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diagnostic: Chronic myelogenous leukemia (cml). Diagnostic

Chronic myeloid leukemia (CML) is malignant disease of the blood caused by structural changes in the 9th and 22nd pairs of granulocyte chromosomes. This genetic disorder is called "Philadelphia chromosome." According to statistics, people aged 30-50 years are the most susceptible to CML. The key to a successful fight against this pathology is early diagnosis.

Procedure

The survey begins with the oncologist’s advice. The physician clarifies complaints, collects the case history and conducts a clinical examination. If there is a suspicion for a pathology, the patient receives a referral for complete blood count and blood chemistry. Certain changes in the hemogram (increased number of white blood cells, decrease in red blood cells and platelets) are a basis for further diagnostics.

The optimum research program includes:

1. Lymphocyte immunophenotyping by flow cytometry. The tumor cells are exposed to antibodies. The resulting complexes are then detected using fluorescent labels. This technique allows not only to diagnose the disease, but also to determine its specific type. This analysis requires the patient’s blood taken from a vein.

2. Cytogenetic analysis by standard karyotyping. Blood elements are stained in a special way and examined under a microscope. The research task is to detect or rule out the chromosomal breakage associated with leukemia.

3. Cytogenetic study by fluorescent hybridization. This study is carried out for the sole purpose of establishing the presence of "Philadelphia chromosome," provoking the CML development. Short DNA sequences (probes) labeled with fluorophores are used for analysis. Interacting with them, the altered chromosomes 9 and 22 are stained red and green.

4. Abdomen ultrasound. The patients diagnosed with CML feature the change of the liver and spleen size.

5. CT scan or MRI of the whole body. Comprehensive scanning allows establishing the prevalence of tumor process (impairment of bones, lymph nodes, brain, and other internal organs).

6. Bone marrow aspiration biopsy (ilium wing punch biopsy). During the procedure, a sample of the bone marrow is taken from the patient. The material is sent for histological analysis by which the chronic myeloid leukemia is distinguished from chronic lymphoblastic leukemia.

Painful procedures are performed under local anesthesia or in a drug-induced sleep. The cost of medication is determined by the treatment intensity. The patient during treatment is under supervision of medical personnel.

According to the test findings, the physician establishes an accurate diagnosis and develops the further treatment tactics.

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See also for chronic myelogenous leukemia (cml):

Vivantes Neukölln Hospital Berlin

10/10 from 23 Votes
location_onGermany, Berlin

Department of Hematology, Oncology and Palliative Medicine

Chronic Myelogenous (Myeloid) Leukemia (CML) Diagnosis #358172

The Department of Hematology, Oncology and Palliative Medicine offers the full range of services in these focuses. The department specializes in the treatment of all blood diseases, oncological diseases of various organs and palliative care.

Include:
people Interpreter up to 5 hours
list_alt Translation of medical documents up to 4 pages
card_membership Visa support
book Insurance against increased costs in case of complications with a cover of 200,000 €

St. Vincentius Clinic Karlsruhe

9.8/10 from 23 Votes
location_onGermany, Karlsruhe

Department of Hematology, Oncology, Immunology and Palliative Care

Chronic Myelogenous (Myeloid) Leukemia (CML) Diagnosis #336330

he Department of Hematology, Oncology, Immunology and Palliative Care specializes in the diagnosis and treatment of patients suffering from blood diseases, oncological and immunological diseases. Palliative medicine also belongs to the main directions of the department.

Charite University Hospital Berlin

9/10 from 95 Votes
location_onGermany, Berlin
certificatecertificatecertificatecertificatecertificatecertificatecertificate

Charité Comprehensive Cancer Center

Chronic Myelogenous (Myeloid) Leukemia (CML) Diagnosis #229163

The Charite Comprehensive Cancer Center integrates all departments and units dealing with cancer treatment. The center offers patients the most advanced comprehensive cancer treatment.

University Hospital of the Ludwig-Maximilians-University Munich (LMU)

9.2/10 from 40 Votes
location_onGermany, Munich

Comprehensive Cancer Center Munich

Chronic Myelogenous (Myeloid) Leukemia (CML) Diagnosis #327162

The Comprehensive Cancer Center Munich (CCC Munich) offers both diagnosis and treatment of all types of cancer.

University Hospital Rechts der Isar of the Munich Technical University

10/10 from 70 Votes
location_onGermany, Munich
certificatecertificate

Department of Hematology and Oncology

Chronic Myelogenous (Myeloid) Leukemia (CML) Diagnosis #126121

The Department of Internal Medicine III at the university hospital Klinikum rechts der Isar focuses on the area of hematology and internistic oncology. Every year an experienced and dedicated team of doctors provides treatment to more than 7. 000 patients from both Germany and abroad.

Academic Hospital Neuperlach Munich

9.8/10 from 11 Votes
location_onGermany, Munich

Department of Hematology and Oncology

Chronic Myelogenous (Myeloid) Leukemia (CML) Diagnosis #145023

The department of hematology and oncology diagnosed and treated malignant tumors. The therapeutic spectrum includes all medicamentous treating methodes including chemotherapy, antibody, immune and hormone therapy. Cancer patients benefit from interdisciplinary treatment.

University Hospital Frankfurt am Main

10/10 from 97 Votes
location_onGermany, Frankfurt am Main
certificatecertificatecertificatecertificate

Department of Hematology, Oncology, Hemostaseology, Rheumatology and Infectiology

Chronic Myelogenous (Myeloid) Leukemia (CML) Diagnosis #76481

The Department of Hematology, Oncology, Hemostaseology, Rheumatology and Infectiology specializes in the treatment of all diseases of the hematopoietic system and solid tumors.

University Hospital Muenster

9.8/10 from 78 Votes
location_onGermany, Muenster
certificatecertificatecertificatecertificatecertificate

Department of Hematology, Hemostaseology, Oncology and Pneumology (Medical Department A)

Chronic Myelogenous (Myeloid) Leukemia (CML) Diagnosis #151081

The Medical Department A (Med A) at the University Hospital Muenster deals with the treatment of all kinds of cancer of various organs, including the hematopoietic system.

HELIOS Clinic Krefeld

9.7/10 from 38 Votes
location_onGermany, Krefeld

Department of Gastroenterology, Hepatology, Neurogastroenterology, Infectology, Hematology, Oncology and Palliative Care

Chronic Myelogenous (Myeloid) Leukemia (CML) Diagnosis #382713

The Department of Gastroenterology, Hepatology, Neurogastroenterology, Infectology, Hematology, Oncology and Palliative Care offers the full range of services in these medical fields.

Academic Hospital Harlaching Munich

9.2/10 from 32 Votes
location_onGermany, Munich
certificate

Department of Hematology, Oncology and Palliative Medicine

Chronic Myelogenous (Myeloid) Leukemia (CML) Diagnosis #144155

The Department of Hematology, Oncology and Palliative Medicine primarily treats patients with cancer or hematologic diseases. The treatment is based on the comprehensive approach, which includes both physical and psychosocial aspects. The department is part of the interdisciplinary Cancer Center Munich Süd.

Academic Hospital Asklepios Barmbek Hamburg

9.5/10 from 23 Votes
location_onGermany, Hamburg

Department of Oncology, Hematology and Palliative Care

Chronic Myelogenous (Myeloid) Leukemia (CML) Diagnosis #356256

The Department of Oncology, Hematology and Palliative Care offers the full range of services in the relevant medical fields. The department is certified by the German Cancer Society, which confirms the outstanding quality of medical care.

Vivantes Humboldt Hospital Berlin

9.7/10 from 23 Votes
location_onGermany, Berlin

Department of Oncology and Hematology

Chronic Myelogenous (Myeloid) Leukemia (CML) Diagnosis #338045

The Department of Oncology provides complex treatment and care for oncological diseases and cancerous blood diseases (hematology).  It offers a full range of services in the field of these two areas. The treatment is conducted in outpatient and inpatient settings. The focus is on the needs of the patients.

Academic Hospital Schwabing Munich

8.5/10 from 7 Votes
location_onGermany, Munich
certificatecertificate

Department of Hematology, Oncology, Immunology, Palliative Medicine, Infectiology and Tropical Medicine

Chronic Myelogenous (Myeloid) Leukemia (CML) Diagnosis #177529

The Department of Hematology, Oncology, Immunology, Palliative Medicine, Infectious Diseases and Tropical Medicine in Schwabing treats all benign blood diseases, disorders of the immune and coagulation system, all forms of blood cancer, and the most of cancers.

University Hospital Duesseldorf

9.9/10 from 71 Votes
location_onGermany, Duesseldorf
certificatecertificatecertificatecertificate

Department of Hematology, Oncology and Clinical Immunology

Chronic Myelogenous (Myeloid) Leukemia (CML) Diagnosis #166227

The Department of Hematology, Oncology and Clinical Immunology at the University Hospital Dusseldorf provides treatment of patients with blood diseases, cancer and immune system diseases. The Department focuses on the treatment of malignant diseases of  blood, bone marrow and lymph nodes.

Tel Aviv Sourasky Medical Center

9.9/10 from 23 Votes
location_onIsrael, Tel Aviv

Department of Hematology

Chronic Myelogenous (Myeloid) Leukemia (CML) Diagnosis #331117

The Department of Hematology at the Tel Aviv Sourasky Medical Center provides expert care for patients with a variety of blood disorders, including malignant hematological diseases.

Hannover Medical School

9.8/10 from 43 Votes
location_onGermany, Hannover
certificate

Department of Hematology, Hemostaseology, Oncology and Stem Cell Transplantation

Chronic Myelogenous (Myeloid) Leukemia (CML) Diagnosis #247027

The Department of Hematology, Hemostasiology, Oncology and Stem Cell Transplantation at the Hannover Medical School specializes in diagnosis and treatment of the entire range of malignant tumors, benign hematological diseases and blood coagulation disorders.




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