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Treatment of Medulloblastoma

Cost for treatment

Medulloblastoma Diagnostics
0.00
Stereotactic biopsy of medulloblastoma with neuronavigation
6650.28
Chemotherapy and radiotherapy for medulloblastoma
14064

University Hospital Rechts der Isar Munich

9.8/10
location_onGermany, Munich

Department of Adult and Pediatric Neurosurgery, Spinal Surgery

The University Hospital Rechts der Isar Munich was founded in 1834. It combines long traditions with the very latest advances in modern medicine. The medical facility includes 33 specialized departments and 20 interdisciplinary centers, where patients can receive top-class medical care in all medical fields. The hospital annuall
Medulloblastoma Diagnostics
0.00
Stereotactic biopsy of medulloblastoma with neuronavigation
27354.93
Chemotherapy and radiotherapy for medulloblastoma
30332.65

Charite University Hospital Berlin

9/10
location_onGermany, Berlin

Department of Adult and Pediatric Neurosurgery

According to the authoritative Focus magazine, the Charite University Hospital Berlin occupies the first place in the rating of the top German medical facilities! The hospital is one of the largest and leading university medical complexes in Europe. The hospital in Germany provides modern diagnostics and treatment of patients, a
Medulloblastoma Diagnostics
0.00
Stereotactic biopsy of medulloblastoma with neuronavigation
27580.97
Chemotherapy and radiotherapy for medulloblastoma
30472.55

University Hospital Freiburg

9.7/10
location_onGermany, Freibung

Department of Adult and Pediatric Neurosurgery

The University Hospital Freiburg is famous for its rich history and is one of the oldest and most prestigious medical facilities in Germany (one of the three best medical institutions in the country). The hospital was based on the Faculty of Medicine of the Albert Ludwig University of Freiburg, which celebrated its 550th anniver
Medulloblastoma Diagnostics
0.00
Stereotactic biopsy of medulloblastoma with neuronavigation
20757.39
Chemotherapy and radiotherapy for medulloblastoma
30074.78

University Hospital Frankfurt am Main

10/10

Department of Adult and Pediatric Neurosurgery

According to the reputable Focus magazine, the University Hospital Frankfurt am Main ranks among the top German medical facilities! The hospital was founded in 1914 and today is a well-known German medical facility, which combines rich traditions and scientific innovations. A medical team of more than 6,500 employees cares about
Medulloblastoma Diagnostics
0.00
Stereotactic biopsy of medulloblastoma with neuronavigation
18930.39
Chemotherapy and radiotherapy for medulloblastoma
24026.89

University Hospital Würzburg

9.2/10
location_onGermany, Würzburg

Department of Adult and Pediatric Neurosurgery

According to the Focus magazine in 2019, the University Hospital Würzburg ranks among the top national German hospitals! The hospital is one of the oldest medical facilities in Germany. The centuries-old traditions of first-class treatment are combined with the very latest achievements of modern evidence-based medicine and
Medulloblastoma Diagnostics
0.00
Stereotactic biopsy of medulloblastoma with neuronavigation
18946.05
Chemotherapy and radiotherapy for medulloblastoma
24098.93

University Hospital Bonn

9.2/10
location_onGermany, Bonn

Department of Neurosurgery

According to the authoritative Focus magazine, the University Hospital Bonn ranks among the top ten medical facilities in Germany! The hospital was opened on January 1, 2001, although in fact it inherits the medical facility, which operated at the Faculty of Medicine of the University of Bonn. The hospital in Germany combin
Medulloblastoma Diagnostics
0.00
Stereotactic biopsy of medulloblastoma with neuronavigation
20706.23
Chemotherapy and radiotherapy for medulloblastoma
23682.37

University Hospital Carl Gustav Carus Dresden

9.1/10
location_onGermany, Dresden

Department of Adult and Pediatric Neurosurgery, Epilepsy Surgery, Spinal Surgery

According to the reputable Focus magazine, the University Hospital Carl Gustav Carus Dresden ranks among the top five German hospitals! The hospital is the benchmark for modern high-quality medicine. Positioning itself as a maximum care medical facility, the hospital represents all medical fields. There are 26 specialized depart
Medulloblastoma Diagnostics
0.00
Stereotactic biopsy of medulloblastoma with neuronavigation
24234.95
Chemotherapy and radiotherapy for medulloblastoma
23939.2

University Hospital Erlangen

9.1/10
location_onGermany, Erlangen

Department of Adult and Pediatric Neurosurgery, Spinal Surgery

According to the Focus magazine, University Hospital Erlangen ranks among the best medical facilities in Germany! The hospital is one of the leading healthcare facilities in Bavaria and offers top-class medical care distinguished by the close intertwining of clinical activities with research and training of medical students. The
Medulloblastoma Diagnostics
0.00
Stereotactic biopsy of medulloblastoma with neuronavigation
19580.8
Chemotherapy and radiotherapy for medulloblastoma
28792.75

University Hospital Hamburg-Eppendorf

9.2/10
location_onGermany, Hamburg

Department of Adult and Pediatric Neurosurgery

According to the Focus magazine, the University Hospital Hamburg-Eppendorf ranks among the top ten hospitals in Germany! Since its foundation in 1889, the hospital has taken a leading position in the European medical arena and still occupies it until today. A highly competent medical team of more than 11,000 employees takes care
Medulloblastoma Diagnostics
0.00
Stereotactic biopsy of medulloblastoma with neuronavigation
24408.26
Chemotherapy and radiotherapy for medulloblastoma
24018.54

University Hospital Ulm

8.7/10
location_onGermany, Ulm

Department of Neurosurgery

The University Hospital Ulm started its activities 35 years ago and during this time it has become one of the most prestigious medical institutions in Europe. The hospital is famous for its numerous discoveries and the world-class achievements in medicine and pharmaceuticals. The medical facility has 29 specialized departments a
Medulloblastoma Diagnostics
0.00
Stereotactic biopsy of medulloblastoma with neuronavigation
19548.44
Chemotherapy and radiotherapy for medulloblastoma
28895.06

University Hospital Heidelberg

9.8/10
location_onGermany, Heidelberg

Department of Adult and Pediatric Neurosurgery

According to Focus magazine, the University Hospital Heidelberg ranks among the top five hospitals in Germany! The hospital is one of the most advanced and reputable medical institutions not only in Germany, but throughout Europe. There are more than 43 specialized departments and 13 medical institutes, which cover all fields of
Medulloblastoma Diagnostics
0
Stereotactic biopsy of medulloblastoma with neuronavigation
0
Chemotherapy and radiotherapy for medulloblastoma
0

University Hospital Essen

9.6/10
location_onGermany, Essen

Department of Adult and Pediatric Neurosurgery

According to the authoritative Focus magazine the University Hospital Essen ranks among the top German hospitals! With 27 specialized departments and 24 institutes, the hospital in Germany is a maximum care medical facility. The hospital has 1,300 beds for inpatient treatment. A highly qualified medical team of more than 6,000 e
Medulloblastoma Diagnostics
0.00
Stereotactic biopsy of medulloblastoma with neuronavigation
18888.63
Chemotherapy and radiotherapy for medulloblastoma
23725.18

University Hospital Jena

8.9/10
location_onGermany, Jena

Department of Adult and Pediatric Neurosurgery

According to the prestigious Focus magazine, the University Hospital Jena regularly ranks among the top German medical facilities! The hospital has positioned itself as a multidisciplinary medical facility with a long history of more than 200 years. Since its foundation, the hospital has been constantly developing and modernizin
Medulloblastoma Diagnostics
0.00
Stereotactic biopsy of medulloblastoma with neuronavigation
20709.36
Chemotherapy and radiotherapy for medulloblastoma
24185.58

University Hospital Halle (Saale)

9.6/10
location_onGermany, Halle

Department of Neurosurgery

According to the prestigious Focus magazine, the University Hospital Halle (Saale) ranks among the top German medical facilities! The history of the hospital has more than 300 years, and during this time it managed to earn an excellent reputation not only in Germany, but throughout the world. The hospital positions itself as a s
Medulloblastoma Diagnostics
0.00
Stereotactic biopsy of medulloblastoma with neuronavigation
18743.51
Chemotherapy and radiotherapy for medulloblastoma
24133.38

University Hospital Marburg UKGM

8.6/10
location_onGermany, Marburg

Department of Adult and Pediatric Neurosurgery

The University Hospital Marburg UKGM offers patients modern diagnostics and comprehensive therapy at the international level. As a maximum care hospital, the medical facility specializes in all fields of modern medicine ranging from ophthalmology to traumatology and dentistry. The main areas of specialization of the hospital are
Medulloblastoma Diagnostics
0.00
Stereotactic biopsy of medulloblastoma with neuronavigation
17395.71
Chemotherapy and radiotherapy for medulloblastoma
28852.26

University Hospital of Ludwig Maximilian University of Munich

10/10
location_onGermany, Munich

Department of Adult and Pediatric Neurosurgery, Spinal Surgery

According to the Focus magazine, the University Hospital of Ludwig Maximilian University of Munich is regularly ranked among the best medical institutions in Germany! The hospital is the largest multidisciplinary medical facility, as well as a leading research and training center in Germany and Europe. The hospital is proud of i
Medulloblastoma Diagnostics
0.00
Stereotactic biopsy of medulloblastoma with neuronavigation
20973.5
Chemotherapy and radiotherapy for medulloblastoma
30237.65
| from Booking Health GmbH

About the disease

Medulloblastoma is a pediatric malignant tumor that already develops in embryonic cells and manifests itself predominantly in childhood. Medulloblastoma is responsible for approximately 20% of all brain tumors in children. It rarely affects adult brain. This tumor develops in the cerebellum which is part of the skull. Medulloblastoma is a relatively rare tumor of central system, which can metastasize to spinal cord and ventricles of the brain. Prognosis depends on the stage of tumor, presence of metastases, patient's age and indications for radical surgery. Postoperative mortality is 5% with a big chance of medulloblastoma recurrence. Survival rate for boys with progressed stage of disease is about 24% and for girls - 10%. The younger is the sick child, the more malignant are neoplasms and the faster is pathological process in the brain stem, which is responsible for vital body functions.

Irradiation and environmental influences may have connection with the development of brain tumors in children. Nevertheless, hereditary predisposition of this disease is a leading cause of this disease. 5% of patients with autosomal dominant carcinoma can later develop medulloblastoma. 40-50% of the children who have chromosome 17 are under the risk.

Symptoms

  • Increased intracranial pressure
  • Headache
  • Vomiting (usually in the morning)
  • Problems with vision
  • Lethargy
  • Cushing's triad (hypertension, bradycardia, hypoventilation) is rare for children with increased intracranial pressure and if this triad is found, then, as a rule, it may indicate impending herniation
  • Fatigue
  • Irritability
  • Diplopia and compression of certain cranial nerves, which can lead to stiffness of facial features
  • Ringing in the ears
  • Problems with hearing

Since cerebellum part of the brain is responsible for muscle coordination, medulloblastoma can cause problems with walking, balance and speech disorders. Other specific symptoms of medulloblastoma are nystagmus, stiff neck and muscle weakness. Children may also have gradually developing ataxia in lower ligaments. 

Diagnosis

Main method of diagnosis is magnetic resonance imaging and contrasted computed tomography. MRI study of the spinal cord gives an indication of the presence or absence of metastases. 

Treatment

Doctors usually use combination of surgery, radiotherapy and chemotherapy to treat this disease. They can also use stereotactic biopsy to cure this disease. Stereotactic biopsy is removal of malignant tissue by three-dimensional computer technology. This is an absolutely innovative treatment option, which is safer than surgery. Also, according to News Medical, which is a medical site, proton beam therapy is a more favorable treatment option for treating child`s tumor. Findings of research on proton beam therapy also state that this treatment is less toxic than radiotherapy.    

  • Surgical removal of the tumor suggests use of microsurgical techniques, such as intraoperative MRI navigation.
  • Radiation is needed in case surgical intervention can not be performed. Radiotherapy can also be used after surgery if there are some malignant cells left. If there are no metastases radiotherapy is assigned in low doses to minimize the side effects. If there are metastases or tumor is not completely removed, radiation therapy is administered in large doses. Children under three years can not receive radiotherapy.
  • Chemotherapy is administration of agents that kill malignant cells.

American scientists have recently offered an innovative treatment option for medulloblastoma. They injected measles virus into the body of the child, so that he could undergo genetic modification. Experiments on mice have confirmed that the modified measles virus kills malignant medulloblastoma cells in just 72 hours. This can be used only for children who have not had measles before.

Authors: Dr. Nadezhda Ivanisova, Dr. Sergey Pashchenko




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