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Treatment of CAR T-cell Therapy in Germany

Due to the difficulties associated with the organization of treatment in Turkey, Switzerland, South Korea and India, we are not currently processing requests to these regions.

If you are interested in treatment in Germany, please leave a request and our specialists will contact you as soon as possible.

 

Cost for treatment

Treatment of acute lymphoblastic leukemia (ALL) with CAR T-cell therapy
81970
Treatment of acute myeloid leukemia (AML) with CAR T-cell therapy
81970
Treatment of Non-Hodgkin lymphoma (B-cell) with CAR T-cell therapy
81970

University Hospital Ulm

8.7/10
location_onGermany, Ulm

Department of Hematology, Oncology, Palliative Care, Rheumatology and Infectology

The University Hospital Ulm started its activities 35 years ago and during this time it has become one of the most prestigious medical institutions in Europe. The hospital is famous for its numerous discoveries and the world-class achievements in medicine and pharmaceuticals. The medical facility has 29 specialized departments a
Treatment of acute lymphoblastic leukemia (ALL) with CAR T-cell therapy
556368
Treatment of acute myeloid leukemia (AML) with CAR T-cell therapy
556463
Treatment of Non-Hodgkin lymphoma (B-cell) with CAR T-cell therapy
556390

University Hospital Freiburg

9.7/10
location_onGermany, Freibung

Department of Hematology and Oncology

The University Hospital Freiburg is famous for its rich history and is one of the oldest and most prestigious medical facilities in Germany (one of the three best medical institutions in the country). The hospital was based on the Faculty of Medicine of the Albert Ludwig University of Freiburg, which celebrated its 550th anniver
Treatment of acute lymphoblastic leukemia (ALL) with CAR T-cell therapy
596567
Treatment of acute myeloid leukemia (AML) with CAR T-cell therapy
596620
Treatment of Non-Hodgkin lymphoma (B-cell) with CAR T-cell therapy
596288

University Hospital Frankfurt am Main

10/10
location_onGermany, Frankfurt am Main

Department of Hematology, Oncology, Hemostaseology, Rheumatology and Infectology

According to the reputable Focus magazine, the University Hospital Frankfurt am Main ranks among the top German medical facilities! The hospital was founded in 1914 and today is a well-known German medical facility, which combines rich traditions and scientific innovations. A medical team of more than 6,500 employees cares about
Treatment of acute lymphoblastic leukemia (ALL) with CAR T-cell therapy
516094
Treatment of acute myeloid leukemia (AML) with CAR T-cell therapy
516538
Treatment of Non-Hodgkin lymphoma (B-cell) with CAR T-cell therapy
516381

University Hospital Heidelberg

9.8/10
location_onGermany, Heidelberg

Department of Hematology, Oncology, Adult and Pediatric Rheumatology

According to Focus magazine, the University Hospital Heidelberg ranks among the top five hospitals in Germany! The hospital is one of the most advanced and reputable medical institutions not only in Germany, but throughout Europe. There are more than 43 specialized departments and 13 medical institutes, which cover all fields of
Treatment of acute lymphoblastic leukemia (ALL) with CAR T-cell therapy
0
Treatment of acute myeloid leukemia (AML) with CAR T-cell therapy
0
Treatment of Non-Hodgkin lymphoma (B-cell) with CAR T-cell therapy
0

University Hospital Würzburg

9.2/10
location_onGermany, Würzburg

Department of Gastroenterology, Hematology, Oncology, Hepatology, Infectology, Rheumatology and Clinical Immunology

According to the Focus magazine in 2019, the University Hospital Würzburg ranks among the top national German hospitals! The hospital is one of the oldest medical facilities in Germany. The centuries-old traditions of first-class treatment are combined with the very latest achievements of modern evidence-based medicine and
Treatment of acute lymphoblastic leukemia (ALL) with CAR T-cell therapy
476528
Treatment of acute myeloid leukemia (AML) with CAR T-cell therapy
476383
Treatment of Non-Hodgkin lymphoma (B-cell) with CAR T-cell therapy
476293

University Hospital RWTH Aachen

8.7/10
location_onGermany, Aachen

Department of Oncology and Hematology

According to the prestigious Focus magazine, the University Hospital RWTH Aachen ranks among the top German hospitals! As a maximum care university medical facility, the hospital guarantees patients first-class medical services combined with a respectful and human attitude. The hospital integrates all the modern options for the
Treatment of acute lymphoblastic leukemia (ALL) with CAR T-cell therapy
596670
Treatment of acute myeloid leukemia (AML) with CAR T-cell therapy
596677
Treatment of Non-Hodgkin lymphoma (B-cell) with CAR T-cell therapy
596714

University Hospital Erlangen

9.1/10
location_onGermany, Erlangen

Department of Hematology and Oncology

According to the Focus magazine, University Hospital Erlangen ranks among the best medical facilities in Germany! The hospital is one of the leading healthcare facilities in Bavaria and offers top-class medical care distinguished by the close intertwining of clinical activities with research and training of medical students. The
Treatment of acute lymphoblastic leukemia (ALL) with CAR T-cell therapy
556601
Treatment of acute myeloid leukemia (AML) with CAR T-cell therapy
556498
Treatment of Non-Hodgkin lymphoma (B-cell) with CAR T-cell therapy
556698

University Hospital Halle (Saale)

9.6/10
location_onGermany, Halle

Department of Hematology and Oncology

According to the prestigious Focus magazine, the University Hospital Halle (Saale) ranks among the top German medical facilities! The history of the hospital has more than 300 years, and during this time it managed to earn an excellent reputation not only in Germany, but throughout the world. The hospital positions itself as a s
Treatment of acute lymphoblastic leukemia (ALL) with CAR T-cell therapy
476373
Treatment of acute myeloid leukemia (AML) with CAR T-cell therapy
476207
Treatment of Non-Hodgkin lymphoma (B-cell) with CAR T-cell therapy
476457

University Hospital Hamburg-Eppendorf

9.2/10
location_onGermany, Hamburg

Department of Hematology, Oncology and Pulmonology

According to the Focus magazine, the University Hospital Hamburg-Eppendorf ranks among the top ten hospitals in Germany! Since its foundation in 1889, the hospital has taken a leading position in the European medical arena and still occupies it until today. A highly competent medical team of more than 11,000 employees takes care
Treatment of acute lymphoblastic leukemia (ALL) with CAR T-cell therapy
476318
Treatment of acute myeloid leukemia (AML) with CAR T-cell therapy
476290
Treatment of Non-Hodgkin lymphoma (B-cell) with CAR T-cell therapy
476076

University Hospital Bonn

9.2/10
location_onGermany, Bonn

Department of Oncology, Hematology, Rheumatology and Immunoncology

According to the authoritative Focus magazine, the University Hospital Bonn ranks among the top ten medical facilities in Germany! The hospital was opened on January 1, 2001, although in fact it inherits the medical facility, which operated at the Faculty of Medicine of the University of Bonn. The hospital in Germany combin
Treatment of acute lymphoblastic leukemia (ALL) with CAR T-cell therapy
596267
Treatment of acute myeloid leukemia (AML) with CAR T-cell therapy
596581
Treatment of Non-Hodgkin lymphoma (B-cell) with CAR T-cell therapy
596682

University Hospital of Ludwig Maximilian University of Munich

10/10
location_onGermany, Munich

Department of Oncology and Hematology

According to the Focus magazine, the University Hospital of Ludwig Maximilian University of Munich is regularly ranked among the best medical institutions in Germany! The hospital is the largest multidisciplinary medical facility, as well as a leading research and training center in Germany and Europe. The hospital is proud of i
Treatment of acute lymphoblastic leukemia (ALL) with CAR T-cell therapy
596727
Treatment of acute myeloid leukemia (AML) with CAR T-cell therapy
596365
Treatment of Non-Hodgkin lymphoma (B-cell) with CAR T-cell therapy
596183

University Hospital Giessen UKGM

9.5/10
location_onGermany, Giessen

Department of Oncology, Hematology and Palliative Care

The University Hospital Giessen UKGM positions itself as an ultramodern medical facility with outstanding quality of medical care. The hospital presents almost all areas of medicine, ranging from ophthalmology to traumatology and dentistry. The priorities of the hospital’s activities include surgery, neurosurgery, oncology
Treatment of acute lymphoblastic leukemia (ALL) with CAR T-cell therapy
476293
Treatment of acute myeloid leukemia (AML) with CAR T-cell therapy
476341
Treatment of Non-Hodgkin lymphoma (B-cell) with CAR T-cell therapy
476525

University Hospital Muenster

9.8/10
location_onGermany, Muenster

Department of Hematology, Hemostaseology, Oncology and Pulmonology

According to the Focus magazine, the University Hospital Muenster ranks among the top German hospitals! The hospital belongs to the most prestigious medical institutions in Germany. The hospital is distinguished by a high professionalism of its doctors, state-of-the-art technological equipment and the availability of the most ad
Treatment of acute lymphoblastic leukemia (ALL) with CAR T-cell therapy
476292
Treatment of acute myeloid leukemia (AML) with CAR T-cell therapy
476504
Treatment of Non-Hodgkin lymphoma (B-cell) with CAR T-cell therapy
476205

University Hospital Marburg UKGM

8.6/10
location_onGermany, Marburg

Department of Hematology, Oncology and Immunology

The University Hospital Marburg UKGM offers patients modern diagnostics and comprehensive therapy at the international level. As a maximum care hospital, the medical facility specializes in all fields of modern medicine ranging from ophthalmology to traumatology and dentistry. The main areas of specialization of the hospital are
Treatment of acute lymphoblastic leukemia (ALL) with CAR T-cell therapy
476576
Treatment of acute myeloid leukemia (AML) with CAR T-cell therapy
476651
Treatment of Non-Hodgkin lymphoma (B-cell) with CAR T-cell therapy
476612

University Hospital Jena

8.9/10
location_onGermany, Jena

Department of Hematology and Oncology

According to the prestigious Focus magazine, the University Hospital Jena regularly ranks among the top German medical facilities! The hospital has positioned itself as a multidisciplinary medical facility with a long history of more than 200 years. Since its foundation, the hospital has been constantly developing and modernizin
Treatment of acute lymphoblastic leukemia (ALL) with CAR T-cell therapy
476610
Treatment of acute myeloid leukemia (AML) with CAR T-cell therapy
476563
Treatment of Non-Hodgkin lymphoma (B-cell) with CAR T-cell therapy
476250

University Hospital Rechts der Isar Munich

9.8/10
location_onGermany, Munich

Department of Hematology and Oncology

The University Hospital Rechts der Isar Munich was founded in 1834. It combines long traditions with the very latest advances in modern medicine. The medical facility includes 33 specialized departments and 20 interdisciplinary centers, where patients can receive top-class medical care in all medical fields. The hospital annuall
Treatment of acute lymphoblastic leukemia (ALL) with CAR T-cell therapy
596624
Treatment of acute myeloid leukemia (AML) with CAR T-cell therapy
596271
Treatment of Non-Hodgkin lymphoma (B-cell) with CAR T-cell therapy
596518
| from Booking Health GmbH

Content

  1. CAR T-cell therapy overview
  2. Indications
  3. Stages
  4. Side effects of CAR T-cell therapy
  5. Where can I undergo CAR T-cell therapy treatment in Germany?
  6. The cost of treatment in Germany
  7. How can I undergo CAR T-cell therapy treatment in Germany?

CAR T-cell therapy is a treatment that teaches the patient's own cells to destroy cancer cells. This is a treatment method that allows complete individualized treatment for acute lymphoblastic leukemia – the most common type of cancer in children.

CAR T-cell therapy overview

 

The idea of using the mechanisms of immunity to treat malignant diseases has been around for over a hundred years. It has always been known that in the body of any person there are special cells – T-lymphocytes, NK-cells (natural killer cells), and macrophages – that are capable of recognizing and destroying pathologically altered cells. For a long time, scientists have tried to understand why anti-tumor immunity does not work well enough and tried to find ways to strengthen its activity.

In recent years, it became clear that, firstly, many tumors have defense mechanisms against the action of cells of the immune system. Secondly, malignant cells are just slightly different in their immunological properties from normal ones, that is, it is difficult for immune cells to distinguish them. The first problem was partially solved with discovering inhibitors with the help of which tumor cells suppress the activation of T-lymphocytes. The information about inhibitors have revolutionized the treatment of patients with skin tumors – melanoma. However, this approach was not effective for all types of tumors.

The development of CAR T-cell therapy, as a type of cell therapies, combines the latest advances in molecular biology, genetic engineering, and biotechnology. This made it possible to make tumor cells visible for the immune system.

CAR T-cell therapy (chimeric antigen receptor T-cell, or T-cells with a chimeric antigen receptors) includes the extraction of T-lymphocytes (cells belonging to the immune system) from the patient's body with the help of apheresis – a technology that separates the blood into components and gets a certain number of lymphocytes. Then the cells are modified so that they can recognize and attack tumor cells, and they are injected back into the patient's body so that, after reprogramming, they recognize, attack, and destroy cancer cells.

Leukemia and B-cell lymphomas resulting from pathological changes or malignant transformation of B-lymphocytes have a common feature – they produce a protein or antigen called CD19. When leukemia and B-cell lymphoma develop, lymphocytes cannot recognize their antigens and, as a result, cannot attack and prevent cancer cells from multiplying. With the help of genetic engineering, it is possible to reprogram lymphocytes and introduce new genetic information into them. After that, these cells start expressing a chimeric receptor, or CAR T, which will recognize the tumor antigen and destroy malignant cells. CAR T-cell therapy for patients with certain types of relapsed/refractory large B-cell lymphoma after at least two other kinds of therapies has been approved internationally.

CAR T-cell therapy combines three types of progressive therapies: cell therapy, immunotherapy, and gene therapy. It is considered a cell therapy because the patients are not given a drug, but receive their natural modified cells. It is also immunotherapy, as the cells of the immune system fight against cancer cells. Finally, this is a gene therapy method (one of the therapies to be approved by the FDA), since lymphocytes are genetically modified to fight the disease.

Indications

 

CAR T-cell therapy treatment is currently prescribed for pediatric and young adult patients under 25 years of age with refractory B-cell lymphoma and acute lymphoblastic leukemia with a poor prognosis. CAR T-cell therapy is indicated for patients with leukemia who have had at least one relapse after bone marrow transplantation, or two to three relapses after using other therapies. In general, we are talking about patients who cannot achieve a response to treatments and cannot choose a therapeutic method among traditional ones (chemotherapy and bone marrow transplantation).

Also, CAR T-cell therapy is indicated for patients with diffuse large B-cell lymphoma with relapse or initial absence of a satisfactory response to therapies and recurrent acute lymphoblastic leukemia in young patients (under the age of 25).

Stages

 

  • Apheresis.

During the patient's hospital stay, white blood cells are removed from the blood using an extraction system (leukapheresis). These cells are sent for modification and subsequent cultivation in the laboratory.

  • Cellular reprogramming.

Immune cells (T-lymphocytes) are genetically modified to recognize cancer cells, as well as other cells that express the specific antigen.

  • Reproduction.

The modified T-cells are multiplied, frozen, and sent to the patient's hospital after going through a rigorous quality control process.

  • Patient’s preparation.

The patient receives chemotherapy to promote the proliferation and antitumor action of CAR T-cells. The ultimate goal is to help the body accept reprogrammed CAR T-cells.

  • Infusion.

Modified T-cells are administered by intravenous infusion, similar to a blood transfusion.

  • Cell attack.

If the CAR T-cell therapy works as planned, it attacks the malignant cells and begins to destroy the cancer antigens once the CAR T-cell concentrate enters the patient's bloodstream.

  • Monitoring.

In 30-40% of patients who received CAR T-cell therapy, unwanted side effects are possible. In some cases, they are not severe, but sometimes they require treatment and additional medical care.

  • Observation and results.

The information in the medical literature indicates that more than 80% of patients who received this new therapy went into remission in the first three months after treatment.

Side effects of CAR T-cell therapy

 

The activation process of CAR T-cells can cause side effects known as cytokine release syndrome. It includes high fever, increased heart rate, low blood pressure, and low blood oxygen levels. After infusion of CAR T-cells, some patients may also experience temporary neurological deficits such as confusion and even communication difficulties.

Due to side effects, patients must spend some time in hospitals. Some patients may even stay in the intensive care unit. And for about a month or more after the infusion of CAR T-cells, the patient needs medical supervision.

The therapy is accompanied by certain side effects, so the patient will need hospitalization and specialist supervision. In general, side effects resemble those of the severe flu: high fever, chills, high blood pressure, shortness of breath. In some cases, neurological symptoms may appear, such as headaches, seizures, and, very rarely, cerebral edema.

The severity of side effects is connected with the severity of the initial malignant condition. With extensive bone marrow damage, the chance of recovery is lower, and the risk of side effects is higher. In such situations, it is advisable to prescribe the patient a preliminary course of chemotherapy to reduce the tumor mass, and only then immunotherapy starts.

According to the results of CAR T-cell therapy, the chance of a complete cure from acute lymphoblastic leukemia (the most common cancer in children) is 90%. In cell lymphoma – a disease more typical for adults – the same figure is 70%.

This treatment is quite difficult and is therefore only available in certified hospitals. But if a patient is diagnosed with a type of cancer that does not respond well to conventional treatment, it is worth exploring the possibility of participating in a clinical trial that uses CAR T-cell therapy.

Where can I undergo CAR T-cell therapy treatment in Germany?

 

Health tourism is becoming more and more popular these days, as medicine in Germany often ensures a much better quality of CAR T-cell therapy.

The following hospitals show the best success rates in treatment with CAR T-cell therapy:

  1. University Hospital Ulm, Germany
  2. University Hospital Freiburg, Germany
  3. University Hospital Frankfurt am Main, Germany
  4. University Hospital Heidelberg, Germany
  5. University Hospital Wurzburg, Germany

You can find more information about the European hospitals on the Booking Health website.

The cost of treatment in Germany

 

The prices in hospitals listed on the Booking Health website are relatively low. With Booking Health, you can undergo CAR T-cell therapy treatment in Germany at an affordable price.

The cost of treatment in Germany varies, as the prices depend on the hospitals, the specifics of the disease, and the complexity of its treatment.

The cost of treatment of B-cell lymphoma with CAR T-cell therapy starts from 436,000 EUR.

You might want to consider the cost of possible additional procedures and follow-up care. Therefore, the ultimate cost of treatment in Germany may differ from the initial price.

To make sure that the overall cost of treatment in Germany is suitable for you, contact us by leaving the request on the Booking Health website.

How can I undergo CAR T-cell therapy treatment in Germany?

 

It is not easy to self-organize any treatment abroad. It requires certain knowledge and expertise. Thus, it is safer, easier, and less stressful to use the services of a medical tourism agency.

As the largest and most transparent medical tourism agency in the world, Booking Health has up-to-date information about the treatment with CAR T-cell therapy in the best hospitals in Germany. We will help you select the right clinic taking into account your wishes for treatment.

We want to help you and take on all the troubles. You can be free of unnecessary stress, while Booking Health takes care of all organizational issues regarding the treatment in German hospitals. Our services are aimed at undergoing CAR T-cell therapy safely and successfully.

Medical tourism can be easy! All you need to do is to leave a request on the Booking Health website, and our manager will contact you shortly.

Authors: Dr. Nadezhda Ivanisova, Dr. Sergey Pashchenko




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