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Neuroendocrine Tumor (NET) of the Pancreas | Embolization or Chemoembolization Treatment. Hospital Prices, Ranking, Reviews - Bookinghealth

Neuroendocrine Tumor (NET) of the Pancreas — Embolization or Chemoembolization: treatment in the Best Hospitals in the World

➤Treatment of neuroendocrine tumor (NET) of the pancreas with embolization or chemoembolization ★ Direct prices from the best hospitals in the world $ We will help you save money on treatment ✔ Patient support 24/7

Treatment prices are regulated by national law of the corresponding countries, but can also include additional hospital coefficients. In order to receive the individual cost calculation, please send us the request and medical records.

University Hospital Rechts der Isar Munich
Specialized hospital

Department of Interventional Radiology

The Department of Interventional Radiology offers the full range of imaging examinations, as well as innovative image-guided minimally invasive techniques for the treatment of tumors, vascular diseases and internal pathologies (for example, CT, MRI, PET-CT, SPECT). The department's doctors have deep knowledge and colossal experience in the field of interventional radiological methods of treatment, which represent an excellent alternative to open surgical interventions. Despite the high level of technical equipment and the presence of advanced computerized systems, the focus is always on the person with his individual needs. Compliance with current clinical protocols and high professionalism of the department's specialists contribute to the successful clinical practice, as well as the reputability of the department among the best medical facilities of this kind in Germany.

Marcus Makowski
Prof. Dr. med.Marcus Makowski
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Price: 31281.65
University Hospital Halle (Saale)
Specialized hospital

Department of Adult and Pediatric Diagnostic, Interventional Radiology, Neuroradiology

The Department of Adult and Pediatric Diagnostic, Interventional Radiology, Neuroradiology offers the full range of modern radiological diagnostics and minimally invasive treatment both on an inpatient and outpatient basis. It has advanced equipment for conducting radiological studies in adults and children, as well as minimally invasive procedures under the guidance of imaging systems. There is maintained close cooperation with many departments of the hospital, which provides an interdisciplinary approach to treatment and comprehensive medical care.

Walter Wohlgemuth
Prof. Dr. Dr. med.Walter Wohlgemuth
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Price: 27591.11
University Hospital Muenster
Specialized hospital

University Hospital Muenster

Overall rating 9.8 / 10

Department of Adult and Pediatric Diagnostic, Interventional Radiology, Neuroradiology

The Department of Adult and Pediatric Diagnostic, Interventional Radiology, Neuroradiology is one of the best institutions of its kind in Germany and offers patients the full range of radiological studies and imaging-guided minimally invasive therapy. The department’s scope of tasks also includes imaging diagnostics in children of all age groups, detection and invasive treatment of cerebral vascular pathology (neuroradiology). Patient care is provided both on an inpatient and outpatient basis.

Walter Heindel
Prof. Dr. med.Walter Heindel
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Price: 27646.44
University Hospital Saarland Homburg
Specialized hospital

Department of Interventional Neuroradiology

The Department of Interventional Neuroradiology offers the full range of services in the areas of ​its ​specialization. The medical facility provides imaging diagnostics and low-traumatic image-guided interventional treatment of nervous system diseases. The department's specialists have rich experience and exceptional professional skills in the field of interventional procedures for acute and chronic vascular diseases, such as ischemic strokes, brain hemorrhages, cerebral artery stenosis, brain aneurysms, and vascular malformations. The department's neuroradiologists cooperate closely with neurologists and neurosurgeons so that each patient receives an optimal treatment regimen based on the expert opinions of the specialists. The department's medical team has state-of-the-art computed tomography (CT), magnetic resonance imaging (MRI), and MR angiography systems that are actively used for diagnosing patients and therapeutic procedures. Medical care is provided in compliance with current clinical protocols. The department also offers many outpatient medical services, which is an advantage for many patients.

Wolfgang Reith
Prof. Dr. med.Wolfgang Reith
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Price: 26147.26
HELIOS University Hospital Wuppertal
Specialized hospital

Department of Neuroradiology

The Department of Neuroradiology provides the full range of diagnostic and therapeutic services in the areas of ​​its specialization. The team of the department's doctors deals with the diagnostics and treatment of brain and spinal cord pathologies. The department has at its disposal state-of-the-art medical equipment, including systems for CT, MRI and myelography, thanks to which specialists can comprehensively assess the state of the nervous system, detect pathological processes at the initial stages and provide effective treatment. Among the department's therapeutic options, a special focus is on the interventional treatment of acute stroke – thrombectomy. Another important focus of the specialists' work is the treatment of cerebral vascular malformations, stenosis of the arteries of the brain and spinal cord, and cerebral aneurysms. In addition, the department provides CT-guided interventional pain management to relieve chronic back pain. The department's neuroradiologists cooperate closely with doctors from the related medical specialties: neurologists, neurosurgeons, ophthalmologists, otolaryngologists and radiation therapists. The specialists strive to provide each patient with high quality medical care meeting his needs and wishes.

Thorsten Schmidt
Dr. med.Thorsten Schmidt
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Price: 27668.36
University Hospital Oldenburg
Specialized hospital

Department of Adult and Pediatric Diagnostic, Interventional Radiology

The Department of Adult and Pediatric Diagnostic, Interventional Radiology offers the full range of services in these medical fields. To ensure the accurate diagnostics and effective treatment, the department has state-of-the-art medical equipment, particularly 64-slice CT scanner, two 1.5 Tesla high-performance MRI devices, modern equipment for digital subtraction angiography (DSA), pulsed fluoroscopy and many other devices. All medical services are carried out in strict accordance with the protocols of professional societies.

Tobias Kowald
Dr. med.Tobias Kowald
Price: 24239.87
Charite University Hospital Berlin
Specialized hospital

Department of Adult and Pediatric Diagnostic, Interventional Radiology

The Department of Adult and Pediatric Diagnostic, Interventional Radiology offers the full range of medical services in these fields. In order to ensure the most accurate and reliable diagnostics, the department has state-of-the-art systems for CT, MRI, PET, ultrasound and X-ray examinations, as well as PET-CT and SPECT-CT hybrid examinations. The department specializes in interventional radiology, namely, imaging-guided therapy. It performs all vascular (for example, vascular recanalization) and non-vascular imaging-guided interventions (for example, tumor ablation). The department is one of the largest and leading medical facilities of this kind in Europe.

Bernd Hamm
Prof. Dr. med.Bernd Hamm
Price: 41393.83
University Hospital Ulm

University Hospital Ulm

Overall rating 8.7 / 10

Department of Adult and Pediatric Interventional Radiology, Neuroradiology

The Department of Adult and Pediatric Interventional Radiology, Neuroradiology specializes in modern imaging examinations and minimally traumatic image-guided interventional procedures. Of particular interest to the department's experienced medical team is individualized minimally invasive therapy for cancer and the treatment of pain syndromes and vascular pathologies. The medical facility has state-of-the-art equipment for X-ray scanning, angiography, ultrasound scanning, CT, MRI, and PET/MRI. The diagnostic devices are adapted for children, including newborns. During examinations and treatment, the department's specialists strictly meet radiation protection standards. As for treatment, special attention in clinical practice is paid to interventional procedures for vascular diseases and malignant tumors. These procedures are performed using catheter-based techniques under CT, MRI, or angiography guidance. Despite the low trauma rate of interventional manipulations, their effectiveness is comparable to full-fledged surgery. The medical facility cooperates closely with other departments at the hospital, thus providing comprehensive medical care at the highest level of university medicine. The department's successful clinical practice has been recognized by prestigious quality certificates, including the ClarZert certificate and certificates from the German Cancer Society (DKG) and the German Radiological Society (DRG).

Meinrad Beer
Prof. Dr. med.Meinrad Beer
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Price: 29259.42

Department of Adult and Pediatric Diagnostic, Interventional Radiology

The Department of Adult and Pediatric Diagnostic, Interventional Radiology provides the full range of services in these fields and specializes in conducting radiologic examinations, high-intensity focused ultrasound (HIFU) therapy, vascular, oncological, orthopedic and urologic interventions. The department includes specialized Sections for Gynecologic, Pediatric and Orthopedic Radiology.

Thomas Vogl
Prof. Dr. med.Thomas Vogl
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Price: 27640.18

Department of Adult and Pediatric Diagnostic Radiology, Interventional Radiology and Neuroradiology

The Department of Adult and Pediatric Diagnostic Radiology, Interventional Radiology and Neuroradiology offers the full range of modern radiological examinations and minimally invasive imaging-guided treatment of various diseases. Most often, radiologists have to deal with the diagnostics and therapy of tumors, inflammatory processes, injuries, pathologies of the heart and vascular diseases. The combination of advanced medical technologies and high professionalism of the doctors working in the department are the key to the successful treatment results.

Gerald Antoch
Prof. Dr. med.Gerald Antoch
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Price: 31177.25

Department of Adult and Pediatric Interventional Radiology

The Department of Adult and Pediatric Interventional Radiology provides the full range of medical services in the area of its specialization. The department offers modern diagnostic rooms with advanced equipment for imaging examinations for patients with suspected cancer, diseases of the cardiovascular system, thorax, abdominal organs, musculoskeletal system, and breast diseases. The department's diagnostic systems are adapted for examining children of different age groups. The medical facility also offers many therapeutic services, the most popular of which include MRI-guided treatment of uterine fibroids with high-intensity focused ultrasound (HIFU) and uterine artery embolization, prostate adenoma treatment with prostate artery embolization, tumor treatment with brachytherapy, percutaneous radiofrequency ablation, percutaneous microwave ablation, and transarterial chemoembolization. The doctors working at the medical facility also have rich experience in the interventional treatment of vascular pathologies and arteriovenous malformations. The department has an excellent reputation and regularly diagnoses and treats patients not only from Germany but also from other countries in the world.

Jens Ricke
Prof. Dr. med.Jens Ricke
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Price: 31380.83
University Hospital Jena

University Hospital Jena

Overall rating 9.5 / 10

Department of Adult and Pediatric Diagnostic, Interventional Radiology, Neuroradiology

The Department of Adult and Pediatric Diagnostic, Interventional Radiology, Neuroradiology offers the full range of services in these medical fields. Here patients can undergo all modern imaging diagnostic studies and therapeutic procedures, the quality of which corresponds to high international standards. The department also specializes in conducting radiological studies in children and adolescents. The cutting-edge technical equipment and the rich clinical experience of doctors contribute to the successful work of the department.

Ulf Teichgräber
Prof. Dr. med.Ulf Teichgräber
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Price: 27692.38
University Hospital Tuebingen

University Hospital Tuebingen

Overall rating 9.13333 / 10

Department of Adult and Pediatric Diagnostic Radiology, Interventional Radiology

The Department of Adult and Pediatric Diagnostic Radiology, Interventional Radiology offers the full range of services in these fields. It conducts all types of modern imaging studies: sonography, digital X-ray, angiography, multilayer computed tomography and conventional MRI, positron emission tomography (PET/CT), etc. The department also specializes in minimally invasive treatment of various tumors, vascular pathology (obstruction and vascular stenosis). The Section of Experimental Radiology is engaged in active research to optimize existing methods and develop new ones.

Konstantin Nikolaou
Prof. Dr. med.Konstantin Nikolaou
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Price: 29282.39

Department of Adult and Pediatric Diagnostic, Interventional Radiology

The Department of Adult and Pediatric Diagnostic, Interventional Radiology offers the full range of modern diagnostic and therapeutic procedures in this field. For this purpose, it has advanced medical equipment: magnetic resonance imaging (MRI), multispiral computed tomography (CT), duplex sonography and digital X-ray, fluoroscopy, etc. In the field of interventional radiology, the focus is on the treatment of vascular diseases, for example, the doctors of the department conduct special measures for dilating the vessels in peripheral arterial occlusive disease and closing the vessels in complicated bleedings. Also, the range of services in this field is complemented by the installation of drainage and port systems, punctures, and special percutaneous methods for tumor treatment.

Thorsten Bley
Prof. Dr. med.Thorsten Bley
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Price: 27941.89

Department of Adult and Pediatric Diagnostic, Interventional Radiology

The Department of Adult and Pediatric Diagnostic, Interventional Radiology offers the full range of services in these medical fields. It conducts all modern radiological examinations and imaging-guided minimally invasive interventions for the treatment of various benign and malignant diseases. A feature of the department is imaging diagnostics in children and adolescents. There are specially adapted devices with minimal irradiation for this purpose.

Hans-Ulrich Kauczor
Prof. Dr. med.Hans-Ulrich Kauczor
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Helios Hospital Hildesheim

Helios Hospital Hildesheim

Overall rating 9.5 / 10

Department of Interventional Radiology

The Department of Interventional Radiology provides the full range of medical services in the area of its specialization. The team of the department's doctors specializes in diagnostic and therapeutic image-guided interventional procedures. The doctors have at their disposal the most advanced imaging devices, including X-ray systems, ultrasound devices, equipment for computed tomography and magnetic resonance imaging. In most cases, the department's specialists perform interventions on the vessels, and therefore doctors from the Department of Vascular Surgery are often involved in the therapeutic process. The use of state-of-the-art equipment allows the patients to get rid of pathological changes in the vessels of any part of the body, excluding open invasive surgery with its high risks. The department's medical staff has excellent qualifications and vast clinical experience, so patients confidently trust their health to real professionals.

Jörg Werhand
Dr. med.Jörg Werhand
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Price: 24522.79

Neuroendocrine tumors are a rare group of neoplasms, which develop from hormone-producing cells. They can be both benign and malignant. The pancreas is one of the most frequent localizations of neuroendocrine tumors. The surgical method is mainly used for the treatment of the disease. If liver metastases develop, hepatic artery embolization is additionally performed. With unresectable pancreatic tumors, European doctors often resort to pancreatic artery embolization.

Content

  1. What is pancreatic NET
  2. Treatment methods
  3. What is embolization
  4. Hepatic artery embolization
  5. Pancreatic artery embolization
  6. Why is it worth undergoing embolization abroad
  7. Treatment in Europe with Booking Health at an affordable price

What is pancreatic NET

 

Neuroendocrine tumors (NETs) are a group of neoplasms, which develop from hormone-producing cells. They account for approximately 3% of all pancreatic tumors. Tumors are often detected in young people. The peak incidence falls on the working age of 30-60 years.

Pancreatic neuroendocrine tumors are divided into highly differentiated and poorly differentiated ones. The last ones are related to pancreatic cancer, but they are more favorable than normal carcinoma. Such malignant tumors grow relatively slowly. Patients with malignant NETs have relatively good survival rates, as compared to "normal" pancreatic cancer: five-year survival rates are about 33%, ten-year – 10%.

Tumors may or may not produce hormones. "Silent" NETs account for about 60% of cases. In fact, these neoplasms can also produce biologically active substances. They just do not produce very active hormones or not much of them, so there are no common symptoms. The most common hormone-producing neoplasms are insulinoma, gastrinoma, glucagonoma and VIPoma. Other neuroendocrine tumors are much less common.

To assess the grade of neuroendocrine tumors, doctors use the proliferation index and the mitotic index. Simply put, they determine how quickly cells divide. The grade can be G1, G2, or G3. The last one is malignant, the first two are considered benign. However, their "bening course" is very conditional, since even such slowly growing neoplasms are capable of metastasizing, reaching large sizes and producing a large amount of hormones, which cause severe metabolic disorders or local symptoms from the gastrointestinal tract.

There can be only three stages of pancreatic NET. If distant metastases develop, stage IIIB is determined.

Most neoplasms are benign. On average, the five-year survival rate for patients with pancreatic neuroendocrine tumor is 80%. It is almost 100% with localized small neoplasms, which doctors managed to remove totally, but only 40% with a locally advanced form of pathology and 25% with a metastatic form.

Treatment methods

 

The standard treatment for patients with pancreatic neuroendocrine tumors is surgery. Doctors perform an organ resection. They remove the part of the pancreas where the tumor is located. Whenever required, a single-stage resection of metastatic tumor foci can be performed (combined surgical interventions).

Some patients do not need any other treatment. However, if the tumor is malignant, and if it is metastatic neuroendocrine tumour or it has not been completely removed, additional therapeutic techniques can be used. These may include:

  • Chemotherapy.
  • Targeted therapy.
  • Immunotherapy.
  • Radionuclide treatment.
  • Ablation.
  • Embolization.
  • Chemoembolization.

What is embolization

 

Embolization is used for neuroendocrine pancreatic tumors or metastatic foci suppression. This is a treatment method, which involves closing the lumen of the vessels supplying the tumor. It has been used in oncology for decades. The technique is constantly being improved, so the response to the treatment becomes more common, while the complications are less and less frequent.

Basically, embolization is used together with regional chemotherapy. This treatment option is called chemoembolization. The most common methods include drug-eluting microspheres or oily chemoembolization: the injection of an oily emulsion of lipiodol with chemotherapy drugs.

This method has the following advantages:

  • Minimal invasion – a small incision in the leg or arm is enough to penetrate the vessels of the pancreas through the vasculature.
  • Hospital stay is up to 4 days.
  • Fast recovery.
  • Good tolerance of the procedure as compared to other cancer treatment options, including surgery or ablation.
  • Low risk of complications.
  • It can be combined with any other treatment for the disease.

Embolization is not usually used as the first choice for pancreatic neuroendocrine tumors. The best options are surgical interventions. However, chemoembolization is a good treatment for patients with unresectable, recurrent, or metastatic neuroendocrine tumors.

Hepatic artery embolization

 

With neuroendocrine tumors, patients treated with pancreatic resection often require additional medical procedures to eliminate metastatic foci in the liver. Whenever possible, they are also removed. However, resection is not possible in all patients. The second most effective treatment method is hepatic chemoembolization.

Surgery and embolization are good treatment options for patients with metastatic tumors. The primary pancreatic neoplasm can be completely removed by surgery. Metastatic foci in the liver are suppressed by chemoembolization.

To close the lumen of the vessels, drug-eluting microspheres are usually used. Doctors inject them into the branches of the hepatic artery. They block blood flow in metastases, which die off within a few days. As a result, metastatic tumors can decrease in size by 5-10 times, and sometimes disappear completely (they are not detected by radiation diagnostics). Drugs are released from the microspheres within a few weeks and destroy the remaining cancer cells in the liver.

The procedure is performed with preserved liver function. It usually does not lead to severe liver failure. This is due to the fact that most of the parenchyma receives blood from the portal vein, and only a quarter is supplied by the hepatic artery. On the contrary, the tumor receives mainly arterial blood. Therefore, after the closure of these vessels, it is damaged much more than the healthy part of the liver.

Pancreatic artery embolization 

 

Embolization of the vessels of the pancreas is used less frequently in oncology. The procedure is basically used for malignant tumors.

The doctors can use this treatment method for pancreatic tumors in the following situations:

  • Unresectable tumor – for its local control.
  • Prior to surgery – for reducing blood loss, reducing the trauma rate of the surgery, and reducing the risk of recurrence.

Embolization reduces the tumor and also relieves the symptoms of the disease: jaundice and abdominal pain.

The procedure is performed through the femoral, less often – radial, brachial, axillary artery. The doctor makes an incision in the leg and inserts a catheter. It reaches the pancreatic arteries. Angiography is performed – a specialist injects a contrast agent into the vessels to assess the type of blood supply to the tumor. A series of X-rays are then taken. This is how the doctor determines whether a patient can be treated using embolization, which vessels should be blocked, and which vessels should be protected from the penetration of embolization agents into them.

Oily chemoembolization is mainly used for the treatment of pancreatic tumors. The doctor injects an emulsion, which blocks blood flow. It persists for a long time in the tumor, damaging it with chemotherapy. The vessels are not closed forever, but only for a while. Then the blood flow is restored and the cancer cells die from a lack of blood supply by that time. In the future, the procedure can be repeated. It is used as long as the patient responds to treatment.

It is important not only to achieve reduction of the tumor size, but also to prevent complications. They can develop if the embolysate enters non-target vessels. To prevent this, the doctor accurately examines the blood flow in the tumor area. If the contrast agent enters the non-target vessels, then the embolization agent can also penetrate there. Such vessels are closed with a balloon catheter during the embolization procedure.

Vascular embolization can cause the following symptoms: abdominal pain, nausea, vomiting, fever. Their occurrence indicates the development of postembolization syndrome. It lasts for 2-3 days. Symptoms are caused by the death of cells, which are "disconnected" from the blood supply. To reduce the severity of postembolization syndrome, doctors use drug therapy. Patients receive drugs to relieve fever and pain. Doctors provide the treatment to improve the function of internal organs, if necessary.

Why is it worth undergoing embolization abroad

 

The patients suffering from severe diseases, including oncology, often prefer to undergo treatment abroad. They visit developed countries. The best hospitals in the world use innovative techniques, which are more effective and safer.

There are several reasons why you should go to Europe for endovascular embolization for pancreatic neuroendocrine tumors:

  • Vast experience in the procedure. In most hospitals in the world, embolization cannot be performed at all, and if it is still carried out, then the experience of its use is poor. However, we will select a hospital for you where the procedure is performed frequently and with great success.
  • Specialists in Europe use various options for chemoembolization, including oily chemoembolization and the application of drug-eluting microspheres.
  • Embolization of both pancreatic and hepatic arteries can be performed.
  • High-precision diagnostics allows the doctors to perfectly assess the blood supply to the tumor.
  • The use of superselective embolization: the vessels are blocked as close to the tumor as possible in order to improve the accumulation of chemotherapy drugs and minimize the risk of complications.
  • Non-target vessels are protected with a balloon catheter to prevent the penetration of embolization agents into them.
  • Embolization can be successfully combined with other treatment methods for neuroendocrine tumors, including surgery, drug therapy, and radionuclide therapy.

In Europe, the departments for x-ray-guided surgery have state-of-the-art equipment. Doctors successfully perform catheterization of even small vessels. They can access the arteries of the pancreas or liver not only through the femoral artery, but also through the radial artery. In this case, the risk of complications from the puncture is reduced and strict bed rest for 24 hours is not required.

Treatment in Europe with Booking Health at an affordable price

 

To undergo treatment in one of the European hospitals, please use the services of the Booking Health company. On our website, you can see the cost of treatment in different European hospitals, compare prices and book a medical care program at an affordable price. Arterial embolization in European hospitals will be easier and faster for you, and the cost of treatment will be lower.

Please leave your request on our website. Our employee will contact you and provide consultation about the treatment in Europe. Booking Health will take care of the organization of your trip. We will provide many benefits for you. These include:

  • We will select a hospital for treatment in Europe, whose doctors specialize in the treatment of pancreatic neuroendocrine tumors.
  • We will help you overcome the language barrier, establish communication with your attending physician.
  • We will reduce the waiting period for the medical care program and book a doctor's appointment on the most suitable dates.
  • We will reduce the price. The cost of treatment in European hospitals will be lower due to the lack of coefficients for foreign patients.
  • We will take care of all organizational issues: documents for entering the country, transfer from the airport, hotel, interpreting services, etc.
  • We will prepare a medical care program and translate medical records. You do not have to undergo previously performed diagnostic procedures.
  • We will provide communication with the hospital after treatment in Europe.
  • We will organize additional examinations and treatment in European hospitals, if necessary.
  • We will buy medicines abroad and forward them to your native country.
  • We will help you keep in touch with the hospital and the attending physician after treatment in Europe.

You will receive treatment from the best doctors in the world. The Booking Health specialists will help you reduce the cost of treatment and take care of all organizational issues, and you will only have to focus on restoring your health.

Authors: Dr. Vadim ZhiliukDr. Sergey Pashchenko