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Skin Cancer — Cryosurgery: treatment in the Best Hospitals in the World

University Hospital of Ludwig Maximilian University of Munich

10/10
location_onGermany, Munich

Department of Adult and Pediatric Dermatology, Allergology and Phlebology

The Department of Adult and Pediatric Dermatology, Allergology and Phlebology offers all the options of modern medicine for diagnosing and treating skin diseases, allergies, and venereal pathologies. The focus of the department's dermatologists is on patients with various types of skin cancer, psoriasis, eczema, neurodermatitis, acne, venous diseases, and chronic non-healing leg ulcers. The medical facility also admits young patients, including those with rare and genetic skin diseases. The department has an excellent technical base, thanks to which modern laser treatment, light therapy, phototherapy, and advanced sparing surgical interventions are successfully performed here. Top-class medical care is provided by a highly professional team of 60 specialized doctors and 130 nurses, as well as medical and technical workers. About 90,000 patients undergo outpatient treatment, and more than 5,800 patients receive medical care on an inpatient basis annually. The hospital has 160 beds to accommodate patients. The department is thus one of the largest medical facilities of this kind in Germany.

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Helios Hospital Berlin-Buch

9.7/10
location_onGermany, Berlin

Department of Dermatology and Allergology

The Department of Dermatology and Allergology provides all diagnostic tests and therapeutic measures for the treatment of skin diseases and allergic reactions. The priority area of the department's work is the treatment of malignant skin neoplasms (certification as a Skin Cancer Center of the German Cancer Society). Each patient receives an individual treatment regimen for skin pathology or allergies, which includes the most effective and sparing therapeutic methods.

University Hospital Frankfurt am Main

10/10
location_onGermany, Frankfurt am Main

Department of Dermatology, Venereology and Allergology

The Department of Dermatology, Venereology and Allergology offers the diagnostics and treatment of all dermatological diseases. The department specializes in the very latest methods of surgical dermatology, diagnostics and treatment of skin cancer, venous diseases, as well as all diagnostic and therapeutic methods of modern dermatology, including laser dermatological therapy, phototherapy, photodynamic therapy, etc. The treatment of patients with skin cancer is carried out in close cooperation with colleagues from the University Cancer Center Frankfurt.

Charite University Hospital Berlin

9/10
location_onGermany, Berlin

Department of Adult and Pediatric Dermatology, Venereology and Allergology

The Department of Adult and Pediatric Dermatology, Venereology and Allergology offers the full range of medical services in these fields. The department's specialists treat all skin diseases, including rare clinical cases, sexually transmitted infections and allergic reactions. The department's modern technical facilities and fruitful research activities aimed at the optimization and development of therapeutic techniques are the key to the successful clinical practice. Also, the department uses the concept of holistic approach to treatment, which provides for the adaptation of therapy to specific indications and needs of the patient, respectful and sympathetic attitude.

University Hospital RWTH Aachen

8.7/10
location_onGermany, Aachen

Department of Dermatology and Allergology

The Department of Dermatology and Allergology treats all skin diseases and is one of the leading medical facilities of this kind in Germany. The department's doctors specialize in the treatment of inflammatory skin diseases (for example, psoriasis, eczema), allergies, skin infections, diseases of the mucous membranes, nails and hair. The key focus of the department’s work is the treatment of skin tumors. In addition, the department's dermatologists have unique experience in the treatment of rare skin diseases. The department positions itself as maximum care medical facility, in which all classical and advanced methods of diagnostics and therapy are available. The primary task of each employee is the effective treatment, which meets the very latest medical standards.

University Hospital Ulm

8.7/10
location_onGermany, Ulm

Department of Dermatology and Allergology

The Department of Dermatology and Allergology offers the full range of therapy and diagnostics of skin diseases and allergic reactions. The department has 35 inpatient and 14 partially inpatient beds. The doctors use the very latest treatment methods, modern laser technologies, allowing to achieve the optimal therapeutic and aesthetic effect. Also, the department has an in-house laboratory for conducting all the necessary skin examinations.

University Hospital Würzburg

9.2/10
location_onGermany, Würzburg

Department of Adult and Pediatric Dermatology, Venereology and Allergology

The Department of Adult and Pediatric Dermatology, Venereology and Allergology is one of the largest advanced Dermatology Centers in Germany with rich traditions. The department offers the diagnostics and treatment of the entire spectrum of dermatological and allergic diseases. The department specializes in the treatment of psoriasis, eczema, allergies, skin infections, diseases of the mucous membranes, nails and hair. The specialists have a special competence in the treatment of skin cancer.

University Hospital Erlangen

9.1/10
location_onGermany, Erlangen

Department of Dermatology, Allergology and Andrology

The Department of Dermatology, Allergology and Andrology offers accurate diagnostics and effective treatment of diseases of the skin and its appendages, allergic reactions, as well as male infertility and erectile dysfunction. Priority is given to the diagnostics and treatment of skin tumors, inflammatory skin diseases, vitiligo, psoriasis, neurodermatitis and chronic non-healing wounds. Skin cancer therapy is carried out within a specialized Skin Cancer Center certified by the German Cancer Society. The department's dermatologists successfully apply conservative treatment methods (ointments, gels, pills), advanced laser technologies and surgical techniques. Every year, the department admits more than 3,000 inpatients and about 50,000 outpatients. Close interdisciplinary cooperation and the very latest infrastructure of the university hospital ensure the highest level of medical services and the best treatment results, thanks to which the department has an impeccable reputation throughout Europe and beyond.

University Hospital Hamburg-Eppendorf

9.2/10
location_onGermany, Hamburg

Department of Dermatology and Venereology

The Department of Dermatology and Venereology offers the broadest options for the diagnostics and treatment of all skin diseases and sexually transmitted diseases. Of particular interest is the treatment of patients with skin tumors, chronic wounds, phlebological disorders, autoimmune pathologies and chronic inflammatory skin diseases, such as eczema, psoriasis, neurodermatitis. In addition, the service spectrum covers the comprehensive diagnostics and treatment of allergic diseases, the most modern treatment methods in the field of aesthetic dermatology.

University Hospital Muenster

9.8/10
location_onGermany, Muenster

Department of Adult and Pediatric Dermatology, Venereology

The Department of Adult and Pediatric Dermatology, Venereology offers the full range of medical services in these fields. The department is one of the largest medical facilities in Germany specializing in the treatment of congenital and acquired skin diseases. The department's doctors have in their arsenal many classic and innovative treatment methods, which provide the best therapeutic and aesthetic result. For patients with incurable diseases, the doctors develop individual therapy concepts aimed at the prevention of disease progression and improvement of the patient’s quality of life. One of the priorities is the treatment of skin cancers (certification of the German Cancer Society).

University Hospital Bonn

9.2/10
location_onGermany, Bonn

Department of Dermatology and Allergology

The Department of Dermatology and Allergology offers the diagnostics and treatment of all dermatological pathologies. The department specializes in the treatment of chronic inflammatory dermatoses, autoimmune diseases, skin tumors, operative dermatology, etc. The department also offers the high-quality medical services in the treatment of venous disease of the lower extremities, treatment of all types of allergies, impaired fertility in men, etc.

University Hospital Heidelberg

9.8/10
location_onGermany, Heidelberg

Department of Adult and Pediatric Dermatology

The Department of Adult and Pediatric Dermatology offers the full range of diagnostics and treatment of skin diseases, including extremely complex and rare clinical cases in this field. The department became the first in Germany, which was certified in accordance with the standards of the German Cancer Society, and today occupies a leading position in the treatment of skin cancer both at the national and international level. The priority task of the specialists of the department is to provide patients with the interdisciplinary, individualized medical care.

University Hospital Halle (Saale)

9.6/10
location_onGermany, Halle

Department of Dermatology and Venereology

The Department of Dermatology and Venereology offers the full range of services for the diagnostics and treatment of all skin and sexually transmitted diseases. Of particular interest are general dermatology, oncological, allergic and surgical dermatology. The department has specialized laboratories, which conduct all modern laboratory tests. The department's competent specialists have a huge number of effective surgical techniques and vast experience in the treatment of diseases of the veins, lymphatic vessels and capillaries.

University Hospital Essen

9.6/10
location_onGermany, Essen

Department of Dermatology

The Department of Dermatology offers the full range of medical services for the diagnostics and treatment of skin, sexually transmitted diseases, and allergic reactions. The key clinical focus is the therapy of benign and malignant skin tumors. Particular attention is also paid to cosmetic dermatology, for example, keloid scar revision, removal of pigment spots, spider veins, etc. The department treats about 2,700 inpatients and 49,500 outpatients every year. Thus, the department ranks among the largest and leading German medical facilities of this kind.

University Hospital Jena

8.9/10
location_onGermany, Jena

Department of Dermatology

The Department of Dermatology offers the full range of diagnostics and treatment for patients with various skin diseases, including rare and severe types, as well as with allergic reactions and sexually transmitted diseases. The treatment is provided both on an inpatient and outpatient basis. In addition, the department has a specialized Skin Cancer Center (certified by the German Cancer Society) and the Hives Center. The department is proud of its successful clinical practice, which has been conducted for more than 100 years, providing patients with the first-class medical care.

University Hospital Marburg UKGM

8.6/10
location_onGermany, Marburg

Department of Dermatology and Allergology

The Department of Dermatology and Allergology offers all the modern diagnostic and therapeutic options for patients with skin diseases, including skin manifestations of allergic reactions. The department has been conducting successful clinical activities for more than 100 years, and therefore it has extensive experience and unique achievements in its area of specialization. Such advanced fields of dermatology as laser therapy, light therapy, dermatohistology, etc. are well developed in the department. It operates an emergency dermatological care service, which provides round-the-clock patient care.

Skin cancer is a malignant tumor that ranks among the most common in the world. 75% of cases of non-melanoma neoplasms occur in basal cell carcinoma, most of the remaining cases are squamous cell carcinoma. According to the WHO, skin cancer is one of the five most common malignant tumors in the world. Nonetheless, people rarely die from this disease, since the existing treatments can remove the neoplasm and prevent the development of relapse.

What is cryodestruction? 

Cryodestruction (cryosurgery) involves the destruction of cancer cells with liquid nitrogen. The tissues freeze when exposed to temperatures minus 196 degrees. This results in the formation of crystals that mechanically damage cell membranes. The freezing worsens blood circulation in the affected area, which leads to tissue necrosis.

An important condition for successful treatment of skin cancer and melanoma is complete and irreversible necrosis. It eliminates the possibility of restoration of cell activity after thawing.

Advantages of cryodestruction: 

  • Sparing effect 
  • Good aesthetic result 
  • Possibility to use on an outpatient basis 
  • Possibility to use in elderly and debilitated patients 
  • Bloodless intervention 
  • Minimal pain, most patients do not even need anesthesia 

Disadvantages of removing skin cancer using cryotherapy: 

  • Inflammatory reactions after the procedure 
  • Risk of infectious complications, to prevent which the patient has to take antibiotics or use local antibacterial agents
  • Exposure depth reaches a maximum of 1 cm, so the method is not suitable for the removal of large neoplasms

Cryotherapy gives relatively many relapses. Their frequency reaches 4-9% during 5 years of monitoring with primary tumors, 13-22% with recurrent skin cancer. The method is not suitable for removing tumors on the nose, ears, it can rarely be used to remove tumors on the eyelids, because the effect is not too precise, and this leads to gross aesthetic defects and impaired organ function.

How is cryodestruction performed?

There are two main ways of tissue freezing: 

  • Applique 
  • Dispersion

The indication for dispersing or irrigation of liquid nitrogen over the tumor is a large area of formation with a minimal depth of invasion. This is how superficial neoplasms are treated.

Application is performed when the volume of the malignant tumor is up to 2 cm, the invasion depth dos not exceed 0.7 cm. To remove such neoplasms, the tip of the cryogenic instrument must be fixed directly to the tumor. In total, 2 or 3 cycles of freezing and thawing are required to completely destroy skin cancer. The application time is from 0.5 to 3 minutes. It depends on the location of the tumor and the depth of invasion. The thawing of tissues lasts an average of 3 minutes, after which they are again exposed to liquid nitrogen.

Skin cancer is affected in the center of the tumor. The necrosis zone is gradually spreading to the periphery. The exposure is stopped when the frozen area extends 5 mm or more from the edge of the tumor towards the visually unchanged skin integument.

Cryodestruction results in a skin defect. It is treated with an antiseptic. A scar is formed on average after 1 month. 

Puncture cryodestruction 

Puncture cryodestruction is a new method of cryosurgery used in foreign clinics. It can be used to treat large or recurrent tumors.

Puncture cryodestruction involves the introduction of thin probes under ultrasound guidance. The first stage is tumor imaging. It determines the zones of its spread. Skin cancer invasion usually goes along the blood vessels and between the muscles. A doctor determines a tumor map, plans healthy tissue capture by 5 mm in each direction. In the area of skin cancer spread, the doctor inserts thin tubes, through which liquid nitrogen is supplied.

Such operations are performed under general anesthesia. They are technically more complex and can be used in specialized centers. The procedure is performed under continuous ultrasound guidance. Commonly used puncture cryodestruction apparatuses contain probes with a diameter of 1.5 to 5 mm and a needle length of up to 20 cm.

After the cryosurgery procedure, edema in the area of exposure remains for 2-3 days. In those areas where cryotherapy was performed superficially (using the application method), lymphorrhea (lymph secretion) is noted. Within 1 week, a change of dressings and treatment of the wound with antiseptics is required. The doctors often prescribe antibacterial agents inside.

A dry necrotic scab forms 1 week later. After this, further medical supervision is not required. After 2-4 weeks, the scab disappears and the wound heals. The puncture sites do not require any treatment. They heal quickly and do not leave large scars.

Puncture cryodestruction for recurrent forms of skin cancer has an efficiency of up to 93%. Nevertheless, the possibilities of the method are limited. The procedure cannot be used when bone tissue, large blood vessels, joints, airways, genitals and topographically complex areas of the body are involved in the tumor process. 

Treatment abroad with the Booking Health company

To undergo treatment abroad, in the best hospitals in the world, please contact Booking Health. We offer the following benefits: 

  • Selection of the best clinic that specializes in cryosurgery for skin cancer and achieves the best results in this field of oncology.
  • Reduced cost of cryotherapy up to 50% due to the lack of overpricing and additional coefficients for foreign patients.
  • Booking an appointment for the diagnostics and treatment on the most suitable dates for you. 
  • Preparation of a cryosurgery program based on the studies performed.
  • Establishment of communication directly with the attending physician.
  • Monitoring all stages of the cryotherapy program.
  • Control of invoices, return of unspent funds.
  • Buying and forwarding medicines. 
  • Organization of additional diagnostic or therapeutic procedures.
  • Communication with the clinic after cryotherapy completion.

The Booking Health company will provide you with top-class services. We will help you with paperwork, book a hotel and airline tickets, meet you at the airport and take you to the hospital by car.




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