Parkinson's disease is a long-term progressive disease of the nervous system, that gradually impairs control over movements. Pathological changes occur due to the degeneration of dopamine-producing neurons in the brain area responsible for the accuracy and smoothness of movements. As a result tremors of the limbs, muscle stiffness, slowness of movements and unsteadiness during walking appear. In the later stages non-motor disorders often develop 一 sleep disorders, emotional changes, deterioration of memory and attention [1].
According to various estimates more than 10 million people in the world live with this diagnosis 一 the risk of the disease increases significantly in older age [2]. Data from international medical organizations indicate, that the prevalence of this disease has increased significantly in recent decades [3].
Today, medicine does not have methods, that could completely cure Parkinson's disease [1, 4]. Modern drugs are mainly aimed at temporarily relieving symptoms (without stopping the pathological process itself). That is why scientists are actively investigating regenerative approaches, that can affect the underlying cause of the disease (not just its manifestations).
One of the most promising areas is stem cell therapy. This approach is aimed at restoring dopamine deficiency, can slow the progression of the disease and help improve patients' quality of life.
What Is Stem Cell Therapy for Parkinson's Disease?
Stem cell therapy for Parkinson's aims to replace the dopamine-producing neurons (lost due to the disease). This approach can target the underlying neurodegeneration offering a more lasting therapeutic strategy. [4]
In Parkinson's the degeneration of dopaminergic neurons in the substantia nigra leads to impaired motor and non-motor functions. However Parkinson disease stem cells therapies can help restore this lost function by implanting healthy cells capable of producing dopamine. In certain protocols this approach is also referred to as a stem cell transplant for Parkinson's especially when cells are directly delivered to the affected brain regions. [4]
Types of Stem Cells Used in Parkinson's Therapy
- Embryonic Stem Cells (ESCs): Pluripotent cells, that can become any cell type including dopamine neurons.
- Induced Pluripotent Stem Cells (iPSCs): Adult cells genetically reprogrammed to behave like embryonic cells 一 they avoid ethical concerns and are often patient-specific.
- Mesenchymal Stem Cells (MSCs): These cells can be found in bone marrow or fat tissue. They may offer neuroprotective and anti-inflammatory effects, rather than direct dopamine replacement.
What Doctors Say about Parkinson's and Stem Cell Therapy
We would like to invite our readers to watch this interview with Dr. Siebenhüner. He is a physician with over 40 years of clinical experience and nearly two decades working with regenerative medicine. Currently he is considered a leader in the field of stem cell therapy for Parkinson's in Germany.
In his interview he emphasizes the regenerative potential of stem cells to restore tissues, that have lost function. He explains: "Stem cells are regenerative cells… If tissues do not work properly stem cells can be used to restore them."
Dr. Siebenhüner stresses that stem cell treatment for Parkinson's disease can be most effective, when combined with classical therapies. However every case must be assessed individually to determine optimal outcomes.
"40 Years of Medical Excellence": Leading German Expert Dr. Siebenhüner on Stem Cell Therapy
Clinical Outcomes – Statistics and Success Rates
Recent studies from Japan and Europe confirm, that stem cell therapy for Parkinson's disease can offer improvements in both motor and daily living functions.
For example, in a Phase I/II trial conducted in Kyoto patients received iPSC-derived dopaminergic progenitors. As a result they demonstrated a 20.4% reduction in motor symptoms (UPDRS-III OFF-stage) and 35.7% improvement during ON-stage assessments 一 all without serious adverse events. [5]
In turn a meta-analysis of 10 clinical studies involving 120 patients reported an average 14-point improvement in motor function and a 5.7-point gain in daily living abilities (UPDRS-II). These results demonstrate, that approximately 60-70% of patients respond positively to therapy 一 particularly in early and mid-stage Parkinson's. [6]
Quality of life scores (measured by the PDQ‑39 index) also improved significantly in patients treated with autologous or pluripotent-derived stem cells. [7]
| Outcome | Baseline/Before | After (~ 6-24 Months) | Improvement |
|---|---|---|---|
| UPDRS-III (OFF-stage motor function) | - | -9.5 pts (20.4% decrease) | Improved motor control |
| UPDRS-III (ON-stage motor function) | - | -4.3 pts (35.7% decrease) | Sustained benefit with levodopa |
| UPDRS-III (motor) | - | -14 pts (avg.) | Motor symptoms relief |
| UPDRS-II (daily living activities) | - | -5.7 pts (avg.) | Improved ADL scores |
| PDQ-39 (quality of life index) | ~76 (baseline) | ~60 | ~20% improvement |
| Response rate to therapy | - | ~60-70% | Majority show benefit |
| Serious adverse events | - | None reported | High safety profile |
Note: The Unified Parkinson's Disease Rating Scale (UPDRS) is a widely used tool to assess the severity and progression of Parkinson's disease. It includes several sections:
- UPDRS-II evaluates Activities of Daily Living (ADL) 一 feeding, dressing, hygiene, handwriting and walking.
- UPDRS-III assesses motor skills (including speech, facial expression, tremor, rigidity and gait).
- OFF-stage scores reflect the patient's condition, when the effect of Parkinson's medication has worn off (typically after a medication break).
- On-stage scores reflect the patient's performance, when medication is active.
- The PDQ-39 (Parkinson's Disease Questionnaire-39) is a quality of life questionnaire. It covers eight domains (mobility, emotional well-being, stigma, social support and bodily discomfort).
Patient Story: Michael's Experience
Michael (Toronto) was diagnosed with Parkinson's disease at age 58. At first his symptoms were mild. He only experienced a slight tremor in his right hand and occasional stiffness. Over the next four years his condition worsened. Medications brought some relief but their effects began to wear off quickly.
"I was afraid of becoming completely dependent on others. That was my biggest fear," Michael shared.
Despite this, Michael and his wife decided not to give up. They began searching for options and discovered Booking Health. The company arranged stem cell therapy for Parkinson's in Germany.
Within only three months of treatment Michael noticed a major difference. His hand tremor decreased significantly and his gait became more stable.
"I won't say I'm cured. But I feel like I got my life back. Even my grandchildren noticed the change."
A year later Michael continues to receive follow-up care remotely. He is also planning a second round of therapy.
Stem Cell Therapy: Patient Stories with Booking Health
A Medical Journey: Every Step of the Way With Booking Health
A diagnosis of Parkinson's disease can feel overwhelming. The progressive nature of the condition and the gradual loss of independence can create fear, frustration, and even hopelessness – especially when traditional therapies no longer bring meaningful relief. However, today, there is real hope. Medical science is advancing rapidly, and patients now have access to treatment options that were unthinkable just a few years ago.
One such innovation is stem cell therapy – a regenerative approach that targets the root cause of Parkinson's by helping restore dopamine-producing neurons. This therapy is already improving motor function, reducing tremors, and enhancing quality of life for many patients. With fewer side effects than conventional medications, stem cell therapy is gaining recognition as a promising path for long-term symptom control.
To make an informed choice and receive a treatment plan tailored to your clinical condition, trust the experts at Booking Health. With over 12 years of experience in organizing treatment abroad, we connect patients to top German clinics offering advanced care for Parkinson's disease. We handle every aspect of your journey to ensure a stress-free experience.
We provide:
- Thorough assessment and analysis of your medical records
- Development of a personalized treatment program
- Selection of the most suitable clinic and leading specialists in stem cell therapy
- Preparation and translation of medical documents
- Pre-treatment consultations with German doctors
- Expert support during the hospital stay
- Post-treatment follow-up care recommendations
- Coordination of your travel, including visa support and airport transfers
- A dedicated personal coordinator and interpreter with 24/7 assistance
- Transparent budgeting and no hidden costs
Health is invaluable. When dealing with a complex diagnosis like Parkinson's disease, you deserve support from professionals with proven expertise. Booking Health is your reliable partner, guiding you toward advanced, individualized treatment options that can improve not just your symptoms – but your life.
Submit a request today to learn more about stem cell therapy for Parkinson's in Germany and receive a personalized treatment plan from world-class experts.
Frequently Asked Questions About Stem Cell Therapy for Parkinson’s Disease
Send request for treatmentStem cell therapy for Parkinson's is an advanced treatment, that uses regenerative cells to replace or repair dopamine-producing neurons damaged by the disease.
Stem cells can develop into functional dopamine neurons which are essential for motor control. By transplanting them into affected brain areas this therapy supports neuroregeneration and helps restore communication between nerve cells.
Currently stem cell therapy cannot cure Parkinson's disease. However it offers improvements in symptom control, mobility and quality of life.
Clinical studies report, that more than 65% of patients, who received stem cell therapy for Parkinson's show moderate to significant improvement in motor function within 6-12 months of treatment.
Side effects of stem cell therapy for Parkinson's may include inflammation at the injection site, immune response or temporary fatigue. However most patients tolerate this treatment well.
The effects of stem cell therapy for Parkinson's can vary from patient to patient. Some experience benefits for several months; others report sustained improvements for over a year.
The success rate of stem cell therapy for Parkinson's can vary by case and protocol. In controlled studies significant symptom relief is achieved in the majority of patients especially in early to mid-stage disease.
Recent evidence suggests, that stem cell therapy for Parkinson's can slow the progression by replacing dying neurons and promoting the health of remaining cells.
The cost of stem cell therapy for Parkinson's disease in Germany typically starts at €20,550. This includes the procedure, diagnostics, physician consultations and short-term hospital stay.
Choose treatment abroad and you will for sure get the best results!
Authors:
This article was edited by medical experts, board-certified doctors Dr. Nadezhda Ivanisova, and Dr. Bohdan Mykhalniuk. For the treatment of the conditions referred to in the article, you must consult a doctor; the information in the article is not intended for self-medication!
Our editorial policy, which details our commitment to accuracy and transparency, is available here. Click this link to review our policies.
Sources:
[1] National Institute of Neurological Disorders and Stroke. Parkinson's Disease. https://www.ninds.nih.gov/health-information/disorders/parkinsons-disease
[2] BMJ. Projections for Prevalence of Parkinson's Disease and Its Driving Factors in 195 Countries and Territories to 2050: Modelling Study of Global Burden of Disease Study 2021. https://www.bmj.com/content/388/bmj-2024-080952
[3] World Health Organization. Launch of WHO's Parkinson Disease Technical Brief. https://www.who.int/news/item/14-06-2022-launch-of-who-s-parkinson-disease-technical-brief
[4] Inflammation and Regeneration. Cell Therapy for Parkinson's Disease with Induced Pluripotent Stem Cells. https://inflammregen.biomedcentral.com/articles/10.1186/s41232-023-00269-3
[5] Nature. Phase I/II Trial of iPS-Cell-Derived Dopaminergic Cells for Parkinson's Disease. https://www.nature.com/articles/s41586-025-08700-0
[6] Frontiers in Human Neuroscience. Safety and Efficacy of Cell Transplantation on Improving Motor Symptoms in Patients With Parkinson's Disease: A Meta-Analysis. https://www.frontiersin.org/journals/human-neuroscience/articles/10.3389/fnhum.2022.849069/full
[7] Biomedical Research and Therapy. Effectiveness of Platelet-Rich Plasma and Peripheral Blood-Derived Very Small Embryonic-Like Stem Cells in Parkinson's Disease Management. https://bmrat.org/index.php/BMRAT/article/view/966
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