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Treatment of Chronic Lymphocytic Leukemia (CLL) in Germany

Due to the difficulties associated with the organization of treatment in Turkey, Switzerland, South Korea and India, we are not currently processing requests to these regions.

If you are interested in treatment in Germany, please leave a request and our specialists will contact you as soon as possible.

 

Cost for treatment

Chronic lymphocytic leukemia (CLL) diagnosis
1718
Allogeneic bone marrow transplantation in chronic lymphocytic leukemia
97193
Chemotherapy and immunotherapy in chronic lymphocytic leukemia (CLL) (1 curse)
6142

University Hospital Mannheim

9.8/10
location_onGermany, Mannheim

Department of Hematology and Oncology

According to the reputable Focus magazine, the University Hospital Mannheim ranks among the top medical institutions of Germany, which is an undeniable confirmation of the impeccable medical care and excellent reputation of the hospital! The hospital is a high-tech modern medical institution, which provides accurate diagnosis an
Chronic lymphocytic leukemia (CLL) diagnosis
3225
Allogeneic bone marrow transplantation in chronic lymphocytic leukemia
212310
Chemotherapy and immunotherapy in chronic lymphocytic leukemia (CLL) (1 curse)
10917

University Hospital Ulm

8.7/10
location_onGermany, Ulm

Department of Hematology, Oncology, Palliative Care, Rheumatology and Infectology

The University Hospital Ulm started its activities 35 years ago and during this time it has become one of the most prestigious medical institutions in Europe. The hospital is famous for its numerous discoveries and the world-class achievements in medicine and pharmaceuticals. The medical facility has 29 specialized departments a
Chronic lymphocytic leukemia (CLL) diagnosis
3552
Allogeneic bone marrow transplantation in chronic lymphocytic leukemia
271687
Chemotherapy and immunotherapy in chronic lymphocytic leukemia (CLL) (1 curse)
11935

University Hospital Freiburg

9.7/10
location_onGermany, Freibung

Department of Hematology and Oncology

The University Hospital Freiburg is famous for its rich history and is one of the oldest and most prestigious medical facilities in Germany (one of the three best medical institutions in the country). The hospital was based on the Faculty of Medicine of the Albert Ludwig University of Freiburg, which celebrated its 550th anniver
Chronic lymphocytic leukemia (CLL) diagnosis
3598
Allogeneic bone marrow transplantation in chronic lymphocytic leukemia
291173
Chemotherapy and immunotherapy in chronic lymphocytic leukemia (CLL) (1 curse)
12651

University Hospital Heidelberg

9.8/10
location_onGermany, Heidelberg

Department of Hematology, Oncology, Adult and Pediatric Rheumatology

According to Focus magazine, the University Hospital Heidelberg ranks among the top five hospitals in Germany! The hospital is one of the most advanced and reputable medical institutions not only in Germany, but throughout Europe. There are more than 43 specialized departments and 13 medical institutes, which cover all fields of
Chronic lymphocytic leukemia (CLL) diagnosis
0
Allogeneic bone marrow transplantation in chronic lymphocytic leukemia
0
Chemotherapy and immunotherapy in chronic lymphocytic leukemia (CLL) (1 curse)
0

University Hospital Frankfurt am Main

10/10
location_onGermany, Frankfurt am Main

Department of Hematology, Oncology, Hemostaseology, Rheumatology and Infectology

According to the reputable Focus magazine, the University Hospital Frankfurt am Main ranks among the top German medical facilities! The hospital was founded in 1914 and today is a well-known German medical facility, which combines rich traditions and scientific innovations. A medical team of more than 6,500 employees cares about
Chronic lymphocytic leukemia (CLL) diagnosis
3373
Allogeneic bone marrow transplantation in chronic lymphocytic leukemia
251809
Chemotherapy and immunotherapy in chronic lymphocytic leukemia (CLL) (1 curse)
11541

University Hospital RWTH Aachen

8.7/10
location_onGermany, Aachen

Department of Oncology and Hematology

According to the prestigious Focus magazine, the University Hospital RWTH Aachen ranks among the top German hospitals! As a maximum care university medical facility, the hospital guarantees patients first-class medical services combined with a respectful and human attitude. The hospital integrates all the modern options for the
Chronic lymphocytic leukemia (CLL) diagnosis
3634
Allogeneic bone marrow transplantation in chronic lymphocytic leukemia
291298
Chemotherapy and immunotherapy in chronic lymphocytic leukemia (CLL) (1 curse)
12596

University Hospital Würzburg

9.2/10
location_onGermany, Würzburg

Department of Gastroenterology, Hematology, Oncology, Hepatology, Infectology, Rheumatology and Clinical Immunology

According to the Focus magazine in 2019, the University Hospital Würzburg ranks among the top national German hospitals! The hospital is one of the oldest medical facilities in Germany. The centuries-old traditions of first-class treatment are combined with the very latest achievements of modern evidence-based medicine and
Chronic lymphocytic leukemia (CLL) diagnosis
3095
Allogeneic bone marrow transplantation in chronic lymphocytic leukemia
232021
Chemotherapy and immunotherapy in chronic lymphocytic leukemia (CLL) (1 curse)
10818

University Hospital Erlangen

9.1/10
location_onGermany, Erlangen

Department of Hematology and Oncology

According to the Focus magazine, University Hospital Erlangen ranks among the best medical facilities in Germany! The hospital is one of the leading healthcare facilities in Bavaria and offers top-class medical care distinguished by the close intertwining of clinical activities with research and training of medical students. The
Chronic lymphocytic leukemia (CLL) diagnosis
3450
Allogeneic bone marrow transplantation in chronic lymphocytic leukemia
271338
Chemotherapy and immunotherapy in chronic lymphocytic leukemia (CLL) (1 curse)
12051

University Hospital Halle (Saale)

9.6/10
location_onGermany, Halle

Department of Hematology and Oncology

According to the prestigious Focus magazine, the University Hospital Halle (Saale) ranks among the top German medical facilities! The history of the hospital has more than 300 years, and during this time it managed to earn an excellent reputation not only in Germany, but throughout the world. The hospital positions itself as a s
Chronic lymphocytic leukemia (CLL) diagnosis
3204
Allogeneic bone marrow transplantation in chronic lymphocytic leukemia
231907
Chemotherapy and immunotherapy in chronic lymphocytic leukemia (CLL) (1 curse)
10661

University Hospital Hamburg-Eppendorf

9.2/10
location_onGermany, Hamburg

Department of Hematology, Oncology and Pulmonology

According to the Focus magazine, the University Hospital Hamburg-Eppendorf ranks among the top ten hospitals in Germany! Since its foundation in 1889, the hospital has taken a leading position in the European medical arena and still occupies it until today. A highly competent medical team of more than 11,000 employees takes care
Chronic lymphocytic leukemia (CLL) diagnosis
3224
Allogeneic bone marrow transplantation in chronic lymphocytic leukemia
232317
Chemotherapy and immunotherapy in chronic lymphocytic leukemia (CLL) (1 curse)
10884

Charite University Hospital Berlin

9/10
location_onGermany, Berlin

Charité Comprehensive Cancer Center

According to the authoritative Focus magazine, the Charite University Hospital Berlin occupies the first place in the rating of the top German medical facilities! The hospital is one of the largest and leading university medical complexes in Europe. The hospital in Germany provides modern diagnostics and treatment of patients, a
Chronic lymphocytic leukemia (CLL) diagnosis
3207
Allogeneic bone marrow transplantation in chronic lymphocytic leukemia
231900
Chemotherapy and immunotherapy in chronic lymphocytic leukemia (CLL) (1 curse)
10694

University Hospital Bonn

9.2/10
location_onGermany, Bonn

Department of Oncology, Hematology, Rheumatology and Immunoncology

According to the authoritative Focus magazine, the University Hospital Bonn ranks among the top ten medical facilities in Germany! The hospital was opened on January 1, 2001, although in fact it inherits the medical facility, which operated at the Faculty of Medicine of the University of Bonn. The hospital in Germany combin
Chronic lymphocytic leukemia (CLL) diagnosis
3636
Allogeneic bone marrow transplantation in chronic lymphocytic leukemia
291069
Chemotherapy and immunotherapy in chronic lymphocytic leukemia (CLL) (1 curse)
12718

University Hospital Giessen UKGM

9.5/10
location_onGermany, Giessen

Department of Oncology, Hematology and Palliative Care

The University Hospital Giessen UKGM positions itself as an ultramodern medical facility with outstanding quality of medical care. The hospital presents almost all areas of medicine, ranging from ophthalmology to traumatology and dentistry. The priorities of the hospital’s activities include surgery, neurosurgery, oncology
Chronic lymphocytic leukemia (CLL) diagnosis
3142
Allogeneic bone marrow transplantation in chronic lymphocytic leukemia
231728
Chemotherapy and immunotherapy in chronic lymphocytic leukemia (CLL) (1 curse)
10689

University Hospital of Ludwig Maximilian University of Munich

10/10
location_onGermany, Munich

Department of Oncology and Hematology

According to the Focus magazine, the University Hospital of Ludwig Maximilian University of Munich is regularly ranked among the best medical institutions in Germany! The hospital is the largest multidisciplinary medical facility, as well as a leading research and training center in Germany and Europe. The hospital is proud of i
Chronic lymphocytic leukemia (CLL) diagnosis
3677
Allogeneic bone marrow transplantation in chronic lymphocytic leukemia
290955
Chemotherapy and immunotherapy in chronic lymphocytic leukemia (CLL) (1 curse)
12527

University Hospital Marburg UKGM

8.6/10
location_onGermany, Marburg

Department of Hematology, Oncology and Immunology

The University Hospital Marburg UKGM offers patients modern diagnostics and comprehensive therapy at the international level. As a maximum care hospital, the medical facility specializes in all fields of modern medicine ranging from ophthalmology to traumatology and dentistry. The main areas of specialization of the hospital are
Chronic lymphocytic leukemia (CLL) diagnosis
3272
Allogeneic bone marrow transplantation in chronic lymphocytic leukemia
232303
Chemotherapy and immunotherapy in chronic lymphocytic leukemia (CLL) (1 curse)
10568

University Hospital Muenster

9.8/10
location_onGermany, Muenster

Department of Hematology, Hemostaseology, Oncology and Pulmonology

According to the Focus magazine, the University Hospital Muenster ranks among the top German hospitals! The hospital belongs to the most prestigious medical institutions in Germany. The hospital is distinguished by a high professionalism of its doctors, state-of-the-art technological equipment and the availability of the most ad
Chronic lymphocytic leukemia (CLL) diagnosis
3086
Allogeneic bone marrow transplantation in chronic lymphocytic leukemia
232020
Chemotherapy and immunotherapy in chronic lymphocytic leukemia (CLL) (1 curse)
10614
| from Booking Health GmbH

Chronic lymphoblastic leukemia is the most common type of leukemia in adults and occasionally occurs in children. Chronic leukemia is not as aggressive as acute leukemia, but it is more difficult to cure completely. The treatment of pathology mainly involves drug therapies; less often, doctors resort to splenectomy, radiation therapy and stem cell transplantation.

Content

  1. Main treatment methods
  2. Complementary treatment methods

In most cases, drug therapy is indicated. Doctors use medications that are administered intravenously or taken orally in the form of pills and capsules. Sometimes irradiation, spleen removal surgery, leukapheresis, and allogeneic stem cell transplantation are required.

You can go to the University Hospital Freiburg, the University Hospital Heidelberg, or the University Hospital Frankfurt am Main.

You do not have to organize your trip on your own. The specialists of Booking Health company will take care of your treatment arrangement in Germany.

Main treatment methods

 

Chemotherapy is the main treatment for chronic lymphoblastic leukemia in adults and children. Physicians use purine analogs, glucocorticoids, and alkylating agents. The treatment is carried out in cycles of 3-4 weeks.

Monoclonal antibodies usually complement chemotherapy. Doctors use antibodies that target these molecular targets:

  • CD20 is the primary, most commonly used drug. Some drugs are given immediately, and others are used as second-line therapy.
  • CD52 is used when patients no longer respond to other treatments.
  • CD22 – drugs targeting this antigen are used to treat patients with hairy cell leukemia. Physicians use an antibody-drug conjugate. Antibodies deliver chemotherapy agents directly to cancer cells.

Targeted therapy involves using drugs that target particular molecular targets in cancer cells. Some targeted therapy drugs are combined with chemotherapy to treat patients initially. The following groups of drugs are used in Germany:

  • Bruton's tyrosine kinase inhibitors (they are often used as first-line drugs and also successfully cope with recurrences of chronic leukemia and are used for chromosome 17 deletion);
  • PI3K inhibitors are used in cases where other therapy options do not work;
  • specific inhibitors of Bcl-2 protein (BH3 mimetics).

Stem cell transplantation is used for severe types of leukemia: with deletions of chromosome 17 and TP53 mutations, no response to chemotherapy. Doctors conduct high-dose chemotherapy to destroy all cancer cells in the body and then perform stem cell transplantation to restore the bone marrow. In the case of leukemia, allogeneic cell transplantation from a donor is more often performed.

Complementary treatment methods

 

Splenectomy is a rarely performed operation for chronic lymphocytic leukemia, which can relieve the symptoms of the disease. With this pathology, the spleen can greatly increase in size, and in this case, it begins to compress the adjacent organs. Doctors first try to shrink the spleen with drugs and irradiation, and if this fails or if acute complications develop, surgery becomes an option of choice. After splenectomy, the number of cells in the blood increases, and the need for blood transfusions decreases. Splenectomy is most effective in patients with hairy cell leukemia. However, the treatment method also has disadvantages: a weakened immune system and an increased risk of infection.

Radiation therapy is used infrequently. It is used when necessary to quickly suppress symptoms, for example, caused by an enlarged spleen. When the neoplasm spreads to the bones, radiation helps to relieve pain and prevent bone fractures. In addition, total body irradiation is carried out along with high-dose chemotherapy before stem cell transplantation.

Leukapheresis is performed in case of blood thickening due to the accumulation of many pathological white blood cells. This procedure is required to prevent respiratory and heart failure. During the procedure, blood is passed through a special apparatus that selects excess cells. Manipulation takes several hours. It is usually performed before the start of chemotherapy.

Maintenance therapy eliminates not the disease itself but its consequences. Doctors use intravenous immunoglobulin, antibiotics, vaccines, and antivirals to prevent and treat infections. With a low level of platelets and red blood cells, blood and its components are transfused. Doctors also use medications that increase the production of red blood cells. In the case of the development of hemolytic anemia during the treatment of chronic lymphoblastic leukemia, glucocorticoid therapy is performed to suppress autoimmune reactions.

To undergo treatment for chronic lymphoblastic leukemia in Germany, please use the Booking Health service. Our website presents information on how much the price of treatment is. You are welcome to compare the cost of treatment and diagnostics in different clinics in Germany to book a medical care program at affordable prices. The Booking Health specialists will help you choose a medical center and arrange your trip.

 

Authors: 

The article was edited by medical experts, board certified doctors Dr. Vadim Zhiliuk and Dr. Sergey Pashchenko. For the treatment of the conditions referred to in the article, you must consult a doctor; the information in the article is not intended for self-medication!

 

Sources:

National Cancer Institute

Cancer Research Institute

Sience Direct




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