google_counter
background_img

CAR T-cell Therapy for cancer treatment

It is now possible to go to Germany and other countries for treatment!

We issue urgent medical visas to enter Germany and other countries!

Please contact us! We know everything about the available flights around the world!

 

Cost for treatment

Treatment of acute lymphoblastic leukemia (ALL) with CAR T-cell therapy
 from  81970
Treatment of acute myeloid leukemia (AML) with CAR T-cell therapy
 from  81970
Treatment of Non-Hodgkin lymphoma (B-cell) with CAR T-cell therapy
 from  81970

University Hospital Ulm

8.7/10
location_onGermany, Ulm

Department of Hematology, Oncology, Palliative Care, Rheumatology and Infectology

The University Hospital Ulm started its activities 35 years ago and during this time it has become one of the most prestigious medical institutions in Europe. The hospital is famous for its numerous discoveries and the world-class achievements in medicine and pharmaceuticals. The medical facility has 29 specialized departments a
Treatment of acute lymphoblastic leukemia (ALL) with CAR T-cell therapy
556368
Treatment of acute myeloid leukemia (AML) with CAR T-cell therapy
556463
Treatment of Non-Hodgkin lymphoma (B-cell) with CAR T-cell therapy
556390

University Hospital Freiburg

9.7/10
location_onGermany, Freibung

Department of Hematology and Oncology

The University Hospital Freiburg is famous for its rich history and is one of the oldest and most prestigious medical facilities in Germany (one of the three best medical institutions in the country). The hospital was based on the Faculty of Medicine of the Albert Ludwig University of Freiburg, which celebrated its 550th anniver
Treatment of acute lymphoblastic leukemia (ALL) with CAR T-cell therapy
596567
Treatment of acute myeloid leukemia (AML) with CAR T-cell therapy
596620
Treatment of Non-Hodgkin lymphoma (B-cell) with CAR T-cell therapy
596288

University Hospital Frankfurt am Main

10/10
location_onGermany, Frankfurt am Main

Department of Hematology, Oncology, Hemostaseology, Rheumatology and Infectology

According to the reputable Focus magazine, the University Hospital Frankfurt am Main ranks among the top German medical facilities! The hospital was founded in 1914 and today is a well-known German medical facility, which combines rich traditions and scientific innovations. A medical team of more than 6,500 employees cares about
Treatment of acute lymphoblastic leukemia (ALL) with CAR T-cell therapy
516094
Treatment of acute myeloid leukemia (AML) with CAR T-cell therapy
516538
Treatment of Non-Hodgkin lymphoma (B-cell) with CAR T-cell therapy
516381

University Hospital Heidelberg

9.8/10
location_onGermany, Heidelberg

Department of Hematology, Oncology, Adult and Pediatric Rheumatology

According to the Focus magazine, the University Hospital Heidelberg ranks among the top five hospitals in Germany! The hospital is one of the most advanced and reputable medical institutions not only in Germany, but throughout Europe. There are more than 43 specialized departments and 13 medical institutes, which cover all field
Treatment of acute lymphoblastic leukemia (ALL) with CAR T-cell therapy
0
Treatment of acute myeloid leukemia (AML) with CAR T-cell therapy
0
Treatment of Non-Hodgkin lymphoma (B-cell) with CAR T-cell therapy
0

University Hospital Würzburg

9.2/10
location_onGermany, Würzburg

Department of Gastroenterology, Hematology, Oncology, Hepatology, Infectology, Rheumatology and Clinical Immunology

According to the Focus magazine in 2019, the University Hospital Würzburg ranks among the top national German hospitals! The hospital is one of the oldest medical facilities in Germany. The centuries-old traditions of first-class treatment are combined with the very latest achievements of modern evidence-based medicine and
Treatment of acute lymphoblastic leukemia (ALL) with CAR T-cell therapy
476528
Treatment of acute myeloid leukemia (AML) with CAR T-cell therapy
476383
Treatment of Non-Hodgkin lymphoma (B-cell) with CAR T-cell therapy
476293

University Hospital RWTH Aachen

8.7/10
location_onGermany, Aachen

Department of Oncology and Hematology

According to the prestigious Focus magazine, the University Hospital RWTH Aachen ranks among the top German hospitals! As a maximum care university medical facility, the hospital guarantees patients first-class medical services combined with a respectful and human attitude. The hospital integrates all the modern options for the
Treatment of acute lymphoblastic leukemia (ALL) with CAR T-cell therapy
596670
Treatment of acute myeloid leukemia (AML) with CAR T-cell therapy
596677
Treatment of Non-Hodgkin lymphoma (B-cell) with CAR T-cell therapy
596714

University Hospital Erlangen

9.1/10
location_onGermany, Erlangen

Department of Hematology and Oncology

According to the Focus magazine, the University Hospital Erlangen ranks among the top German medical facilities! The hospital is one of the leading medical facilities in Bavaria and offers the highest level of medical care, which is characterized by the close intertwining of clinical activities with research and training of medi
Treatment of acute lymphoblastic leukemia (ALL) with CAR T-cell therapy
556601
Treatment of acute myeloid leukemia (AML) with CAR T-cell therapy
556498
Treatment of Non-Hodgkin lymphoma (B-cell) with CAR T-cell therapy
556698

University Hospital Halle (Saale)

9.6/10
location_onGermany, Halle

Department of Hematology and Oncology

According to the prestigious Focus magazine, the University Hospital Halle (Saale) ranks among the top German medical facilities! The history of the hospital has more than 300 years, and during this time it managed to earn an excellent reputation not only in Germany, but throughout the world. The hospital positions itself as a s
Treatment of acute lymphoblastic leukemia (ALL) with CAR T-cell therapy
476373
Treatment of acute myeloid leukemia (AML) with CAR T-cell therapy
476207
Treatment of Non-Hodgkin lymphoma (B-cell) with CAR T-cell therapy
476457

University Hospital Hamburg-Eppendorf

9.2/10
location_onGermany, Hamburg

Department of Hematology, Oncology and Pulmonology

According to the Focus magazine, the University Hospital Hamburg-Eppendorf ranks among the top ten hospitals in Germany! Since its foundation in 1889, the hospital has taken a leading position in the European medical arena and still occupies it until today. A highly competent medical team of more than 11,000 employees takes care
Treatment of acute lymphoblastic leukemia (ALL) with CAR T-cell therapy
476318
Treatment of acute myeloid leukemia (AML) with CAR T-cell therapy
476290
Treatment of Non-Hodgkin lymphoma (B-cell) with CAR T-cell therapy
476076

University Hospital Bonn

9.2/10
location_onGermany, Bonn

Department of Oncology, Hematology, Rheumatology and Immunoncology

According to the authoritative Focus magazine, the University Hospital Bonn ranks among the top ten medical facilities in Germany! The hospital was opened on January 1, 2001, although in fact it inherits the medical facility, which operated at the Faculty of Medicine of the University of Bonn. The hospital in Germany combin
Treatment of acute lymphoblastic leukemia (ALL) with CAR T-cell therapy
596267
Treatment of acute myeloid leukemia (AML) with CAR T-cell therapy
596581
Treatment of Non-Hodgkin lymphoma (B-cell) with CAR T-cell therapy
596682

University Hospital of Ludwig Maximilian University of Munich

10/10
location_onGermany, Munich

Department of Oncology and Hematology

According to the Focus magazine, the University Hospital of Ludwig Maximilian University of Munich is regularly ranked among the best medical institutions in Germany! The hospital is the largest multidisciplinary medical facility, as well as a leading research and training center in Germany and Europe. The hospital is proud of i
Treatment of acute lymphoblastic leukemia (ALL) with CAR T-cell therapy
596727
Treatment of acute myeloid leukemia (AML) with CAR T-cell therapy
596365
Treatment of Non-Hodgkin lymphoma (B-cell) with CAR T-cell therapy
596183

University Hospital Giessen UKGM

9.5/10
location_onGermany, Giessen

Department of Oncology, Hematology and Palliative Care

The University Hospital Giessen UKGM positions itself as an ultramodern medical facility with outstanding quality of medical care. The hospital presents almost all areas of medicine, ranging from ophthalmology to traumatology and dentistry. The priorities of the hospital’s activities include surgery, neurosurgery, oncology
Treatment of acute lymphoblastic leukemia (ALL) with CAR T-cell therapy
476293
Treatment of acute myeloid leukemia (AML) with CAR T-cell therapy
476341
Treatment of Non-Hodgkin lymphoma (B-cell) with CAR T-cell therapy
476525

University Hospital Muenster

9.8/10
location_onGermany, Muenster

Department of Hematology, Hemostaseology, Oncology and Pulmonology

According to the Focus magazine, the University Hospital Muenster ranks among the top German hospitals! The hospital belongs to the most prestigious medical institutions in Germany. The hospital is distinguished by a high professionalism of its doctors, state-of-the-art technological equipment and the availability of the most ad
Treatment of acute lymphoblastic leukemia (ALL) with CAR T-cell therapy
476292
Treatment of acute myeloid leukemia (AML) with CAR T-cell therapy
476504
Treatment of Non-Hodgkin lymphoma (B-cell) with CAR T-cell therapy
476205

University Hospital Marburg UKGM

8.6/10
location_onGermany, Marburg

Department of Hematology, Oncology and Immunology

The University Hospital Marburg UKGM offers patients modern diagnostics and comprehensive therapy at the international level. As a maximum care hospital, the medical facility specializes in all fields of modern medicine ranging from ophthalmology to traumatology and dentistry. The main areas of specialization of the hospital are
Treatment of acute lymphoblastic leukemia (ALL) with CAR T-cell therapy
476576
Treatment of acute myeloid leukemia (AML) with CAR T-cell therapy
476651
Treatment of Non-Hodgkin lymphoma (B-cell) with CAR T-cell therapy
476612

University Hospital Jena

8.9/10
location_onGermany, Jena

Department of Hematology and Oncology

According to the prestigious Focus magazine, the University Hospital Jena regularly ranks among the top German medical facilities! The hospital has positioned itself as a multidisciplinary medical facility with a long history of more than 200 years. Since its foundation, the hospital has been constantly developing and modernizin
Treatment of acute lymphoblastic leukemia (ALL) with CAR T-cell therapy
476610
Treatment of acute myeloid leukemia (AML) with CAR T-cell therapy
476563
Treatment of Non-Hodgkin lymphoma (B-cell) with CAR T-cell therapy
476250

University Hospital Rechts der Isar Munich

9.8/10
location_onGermany, Munich

Department of Hematology and Oncology

According to the prestigious FOCUS magazine, the University Hospital Rechts der Isar Munich ranks among the Germany's top medical institutions! Founded in 1834, the hospital combines long traditions and the very latest achievements of modern medicine. The medical facility includes 33 specialized departments, 20 interdiscipli
Treatment of acute lymphoblastic leukemia (ALL) with CAR T-cell therapy
596624
Treatment of acute myeloid leukemia (AML) with CAR T-cell therapy
596271
Treatment of Non-Hodgkin lymphoma (B-cell) with CAR T-cell therapy
596518

CAR T-cell therapy includes modification of patient’s own T-cells so that they become able to attack and destroy cancer cells.

Children and adults with acute myeloid leukemia, acute lymphoblastic leukemia, and non-Hodgkin B-cell lymphoma are eligible to receive CAR T-cell therapy.

In Europe (large university hospitals in Germany), Israel, and the USA.

Blood cancer, including acute lymphoblastic and myeloid leukemia, non-Hodgkin B-cell lymphoma.

Prices for treatment are listed below:

Disease

Cost in Germany

Cost in Israel
Acute lymphoblastic leukemiafrom 436,190 €from 81,970 €
Acute myeloid leukemiafrom 436,190 €from 81,970 €
Non-Hodgkin B-cell lymphomafrom 436,190 €from 81,970 €

 

 

CAR T-cell therapy, or adoptive cell therapy, is one of the new directions in cancer treatment. CAR T-cell therapy allows acute forms of lymphoblastic and myeloid leukemia to be treated. Today CAR T-cell therapy is performed in a limited number of specialized clinics. The greatest experience in the treatment of patients with leukemia using CAR T-cell therapy has been accumulated in leading hospitals in Germany, Israel and the USA.

CAR T-cell therapy overview

CAR T-cell therapy is an innovative treatment for certain types of blood cancer, including leukemia. The patient's white blood cells are genetically programmed to destroy cancer cells. With the help of high-tech equipment, leukocytes (white blood cells, which are an important component of the immune system) are separated from the rest of the blood. In a specialized laboratory, the leukocytes undergo genetic modification to express chimeric antigen receptors (CAR). At the next stage, they are multiplied in laboratory conditions until there are millions of modified cells that are used for further cancer treatment.

The return of CAR T-cells to the patient's bloodstream is carried out by infusion. Now, chimeric antigen receptors will help genetically modified cells to bind to the corresponding antigens of cancer cells, effectively detecting and destroying them.

Antigens are substances that activate (turn on) the immune system. The immune system helps the body fight cancer. Antigens are located on the surface of all cells in the body. They are also found on the surface of elements that enter the body from the outside, such as bacteria and viruses.

The immune system uses T-cells to recognize which antigens do not belong to the body. T-cells have receptors with the help of which they bind to certain antigens. When a T-cell binds to an antigen, it sends messages to other cells in the immune system. These cells help to kill the atypical cells with the antigen on their surface and remove them from the body. CAR-T-cells are T-cells that have been genetically modified in the laboratory to bind to antigens on cancer cells. When a CAR T-cell binds to a cancer cell, the immune system sends immune cells to destroy the cancer cell and remove it from the body.

Diagnostics

Before the start of CAR T-cell therapy, patients undergo a comprehensive examination to assess the overall health condition. This will help to make sure the patient is ready for medical treatment. It also allows the CAR T-cell therapy team to predict the results of the treatment.

As part of the examination, the patient will need to complete some (perhaps not all) of the tests that are listed below.

Chest X-ray. It allows doctors to obtain information on the condition of the lungs are signs of cancer in them.

Blood tests. These are done to get the information on the kidney and liver function, blood cell counts, state of the immune system.

Analysis of urine. This is done to get the information on the kidney function and the state of the urinary tract.

Electrocardiogram (ECG) and echocardiogram. They provide the CAR T team with the information about the patient's heart condition.

Pulmonary function tests. These breath tests allow assessing lung function.

Computed tomography (CT). This radiologic examination provides more detailed information on the state of soft tissue and bone tissue compared to a standard radiological examination. In some cases, a CT scan is performed with contrast enhancement. In case of a mild allergic reaction, the use of a contrast agent is acceptable, but the patient must take medication before administering it, in order to avoid such a reaction.

Positron emission tomography (PET). This radiological test is done to study certain types of cancer, its location, and functional activity of inner organs.

Brain scan using magnetic resonance imaging (MRI). This is done to investigate the brain and its functioning.

Examination of the skeleton. This is done to get the information on bone tissue damage caused by cancer. Usually, patients with multiple myeloma have signs of bone damage. The procedure involves obtaining X-ray images of the large bones of the body.

Bone marrow biopsy. A bone marrow puncture includes harvesting a small sample of bone marrow from the pelvic bone. The pelvic bone is anesthetized, a needle is inserted into the marrow, and a small amount of the marrow is harvested.

Treatment with CAR T-cell therapy

CAR T-cell therapy is to some extent a hybrid method that combines the techniques of immunotherapy and genetic engineering.

In the immunotherapy part of CAR T-cell therapy, immunocompetent cells T-lymphocytes are extracted from the patient's peripheral blood. Being returned to the patient’s blood after the genetic modification, they activate antitumor immune mechanisms.

In the genetic engineering part of CAR T-cell therapy, T-cells are sent to the laboratory, where a new gene is added to them. This process is called a genetic modification. The new gene helps them find and destroy cancer cells. Once this new gene is added, the T-cells are called CAR T-cells.

When the CAR T-cells are ready, cancer patients receive low doses of chemotherapy. Chemotherapy is not given with the purpose of cancer cells being treated but helps to prepare the body for maximum efficiency of CAR T-cell therapy. When the body is ready, CAR T-cells are injected into the bloodstream.

CAR T-cell therapy is performed in hospitals, as it requires certain preparation and monitoring of the patient's condition after the procedure.

During the first visit, the cancer patient sees a doctor and other specialists from the CAR T-cell therapy team. The doctor will review the medical history, conduct a physical examination, and discuss the most appropriate medical treatment regimen. A doctor also discusses this plan with other CAR T-cell therapy doctors so that they can work together to agree on the best option for the medical treatment of cancer patients.

The patient will visit the blood donor office to see if the diameter of the veins allows collecting T-cells from a vein in the arm. If the veins are not wide enough, a special type of intravenous (IV) catheter designed for the leukapheresis procedure will be used to collect T-cells.

The blood donor office staff will tell the healthcare team if a cancer patient needs a leukapheresis catheter. If needed, the medical team will provide the patient with additional information.

The patient is supervised by a medical team throughout the whole duration of CAR T-cell therapy.

Medical treatment of leukemia with CAR T-cell therapy

Previously, CAR T-cell therapy in the treatment of leukemia was used only in the US hospitals. Today, the qualifications of specialists and the availability of a technical base allow applying the method in European hospitals.

The results of clinical trials and the application of this type of immunotherapy in medical treatment speak for themselves – in 70% of cases, it is possible to achieve positive dynamics of the cancer course or prolonged remission, which is equivalent to a cure. In the medical treatment of acute lymphoblastic leukemia, which mainly affects children from one to six years of age, success rates reach 80-90%, depending on the child's age and the stage of cancer.

Cancer treatment takes about a month. The actual procedure of CAR T-cell therapy resembles a blood transfusion. At the first stage, a comprehensive diagnostic examination is carried out to determine indications and possible contraindications for treatment. During the second stage, lymphocytes are separated from the patient's blood. Over the next two weeks, specialists artificially multiply cells in the laboratory and integrate chimeric receptors in them to fight leukemia and lymphoma.

At this time, the patient undergoes chemotherapy aimed at suppressing his own immunity. This will subsequently increase the activity of artificial cells and allow them to kill cancer cells more efficiently. The number of artificial cells is relatively low and amounts to 1 million per 1 kg of body weight. Once they enter the body, they continue to multiply and destroy malignant cells.

After the administration of cells with chimeric receptors, the patient stays in the clinic for another two weeks, under the supervision of specialists to assess the effectiveness of medical treatment and side effects. As a rule, possible side effects are similar to the symptoms of the flu and manifest themselves as chills, muscle pain, fever, migraines, and seizures.

Side effects of CAR T-cell therapy

The most common side effects of CAR T-cell therapy are:

  • Flu-like symptoms: high fever, chills, low blood pressure, muscle or joint pain, shortness of breath, and quickening of the heartbeat
  • Neurological disorders such as confusion, fatigue, seizures, restlessness, aphasia (impaired speech or understanding of speech), encephalopathy (impaired brain function)
  • Anemia (low red blood cell count)
  • Neutropenia (low leukocyte count in the blood)

The severity of these symptoms ranges from mild to severe one. Potential side effects of the procedure may require the administration of additional medications and prolongation of the hospital stay.

Where can I undergo CAR T-cell therapy abroad?

Health tourism is becoming more and more popular these days, as medicine abroad often ensures a much better quality of CAR T-cell therapy.

The following hospitals show the best success rates in CAR T-cell therapy:

  1. University Hospital Ulm, Germany
  2. University Hospital Freiburg, Germany
  3. Sheba Medical Center Ramat Gan, Israel
  4. University Hospital Frankfurt am Main, Germany
  5. University Hospital Heidelberg, Germany

You can find more information about the hospitals on the Booking Health website.

The cost of treatment with CAR T-cell therapy

The prices in hospitals listed on the Booking Health website are relatively low. With Booking Health, you can undergo CAR T-cell therapy at an affordable price.

The cost of treatment varies, as the price depends on the hospital, the specifics of the disease, and the complexity of its treatment.

The cost of treatment with CAR T-cell therapy in Germany starts from 556,000 EUR, depending on the diagnosis.

You might want to consider the cost of possible additional procedures and follow-up care. Therefore, the ultimate cost of treatment may differ from the initial price.

To make sure that the overall cost of treatment is suitable for you, contact us by leaving the request on the Booking Health website.

How can I undergo CAR T-cell therapy abroad?

It is not easy to self-organize any treatment abroad. It requires certain knowledge and expertise. Thus, it is safer, easier, and less stressful to use the services of a medical tourism agency.

As the largest and most transparent medical tourism agency in the world, Booking Health has up-to-date information about the CAR T-cell therapy in the best hospitals in the world. We will help you select the right clinic taking into account your wishes for treatment.

We want to help you and take on all the troubles. You can be free of unnecessary stress, while Booking Health takes care of all organizational issues regarding the treatment. Our services are aimed at undergoing CAR T-cell therapy safely and successfully.

Medical tourism can be easy! All you need to do is to leave a request on the Booking Health website, and our manager will contact you shortly.

Author: Dr. Nadezhda Ivanisova




Feedback of our customers from other resources

Need Help?

Thank you!

We received your treatment application in the best Europe clinics. Our manager will contact you within the next 24 hours.