedures are available here, including bone marrow transplantation, which is often the most effective treatment method for blood cancer. The health of patients is in the safe hands of a highly qualified medical team, consisting of 65 doctors and 130 nurses. The department treats about 2,800 inpatients and more than 10,000 outpatients every year. The department's specialists pay due attention to the psychological state of their patients diagnosed with cancer, so a program of psycho-oncological care is being successfully implemented here.

University Hospital Giessen UKGM

9.5/10
location_onGermany, Giessen

Department of Oncology, Hematology and Palliative Care

The Department of Oncology, Hematology and Palliative Care offers all the options of modern medicine for the treatment of patients with the pathologies in these fields. Specialization covers the treatment of cancer of the internal organs, blood cancer, symptomatic treatment of progressive incurable diseases. Other focuses of the department are intensive care medicine and special pain therapy. To achieve successful and long-term results, the clinical practice is based on the use of effective classic and innovative treatment methods.

University Hospital Muenster

9.8/10
location_onGermany, Muenster

Department of Hematology, Hemostaseology, Oncology and Pulmonology

The Department of Hematology, Hemostaseology, Oncology and Pulmonology offers the full range of diagnostics and treatment of blood diseases, including oncopathologies and blood coagulation disorders, lung diseases, and rare malignant diseases. The department incorporates two modern Bone Marrow Transplantation Centers. In addition, the department belongs to the largest medical facilities in Germany, which specialize in the treatment of malignant lymphomas, acute leukemias, sarcomas, as well as bone marrow transplantation. The physicians of the department are committed to providing patients with the comprehensive medical care of the highest quality, based on the respective attitude towards patients.

University Hospital Marburg UKGM

8.6/10
location_onGermany, Marburg

Department of Hematology, Oncology and Immunology

According to the Focus magazine, the Department of Hematology, Oncology and Immunology ranks among the top German medical facilities specializing in leukemia treatment! The department offers accurate diagnostics and effective treatment of malignant and benign blood diseases, solid tumors. The patients are treated in close collaboration with the Comprehensive Cancer Center. Of particular interest to the department's doctors is the treatment of various types of leukemia (within the specialized center with advanced infrastructure). The department takes part in many national and international clinical trials, which makes it possible for patients with advanced stages of cancer to receive treatment using innovative therapeutic methods.

University Hospital Jena

8.9/10
location_onGermany, Jena

Department of Hematology and Oncology

According to the Focus magazine, the Department of Hematology and Oncology ranks among the top German medical facilities of this kind! The department offers the full range of diagnostics and treatment of oncological and hematological diseases in adults. To achieve the best result, there is maintained close cooperation with all specialists in the related fields. The interdisciplinary tumor boards serve for a detailed discussion of each clinical case and the development of an optimal treatment strategy. The department has strict quality management system. It is also certified according to DIN EN ISO 9001: 2008.

University Hospital Rechts der Isar Munich

9.8/10
location_onGermany, Munich

Department of Hematology and Oncology

The Department of Hematology and Oncology offers the full range of diagnostic and therapeutic services in these fields. The highly qualified team of the department's doctors provides effective treatment of all cancers and blood pathologies (for example, leukemia, multiple myeloma, non-Hodgkin's and Hodgkin's lymphoma) in accordance with the very latest international standards. The department performs autologous and allogeneic bone marrow transplantation, as well as provides innovative CAR T-cell therapy. It should be noted that the department is certified as the Comprehensive Cancer Center Munich, and also has a quality certificate from the German Cancer Society. The medical facility has the very latest equipment, implements innovative treatment methods, and at the same time pays due attention to comprehensive consultations and a humane attitude towards patients. Patients can get special nutrition counselling, as well as competent psychological care.

Chronic myelogenous leukemia is an oncohematological disease that develops as a result of uncontrolled division of precursor cells of erythrocytes, platelets, and most types of leukocytes. Pathological changes are associated with the BCR-ABL gene, which turns normal cells into leukemic ones. The disease slowly progresses, but can subsequently turn into acute myeloid leukemia (AML) with a severe clinical course.

Content

  1. Targeted therapy
  2. Other drugs for chronic myelogenous leukemia
  3. Radiation therapy
  4. Surgical treatment
  5. Stem cell transplant
  6. Other treatment methods

In most cases, the disease can be well controlled with targeted therapy. Patients rarely require radiation therapy or surgery to remove the spleen. With an insufficient effect of targeted therapy for chronic myeloid leukemia treatment, German doctors use chemotherapy, immunotherapy, and a stem cell transplant.

You can undergo your treatment at one of the university hospitals: University Hospital Ulm, University Hospital Heidelberg, or University Hospital Freiburg.

The Booking Health company will take care of the organization of your trip so you don't have to worry about anything. Our employees will select a hospital and tell you about possible treatment methods. They will make an appointment without a long wait, help you to get a visa and collect the necessary medical documents. An interpreter will accompany you to the clinic. Your medical records and recommendations will also be translated into your native language. You can contact the Booking Health coordinator with any questions during the treatment process.

Targeted therapy

 

The basis of chronic myelogenous leukemia treatment in Germany is targeted therapy with tyrosine kinase inhibitors. Drugs targeting the BCR-ABL gene are used. They work best in the chronic phase of the disease and are less effective (although they are used by doctors) in the acceleration phase or the blast stage.

Drugs do not cure the disease once and for all, so they need to be taken constantly. With poor tolerance to drugs, dosages may be reduced. It is important to follow the regimen prescribed by a doctor, since skipping entails a decrease in the effectiveness of therapy.

Other drugs for chronic myelogenous leukemia

 

Interferon alpha is an artificial drug that acts like endogenous interferon produced in the human body. It blocks the growth and division of leukemic cells.

In recent years, interferons have been used less frequently in developed countries. This is because tyrosine kinase inhibitors provide better results with fewer side effects. They are also more convenient to use as they are taken as tablets, while interferons have to be injected subcutaneously every day.

Cytotoxic chemotherapy is still occasionally used for chronic myeloid leukemia, but this treatment option is much less frequent. In the 20th century, it was the main treatment method, but now doctors in clinics in Germany prescribe these drugs only in cases where targeted therapy no longer works. Chemotherapy can also be used before a stem cell transplant.

Radiation therapy

 

Radiation therapy can rarely be used. This is prescribed in cases where the affected organs become too large and need to be quickly reduced to relieve symptoms and prevent complications. Doctors mostly irradiate the spleen so that it does not press on the stomach.

Surgical treatment

 

Unlike other types of cancer, chronic myeloid leukemia does not require surgical tumor removal. However, some patients require surgery to relieve symptoms.

A splenectomy is the most common intervention for chronic myeloid leukemia. The operation involves the removal of the spleen. As a result, not only does the pressure on the surrounding organs decrease, but the process of destruction of blood cells slows down, which reduces the need for blood transfusions.

Doctors in Germany perform a splenectomy using a minimally invasive laparoscopic method, that is, through short incisions. Such surgical interventions are less traumatic, safer and provide a quick rehabilitation of patients.

Stem cell transplant

 

With the advent of highly effective targeted therapies, a stem cell transplant for chronic myelogenous leukemia is performed less frequently than before. But still, some patients need this procedure.

Doctors perform a donor stem cell transplant, as only this transplant option helps to cure the disease. Since the procedure is unsafe, it is preferred for young patients and children. It is better that the donor is a sibling, as it is not always possible to find a suitable unrelated donor.

Other treatment methods

 

Other treatment options are being tested in clinical trials. For patients with severe forms of the disease that do not respond to standard therapy, doctors try to use the following methods:

  • a combination of targeted therapy, chemotherapy and interferon;
  • drugs against T315I mutant cells (patients with this mutation do not respond well to standard targeted therapy);
  • cancer vaccines; 
  • CAR T-cell therapy (injection of a patient's own immune modified cells).

You are welcome to use the Booking Health service to undergo your diagnostics and treatment of chronic myeloid leukemia in one of the medical centers in Germany. On our website, you can find prices, compare the cost of treatment, and make your appointment at the best price. The specialists of the Booking Health company will help you to choose the most suitable hospitals in Germany and organize your trip.

 

Authors: 

The article was edited by medical experts, board-certified doctors Dr. Nadezhda Ivanisova and Dr. Sergey Pashchenko. For the treatment of the conditions referred to in the article, you must consult a doctor; the information in the article is not intended for self-medication!

 

Sources:

National Center for Biotechnology

Cancer Research Institute

Verywell Health




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