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Treatment of Testicular Embryonal Carcinoma

Due to the difficulties associated with the organization of treatment in Turkey, Switzerland, South Korea and India, we are not currently processing requests to these regions.

If you are interested in treatment in Germany, please leave a request and our specialists will contact you as soon as possible.

 

Cost for treatment

Diagnostic tests for testicular embryonal carcinoma
1591
Chemotherapy of testicular embryonal carcinoma (1 course)
1601
Surgery treatment of testicular embryonal carcinoma
8015

University Hospital of Ludwig Maximilian University of Munich

10/10
location_onGermany, Munich

Department of Adult and Pediatric Urology

According to the Focus magazine, the University Hospital of Ludwig Maximilian University of Munich is regularly ranked among the best medical institutions in Germany! The hospital is the largest multidisciplinary medical facility, as well as a leading research and training center in Germany and Europe. The hospital is proud of i
Diagnostic tests for testicular embryonal carcinoma
3654
Chemotherapy of testicular embryonal carcinoma (1 course)
5827
Surgery treatment of testicular embryonal carcinoma
15294

University Hospital Ulm

8.7/10
location_onGermany, Ulm

Department of Adult and Pediatric Urology

The University Hospital Ulm started its activities 35 years ago and during this time it has become one of the most prestigious medical institutions in Europe. The hospital is famous for its numerous discoveries and the world-class achievements in medicine and pharmaceuticals. The medical facility has 29 specialized departments a
Diagnostic tests for testicular embryonal carcinoma
3418
Chemotherapy of testicular embryonal carcinoma (1 course)
5503
Surgery treatment of testicular embryonal carcinoma
14349

Urology Hospital Munich-Planegg Munich

10/10
location_onGermany, Munich

Department of Adult and Pediatric Urology

According to Focus magazine, the Urology Hospital Munich-Planegg Munich ranks among the top specialized German hospitals! The hospital was founded in 1970 by Dr. Rudolf Castringius. During this time, it became the leading provider of male health care in Germany. In addition, the hospital has the status of one of the best medical
Diagnostic tests for testicular embryonal carcinoma
3761 help3261
Surgery treatment of testicular embryonal carcinoma
13691

University Hospital Frankfurt am Main

10/10
location_onGermany, Frankfurt am Main

Department of Urology

According to the reputable Focus magazine, the University Hospital Frankfurt am Main ranks among the top German medical facilities! The hospital was founded in 1914 and today is a well-known German medical facility, which combines rich traditions and scientific innovations. A medical team of more than 6,500 employees cares about
Diagnostic tests for testicular embryonal carcinoma
3333
Chemotherapy of testicular embryonal carcinoma (1 course)
5337
Surgery treatment of testicular embryonal carcinoma
13493

University Hospital Heidelberg

9.8/10
location_onGermany, Heidelberg

Department of Adult and Pediatric Urology

According to the Focus magazine, the University Hospital Heidelberg ranks among the top five hospitals in Germany! The hospital is one of the most advanced and reputable medical institutions not only in Germany, but throughout Europe. There are more than 43 specialized departments and 13 medical institutes, which cover all field
Diagnostic tests for testicular embryonal carcinoma
0
Chemotherapy of testicular embryonal carcinoma (1 course)
0
Surgery treatment of testicular embryonal carcinoma
0

Charite University Hospital Berlin

9/10
location_onGermany, Berlin

Department of Adult and Pediatric Urology

According to the authoritative Focus magazine, the Charite University Hospital Berlin occupies the first place in the rating of the top German medical facilities! The hospital is one of the largest and leading university medical complexes in Europe. The hospital in Germany provides modern diagnostics and treatment of patients, a
Diagnostic tests for testicular embryonal carcinoma
4539
Chemotherapy of testicular embryonal carcinoma (1 course)
4949
Surgery treatment of testicular embryonal carcinoma
19731

University Hospital Jena

8.9/10
location_onGermany, Jena

Department of Adult and Pediatric Urology

According to the prestigious Focus magazine, the University Hospital Jena regularly ranks among the top German medical facilities! The hospital has positioned itself as a multidisciplinary medical facility with a long history of more than 200 years. Since its foundation, the hospital has been constantly developing and modernizin
Diagnostic tests for testicular embryonal carcinoma
3654
Chemotherapy of testicular embryonal carcinoma (1 course)
5079
Surgery treatment of testicular embryonal carcinoma
14879

University Hospital Erlangen

9.1/10
location_onGermany, Erlangen

Department of Adult and Pediatric Urology, Andrology

According to the Focus magazine, University Hospital Erlangen ranks among the best medical facilities in Germany! The hospital is one of the leading healthcare facilities in Bavaria and offers top-class medical care distinguished by the close intertwining of clinical activities with research and training of medical students. The
Diagnostic tests for testicular embryonal carcinoma
3503
Chemotherapy of testicular embryonal carcinoma (1 course)
5625
Surgery treatment of testicular embryonal carcinoma
14311

University Hospital Halle (Saale)

9.6/10
location_onGermany, Halle

Department of Urology

According to the prestigious Focus magazine, the University Hospital Halle (Saale) ranks among the top German medical facilities! The history of the hospital has more than 300 years, and during this time it managed to earn an excellent reputation not only in Germany, but throughout the world. The hospital positions itself as a s
Diagnostic tests for testicular embryonal carcinoma
3236
Chemotherapy of testicular embryonal carcinoma (1 course)
5073
Surgery treatment of testicular embryonal carcinoma
13628

University Hospital Hamburg-Eppendorf

9.2/10
location_onGermany, Hamburg

Department of Adult and Pediatric Urology

According to the Focus magazine, the University Hospital Hamburg-Eppendorf ranks among the top ten hospitals in Germany! Since its foundation in 1889, the hospital has taken a leading position in the European medical arena and still occupies it until today. A highly competent medical team of more than 11,000 employees takes care
Diagnostic tests for testicular embryonal carcinoma
4078
Chemotherapy of testicular embryonal carcinoma (1 course)
5100
Surgery treatment of testicular embryonal carcinoma
17369

University Hospital Würzburg

9.2/10
location_onGermany, Würzburg

Department of Adult and Pediatric Urology

According to the Focus magazine in 2019, the University Hospital Würzburg ranks among the top national German hospitals! The hospital is one of the oldest medical facilities in Germany. The centuries-old traditions of first-class treatment are combined with the very latest achievements of modern evidence-based medicine and
Diagnostic tests for testicular embryonal carcinoma
3359
Chemotherapy of testicular embryonal carcinoma (1 course)
5086
Surgery treatment of testicular embryonal carcinoma
13731

University Hospital RWTH Aachen

8.7/10
location_onGermany, Aachen

Department of Adult and Pediatric Urology

According to the prestigious Focus magazine, the University Hospital RWTH Aachen ranks among the top German hospitals! As a maximum care university medical facility, the hospital guarantees patients first-class medical services combined with a respectful and human attitude. The hospital integrates all the modern options for the
Diagnostic tests for testicular embryonal carcinoma
3736
Chemotherapy of testicular embryonal carcinoma (1 course)
5841
Surgery treatment of testicular embryonal carcinoma
15254

University Hospital Duesseldorf

9.5/10
location_onGermany, Duesseldorf

Department of Adult and Pediatric Urology

According to the authoritative Focus magazine, the University Hospital Duesseldorf ranks among the top Germany hospitals! The hospital is an excellent example of a combination of high-quality health care, research and teaching activities. With more than 50,000 inpatients and about 300,000 outpatients every year, the hospital is
Diagnostic tests for testicular embryonal carcinoma
3693
Chemotherapy of testicular embryonal carcinoma (1 course)
4969
Surgery treatment of testicular embryonal carcinoma
15058

University Hospital Rechts der Isar Munich

9.8/10
location_onGermany, Munich

Department of Adult and Pediatric Urology

According to the prestigious FOCUS magazine, the University Hospital Rechts der Isar Munich ranks among the Germany's top medical institutions! Founded in 1834, the hospital combines long traditions and the very latest achievements of modern medicine. The medical facility includes 33 specialized departments, 20 interdiscipli
Diagnostic tests for testicular embryonal carcinoma
3711
Chemotherapy of testicular embryonal carcinoma (1 course)
5899
Surgery treatment of testicular embryonal carcinoma
14874

University Hospital Tuebingen

9.2/10
location_onGermany, Tuebingen

Department of Urology

According to the prestigious medical publication Focus, the University Hospital Tuebingen ranks among the top five German hospitals! The hospital was founded in 1805, therefore it is proud of its long history, unique experience, and outstanding achievements in the field of medical care, as well as research and teaching activitie
Diagnostic tests for testicular embryonal carcinoma
3558
Chemotherapy of testicular embryonal carcinoma (1 course)
5613
Surgery treatment of testicular embryonal carcinoma
14203

University Hospital Marburg UKGM

8.6/10
location_onGermany, Marburg

Department of Adult and Pediatric Urology

The University Hospital Marburg UKGM offers patients modern diagnostics and comprehensive therapy at the international level. As a maximum care hospital, the medical facility specializes in all fields of modern medicine ranging from ophthalmology to traumatology and dentistry. The main areas of specialization of the hospital are
Diagnostic tests for testicular embryonal carcinoma
3062
Chemotherapy of testicular embryonal carcinoma (1 course)
4980
Surgery treatment of testicular embryonal carcinoma
12923
| from Booking Health GmbH

Testicular embryonal carcinoma is a high-grade tumor. It often spreads metastases, and therefore requires more aggressive treatment tactics. Unlike seminoma, testicular embryonal carcinoma is minimally sensitive to radiation. The main treatment methods for testicular cancer are surgery and chemotherapy. Radiation therapy for testicular cancer is used only at the advanced stage for suppressing metastases. Doctors in developed countries successfully treat testicular embryonal carcinoma at all stages, even at the advanced ones. In most men, testicular cancer does not recur after well-performed surgery and pharmacotherapy.

Content

  1. What is testicular embryonal carcinoma
  2. Diagnostics of testicular cancer
  3. Treatment of cancer
  4. Surgical removal of cancer
  5. Chemotherapy for testicular cancer
  6. Radiation therapy
  7. Treatment in Europe with Booking Health at an affordable price

What is testicular embryonal carcinoma

 

Embryonal cancer refers to testicular germ cell tumors. They are formed from germ cells. These are uncommon neoplasms, accounting for about 1% of all malignant tumors in men. However, a specificity of this cancer is a frequent occurrence in young men. The average age at the time of diagnosis is 35 years.

Embryonal carcinoma is one of the most common components of mixed tumors. According to the results of histological examination, these cancer cells are detected in 40% of patients. However, the proportion of cancer may be insignificant. Other histologic types of cancer, such as seminoma, usually predominate. Pure embryonal cancer occurs in up to 1 in 30 patients with germ cell tumors.

However, the presence of embryonal cancer in the neoplasm worsens the prognosis. It is an aggressive type of cancer  that grows rapidly, metastasizes early, and recurs frequently. The literature describes cases of late cancer metastases that occur 10 and even 20 years after the seemingly successful cure of the pathology. Doctors detect the repeated growth of tumor foci in the liver, lungs, or other organs.

Since cancer recurrence can occur even in the long term, patients continue to be regularly examined after tumor removal. Embryonal carcinoma is characterized by an increase in the tumor marker levels: alpha-fetoprotein (AFP) and human chorionic gonadotropin (hCG). Therefore, if tests are regularly done, a relapse can be suspected in time. The origin of cancer recurrence can be determined by instrumental diagnostic data.

Since embryonal cancer is considered one of the most aggressive, the presence of such cancer in the tumor changes the treatment regimen. It becomes more aggressive: more chemotherapy and radiation are required after surgery, and more surgical interventions for cancer removal are performed. The proportion of embryonal cancer in the tumor of more than 50% is considered an unfavorable prognostic factor.

Although cancer is aggressive, most cases of oncology are successfully cured abroad. After surgery, patients receive chemotherapy to destroy all remaining cancer cells that may have spread to the lymph nodes or other organs. Pharmacotherapy works well even at the advanced stage of testicular cancer.

Diagnostics of testicular cancer

 

Embryonal carcinoma causes the same symptoms as any other testicular cancer. In 92% of cases, the patient's first complaint is the presence of a palpable mass in the scrotum. In 50% of cases, cancer causes pain in the scrotum. In 8%, pain becomes the first symptom of cancer and the only reason to see a doctor. At the time of cancer detection, enlarged lymph nodes are palpable in 15% of patients, and intoxication syndrome is detected in 12%, which usually indicates a metastatic stage of testicular cancer.

Imaging diagnostic methods for testicular cancer are:

  • Ultrasound examination.
  • Chest X-ray, CT scan, MRI, PET – with suspected distant metastases of testicular cancer.

At the time of the diagnosis of cancer, 40% of patients already have metastases in the retroperitoneal lymph nodes, while 20% of patients have distant metastases of testicular cancer.

Treatment of cancer

 

Therapeutic tactics for embryonal carcinoma depend on the prognosis. According to the IGCCCG classification, patients are divided into three groups: favorable, intermediate and unfavorable prognosis of cancer. The histological type of cancer, stage, presence and location of metastases, tumor marker levels are taken into account.

More than 50% of embryonal cancer is considered a poor prognostic factor. These are more aggressive types of cancer and their treatment is more complex. Therefore, in the fight against embryonal carcinoma, doctors perform more extensive surgical procedures and use more medications for cancer chemotherapy.

Surgical removal of cancer

 

With embryonal carcinoma of any stage, the testicle is removed. This surgery is called orchifuniculectomy. The intervention for cancer treatment is minimally traumatic. The doctor makes a small incision just above the pubis and removes the testicle along with the spermatic cord.

It contains the vas deferens, large vessels – blood and lymphatic vessels. The cancer can spread through these vessels during the surgery. To prevent this, the doctor ligates the spermatic cord.

At the time of the surgery, it is usually not yet clear what type of cancer the surgeon is dealing with. No biopsy is done to diagnose testicular cancer. The histological type of cancer is determined according to the results of the histological examination of the surgical material obtained. However, taking into account the elevated tumor marker levels, the doctor may suspect that he deals with an aggressive type of cancer even prior to the intervention. In addition, metastases in the retroperitoneal lymph nodes and distant organs can be detected with the help of imaging diagnostics.

In aggressive types of cancer, including embryonal carcinoma, surgical treatment of cancer is complemented by retroperitoneal lymphadenectomy. Even at the first stage, the testicle is removed along with the lymph nodes, because the cancer can recur. Retroperitoneal lymphadenectomy is a more traumatic procedure than testicle removal. It often causes complications for reproductive health, the most common of which is retrograde ejaculation.

Surgical treatment options for cancer are the following:

  • Two-stage – the doctor removes the testicle, and if an aggressive type of cancer and other signs of an unfavorable prognosis are detected, then a second intervention is performed to remove the retroperitoneal lymph nodes.
  • One-stage – the testicle and retroperitoneal lymph nodes are immediately removed within a single surgery for cancer treatment.

To successfully perform retroperitoneal lymphadenectomy for testicular cancer, the surgeon must have considerable experience. Otherwise, the risk of complications increases. In addition, an inexperienced doctor may not remove all lymph nodes, which increases the risk of cancer recurrence from regional metastases. Therefore, it is important to undergo surgery in a good hospital. The large Cancer Centers abroad employ highly qualified surgeons with vast experience in such surgeries. They can perform high-quality lymphadenectomy, which will be safe for health, and with minimal risk of cancer recurrence.

In the case of testicular cancer, the removal of the retroperitoneal lymph nodes is usually done through a large skin incision. However, hospitals in developed countries also perform laparoscopic and robot-assisted surgeries. Studies show that with sufficient experience of the surgeon, they provide the same oncological results in testicular cancer as open surgery. At the same time, laparoscopic and robot-assisted interventions are safer for health, because:

  • They are performed through minimal incisions.
  • They reduce blood loss.
  • The use of a robot-assisted surgical system reduces the health risks caused by human factors.

After minimally invasive interventions for testicular cancer, patients suffer less pain, complications, recover faster and spend less time in the hospital. They are less likely to need additional treatment, and blood transfusion is less often required.

Chemotherapy for testicular cancer

 

Chemotherapy for patients with embryonal cancer is an important part of treatment. The decision on the need for this option for cancer treatment is made based on the results of histological examination of the removed material. Doctors determine the type of cancer, the presence of cancer metastases in the lymph nodes, accurately assess the stage of cancer, and also take into account the tumor marker levels: their normalization indicates successful surgical treatment of cancer.

Since embryonal cancer is very aggressive, most patients receive chemotherapy after testicular cancer surgery. Indications for chemotherapy for testicular cancer treatment are as follows:

  • Retroperitoneal lymph node dissection has not been performed.
  • Retroperitoneal lymph nodes were removed, and cancer metastases were detected in them.
  • Tumor marker levels in testicular cancer remain elevated even after surgery.

Sometimes metastases are detected even before surgery, using imaging diagnostics. In this case, doctors often resort to preoperative (induction) chemotherapy. Chemotherapy is then continued after removal of the tumor and metastases.

At the advanced stage, testicular cancer treatment with chemotherapy plays a key role. Metastases spread to the lungs, liver, brain, and other organs. Not all testicular cancer metastases can be surgically removed or destroyed by radiation. In addition, many testicular metastases remain undetected due to their minimal size. Chemotherapy affects all cancer foci at once, regardless of their location. Combined with surgery and radiation, chemotherapy can often help cure even advanced testicular cancer.

For testicular cancer with a high proportion of embryonal carcinoma, more aggressive chemotherapy regimens are used. A total of 3-4 cycles are required. Each chemotherapy cycle lasts 3-4 weeks. There are breaks between cycles so that the body can recover.

In the most severe cases, when the usual doses of chemotherapy drugs for testicular cancer do not work, high-dose chemotherapy with stem cell transplantation is used. This treatment option for testicular cancer is expensive and unsafe, as well as requires a long hospital stay. However, sometimes this is the only way to cure the disease. Higher doses of chemotherapy are more likely to kill all cancer cells in the body. Nonetheless, aggressive chemotherapy destroys the bone marrow, so the formation of blood cells stops. After high-dose chemotherapy, stem cells are injected into the patient's body in order to restore bone marrow.

Radiation therapy

 

Radiation therapy for testicular cancer is rarely used. Irradiation is not part of the standard treatment for non-seminoma tumors. Basically, radiation is used at the advanced stage or in case of recurrence of testicular cancer.

However, embryonal cancer can rarely be pure. As a rule, it is only one of the components of mixed tumors. A large proportion of cancer can be seminoma. This is the most common type of testicular cancer. Seminoma is very sensitive to radiation. It can be destroyed even with a small dose of radiation. Therefore, if there is a significant proportion of seminoma in the tumor, doctors may carry out a course of postoperative radiation therapy.

Nevertheless, radiation is rarely used for testicular cancer. Whenever possible, doctors prefer chemotherapy, even if there are seminoma cells in the tumor, because it is safer and more effective.

Radiation is mainly used at the advanced stages of testicular cancer. Brain metastases are destroyed with the help of radiation. Radiation is chosen when a tumor bleeds or cancer causes severe central nervous system symptoms. However, if the threat of complications is minimal, then chemotherapy is preferred for cancer treatment – although it does not work so quickly, it provides better results with a lower risk of complications.

Treatment in Europe with Booking Health at an affordable price

 

To undergo treatment of seminoma and testicular embryonal carcinoma in one of the European hospitals, you can use the services of the Booking Health company. On our website, you can see the cost of treatment and compare prices in different hospitals in order to book a medical care program at a favorable price. Seminoma and testicular embryonal carcinoma treatment at a European hospital will be easier and faster for you, and the cost of cancer treatment will be lower.

You are welcome to leave your request on the Booking Health website. Our specialist will contact you and provide a consultation on treatment in Europe. Booking Health will fully organize your trip abroad. We will provide the following benefits for you:

  • We will choose the best European hospital, whose doctors specialize in the treatment of testicular embryonal carcinoma.
  • We will help you overcome the language barrier and establish communication with the doctor of the European hospital.
  • We will reduce the waiting time for the medical care program. You will undergo treatment for testicular embryonal cancer or seminoma on the most suitable dates for you.
  • We will reduce the price. The cost of treatment in Europe will be reduced due to the lack of overpricing and additional coefficients for foreign patients.
  • We will take care of all organizational issues: we will prepare documents, meet you abroad and take you to the hospital, book a hotel, and provide interpreting services.
  • We will prepare a program and translate medical records. You do not have to repeat the previously performed diagnostic procedures.
  • We will help you keep in touch with doctors after the completion of treatment in Europe.
  • We will organize additional diagnostic examinations and cancer treatment in European hospitals.
  • We will buy medicines abroad and forward them to your native country.

Your health will be in the safe hands of the world's leading doctors. The Booking Health specialists will help you reduce the cost of treatment, organize your trip to the European hospital, and you will only have to focus on restoring your health.

Authors: Dr. Vadim ZhiliukDr. Sergey Pashchenko




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