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Treatment of Liver cancer

Due to the difficulties associated with the organization of treatment in Turkey, Switzerland, South Korea and India, we are not currently processing requests to these regions.

If you are interested in treatment in Germany, please leave a request and our specialists will contact you as soon as possible.

 

Cost for treatment

Liver cancer diagnosis
 from  972
Liver cancer treatment with atypical marginal or wedge liver resection
 from  11918
Treatment of liver cancer with percutaneous embolization (coiling) or chemoembolization
 from  4640

University Hospital of Ludwig Maximilian University of Munich

10/10
location_onGermany, Munich

Department of Gastroenterology and Hepatology

According to the Focus magazine, the University Hospital of Ludwig Maximilian University of Munich is regularly ranked among the best medical institutions in Germany! The hospital is the largest multidisciplinary medical facility, as well as a leading research and training center in Germany and Europe. The hospital is proud of i
Liver cancer diagnosis
3641
Liver cancer treatment with atypical marginal or wedge liver resection
21905
Treatment of liver cancer with percutaneous embolization (coiling) or chemoembolization
9967

University Hospital Duesseldorf

8.5/10
location_onGermany, Duesseldorf

Department of Gastroenterology, Hepatology and Infectology

According to the authoritative Focus magazine, the University Hospital Duesseldorf ranks among the top Germany hospitals! The hospital is an excellent example of a combination of high-quality health care, research and teaching activities. With more than 50,000 inpatients and about 300,000 outpatients every year, the hospital is
Liver cancer diagnosis
3629
Liver cancer treatment with atypical marginal or wedge liver resection
21668
Treatment of liver cancer with percutaneous embolization (coiling) or chemoembolization
9645

University Hospital Ulm

8.7/10
location_onGermany, Ulm

Department of Gastroenterology and Hepatology

The University Hospital Ulm started its activities 35 years ago and during this time it has become one of the most prestigious medical institutions in Europe. The hospital is famous for its numerous discoveries and the world-class achievements in medicine and pharmaceuticals. The medical facility has 29 specialized departments a
Liver cancer diagnosis
3548
Treatment of liver cancer with percutaneous embolization (coiling) or chemoembolization
9460
Liver cancer treatment with alcohol or radiofrequency ablation of tumor nodes
9357

University Hospital Heidelberg

9.8/10
location_onGermany, Heidelberg

Department of Gastroenterology, Hepatology and Infectology

According to the Focus magazine, the University Hospital Heidelberg ranks among the top five hospitals in Germany! The hospital is one of the most advanced and reputable medical institutions not only in Germany, but throughout Europe. There are more than 43 specialized departments and 13 medical institutes, which cover all field
Liver cancer diagnosis
0
Liver cancer treatment with atypical marginal or wedge liver resection
0
Treatment of liver cancer with percutaneous embolization (coiling) or chemoembolization
0

University Hospital Bonn

9.2/10
location_onGermany, Bonn

Department of Gastroenterology, Hepatology, Nephrology, Infectology, Endocrinology and Diabetology

According to the authoritative Focus magazine, the University Hospital Bonn ranks among the top ten medical facilities in Germany! The hospital was opened on January 1, 2001, although in fact it inherits the medical facility, which operated at the Faculty of Medicine of the University of Bonn. The hospital in Germany combin
Liver cancer diagnosis
3572
Treatment of liver cancer with chemotherapy
9046

University Hospital Carl Gustav Carus Dresden

9.1/10
location_onGermany, Dresden

Department of Gastroenterology and Hepatology

According to the prestigious Focus magazine, the University Hospital Carl Gustav Carus Dresden is among the top three hospitals in Germany! The hospital is the embodiment of the standards of modern high-quality medicine. Since the hospital positions itself as a maximum care medical facility, it represents all medical fields. The
Liver cancer diagnosis
4197
Treatment of liver cancer with percutaneous embolization (coiling) or chemoembolization
11175
Liver cancer treatment with alcohol or radiofrequency ablation of tumor nodes
11163

Charite University Hospital Berlin

9/10
location_onGermany, Berlin

Department of Hepatology and Gastroenterology

According to the authoritative Focus magazine, the Charite University Hospital Berlin occupies the first place in the rating of the top German medical facilities! The hospital is one of the largest and leading university medical complexes in Europe. The hospital in Germany provides modern diagnostics and treatment of patients, a
Liver cancer diagnosis
4595
Liver cancer treatment with atypical marginal or wedge liver resection
29130
Treatment of liver cancer with percutaneous embolization (coiling) or chemoembolization
12700

University Hospital Jena

8.9/10
location_onGermany, Jena

Department of Gastroenterology, Hepatology and Infectology

According to the prestigious Focus magazine, the University Hospital Jena regularly ranks among the top German medical facilities! The hospital has positioned itself as a multidisciplinary medical facility with a long history of more than 200 years. Since its foundation, the hospital has been constantly developing and modernizin
Liver cancer diagnosis
3663
Treatment of liver cancer with percutaneous embolization (coiling) or chemoembolization
8793
Liver cancer treatment with alcohol or radiofrequency ablation of tumor nodes
8861

University Hospital Rechts der Isar Munich

9.8/10
location_onGermany, Munich

Department of Gastroenterology, Hepatology, Endocrinology, Diabetology and Infectology

According to the prestigious FOCUS magazine, the University Hospital Rechts der Isar Munich ranks among the Germany's top medical institutions! Founded in 1834, the hospital combines long traditions and the very latest achievements of modern medicine. The medical facility includes 33 specialized departments, 20 interdiscipli
Liver cancer diagnosis
3562
Liver cancer treatment with atypical marginal or wedge liver resection
21977
Treatment of liver cancer with percutaneous embolization (coiling) or chemoembolization
9938

University Hospital Tuebingen

9.2/10
location_onGermany, Tuebingen

Department of Gastroenterology, Hepatology and Infectology

According to the prestigious medical publication Focus, the University Hospital Tuebingen ranks among the top five German hospitals! The hospital was founded in 1805, therefore it is proud of its long history, unique experience, and outstanding achievements in the field of medical care, as well as research and teaching activitie
Liver cancer diagnosis
3409
Liver cancer treatment with atypical marginal or wedge liver resection
20811
Treatment of liver cancer with percutaneous embolization (coiling) or chemoembolization
9202

University Hospital Essen

9.6/10
location_onGermany, Essen

Department of Gastroenterology and Hepatology

According to the authoritative Focus magazine the University Hospital Essen ranks among the top German hospitals! With 27 specialized departments and 24 institutes, the hospital in Germany is a maximum care medical facility. The hospital has 1,300 beds for inpatient treatment. A highly qualified medical team of more than 6,000 e
Liver cancer diagnosis
3337
Treatment of liver cancer with proton therapy
80542

University Hospital Saarland Homburg

9.8/10
location_onGermany, Homburg

Department of Gastroenterology, Hepatology, Endocrinology, Diabetology and Nutritional Medicine

The University Hospital Saarland is the largest hospital in the city of Homburg and the most important medical facility in the region. The hospital, which currently has 30 specialized departments and 20 institutes, was founded in 1947 and operates on the basis of the Saarland University. The hospital plays a leading role in medi
Liver cancer diagnosis
3064
Liver cancer treatment with atypical marginal or wedge liver resection
18134
Treatment of liver cancer with percutaneous embolization (coiling) or chemoembolization
8558

HELIOS University Hospital Wuppertal

9.8/10
location_onGermany, Wuppertal

Department of Gastroenterology, Hepatology, Diabetology and Endocrinology

The HELIOS University Hospital Wuppertal is a well-known maximum care hospital and an advanced rehabilitation center in Germany. The hospital belongs to the Witten-Herdecke University and, with its 1000 beds, is the largest one in the Bergisches Land region. Within the 26 departments of the hospital, the whole spectrum of medica
Liver cancer diagnosis
3367
Liver cancer treatment with atypical marginal or wedge liver resection
19595
Treatment of liver cancer with percutaneous embolization (coiling) or chemoembolization
8733

Memorial Sisli Hospital Istanbul

9.2/10
location_onTurkey, Istanbul

Department of Gastroenterology and Hepatology

The Memorial Sisli Hospital Istanbul is the largest and leading medical complex in Turkey, which meets the highest standards of medical care when providing the advanced diagnostics and treatment using the very latest methods. The hospital is part of the Memorial Health Group – it was the first project of this provider of m
Liver cancer diagnosis
3215
Liver cancer treatment with atypical marginal or wedge liver resection
24602
Liver cancer treatment with extensive liver resection
44750

Primus Super Speciality Hospital New Delhi

9/10
location_onIndia, New Delhi

Department of Gastroenterology and Hepatology

The Primus Super Speciality Hospital New Delhi is a modern medical facility, which is distinguished by extremely high quality and standards of medical service. The hospital is located in the heart of New Delhi, in the capital of India. During its design and construction, the most advanced medical technologies from around the wor
Liver cancer diagnosis
3122
Treatment of liver cancer with chemotherapy
8105

Memorial Bahcelievler Hospital Istanbul

9.2/10
location_onTurkey, Istanbul

Department of Adult and Pediatric Gastroenterology, Hepatology

The Memorial Bahçelievler Hospital Istanbul is an advanced multidisciplinary medical center that began its clinical practice in 2018. It is part of the world famous Memorial Healthcare Group. The hospital was designed in accordance with the very latest standards of modern architecture with the aim of providing top-class m
Liver cancer diagnosis
3298
Liver cancer treatment with atypical marginal or wedge liver resection
24209
Treatment of liver cancer with percutaneous embolization (coiling) or chemoembolization
9620
| from Booking Health GmbH

Content

  1. Symptoms
  2. Types of liver cancer
  3. Stages and prognosis
  4. Diagnostics
  5. Treatment methods
  6. Minimally invasive treatment
  7. Innovative treatment methods
  8. Where to treat liver cancer?
  9. The cost of treatment of liver cancer
  10. How to go abroad for treatment of liver cancer?

 

Liver cancer is a severe oncological disease characterized by an aggressive course, rapid onset of metastases, and damage to nearby and distant anatomical structures. New therapeutic interventions are developed for both early-stage and advanced-stage liver cancer. For instance, patients with stage IV liver cancer and recurrent tumors may receive targeted drugs, undergo immunotherapy or chemoembolization (as the additional treatment).

Liver cancer is a malignant neoplasm that begins in liver.

Stage 4 liver cancer is cancer that has spread to lymph nodes and distant organs.

Liver cancer treatment includes surgery, radiation therapy, ablation, embolization, targeted therapy, immunotherapy, and chemotherapy.

Cost of treatment with chemoembolization starts at €4,711. Price for unilateral hepatectomy starts at €12,076. Cost of radiofrequency ablation starts at €4,687.

Best hospitals in Europe are:

  • University Hospital of Ludwig Maximilian University of Munich
  • Helios Hospital Berlin-Buch
  • University Hospital Rechts der Isar Munich
  • University Hospital Frankfurt am Main
  • Clinic of Advanced Biological Medicine Frankfurt am Main

Symptoms

 

Liver cancer has specific symptoms, but they appear only at advanced stages. The signs of liver cancer are quite nonspecific and can be easily confused with other diseases of this organ (e.g. with gallstone disease or exacerbation of chronic hepatitis).

Still, early symptoms of liver cancer include:

  • Constant bloating and digestive discomfort
  • Frequent diarrhea or constipation
  • Nausea, which may be accompanied by vomiting (this is one of the most common symptoms in liver cancer)
  • Decreased appetite
  • Constant feeling of tiredness and even malaise
  • Chills and fever are sometimes a sign of liver cancer

Note that the primary and secondary types of liver cancer have identical manifestations.

Types of liver cancer

 

By origin, primary and secondary liver cancer types are distinguished. Primary pathology includes all types of malignant tumors that have developed from the liver’s own tissues. Secondary cancer is metastases of tumors located elsewhere (e.g. metastases of breast cancer, prostate cancer, stomach cancer, colon cancer, esophageal cancer, etc.).

Primary liver cancer is classified as hepatocellular carcinoma (a tumor that grows from liver cells) and cholangiocarcinoma (cancer of the internal bile ducts).

In the majority of cases, primary hepatocellular cancer develops against the background of chronic hepatitis or cirrhosis of the liver. Therefore, the prognosis of the disease will largely depend on the state of the liver tissue at the time of tumor development.

Cholangiocarcinoma is much less common and usually affects elderly patients (70 years and older). In such cases, the prognosis depends largely on the general condition of the patient.

Besides, the clinical prognosis is influenced by the morphological form of the tumor. The prognosis for patients with nodular liver cancer will be better than for patients with diffuse one since the latter excludes the possibility of surgical treatment for liver cancer.

As in the case of other oncological diseases, the clinical prognosis for patients with liver cancer depends on the properties of the tumor cells. With undifferentiated cancer, the prognosis is always worse than with moderately differentiated cancer.

Diagnostics and treatment of secondary (metastatic) liver cancer have their own peculiarities. In such cases, the prognosis is often poor.

Stages and prognosis

 

At stage I of the disease, a single malignant node is formed in the affected organ. Its size does not exceed 2 cm, and it also does not affect the blood vessels (does not grow in them or does not violate their integrity). At this stage of the disease, doctors can achieve complete recovery with the help of radical surgery for liver cancer.

At stage II, the primary tumor grows, but its size does not exceed 5 cm. The patient does not have metastases spreading through the blood or lymph. It is more difficult to treat such a disease. Not only surgical treatment is required, but also additional chemotherapy and other measures. However, with proper treatment the chances of recovery are very high.

At stage III of liver cancer, the neoplasm exceeds the size of 5 cm or the patient has metastatic foci in the regional lymph nodes. The clinical prognosis for liver cancer worsens significantly, but doctors are doing everything to achieve recovery or prolong the patient's life as much as possible.

In stage IV liver cancer, doctors detect distant metastatic foci in the lungs or other organs. It is still impossible to cure such cancer. Even with an advanced stage of oncology, doctors still come to the aid of the patient. Patients receive palliative treatment, which relieves unpleasant symptoms and prolongs life.

Diagnostics

 

The diagnostics begins with physical examination and anamnesis collection. During palpation, the organ is dense and enlarged. Large tumors can be palpable. The distinctive clinical picture arises at the advanced stages. The onset of the disease has no characteristic clinical signs and often goes unnoticed.

The most informative liver cancer diagnostics includes computed tomography with hepatotropic contrast agents. The study allows determining the nature of liver cancer, its exact localization and spreading. This is especially important when surgery is planned. If after a CT scan the doctor has doubts about the nature of the tumor, a biopsy is performed with harvesting the material from the pathological site for further cytological examination.

The patient may also undergo an ultrasound examination. If metastases are suspected, chest X-ray, colonoscopy, and abdominal sonography are prescribed. Several laboratory tests are carried out as well as tumor marker tests, tests for viral hepatitis, complete blood count, and biochemical blood tests.

Treatment methods

 

After carrying out all the diagnostic procedures, determining the size and spreading of the tumor, the doctors elaborate a therapeutic scheme. To treat liver cancer doctors choose:

  • Surgical removal of part of the liver or the entire organ, followed by possible liver transplantation
  • Radiation treatment (selective internal or external one)
  • Radio- of chemoembolization of the vessels that are feeding the tumor
  • Systemic chemotherapy drugs that kills cancer cells
  • Targeted immunotherapy
  • Cytoreductive surgery and chemotherapy

Minimally invasive treatment

 

When doctors treat liver cancer, they give preference to the most effective methods of treatment. Sometimes it is possible to use minimally invasive methods, which do not harm the patient much and allow recovery within a relatively short period. They are used in the presence of contraindications to conservative treatment, for example, with cirrhosis, general serious health problems, and/or old age. The minimally invasive methods of therapy include:

  • Laser therapy, when a malignant lesion is removed using directed laser energy
  • Cryoablation, when the tumor is frozen with liquid hydrogen passed through a special probe (it has an ultra-low temperature)
  • Radiofrequency ablation, in which the tumor is burned out by high-frequency waves
  • Electroporation, in which malignant cells are destroyed by exposing them to short but intense electrical impulses
  • Radiosurgical methods, which include the innovative CyberKnife
  • The progressive method of proton treatment

Innovative treatment methods

 

Radiation treatment and chemotherapy are usually used at the advanced stages of the disease. Thanks to a combination of operative and conservative methods, doctors can increase the chances of a full recovery, as well as reduce the risk of recurrence of the neoplasm.

Of course, both radiation and chemotherapy may have serious side effects. These methods of treatment have a systemic, toxic effect on the body. They can cause multiple functional complications, e.g. disrupt the functions of the bone marrow, gastrointestinal tract, and cause other side effects.

Liver cancer treatment can be carried out using new progressive methods that reduce the severity of side effects and make it possible to target the tumor precisely.

In chemoembolization, doctors inject chemotherapeutic drugs (cytostatics) mixed with microemboli into the hepatic artery. Thanks to this injection technique, the drugs continue to act on the tumor for about a month. Chemoembolization gives about 2 additional years of survival in 30% of patients, even without surgery. Chemoembolization may be used as the supplementary therapeutic measure in patients with stage IV liver cancer.

In cryosurgery, the doctor cools the neoplasm to an ultra-low temperature with liquid nitrogen, which leads to the death of malignant tissues. This method of liver cancer treatment can be used when the tumor size is under 5 cm. The three-year survival rate when using it is about 20%.

With percutaneous alcoholization, the doctor injects ethyl alcohol into the tumor nodes. This process is performed under the ultrasound guidance, and may require several procedures. The five-year survival rate is 30% (the same as for surgery).

Brachytherapy is an innovative method of radiation therapy that minimizes the negative effects of radiation on healthy organ tissues. The doctor inserts small catheters with the radiation sources in the tumor tissue. Due to this, gamma rays act locally, within the borders of a malignant neoplasm.

Targeted treatment of liver cancer involves the use of angiogenesis inhibitors. These are drugs that can suppress the formation of new vessels that feed the tumor. This slows down the progression of liver cancer and, in combination with other methods, allows achieving good treatment results.

Viral therapy is a new advanced treatment method that involves the use of a modified smallpox virus. This pathogen is capable of destroying cancer cells without harming healthy tissues. This method is currently at the stage of clinical trials, but it demonstrates encouraging treatment results.

Where to treat liver cancer?

 

In the treatment of liver cancer, it is important to choose the right medical facility among the best hospitals.

We recommend the following hospitals for the treatment of liver cancer:

  1. University Hospital of Ludwig Maximilian University of Munich, Germany
  2. University Hospital Heidelberg, Germany
  3. University Hospital Bonn, Germany
  4. University Hospital Carl Gustav Carus Dresden, Germany
  5. Charite University Hospital Berlin, Germany

Feel free to visit the Booking Health website to learn more about the clinical practice of the hospitals.

The cost of treatment of liver cancer

 

The prices for the treatment of liver cancer depend on the stage of the disease and the treatment plan prescribed by the doctor according to the clinical indications. The approximate price for treatment will be estimated after hospitals receive patient’s medical information and results of the diagnostics. Based on this, the specialists will draw up a preliminary medical plan and give a price for treatment.

Generally, the cost of treatment with surgery, depending on the method of surgery, will start at 12,076 EUR. The cost of treatment with chemotherapy will start at 7,239 EUR. The cost of treatment with percutaneous embolization will start at 7,862 EUR.

How to go abroad for treatment of liver cancer?

 

You don't have to organize the treatment abroad by yourself. If you want to, you can use the services of a medical tourism company, which will be cheaper, safer, and easier.

Booking Health is one the most experienced and reliable medical tourism companies out there.

Booking Health provides full support throughout your treatment and offers additional services, such as translation services, transfers, visa issuing, booking accommodation for you and an accompanying person, as well as advice on any administrative issues.

If you are interested, leave a request on the Booking Health website to get more detailed info.

Authors: Dr. Nadezhda Ivanisova, Dr. Sergey Pashchenko




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