Treatment of Thyroid Lymphoma

Cost for treatment

Thyroid lymphoma diagnosis
Resection of thyroid lymphoma
General therapeutic rehabilitation

University Hospital Mannheim

location_onGermany, Mannheim

Department of Hematology and Oncology

According to the reputable Focus magazine, the University Hospital Mannheim ranks among the top medical institutions of Germany, which is an undeniable confirmation of the impeccable medical care and excellent reputation of the hospital! The hospital is a high-tech modern medical institution, which provides accurate diagnosis an
Thyroid lymphoma diagnosis

University Hospital Ulm

location_onGermany, Ulm

Department of Hematology, Oncology, Palliative Care, Rheumatology and Infectology

The University Hospital Ulm started its activities 35 years ago and during this time it has become one of the most prestigious medical institutions in Europe. The hospital is famous for its numerous discoveries and the world-class achievements in medicine and pharmaceuticals. The medical facility has 29 specialized departments a
Thyroid lymphoma diagnosis
Resection of thyroid lymphoma

University Hospital Freiburg

location_onGermany, Freibung

Department of Hematology and Oncology

The University Hospital Freiburg is famous for its rich history and is one of the oldest and most prestigious medical facilities in Germany (one of the three best medical institutions in the country). The hospital was based on the Faculty of Medicine of the Albert Ludwig University of Freiburg, which celebrated its 550th anniver
Thyroid lymphoma diagnosis
Resection of thyroid lymphoma

University Hospital Heidelberg

location_onGermany, Heidelberg

Department of Hematology, Oncology, Adult and Pediatric Rheumatology

According to Focus magazine, the University Hospital Heidelberg ranks among the top five hospitals in Germany! The hospital is one of the most advanced and reputable medical institutions not only in Germany, but throughout Europe. There are more than 43 specialized departments and 13 medical institutes, which cover all fields of
Thyroid lymphoma diagnosis
Resection of thyroid lymphoma

University Hospital Frankfurt am Main


Department of Hematology, Oncology, Hemostaseology, Rheumatology and Infectology

According to the reputable Focus magazine, the University Hospital Frankfurt am Main ranks among the top German medical facilities! The hospital was founded in 1914 and today is a well-known German medical facility, which combines rich traditions and scientific innovations. A medical team of more than 6,500 employees cares about
Thyroid lymphoma diagnosis
Resection of thyroid lymphoma

University Hospital RWTH Aachen

location_onGermany, Aachen

Department of Oncology and Hematology

According to the prestigious Focus magazine, the University Hospital RWTH Aachen ranks among the top German hospitals! As a maximum care university medical facility, the hospital guarantees patients first-class medical services combined with a respectful and human attitude. The hospital integrates all the modern options for the
Thyroid lymphoma diagnosis
Resection of thyroid lymphoma

University Hospital Würzburg

location_onGermany, Würzburg

Department of Gastroenterology, Hematology, Oncology, Hepatology, Infectology, Rheumatology and Clinical Immunology

According to the Focus magazine in 2019, the University Hospital Würzburg ranks among the top national German hospitals! The hospital is one of the oldest medical facilities in Germany. The centuries-old traditions of first-class treatment are combined with the very latest achievements of modern evidence-based medicine and
Thyroid lymphoma diagnosis
Resection of thyroid lymphoma

University Hospital Erlangen

location_onGermany, Erlangen

Department of Hematology and Oncology

According to the Focus magazine, University Hospital Erlangen ranks among the best medical facilities in Germany! The hospital is one of the leading healthcare facilities in Bavaria and offers top-class medical care distinguished by the close intertwining of clinical activities with research and training of medical students. The
Thyroid lymphoma diagnosis
Resection of thyroid lymphoma

University Hospital Halle (Saale)

location_onGermany, Halle

Department of Hematology and Oncology

According to the prestigious Focus magazine, the University Hospital Halle (Saale) ranks among the top German medical facilities! The history of the hospital has more than 300 years, and during this time it managed to earn an excellent reputation not only in Germany, but throughout the world. The hospital positions itself as a s
Thyroid lymphoma diagnosis
Resection of thyroid lymphoma

University Hospital Hamburg-Eppendorf

location_onGermany, Hamburg

Department of Hematology, Oncology and Pulmonology

According to the Focus magazine, the University Hospital Hamburg-Eppendorf ranks among the top ten hospitals in Germany! Since its foundation in 1889, the hospital has taken a leading position in the European medical arena and still occupies it until today. A highly competent medical team of more than 11,000 employees takes care
Thyroid lymphoma diagnosis
Resection of thyroid lymphoma

Charite University Hospital Berlin

location_onGermany, Berlin

Charité Comprehensive Cancer Center

According to the authoritative Focus magazine, the Charite University Hospital Berlin occupies the first place in the rating of the top German medical facilities! The hospital is one of the largest and leading university medical complexes in Europe. The hospital in Germany provides modern diagnostics and treatment of patients, a
Thyroid lymphoma diagnosis
Resection of thyroid lymphoma

University Hospital Bonn

location_onGermany, Bonn

Department of Oncology, Hematology, Rheumatology and Immunoncology

According to the authoritative Focus magazine, the University Hospital Bonn ranks among the top ten medical facilities in Germany! The hospital was opened on January 1, 2001, although in fact it inherits the medical facility, which operated at the Faculty of Medicine of the University of Bonn. The hospital in Germany combin
Thyroid lymphoma diagnosis
Resection of thyroid lymphoma

University Hospital Giessen UKGM

location_onGermany, Giessen

Department of Oncology, Hematology and Palliative Care

The University Hospital Giessen UKGM positions itself as an ultramodern medical facility with outstanding quality of medical care. The hospital presents almost all areas of medicine, ranging from ophthalmology to traumatology and dentistry. The priorities of the hospital’s activities include surgery, neurosurgery, oncology
Thyroid lymphoma diagnosis
Resection of thyroid lymphoma

University Hospital of Ludwig Maximilian University of Munich

location_onGermany, Munich

Department of Oncology, Hematology and Bone Marrow Transplantation

According to the Focus magazine, the University Hospital of Ludwig Maximilian University of Munich is regularly ranked among the best medical institutions in Germany! The hospital is the largest multidisciplinary medical facility, as well as a leading research and training center in Germany and Europe. The hospital is proud of i
Thyroid lymphoma diagnosis
Resection of thyroid lymphoma

University Hospital Marburg UKGM

location_onGermany, Marburg

Department of Hematology, Oncology and Immunology

The University Hospital Marburg UKGM offers patients modern diagnostics and comprehensive therapy at the international level. As a maximum care hospital, the medical facility specializes in all fields of modern medicine ranging from ophthalmology to traumatology and dentistry. The main areas of specialization of the hospital are
Thyroid lymphoma diagnosis
Resection of thyroid lymphoma

University Hospital Muenster

location_onGermany, Muenster

Department of Hematology, Hemostaseology, Oncology and Pulmonology

According to the Focus magazine, the University Hospital Muenster ranks among the top German hospitals! The hospital belongs to the most prestigious medical institutions in Germany. The hospital is distinguished by a high professionalism of its doctors, state-of-the-art technological equipment and the availability of the most ad
Thyroid lymphoma diagnosis
Resection of thyroid lymphoma
| from Booking Health GmbH

Thyroid lymphoma is a malignant tumor of the lymphoid tissue. In developed countries, it is a curable disease. Doctors successfully deal with the treatment of patients with the aggressive types of neoplasms, including those with relapses or when the disease is detected at an advanced stage.

You can travel abroad for your thyroid lymphoma treatment with good results and minimal health risks. You are kindly welcome to make your treatment appointment at the best price through the Booking Health service.


  1. What is thyroid lymphoma?
  2. Surgical treatment
  3. Radiation therapy
  4. Chemotherapy
  5. Immunotherapy and targeted therapy
  6. Treatment of relapses of therapy-refractory lymphoma
  7. Where to undergo treatment?

What is thyroid lymphoma?


Thyroid lymphoma is a rare oncological disease that accounts for up to 3% of all the neoplasms of this organ and up to 5% of extranodal lymphomas (developing outside the lymph nodes). In developed countries, the disease can be successfully treated. Doctors use surgery, radiation therapy, chemotherapy, and immunotherapy. The five-year survival rate for the patients with this disease is 80%, and the median survival is almost 12 years.

The term lymphoma of the thyroid gland reflects the location of the tumor, but not its type. The organ can be affected by various types of lymphomas. The most common is diffuse large B-cell lymphoma. Less common are MALT lymphoma and follicular lymphoma. Other histological variants also occur, but very rarely.

Diffuse large B-lymphoma has a poorer prognosis because it is usually diagnosed at the advanced stage. Nonetheless, doctors abroad have also learned how to deal with this disease successfully: the five-year survival rate of the patients has already reached 75%. It will only increase as new and more effective drugs appear. In other variants of the disease, the prognosis is more favorable: the five-year tumor-specific survival rate for follicular lymphoma is 87%, for MALT lymphoma, it reaches 96%, and for other non-Hodgkin's lymphomas, this indicator makes up 83%.

Thyroid lymphoma usually manifests itself as an enlarged mass in the front of the neck. The tumor disrupts breathing and swallowing, as well as causes an enlargement of the cervical lymph nodes. 10% of the patients already have symptoms at the time of establishing their diagnosis: night sweats, weight loss, and fever. The presence of these signs is a factor in a poor prognosis.

Surgical treatment


Doctors usually do not treat lymphoma using surgical techniques. This is due to the fact that the operation is not required. An early-stage disease can be treated with more sparing methods, such as radiation therapy. If the tumor has spread throughout the body, then chemotherapy and immunotherapy become the main methods of treatment.

However, thyroid lymphoma is an exception to this rule. More than half of patients undergo surgical treatment. There are several reasons for this:

  • Insufficient diagnostic accuracy. Doctors suspect thyroid cancer in many patients, but the final diagnosis is made only after the removal of the organ.
  • Compression symptoms. At the time of lymphoma detection, the patient may have breathing problems due to the compression of the larynx and trachea. Surgery is the fastest way to restore respiratory function.
  • Contraindications to radiation therapy. For example, if a person has previously undergone neck irradiation for other diseases, the early-stage thyroid lymphoma can then be cured with the help of surgery. 

A feature of the surgical treatment of lymphoma of the thyroid gland is that it is more sparing than the treatment of cancer of this organ. Doctors usually do not have to remove cervical lymph nodes. The thyroid gland itself is not entirely removed unless an attempt is made to treat the early-stage lymphoma without chemotherapy. As a rule, the diagnosis is already established by a biopsy at the time of treatment, and surgery is followed by radiation therapy or chemotherapy. Therefore, doctors perform a lobectomy or a subtotal thyroidectomy – they remove half of the thyroid gland and sometimes resect most of this organ. But still, a part of the thyroid gland is preserved, which avoids lifelong hormone replacement therapy. The compression symptoms of the neck organs disappear immediately after the operation, and the remaining malignant cells are subsequently destroyed with the help of radiation and medications.

Radiation therapy


Radiation therapy is considered the main treatment for early-stage thyroid lymphoma. It is the technique of choice for approximately 40% of patients with a newly diagnosed disease.

Radiation therapy can also be used after surgery. It allows doctors to destroy the remaining cancer cells in the thyroid gland and lymph nodes in order to cure the disease completely.

In the early stages, radiation therapy alone or in combination with surgery works well even without any chemotherapy. Therefore, approximately 30% of patients with thyroid lymphoma can avoid systemic treatment and the associated side effects accordingly.

Doctors in developed countries use the most advanced methods of radiation therapy. This affects the tumor with radiation and has practically no negative effect on the surrounding organs and tissues of the neck, including; large blood vessels, nerves, larynx, trachea, esophagus, cervical spine, and spinal cord.



For most patients with primary thyroid lymphomas, chemotherapy becomes the main and often the only treatment option. Approximately 70% of patients undergo this type of treatment. If the tumor is large, it is first removed or irradiated, followed by chemotherapy. In the absence of a threat of severe complications, the treatment can be started with chemotherapy: it will gradually reduce the size of both the primary tumor in the thyroid gland and all its metastases. In addition, the inclusion of glucocorticoids in the treatment regimen allows doctors to achieve significant symptom relief for their patients within a few hours after the start of chemotherapy. According to its results, tumor foci completely disappear in most patients.

The CHOP chemotherapy regimen remains the most commonly used one, although other drug combinations may also be applied. They are often supplemented with drugs for immunotherapy (R-CHOP scheme), and targeted therapy works well for some types of thyroid lymphomas. 

Some patients may have their lymphoma spread to the structures of the central nervous system. In such situations, doctors resort to intrathecal chemotherapy (the administration of drugs into the CSF using a lumbar puncture) since the drugs do not penetrate the blood-brain barrier well and therefore do not have a good effect on metastases when administered intravenously.

Immunotherapy and targeted therapy


Immunotherapy is often used in addition to chemotherapy or as a standalone second-line treatment. Targeted therapy is usually not included in the standard treatment regimens and is used when other drugs do not work.

Doctors use the following types of drugs:

CD20 monoclonal antibodies target proteins on the surface of the lymphoma cells. This type of treatment has already become part of the standard first-line therapy for patients with any stage of thyroid lymphoma. The inclusion of monoclonal antibodies in the treatment regimen makes it more likely to cure the disease. The healthcare professionals abroad use both standard forms of drugs for the intravenous administration and more convenient subcutaneous forms, which are administered in just 5-7 minutes.

CD19 monoclonal antibodies are the drugs targeting the CD19 antigen. They are often used as a second-line therapy, along with immunomodulators (drugs that stimulate the immune system). This type of treatment is used in cases where the lymphoma has recurred after the primary treatment, does not respond to chemotherapy, and a stem cell transplant is contraindicated for a person. In addition to standard monoclonal antibodies, antibody-drug conjugates are also used abroad. They consist of an antibody and a chemotherapy drug. The antibody, targeting the CD19 protein, delivers the drug directly to the tumor cells. 

Immune checkpoint inhibitors are rarely used for thyroid lymphomas. They reduce the ability of the tumor to evade the immune response.

Target therapy involves the use of proteasome, Bruton's tyrosine kinase, PI3K, EZH2, or nuclear export inhibitors. Some drugs only work for certain subtypes of lymphoma that have mutations in the genes. The patients are screened for these mutations before starting their treatment.

Treatment of relapses of therapy-refractory lymphoma


Doctors face the greatest challenge when the patient's lymphoma becomes resistant to chemotherapy. Doctors change the regimen of drug use, and sometimes this leads to a good therapeutic effect. But sooner or later, thyroid lymphoma loses its sensitivity to other drugs as well, continuing to grow in size and spread to the new parts of the body, even with the treatment provided.

Even for such severe cases, foreign doctors have the tools to fight against this disease. Doctors in developed countries use the following methods of treatment:

An autologous stem cell transplant is a procedure for transplanting the patient's own stem cells. First, doctors carry out high-dose chemotherapy to destroy all thyroid lymphoma cells in the patient's body. These doses of drugs also destroy the bone marrow. The pre-harvested stem cells are injected intravenously to restore it. They enter the bone marrow and multiply, as a result of which the production of blood cells resumes. In young patients, the bone marrow transplant procedure rarely causes severe complications, and at the same time, it can achieve long-term remission.

An allogeneic stem cell transplant is rarely used for lymphoma, as this variant of the procedure sometimes causes complications, and doctors are not always able to find a suitable donor for the patient. This is the second-line treatment option, which is used if thyroid lymphoma has recurred after the autologous transplant. The stem cell transplant from a donor works better because it activates the graft-versus-tumor effect. The renewed immunity attacks cancer cells and even destroys them completely, thus curing cancer.

CAR T-cell therapy is used to diffuse large B-cell lymphomas and follicular lymphomas if at least two methods of treatment have not led to a good therapeutic effect. Doctors harvest leukocytes (immune cells) from the patient, change their genome, multiply the altered cells and inject them into the patient's body. As a result, leukocytes attack the tumor and destroy it, thereby reducing it in size or destroying it completely.

Where to undergo treatment?


You can undergo your thyroid lymphoma treatment abroad. Doctors in developed countries successfully cure the disease in most patients. Moreover, they treat the pathology with the help of sparing methods and with minimal risk of severe complications. The specialists successfully cope with even the most aggressive and advanced tumors.

There are a few reasons for you to undergo your treatment abroad: 

  • a low frequency of surgical interventions: doctors usually manage to cope with the disease with the help of radiation therapy and drug treatment;
  • the use of modern and patient-safe options for radiation therapy, which destroy the tumor almost without affecting the healthy tissues surrounding it;
  • the use of modern chemotherapy regimens, which are often supplemented with immunotherapy and targeted therapy;
  • patients have access to the latest drugs that are not yet used in countries with poorly developed medicine;
  • even the most severe cases of lymphoma are successfully treated with stem cell transplant and CAR T-cell therapy.

You are kindly welcome to use the Booking Health service to see the cost of treatment in different hospitals, compare prices and make your treatment appointment at the best price. Please leave your request on our website: an employee from the Booking Health company will call you and help you to find the most suitable clinic. Our company's specialists will fully organize your trip abroad. When booking your treatment through the Booking Health service, the cost of treatment for your lymphoma will be lower due to the lack of additional fees for foreign patients.



The article was edited by medical experts, board-certified doctors Dr. Nadezhda Ivanisova and Dr. Sergey Pashchenko. For the treatment of the conditions referred to in the article, you must consult a doctor; the information in the article is not intended for self-medication!



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