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Scleroderma is a disease, when skin and connective tissue hardens and tightens. It usually originates in fibers, responsible for providing the framework to the body of a human. Scleroderma is considered to be a very rare disease. Usually it affects women between 30-50 years of age. In 20% of cases scleroderma damages only the skin of a person. In other 70% structures beyond the skin, such as blood vessels, are also affected. In rare cases scleroderma damages internal organs of a person, most often digestive tract.
100% of all scleroderma cases develop because of abnormal production of collagen in the skin. As a result, collagen accumulated in the skin, causing separate tissues to tighten. Overall, collagen is a special type of protein, responsible for forming connective tissues in the body of a person. It is not known why collagen starts to be produced abnormally. It is believed that disruption in the immune system plays crucial role in collagen overproduction. Exposure to dangerous substances, such as pesticides or solvents, can also trigger development of scleroderma.
It is difficult to diagnose scleroderma, as it can originate in different parts of the body.
Authors: Dr. Nadezhda Ivanisova, Dr. Farrukh Ahmed
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