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Treatment of Duchenne Muscular Dystrophy

Due to the difficulties associated with the organization of treatment in Turkey, Switzerland, South Korea and India, we are not currently processing requests to these regions.

If you are interested in treatment in Germany, please leave a request and our specialists will contact you as soon as possible.

 

Cost for treatment

Duchenne Muscular Dystrophy Diagnosis
986
Diagnosis and conservative treatment of duchenne muscular dystrophy
3829
Neurological rehabilitation Phase C
540

Charite University Hospital Berlin

9/10
location_onGermany, Berlin

Department of Neurology

According to the authoritative Focus magazine, the Charite University Hospital Berlin occupies the first place in the rating of the top German medical facilities! The hospital is one of the largest and leading university medical complexes in Europe. The hospital in Germany provides modern diagnostics and treatment of patients, a
Duchenne Muscular Dystrophy Diagnosis
4762
Diagnosis and conservative treatment of duchenne muscular dystrophy
16967

Beta Klinik Bonn

9.7/10
location_onGermany, Bonn

Department of Neurology and Epileptology

Beta Klinik is a modern hospital which consists of 30 specialized departments. The hospital is equipped with the state-of-the-art equipment of the university level. The operating rooms, an intensive care unit and the rehabilitation center correspond to the highest standards. It also concerns highly qualified physicians of the ho
Duchenne Muscular Dystrophy Diagnosis
3537
Diagnosis and conservative treatment of duchenne muscular dystrophy
11616

University Hospital Ulm

8.7/10
location_onGermany, Ulm

Department of Neurology

The University Hospital Ulm started its activities 35 years ago and during this time it has become one of the most prestigious medical institutions in Europe. The hospital is famous for its numerous discoveries and the world-class achievements in medicine and pharmaceuticals. The medical facility has 29 specialized departments a
Duchenne Muscular Dystrophy Diagnosis
3630
Diagnosis and conservative treatment of duchenne muscular dystrophy
12057

Bundeswehr Academic Hospital Berlin

10/10
location_onGermany, Berlin

Department of Neurology

The Bundeswehr Academic Hospital Berlin is a modern medical facility that offers first-class medical care in the field of emergency care, traumatology, urology, internal medicine, surgery, neurosurgery, neurology, nuclear medicine and other focuses. The hospital has 15 specialized departments, medical teams of which guarantee th
Duchenne Muscular Dystrophy Diagnosis
3645 help3145
Diagnosis and conservative treatment of duchenne muscular dystrophy
12552 help10552

University Hospital of Ludwig Maximilian University of Munich

10/10
location_onGermany, Munich

Department of Neurology

According to the Focus magazine, the University Hospital of Ludwig Maximilian University of Munich is regularly ranked among the best medical institutions in Germany! The hospital is the largest multidisciplinary medical facility, as well as a leading research and training center in Germany and Europe. The hospital is proud of i
Duchenne Muscular Dystrophy Diagnosis
3846
Diagnosis and conservative treatment of duchenne muscular dystrophy
13012

University Hospital Muenster

9.8/10
location_onGermany, Muenster

Department of General Neurology

According to the Focus magazine, the University Hospital Muenster ranks among the top German hospitals! The hospital belongs to the most prestigious medical institutions in Germany. The hospital is distinguished by a high professionalism of its doctors, state-of-the-art technological equipment and the availability of the most ad
Duchenne Muscular Dystrophy Diagnosis
3409
Diagnosis and conservative treatment of duchenne muscular dystrophy
11618

University Hospital Carl Gustav Carus Dresden

9.1/10
location_onGermany, Dresden

Department of Neurology

According to the prestigious Focus magazine, the University Hospital Carl Gustav Carus Dresden is among the top three hospitals in Germany! The hospital is the embodiment of the standards of modern high-quality medicine. Since the hospital positions itself as a maximum care medical facility, it represents all medical fields. The
Duchenne Muscular Dystrophy Diagnosis
4381
Diagnosis and conservative treatment of duchenne muscular dystrophy
14601

University Hospital RWTH Aachen

9.1/10
location_onGermany, Aachen

Department of Neurology

According to the prestigious Focus magazine, the University Hospital RWTH Aachen ranks among the top German hospitals! As a maximum care university medical facility, the hospital guarantees patients first-class medical services combined with a respectful and human attitude. The hospital integrates all the modern options for the
Duchenne Muscular Dystrophy Diagnosis
3897
Diagnosis and conservative treatment of duchenne muscular dystrophy
12733

University Hospital Heidelberg

9.8/10
location_onGermany, Heidelberg

Department of Neurology

According to the Focus magazine, the University Hospital Heidelberg ranks among the top five hospitals in Germany! The hospital is one of the most advanced and reputable medical institutions not only in Germany, but throughout Europe. There are more than 43 specialized departments and 13 medical institutes, which cover all field
Duchenne Muscular Dystrophy Diagnosis
0
Diagnosis and conservative treatment of duchenne muscular dystrophy
0

University Hospital Frankfurt am Main

10/10
location_onGermany, Frankfurt am Main

Department of Neurology

According to the reputable Focus magazine, the University Hospital Frankfurt am Main ranks among the top German medical facilities! The hospital was founded in 1914 and today is a well-known German medical facility, which combines rich traditions and scientific innovations. A medical team of more than 6,500 employees cares about
Duchenne Muscular Dystrophy Diagnosis
3458
Diagnosis and conservative treatment of duchenne muscular dystrophy
11622

University Hospital Erlangen

9.1/10
location_onGermany, Erlangen

Department of Neurology and Epileptology

According to the Focus magazine, University Hospital Erlangen ranks among the best medical facilities in Germany! The hospital is one of the leading healthcare facilities in Bavaria and offers top-class medical care distinguished by the close intertwining of clinical activities with research and training of medical students. The
Duchenne Muscular Dystrophy Diagnosis
3675
Diagnosis and conservative treatment of duchenne muscular dystrophy
12172

University Hospital Hamburg-Eppendorf

9.2/10
location_onGermany, Hamburg

Department of Neurology

According to the Focus magazine, the University Hospital Hamburg-Eppendorf ranks among the top ten hospitals in Germany! Since its foundation in 1889, the hospital has taken a leading position in the European medical arena and still occupies it until today. A highly competent medical team of more than 11,000 employees takes care
Duchenne Muscular Dystrophy Diagnosis
4392
Diagnosis and conservative treatment of duchenne muscular dystrophy
15042

University Hospital Würzburg

9.2/10
location_onGermany, Würzburg

Department of Neurology

According to the Focus magazine in 2019, the University Hospital Würzburg ranks among the top national German hospitals! The hospital is one of the oldest medical facilities in Germany. The centuries-old traditions of first-class treatment are combined with the very latest achievements of modern evidence-based medicine and
Duchenne Muscular Dystrophy Diagnosis
3537
Diagnosis and conservative treatment of duchenne muscular dystrophy
11684

University Hospital Marburg UKGM

8.6/10
location_onGermany, Marburg

Department of Neurology

The University Hospital Marburg UKGM offers patients modern diagnostics and comprehensive therapy at the international level. As a maximum care hospital, the medical facility specializes in all fields of modern medicine ranging from ophthalmology to traumatology and dentistry. The main areas of specialization of the hospital are
Duchenne Muscular Dystrophy Diagnosis
3339
Diagnosis and conservative treatment of duchenne muscular dystrophy
11036

University Hospital Tuebingen

9.2/10
location_onGermany, Tuebingen

Department of Neurology

According to the prestigious medical publication Focus, the University Hospital Tuebingen ranks among the top five German hospitals! The hospital was founded in 1805, therefore it is proud of its long history, unique experience, and outstanding achievements in the field of medical care, as well as research and teaching activitie
Duchenne Muscular Dystrophy Diagnosis
3680
Diagnosis and conservative treatment of duchenne muscular dystrophy
12292

University Hospital Bonn

9.2/10
location_onGermany, Bonn

Department of Neurology

According to the authoritative Focus magazine, the University Hospital Bonn ranks among the top ten medical facilities in Germany! The hospital was opened on January 1, 2001, although in fact it inherits the medical facility, which operated at the Faculty of Medicine of the University of Bonn. The hospital in Germany combin
Duchenne Muscular Dystrophy Diagnosis
3806
Diagnosis and conservative treatment of duchenne muscular dystrophy
12657
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About the disease

Duchenne muscular dystrophy is a genetic illness, characterized by muscle degeneration. Muscles lose their ability to move which results in restricted motor function. Duchenne muscular dystrophy is transmitted from father to son, which means that only males suffer from this disease. It usually manifests in childhood. Besides muscle disorders a person can have skeletal deformations, accompanied by respiratory and heart failures, mental and endocrine disorders. There are no treatments available yet. All existing treatment options only alleviate the symptoms. Rarely patients manage to survive past 35 years of age. The disease was first researched and described approximately in 1860s by a French neurologist Duchenne. One in 4000 is affected by this disease.

Gradual progression of muscle weakness leads to the fact that by 10-12 years many children lose the ability to move independently and they need wheelchair. However, they retain the ability to stand, on average, up to 16 years old. Nevertheless, Duchenne's muscular dystrophy is progressing very slowly. People with Duchenne muscular dystrophy are able to take care of themselves despite of their immobility for up to 15-20 years.

Duchenne muscular dystrophy is caused if X chromosome, which is passed from father to son, does not produce muscle protein dystrophin. This protein is mostly responsible for creating muscle fibers on molecular level. In Duchenne muscular dystrophy this protein is either absent completely or synthesized abnormally, which leads to destruction of muscles` fibers. In this case muscles degenerate and become replaced by fat and connective tissue.

Symptoms

Most common symptoms appear before 3 years. Pathological manifestations of this disease include:

  • Loss of skeletal muscle
  • Skeletal deformities
  • Sometimes changes of the heart muscle
  • Mental disorders
  • Endocrine disorders

Muscle tissue damage is the main manifestation of the disease. Children with Duchenne muscular dystrophy are born without physical abnormalities, however they lag behind in motor development compared to their peers. They are also less active physically.

First symptoms appear when child starts walking and he falls on tiptoes. Children can experience:

  • Weakness and fatigue while learning to talk
  • Can’t bear physical activities
  • Rarely run or jump
  • Gait of these children reminds the duck moves

Child begins to stumble and move from side to side. To rise from his knees, child squats and uses hands to help his weak leg muscles. Weakness first appears in legs, then spreads to pelvis, torso, shoulders, neck and eventually to arms.

Diagnosis

Diagnosis is generally based on several kinds of studies, the main of which is a genetic test (DNA-diagnostics). Only this test can discover defect in X chromosome, which is responsible for synthesis of dystrophin. Muscle biopsy is used to determine the level of dystrophin in muscle. However with the improvement of genetic diagnostics in recent decades, this traumatic procedure is relegated to second place.

Treatment

Conservative treatment can help the child extend the time of his physio activity. There is number of methods aimed to maintain and support muscle strength and compensate for changes in cardiovascular and respiratory systems. Most common drugs are steroids, which maintain muscle strength and slow down disease progression. In addition, steroids can reduce the risk of scoliosis development. It is believed that the best time to start therapy is the age of 4-6 years. Doses of drugs are assigned individually. If there are problems with heart, a child is prescribed with cardiac drugs.

Non-drug therapy for children with Duchennne`s includes physiotherapy and orthopedic care. Physiotherapy techniques allow to maintain flexibility and mobility of joints and to maintain the muscle strength. It is proved that physical activity has a positive effect on course of disease and the inactivity and bed rest on the contrary contribute to more fast progression of the disease. Therefore it is necessary to continue all possible physical activities even while being bound to wheelchair. Regular massage courses and swimming can also have beneficial effect. Usually children with Duchenne do not want to move a lot that is why it is so important for their parents to make children exercise on a regular basis and  stretch muscles as often as possible. Children with Duchenne muscular dystrophy can also attend special classes, where they will be able to strengthen muscles, which will help them move more freely.

Orthopedic devices may significantly improve patient`s condition. Some devices maintain a standing position, some of them help the patient to rise and eliminate contractures in legs. Also special corsets can help a patient not to develop scoliosis and to always have a good posture. Such corsets are worn even at night. Corsets provide improvement and relief to patients thus giving opportunity to walk often and play with their peers.

According to American medical site News Medical, Faculty of Binghamton University conducted a research, which determined that patients with this disease can alleviate their symptoms and prolong time of mobility by treatment with gene CD40, which helps the organism cope with deficiency of dystrophin protein. If this treatment is implemented in used patients will be able to prolong the time they can walk.

Authors: Dr. Nadezhda Ivanisova, Dr. Sergey Pashchenko




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