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University Hospital Muenster

9.8/10 from 78 Votes

The University Hospital Muenster is one of the most respected multi-field medical centers in Germany. It consists of more than 30 departments and numerous research institutes and centers. Every year over 58,000 inpatients are treated here and nearly 475,000 patients receive medical care on the outpatient basis.

Medulloblastoma Diagnostics
1404
Stereotactic biopsy of medulloblastoma with neuronavigation
15595
Chemotherapy and radiotherapy for medulloblastoma
22749
Surgical treatment of medulloblastoma by resection
18302
location_onCountry: Germany
location_searchingCity: Muenster
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Gamma Knife and Radiotherapy Center Krefeld

10/10 from 2 Votes

The Gamma Knife and Radiotherapy Center Krefeld is the advanced Сenter for Neurosurgery and Radiation Therapy, specializing in radiosurgical treatment of tumors and metastases.

Chemotherapy and radiotherapy for medulloblastoma
12000
location_onCountry: Germany
location_searchingCity: Krefeld

University Hospital Cologne

9.8/10 from 82 Votes

The University Hospital Cologne is included in the Focus magazine rating of top German hospitals 2017 and offers patients first-class medical care meeting the latest medical advancements.

Medulloblastoma Diagnostics
1312
Stereotactic biopsy of medulloblastoma with neuronavigation
13248
Surgical treatment of medulloblastoma by resection
16306
location_onCountry: Germany
location_searchingCity: Cologne
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Gamma Knife and Radiotherapy Center Hannover

10/10 from 23 Votes

The Gamma Knife and Radiotherapy Center Hannover is the best clinic for radiosurgery and radiation therapy in Germany. The clinic enjoys authority in the medical world. The treatment of tumors is carried out with the use of an innovative approach.

Chemotherapy and radiotherapy for medulloblastoma
12000
location_onCountry: Germany
location_searchingCity: Hannover

HELIOS Clinic Krefeld

9.7/10 from 38 Votes

Founded in 2014, the HELIOS Clinic Krefeld is one of the most modern medical facilities in Germany today. A team of highly qualified specialists, innovative medical equipment and comfortable accommodation conditions – the clinic has everything to make the treatment run smoothly and efficiently.

Medulloblastoma Diagnostics
1361
Stereotactic biopsy of medulloblastoma with neuronavigation
13909
Chemotherapy and radiotherapy for medulloblastoma
23116
Surgical treatment of medulloblastoma by resection
17641
location_onCountry: Germany
location_searchingCity: Krefeld

University Hospital Rechts der Isar of the Munich Technical University

10/10 from 70 Votes

The Rechts der Isar Hospital is the University Hospital of the Technical University of Munich. There is intensive cooperation between the research facilities of the TU and the hospital in numbers of areas.

Medulloblastoma Diagnostics
1535
Stereotactic biopsy of medulloblastoma with neuronavigation
17382
Chemotherapy and radiotherapy for medulloblastoma
23178
Surgical treatment of medulloblastoma by resection
21418
location_onCountry: Germany
location_searchingCity: Munich
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Vivantes Neukölln Hospital Berlin

10/10 from 23 Votes

The Vivantes Neukölln Hospital is the maximum care hospital and one of the largest healthcare facilities in Berlin.   There are more than 20 specialized departments and centers, including pediatric departments. In total, the hospital has 1,200 beds.

Medulloblastoma Diagnostics
1539
Stereotactic biopsy of medulloblastoma with neuronavigation
17738
Chemotherapy and radiotherapy for medulloblastoma
22980
Surgical treatment of medulloblastoma by resection
21079
location_onCountry: Germany
location_searchingCity: Berlin

Academic Hospital Bogenhausen Munich

9.2/10 from 43 Votes

With more than 36,000 patients annually and 1,000 beds, the Academic Hospital Bogenhausen is one of the largest clinics in Munich.

Medulloblastoma Diagnostics
1407
Stereotactic biopsy of medulloblastoma with neuronavigation
16057
Surgical treatment of medulloblastoma by resection
18468
location_onCountry: Germany
location_searchingCity: Munich

University Hospital Frankfurt am Main

10/10 from 97 Votes

The University Hospital Frankfurt is part of the Johann Wolfgang Goethe University Frankfurt am Main. The hospital was founded in 1914 and today it is a famous German medical institution with rich traditions. The hospital treats about 49,000 inpatients and 220,000 outpatients every year.

Medulloblastoma Diagnostics
1407
Stereotactic biopsy of medulloblastoma with neuronavigation
15974
Chemotherapy and radiotherapy for medulloblastoma
22929
Surgical treatment of medulloblastoma by resection
18548
location_onCountry: Germany
location_searchingCity: Frankfurt am Main
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St. Vincentius Clinic Karlsruhe

9.8/10 from 23 Votes

The St. Vincentius Clinic is the largest multidisciplinary medical institution and academiс hospital of the Albert Ludwig University of Freiburg. Treatment and diagnosis of patients is conducted by doctors with a scientific degree. They are introducing the latest progressive techniques.

Chemotherapy and radiotherapy for medulloblastoma
23161
location_onCountry: Germany
location_searchingCity: Karlsruhe

Charite University Hospital Berlin

9/10 from 95 Votes

Being the medical school for both Humboldt University and Free University of Berlin and having a long experience, the Charite Hospital has gained wide recognition. It is regarded as one of the most research-intensive medical facilities in Germany and the largest university medical center in Europe.

Medulloblastoma Diagnostics
2150
Stereotactic biopsy of medulloblastoma with neuronavigation
23491
Chemotherapy and radiotherapy for medulloblastoma
23183
Surgical treatment of medulloblastoma by resection
28479
location_onCountry: Germany
location_searchingCity: Berlin
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Academic Hospital Schwabing Munich

8.5/10 from 7 Votes

The Schwabing Clinic is a modern medical facility with a high level of service. The clinic has high-tech modern equipment, making it one of the best hospitals not only in Germany but also in Europe. There are comfortable single and double rooms with shower and toilet, TV, telephone and radio.

Medulloblastoma Diagnostics
1340
Stereotactic biopsy of medulloblastoma with neuronavigation
14135
Surgical treatment of medulloblastoma by resection
17335
location_onCountry: Germany
location_searchingCity: Munich

Academic Hospital Asklepios Barmbek Hamburg

9.5/10 from 23 Votes

As an Academic Hospital of the University of Hamburg, the Asklepios Barmbek Hospital offers a wide range of medical services in the field of conservative and surgical treatment. The hospital was opened in 2005 and today it is one of the best and modern medical centers in Europe.

Chemotherapy and radiotherapy for medulloblastoma
23136
location_onCountry: Germany
location_searchingCity: Hamburg

Alfried Krupp Hospital in Essen-Ruettenscheid

7.4/10 from 42 Votes

With 900 beds and approximately 2,050 employees in two branches, the Alfried Krupp Hospital is one of the larger hospital institutions in Essen.

Medulloblastoma Diagnostics
1424
Stereotactic biopsy of medulloblastoma with neuronavigation
15975
Chemotherapy and radiotherapy for medulloblastoma
22719
Surgical treatment of medulloblastoma by resection
18754
location_onCountry: Germany
location_searchingCity: Essen
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Tel Aviv Sourasky Medical Center

9.9/10 from 23 Votes

The Tel Aviv Sourasky Medical Center (Ichilov) is the second largest and one of the most advanced healthcare and research institutions in Israel. Founded in 1961, it still enjoys popularity among the local population and draws thousands of international patients.

Medulloblastoma Diagnostics
0.00
Stereotactic biopsy of medulloblastoma with neuronavigation
0.00
Surgical treatment of medulloblastoma by resection
0.00
location_onCountry: Israel
location_searchingCity: Tel Aviv

Rambam Health Care Campus Haifa

9.8/10 from 23 Votes

Rambam Health Care Campus is the largest and the most advanced hospital in Northern Israel. Founded in 1938, the medical center has a long history and a rich experience in providing comprehensive medical services in all medical specialties.

Medulloblastoma Diagnostics
0.00
Stereotactic biopsy of medulloblastoma with neuronavigation
0.00
Surgical treatment of medulloblastoma by resection
0.00
location_onCountry: Israel
location_searchingCity: Haifa

About the disease

Medulloblastoma is a pediatric malignant tumor that already develops in embryonic cells and manifests itself predominantly in childhood. Medulloblastoma is responsible for approximately 20% of all brain tumors in children. It rarely affects adult brain. This tumor develops in the cerebellum which is part of the skull. Medulloblastoma is a relatively rare tumor of central system, which can metastasize to spinal cord and ventricles of the brain. Prognosis depends on the stage of tumor, presence of metastases, patient's age and indications for radical surgery. Postoperative mortality is 5% with a big chance of medulloblastoma recurrence. Survival rate for boys with progressed stage of disease is about 24% and for girls - 10%. The younger is the sick child, the more malignant are neoplasms and the faster is pathological process in the brain stem, which is responsible for vital body functions.

Irradiation and environmental influences may have connection with the development of brain tumors in children. Nevertheless, hereditary predisposition of this disease is a leading cause of this disease. 5% of patients with autosomal dominant carcinoma can later develop medulloblastoma. 40-50% of the children who have chromosome 17 are under the risk.

Symptoms

  • Increased intracranial pressure
  • Headache
  • Vomiting (usually in the morning)
  • Problems with vision
  • Lethargy
  • Cushing's triad (hypertension, bradycardia, hypoventilation) is rare for children with increased intracranial pressure and if this triad is found, then, as a rule, it may indicate impending herniation
  • Fatigue
  • Irritability
  • Diplopia and compression of certain cranial nerves, which can lead to stiffness of facial features
  • Ringing in the ears
  • Problems with hearing

Since cerebellum part of the brain is responsible for muscle coordination, medulloblastoma can cause problems with walking, balance and speech disorders. Other specific symptoms of medulloblastoma are nystagmus, stiff neck and muscle weakness. Children may also have gradually developing ataxia in lower ligaments. 

Diagnosis

Main method of diagnosis is magnetic resonance imaging and contrasted computed tomography. MRI study of the spinal cord gives an indication of the presence or absence of metastases. 

Treatment

Doctors usually use combination of surgery, radiotherapy and chemotherapy to treat this disease. They can also use stereotactic biopsy to cure this disease. Stereotactic biopsy is removal of malignant tissue by three-dimensional computer technology. This is an absolutely innovative treatment option, which is safer than surgery. Also, according to News Medical, which is a medical site, proton beam therapy is a more favorable treatment option for treating child`s tumor. Findings of research on proton beam therapy also state that this treatment is less toxic than radiotherapy.    

  • Surgical removal of the tumor suggests use of microsurgical techniques, such as intraoperative MRI navigation.
  • Radiation is needed in case surgical intervention can not be performed. Radiotherapy can also be used after surgery if there are some malignant cells left. If there are no metastases radiotherapy is assigned in low doses to minimize the side effects. If there are metastases or tumor is not completely removed, radiation therapy is administered in large doses. Children under three years can not receive radiotherapy.
  • Chemotherapy is administration of agents that kill malignant cells.

American scientists have recently offered an innovative treatment option for medulloblastoma. They injected measles virus into the body of the child, so that he could undergo genetic modification. Experiments on mice have confirmed that the modified measles virus kills malignant medulloblastoma cells in just 72 hours. This can be used only for children who have not had measles before.




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