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Skin Cancer — Photodynamic Therapy (PDT): treatment in the Best Hospitals in the World

University Hospital of Ludwig Maximilian University of Munich

10/10
location_onGermany, Munich

Department of Adult and Pediatric Dermatology, Allergology

The Department of Adult and Pediatric Dermatology, Allergology offers the full range of diagnostic and therapeutic services in these medical fields. The Department specializes in the treatment of all skin diseases, allergic reactions and venereal pathologies. The quality medical care is provided by a highly professional team of 50 specialized doctors and 300 nurses, as well as medical and technical workers. About 90,000 outpatients and more than 5,800 inpatients are treated here annually.

Include:
people Interpreter up to 5 hours
list Translation up to 4 pages
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book Insurance against increased costs in case of complications with a cover of 200,000 €

Medipol Mega University Hospital Istanbul

8/10
location_onTurkey, Istanbul

Department of Dermatology

The Department of Dermatology offers the full range of diagnostics and treatment of diseases of the skin and its appendages, as well as the solution of aesthetic skin problems. The highly qualified team of the department's dermatologists has at its command all modern treatments, including phototherapy, galvanotherapy and a wide selection of dermatologic procedures, such as cryotherapy, electrocautery, puncture and excisional biopsy. The very latest treatment methods in combination with the exceptional qualifications of doctors make it possible to successfully deal even with particularly complex pathologies.

Hospital directly3187
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Primus Super Speciality Hospital New Delhi

9/10
location_onIndia, New Delhi

Department of Adult and Pediatric Dermatology

The Department of Adult and Pediatric Dermatology offers all the options of modern diagnostics and treatment of skin diseases, sexually transmitted infections and leprosy. It also provides many cosmetic services and specialized treatment for skin diseases in infants, children and adolescents. The purpose of the department's doctors is to provide a highly professional and comprehensive medical care focused on the patient with his individual needs and wishes.

University Hospital Frankfurt am Main

10/10
location_onGermany, Frankfurt am Main

Department of Dermatology, Venereology and Allergology

The Department of Dermatology, Venereology and Allergology offers the diagnostics and treatment of all dermatological diseases. The department specializes in the very latest methods of surgical dermatology, diagnostics and treatment of skin cancer, venous diseases, as well as all diagnostic and therapeutic methods of modern dermatology, including laser dermatological therapy, phototherapy, photodynamic therapy, etc. The treatment of patients with skin cancer is carried out in close cooperation with colleagues from the University Cancer Center Frankfurt.

University Hospital RWTH Aachen

8.7/10
location_onGermany, Aachen

Department of Dermatology and Allergology

The Department of Dermatology and Allergology treats all skin diseases and is one of the leading medical facilities of this kind in Germany. The department's doctors specialize in the treatment of inflammatory skin diseases (for example, psoriasis, eczema), allergies, skin infections, diseases of the mucous membranes, nails and hair. The key focus of the department’s work is the treatment of skin tumors. In addition, the department's dermatologists have unique experience in the treatment of rare skin diseases. The department positions itself as maximum care medical facility, in which all classical and advanced methods of diagnostics and therapy are available. The primary task of each employee is the effective treatment, which meets the very latest medical standards.

University Hospital Würzburg

9.2/10
location_onGermany, Würzburg

Department of Adult and Pediatric Dermatology, Venereology and Allergology

The Department of Adult and Pediatric Dermatology, Venereology and Allergology is one of the largest advanced Dermatology Centers in Germany with rich traditions. The department offers the diagnostics and treatment of the entire spectrum of dermatological and allergic diseases. The department specializes in the treatment of psoriasis, eczema, allergies, skin infections, diseases of the mucous membranes, nails and hair. The specialists have a special competence in the treatment of skin cancer.

Charite University Hospital Berlin

9/10
location_onGermany, Berlin

Department of Adult and Pediatric Dermatology, Venereology and Allergology

The Department of Adult and Pediatric Dermatology, Venereology and Allergology offers the full range of medical services in these fields. The department's specialists treat all skin diseases, including rare clinical cases, sexually transmitted infections and allergic reactions. The department's modern technical facilities and fruitful research activities aimed at the optimization and development of therapeutic techniques are the key to the successful clinical practice. Also, the department uses the concept of holistic approach to treatment, which provides for the adaptation of therapy to specific indications and needs of the patient, respectful and sympathetic attitude.

University Hospital Ulm

8.7/10
location_onGermany, Ulm

Department of Dermatology and Allergology

The Department of Dermatology and Allergology offers the full range of therapy and diagnostics of skin diseases and allergic reactions. The department has 35 inpatient and 14 partially inpatient beds. The doctors use the very latest treatment methods, modern laser technologies, allowing to achieve the optimal therapeutic and aesthetic effect. Also, the department has an in-house laboratory for conducting all the necessary skin examinations.

University Hospital Erlangen

9.1/10
location_onGermany, Erlangen

Department of Dermatology

The Department of Dermatology offers the diagnostics and treatment of all skin diseases. The department specializes in the treatment of skin tumors and operative dermatology, the treatment of allergies, autoimmune diseases, hair and scalp diseases. Skin cancers are treated within the framework of the Skin Cancer Center certified by the German Cancer Society. Close interdisciplinary cooperation, state-of-the-art infrastructure of the university hospital provide the highest level of medical services and the best treatment results.

University Hospital Hamburg-Eppendorf

9.2/10
location_onGermany, Hamburg

Department of Dermatology and Venereology

The Department of Dermatology and Venereology offers the broadest options for the diagnostics and treatment of all skin diseases and sexually transmitted diseases. Of particular interest is the treatment of patients with skin tumors, chronic wounds, phlebological disorders, autoimmune pathologies and chronic inflammatory skin diseases, such as eczema, psoriasis, neurodermatitis. In addition, the service spectrum covers the comprehensive diagnostics and treatment of allergic diseases, the most modern treatment methods in the field of aesthetic dermatology.

University Hospital Muenster

9.8/10
location_onGermany, Muenster

Department of Adult and Pediatric Dermatology, Venereology

The Department of Adult and Pediatric Dermatology, Venereology offers the full range of medical services in these fields. The department is one of the largest medical facilities in Germany specializing in the treatment of congenital and acquired skin diseases. The department's doctors have in their arsenal many classic and innovative treatment methods, which provide the best therapeutic and aesthetic result. For patients with incurable diseases, the doctors develop individual therapy concepts aimed at the prevention of disease progression and improvement of the patient’s quality of life. One of the priorities is the treatment of skin cancers (certification of the German Cancer Society).

University Hospital Bonn

9.2/10
location_onGermany, Bonn

Department of Dermatology and Allergology

The Department of Dermatology and Allergology offers the diagnostics and treatment of all dermatological pathologies. The department specializes in the treatment of chronic inflammatory dermatoses, autoimmune diseases, skin tumors, operative dermatology, etc. The department also offers the high-quality medical services in the treatment of venous disease of the lower extremities, treatment of all types of allergies, impaired fertility in men, etc.

University Hospital Heidelberg

9.8/10
location_onGermany, Heidelberg

Department of Adult and Pediatric Dermatology

The Department of Adult and Pediatric Dermatology offers the full range of diagnostics and treatment of skin diseases, including extremely complex and rare clinical cases in this field. The department became the first in Germany, which was certified in accordance with the standards of the German Cancer Society, and today occupies a leading position in the treatment of skin cancer both at the national and international level. The priority task of the specialists of the department is to provide patients with the interdisciplinary, individualized medical care.

University Hospital Halle (Saale)

9.6/10
location_onGermany, Halle

Department of Dermatology and Venereology

The Department of Dermatology and Venereology offers the full range of services for the diagnostics and treatment of all skin and sexually transmitted diseases. Of particular interest are general dermatology, oncological, allergic and surgical dermatology. The department has specialized laboratories, which conduct all modern laboratory tests. The department's competent specialists have a huge number of effective surgical techniques and vast experience in the treatment of diseases of the veins, lymphatic vessels and capillaries.

University Hospital Essen

9.6/10
location_onGermany, Essen

Department of Dermatology

The Department of Dermatology offers the full range of medical services for the diagnostics and treatment of skin, sexually transmitted diseases, and allergic reactions. The key clinical focus is the therapy of benign and malignant skin tumors. Particular attention is also paid to cosmetic dermatology, for example, keloid scar revision, removal of pigment spots, spider veins, etc. The department treats about 2,700 inpatients and 49,500 outpatients every year. Thus, the department ranks among the largest and leading German medical facilities of this kind.

University Hospital Jena

8.9/10
location_onGermany, Jena

Department of Dermatology

The Department of Dermatology offers the full range of diagnostics and treatment for patients with various skin diseases, including rare and severe types, as well as with allergic reactions and sexually transmitted diseases. The treatment is provided both on an inpatient and outpatient basis. In addition, the department has a specialized Skin Cancer Center (certified by the German Cancer Society) and the Hives Center. The department is proud of its successful clinical practice, which has been conducted for more than 100 years, providing patients with the first-class medical care.

Photodynamic therapy for skin cancer is one of the progressive treatments for this disease. It is widely used in the leading Cancer and Dermatology Centers of developed countries. The method has many advantages, such as minimal invasiveness, high selectivity of tumor tissue damage and the absence of severe complications.

Principle of the method 

Photodynamic therapy involves the introduction of a photosensitizer into the patient's body. This is a substance that accumulates in cancer cells. The substance itself is not toxic, but it is activated when exposed to light waves of a certain length. Once the sensitizer has been administered, the tumor will be irradiated with this light. The photosensitizer activates and destroys cancer cells.

Typically, the destruction occurs due to the activation of oxygen and the formation of many free radicals. The cell death initiates singlet oxygen. The photosensitizers of the first generations used to be an option of choice. They were poorly accumulated in cancer cells, did not cause total tumor destruction, and therefore they were used only as palliative treatment. However, today there are new drugs that are more effective. They can completely destroy cancer cells, thereby curing the disease.

The advantages of the method include: 

  • It is more sparing than surgery
  • It can completely cure skin cancer at the initial stages 
  • The procedure is performed on an outpatient basis
  • Accurate tumor targeting, minimal impact on healthy tissue 
  • Wounds heal without large scars, and therefore the procedure provides a good aesthetic effect

At the same time, PDT has limitations. This method can only treat tumors that can be irradiated with light waves after the introduction of the photosensitizer. Therefore, PDT in monotherapy cannot be used for invasive skin cancer and the presence of metastasis. Nonetheless, it can be combined with radiation therapy, chemotherapy and surgical treatment for skin cancer.

What patients can be treated with PDT? 

Photodynamic therapy is suitable for:

  • Patients who do not want to undergo surgery 
  • Patients who have a T1 tumor – up to 2 cm in diameter
  • Patients who have a T2 tumor – more than 2 cm, but without invasion into the deeper layers of the skin 
  • Patients who have a tumor located in aesthetically significant areas of the skin 

The therapy aims not to reduce the tumor and not to slow its growth, but to completely destroy it. The effectiveness depends on the stage of skin cancer, the location of the tumor and the photosensitizer used. On average, when treating stage 1-2 of the disease, it is possible to achieve a complete cure of the disease in 85% of patients.

How is PDT performed?

Photodynamic therapy begins with the introduction of a sensitizer. It is usually administered intravenously. A few hours after this, the tumor is irradiated using a special device. The distance to the radiation source is several centimeters and depends on the area to be exposed. The light spot is directed so that it extends beyond the boundaries of skin cancer by 0.5 cm or more. The radiation time and energy density are calculated individually.

There are photosensitizers that can be applied locally. They are safer, do not require the protection of the patient from light after a course of therapy. They can also be used in elderly patients and in patients with a burdened allergic medical history. At the same time, local photosensitizers are less effective, therefore, they can be used only with a minimal depth of cancer invasion, in the very early stages.

To cure the disease, the patient often requires not one, but several sessions. Each time the patient is under control. The doctor examines the patient 1 month after PDT. The full cure can be achieved in half of the patients the first time. The rest require a second course of photodynamic therapy. After the second exposure, a complete destruction of the tumor occurs in another 30% of patients. The subsequent third and fourth sessions of PDT, which are performed with an interval of 1 month, can cure another 15% of patients. Only 5% have to additionally resort to other treatments.

Most patients do not have a relapse of the tumor. It happen within 5 years in 15% of cases. The relapses can also be treated with photodynamic therapy, and in most patients this approach leads to a cure for the disease.

The treatment process usually does not require local anesthesia. Non-narcotic analgesics can sometimes be used. During the irradiation procedure, the patient may feel a burning or tingling sensation in the irradiation area. In the first two days after the procedure, pain in the affected area is also possible.

What happens after treatment? 

After a course of therapy, the patient has symptoms manifested on the skin. It becomes red and swollen. These phenomena reach their maximum in the first day after PDT. Within 1 week, the symptoms become less severe. The full recovery takes about 1 month.

When examining the patient after 1-2 days, the doctor notices the areas of necrosis. The tumor becomes black or gray. The necrotic processes reach a maximum after two days. The epithelization of the skin occurs later.

The patient will be examined 1 month later. The doctor checks if the tumor has been totally removed. Should skin cancer be cured, no further monitoring will be required. Some patients can be prescribed repeated photodynamic therapy. The indications for another irradiation session are a long non-healing ulcer, small shiny nodules, pathologically altered tissues with a roller on the periphery, or a dense scar welded to the underlying tissues. The total tumor removal is indicated by the complete healing of the wound with the formation of a soft scar. In doubtful cases, a biopsy can be indicated.

Treatment abroad with the Booking Health company 

You can use the services of the best doctors in the world by booking a treatment program abroad through Booking Health. We will arrange your trip for you to receive medical services. You will get many benefits: 

  • Selection of the best clinic that specializes in photodynamic therapy and achieves significant success in this medical field. 
  • Reduced cost of photodynamic therapy for skin cancer. You save up to 50% due to the absence of overpricing and additional coefficients for foreign patients.
  • Booking an appointment on the most suitable dates for you.
  • Preparation of the program taking into account the previously performed tests.
  • Establishment of communication directly with the attending physician.
  • Monitoring of all stages of a photodynamic therapy program.
  • Control of invoices, return of unspent funds.
  • Buying and forwarding medicines.
  • Organization of additional diagnostic or therapeutic procedures.
  • Communication with the clinic upon photodynamic therapy completion.

We will help you with paperwork, book a hotel and airline tickets, pick you up from the airport and provide you with interpreting services. After completing the course of cancer treatment, we will organize a return transfer from the hospital to the airport.




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