Treatment of Hormonal Disorder in Women With Hirsutism in Germany

Causes

The origin of hirsutism may be as follows:

• hyperandrogenic form associated with an increased content of male sex hormones in the blood;
• non-hyperandrogenic form without any increase in male hormones.

The most common cause of hyperandrogenism is polycystic ovary syndrome (75% of all cases), while androgen-secreting tumors and congenital adrenal hyperplasia are less common causes.

Among the causes unrelated to sex hormones, the main ones are taking specific drugs and endocrine disorders. The drugs that can cause hirsutism include corticosteroids, progestins, antiestrogens, some antibiotics, and interferon.

Hirsutism can also develop due to endocrine pathologies such as Cushing's syndrome, thyroid dysfunction, hyperprolactinemia, and acromegaly. However, facial hair growth in these diseases is only one of many symptoms and far from the most severe of them.

Hirsutism is not always a sign of a disease. This can be physiological: for example, in menopause due to decreased estrogen production or during a pregnancy due to increased concentration of prolactin in a woman's blood.

Diagnostics

The very fact of hirsutism is not difficult to establish. A clinical examination is enough for this. The task of doctors who conduct diagnostics is to find out the cause of hirsutism, determine the existing hormonal disorders in women with hirsutism, and assess their impact on their reproductive function.

Doctors use the following diagnostic tests:

• hormone blood tests;
• clinical tests, such as a dexamethasone suppression test;
• pelvic ultrasound;
• adrenal CT and brain MRI scans, if clinically indicated.

Treatment

Doctors mostly use conservative treatment. This depends on the goals of therapy. For most women who do not want to conceive a child in the future, menstrual cycle normalization and excess facial hair elimination is a sufficient goal of treatment.

Medications

Here are some of the main drugs for the treatment of hormonal disorder in women with hirsutism in Germany:

• combined oral contraceptive pills;
• antiandrogens;
• aldosterone receptor antagonists;
• glucocorticoids.

There is no ideal treatment that suits all women. Therapy is selected individually, since each type of drug has its own disadvantages and advantages, and it works in certain cases.

For example, oral contraceptives are safe and cycle stabilizing but are unacceptable for women planning a pregnancy and are not always effective. Aldosterone receptor antagonists are effective, but they take several months to achieve results and affect potassium levels in the blood, so therapy requires constant laboratory monitoring. Antiandrogens provide good results but can damage the liver and are not recommended for women of reproductive age, as they increase the risk of malformations in the fetus during a pregnancy. Adrenal hyperandrogenism can be treated with low doses of corticosteroids. Thus, the treatment may differ depending on the cause of hirsutism, a woman's plans to conceive a baby, her age, the hormone levels in her blood, the effectiveness of her previous treatment, etc.

Non-drug therapy

Non-drug therapy does not correct the hormonal levels but only improves the woman's appearance. This option can be used during the period when therapeutic results from the use of drugs have not yet been achieved (it takes 1-2 years to achieve the final result). Shaving, bleaching with hydrogen peroxide, and chemical or laser hair removal are used to deal with unwanted hair.

Surgical treatment

Surgery is rare. Surgical treatment is mainly used in the following two cases:

1. Androgen-secreting tumors. They only cause 0,2% of cases of hirsutism. In 50% of cases, these tumors are malignant. They most often develop in the pelvis or abdomen. The treatment for these diseases is planned individually, depending on the type of tumor, its location and the stage of the disease.
2. Severe hyperandrogenism in menopause. In this case, surgical removal of the ovaries is indicated. German hospitals perform it using a minimally invasive laparoscopic method: this is a low-traumatic operation with good aesthetic results, a low risk of complications and a rapid rehabilitation period. Doctors can also perform a hysterectomy: removal of the uterus with its appendages if there are concomitant uterine diseases, for example, hyperplastic endometrial processes.

You are welcome to use the Booking Health service to undergo your treatment for hormonal disorders due to hirsutism in one of the German medical centers. You can compare the cost of treatment in different clinics and make your treatment appointment at a favorable price. Our company's specialists will select the most suitable clinics in Germany for you and arrange your trip.

Authors: 

The article was edited by medical experts, board-certified doctors Dr. Nadezhda Ivanisova and Dr. Farrukh Ahmed. For the treatment of the conditions referred to in the article, you must consult a doctor; the information in the article is not intended for self-medication!

Sources:

Healthline

Verywell Health

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