google_counter
background_img

Treatment of Burkitt Lymphoma in Germany

Due to the difficulties associated with the organization of treatment in Turkey, Switzerland, South Korea and India, we are not currently processing requests to these regions.

If you are interested in treatment in Germany, please leave a request and our specialists will contact you as soon as possible.

 

Cost for treatment

Burkitt lymphoma Diagnos
15027.8
Allogeneic bone marrow transplantation (stem cell transplant) in Burkitt lymphoma
140652.9
Chemotherapy in Burkitt lymphoma
33954.65

University Hospital Mannheim

9.8/10
location_onGermany, Mannheim

Department of Hematology and Oncology

According to the reputable Focus magazine, the University Hospital Mannheim ranks among the top medical institutions of Germany, which is an undeniable confirmation of the impeccable medical care and excellent reputation of the hospital! The hospital is a high-tech modern medical institution, which provides accurate diagnosis an
Burkitt lymphoma Diagnos
18677.9
Allogeneic bone marrow transplantation (stem cell transplant) in Burkitt lymphoma
300681.9
Chemotherapy in Burkitt lymphoma
45117.2

University Hospital Ulm

8.7/10
location_onGermany, Ulm

Department of Hematology, Oncology, Palliative Care, Rheumatology and Infectology

The University Hospital Ulm started its activities 35 years ago and during this time it has become one of the most prestigious medical institutions in Europe. The hospital is famous for its numerous discoveries and the world-class achievements in medicine and pharmaceuticals. The medical facility has 29 specialized departments a
Burkitt lymphoma Diagnos
24709.9
Allogeneic bone marrow transplantation (stem cell transplant) in Burkitt lymphoma
387303.45
Chemotherapy in Burkitt lymphoma
51866.95

University Hospital Freiburg

9.7/10
location_onGermany, Freibung

Department of Hematology and Oncology

The University Hospital Freiburg is famous for its rich history and is one of the oldest and most prestigious medical facilities in Germany (one of the three best medical institutions in the country). The hospital was based on the Faculty of Medicine of the Albert Ludwig University of Freiburg, which celebrated its 550th anniver
Burkitt lymphoma Diagnos
23030.8
Allogeneic bone marrow transplantation (stem cell transplant) in Burkitt lymphoma
415713.3
Chemotherapy in Burkitt lymphoma
55036.65

University Hospital Frankfurt am Main

10/10
location_onGermany, Frankfurt am Main

Department of Hematology, Oncology, Hemostaseology, Rheumatology and Infectology

According to the reputable Focus magazine, the University Hospital Frankfurt am Main ranks among the top German medical facilities! The hospital was founded in 1914 and today is a well-known German medical facility, which combines rich traditions and scientific innovations. A medical team of more than 6,500 employees cares about
Burkitt lymphoma Diagnos
19956.8
Allogeneic bone marrow transplantation (stem cell transplant) in Burkitt lymphoma
357977.2
Chemotherapy in Burkitt lymphoma
48536.3

University Hospital Heidelberg

9.8/10
location_onGermany, Heidelberg

Department of Hematology, Oncology, Adult and Pediatric Rheumatology

According to Focus magazine, the University Hospital Heidelberg ranks among the top five hospitals in Germany! The hospital is one of the most advanced and reputable medical institutions not only in Germany, but throughout Europe. There are more than 43 specialized departments and 13 medical institutes, which cover all fields of
Burkitt lymphoma Diagnos
0
Allogeneic bone marrow transplantation (stem cell transplant) in Burkitt lymphoma
0
Chemotherapy in Burkitt lymphoma
0

University Hospital RWTH Aachen

8.7/10
location_onGermany, Aachen

Department of Oncology and Hematology

According to the prestigious Focus magazine, the University Hospital RWTH Aachen ranks among the top German hospitals! As a maximum care university medical facility, the hospital guarantees patients first-class medical services combined with a respectful and human attitude. The hospital integrates all the modern options for the
Burkitt lymphoma Diagnos
22782.85
Allogeneic bone marrow transplantation (stem cell transplant) in Burkitt lymphoma
415748.1
Chemotherapy in Burkitt lymphoma
55684.8

University Hospital Würzburg

9.2/10
location_onGermany, Würzburg

Department of Gastroenterology, Hematology, Oncology, Hepatology, Infectology, Rheumatology and Clinical Immunology

According to the Focus magazine in 2019, the University Hospital Würzburg ranks among the top national German hospitals! The hospital is one of the oldest medical facilities in Germany. The centuries-old traditions of first-class treatment are combined with the very latest achievements of modern evidence-based medicine and
Burkitt lymphoma Diagnos
18924.4
Allogeneic bone marrow transplantation (stem cell transplant) in Burkitt lymphoma
329494.85
Chemotherapy in Burkitt lymphoma
45076.6

University Hospital Bonn

9.2/10
location_onGermany, Bonn

Department of Oncology, Hematology, Rheumatology and Immunoncology

According to the authoritative Focus magazine, the University Hospital Bonn ranks among the top ten medical facilities in Germany! The hospital was opened on January 1, 2001, although in fact it inherits the medical facility, which operated at the Faculty of Medicine of the University of Bonn. The hospital in Germany combin
Burkitt lymphoma Diagnos
22327.55
Allogeneic bone marrow transplantation (stem cell transplant) in Burkitt lymphoma
415791.6
Chemotherapy in Burkitt lymphoma
55783.4

Charite University Hospital Berlin

9/10
location_onGermany, Berlin

Charité Comprehensive Cancer Center

According to the authoritative Focus magazine, the Charite University Hospital Berlin occupies the first place in the rating of the top German medical facilities! The hospital is one of the largest and leading university medical complexes in Europe. The hospital in Germany provides modern diagnostics and treatment of patients, a
Burkitt lymphoma Diagnos
18754.75
Allogeneic bone marrow transplantation (stem cell transplant) in Burkitt lymphoma
330093.7
Chemotherapy in Burkitt lymphoma
45511.6

University Hospital Hamburg-Eppendorf

9.2/10
location_onGermany, Hamburg

Department of Hematology, Oncology and Pulmonology

According to the Focus magazine, the University Hospital Hamburg-Eppendorf ranks among the top ten hospitals in Germany! Since its foundation in 1889, the hospital has taken a leading position in the European medical arena and still occupies it until today. A highly competent medical team of more than 11,000 employees takes care
Burkitt lymphoma Diagnos
18666.3
Allogeneic bone marrow transplantation (stem cell transplant) in Burkitt lymphoma
329710.9
Chemotherapy in Burkitt lymphoma
45452.15

University Hospital Halle (Saale)

9.6/10
location_onGermany, Halle

Department of Hematology and Oncology

According to the prestigious Focus magazine, the University Hospital Halle (Saale) ranks among the top German medical facilities! The history of the hospital has more than 300 years, and during this time it managed to earn an excellent reputation not only in Germany, but throughout the world. The hospital positions itself as a s
Burkitt lymphoma Diagnos
19140.45
Allogeneic bone marrow transplantation (stem cell transplant) in Burkitt lymphoma
329436.85
Chemotherapy in Burkitt lymphoma
45646.45

University Hospital Erlangen

9.1/10
location_onGermany, Erlangen

Department of Hematology and Oncology

According to the Focus magazine, University Hospital Erlangen ranks among the best medical facilities in Germany! The hospital is one of the leading healthcare facilities in Bavaria and offers top-class medical care distinguished by the close intertwining of clinical activities with research and training of medical students. The
Burkitt lymphoma Diagnos
24814.3
Allogeneic bone marrow transplantation (stem cell transplant) in Burkitt lymphoma
387171.5
Chemotherapy in Burkitt lymphoma
51691.5

University Hospital Giessen UKGM

9.5/10
location_onGermany, Giessen

Department of Oncology, Hematology and Palliative Care

The University Hospital Giessen UKGM positions itself as an ultramodern medical facility with outstanding quality of medical care. The hospital presents almost all areas of medicine, ranging from ophthalmology to traumatology and dentistry. The priorities of the hospital’s activities include surgery, neurosurgery, oncology
Burkitt lymphoma Diagnos
18991.1
Allogeneic bone marrow transplantation (stem cell transplant) in Burkitt lymphoma
329462.95
Chemotherapy in Burkitt lymphoma
45446.35

University Hospital of Ludwig Maximilian University of Munich

10/10
location_onGermany, Munich

Department of Oncology and Hematology

According to the Focus magazine, the University Hospital of Ludwig Maximilian University of Munich is regularly ranked among the best medical institutions in Germany! The hospital is the largest multidisciplinary medical facility, as well as a leading research and training center in Germany and Europe. The hospital is proud of i
Burkitt lymphoma Diagnos
22827.8
Allogeneic bone marrow transplantation (stem cell transplant) in Burkitt lymphoma
415321.8
Chemotherapy in Burkitt lymphoma
55665.95

University Hospital Marburg UKGM

8.6/10
location_onGermany, Marburg

Department of Hematology, Oncology and Immunology

The University Hospital Marburg UKGM offers patients modern diagnostics and comprehensive therapy at the international level. As a maximum care hospital, the medical facility specializes in all fields of modern medicine ranging from ophthalmology to traumatology and dentistry. The main areas of specialization of the hospital are
Burkitt lymphoma Diagnos
19144.8
Allogeneic bone marrow transplantation (stem cell transplant) in Burkitt lymphoma
330037.15
Chemotherapy in Burkitt lymphoma
45675.45

University Hospital Muenster

9.8/10
location_onGermany, Muenster

Department of Hematology, Hemostaseology, Oncology and Pulmonology

According to the Focus magazine, the University Hospital Muenster ranks among the top German hospitals! The hospital belongs to the most prestigious medical institutions in Germany. The hospital is distinguished by a high professionalism of its doctors, state-of-the-art technological equipment and the availability of the most ad
Burkitt lymphoma Diagnos
18922.95
Allogeneic bone marrow transplantation (stem cell transplant) in Burkitt lymphoma
329513.7
Chemotherapy in Burkitt lymphoma
45276.7
| from Booking Health GmbH

Burkitt lymphoma is an aggressive, Non-Hodgkin's, B-cell lymphoma. Its development is associated with the Epstein-Barr virus (EBV), the human immunodeficiency virus (HIV), and chromosomal rearrangements. According to the WHO classification, Burkitt lymphoma is divided into three types: endemic, sporadic, and immunodeficiency-associated. The last group is usually made up of patients with HIV, as well as patients who have had organ transplant surgery. The endemic form is associated with malaria and EBV. In Germany, 90% of children and young adult patients are cured of Burkitt lymphoma. You can make an appointment for treatment in this country on the Booking Health website.

Content

  1. Diagnostics of Burkitt lymphoma
  2. Treatment of Burkitt lymphoma in children
  3. Treatment of Burkitt lymphoma in adults
  4. Toxicity and side effects
  5. Why is it worth undergoing treatment in Germany?

Diagnostics of Burkitt lymphoma

 

The tumor will most often develop in the abdominal cavity, while the head and neck are less likely to be affected by the disease. The reasons for seeking a doctor’s diagnosis are as follows:

  • abdominal pain; 
  • bloating;
  • nausea;
  • vomit.

If any complications develop, such as gastrointestinal bleeding or an intestinal obstruction, hospitalization may be required. Adult patients often suffer from systemic symptoms, such as weight loss, night sweats, and fevers.

Occasionally, the following organs may be involved: 

  • jaws (more often in children); 
  • bone marrow;
  • brain or spinal cord; 
  • testicles; 
  • skin;
  • mammary glands;
  • thyroid gland.

Laboratory tests are used when doctors highly suspect lymphoma to be the cause of the patient’s symptoms. The patient will have increased levels of uric acid and lactate dehydrogenase in their blood.

A biopsy is the main method of confirming and clarifying a diagnosis. Doctors obtain samples of the superficial lymph nodes or pleural fluid. The tissues are then examined using immunohistochemical and cytogenetic methods.

A bone marrow biopsy is performed to assess the involvement of the hematopoietic system in the pathological process. If more than 25% of the bone marrow is affected by pathological cells, then Burkitt leukemia is diagnosed. This form of the disease is rare.

A cerebrospinal fluid analysis is conducted to determine the possible involvement of the central nervous system, since brain or spinal cord lesions will change the treatment tactics.

Medical imaging allows doctors to see the tumors on scans, enabling them to determine their location and clarify the stage of the disease. The main imaging tests include CT scans of the chest, abdomen, and pelvis. An MRI scan is rarely conducted. The doctors in Germany also often use PET/CT scans.

To select a treatment regimen, the doctors first determine the stage of the disease. The hospitals in developed countries use different staging systems. The St. Jude Staging System is generally used for children, while the Ann Arbor and Murphy Staging Systems are used for adults. They are based on the number and location of tumors, their presence on both sides of the diaphragm, and the involvement of bone marrow and the central nervous system. Some staging systems also take a patient’s symptoms into account. The first three stages are considered favorable, but the advanced stage is much more difficult to treat.

Treatment of Burkitt lymphoma in children

 

The treatment regimen depends on the stage of the pathology and the child's age. Due to the rapid progression of the disease, the therapy is started within 48 hours of making the diagnosis. Doctors don’t delay treatment until the results of further examinations are obtained.

In children, the tumor sometimes has to be removed surgically. A surgical intervention is followed by two cycles of moderate-intensity chemotherapy.

At stage 1 or 2, Burkitt lymphoma can be cured in 98% of children. In the advanced stages, the percentage of successful treatment in Germany is lower, however, most patients do still manage to get rid of the disease completely or at least achieve many years of remission.

Children with the residual disease or stage 3 cancer receive at least four cycles of high-dose chemotherapy. Simultaneously with a systemic (intravenous) administration of drugs, intrathecal chemotherapy is carried out. The drugs are injected into the cerebrospinal fluid.

Intrathecal chemotherapy is required even in cases where there is no evidence of lymphoma invasion into the central nervous system. There may already be cancer cells in the cerebrospinal fluid, which in the future will become a source of the disease’s recurrence. Chemotherapy drugs that are administered intravenously cannot cross the blood-brain barrier in large quantities, so the drugs are administered using a lumbar puncture.

Children with an affected central nervous system or bone marrow are treated with up to eight cycles of high-dose chemotherapy. After this the doctors can then start maintenance therapy.

Treatment of Burkitt lymphoma in adults

 

The standard CHOP regimen is not suitable for adults. The older the person, the more difficult it is to cure the disease. Therefore, more intensive schemes are applied, including:

  • R-hyper-CVAD; 
  • CODOX-M/IVACA;
  • EPOCH.

To treat Burkitt lymphoma in adult patients, the healthcare professionals in Germany supplement chemotherapy with immunotherapy. The doctors use anti-CD20, as well as CD19 and CD22 monoclonal antibodies. Some drugs are still being studied in clinical trials, while others have already become a part of the standard treatment.

Here are some of the very latest drugs that have introduced new perspectives on lymphoma treatment:

  • histone acetyltransferase inhibitors;
  • mTOR inhibitors; 
  • PD-1 inhibitors; 
  • therapy that inhibits the MYC oncogene. 

The treatment of HIV-associated Burkitt lymphoma involves the use of highly active antiretroviral therapy, which is combined with chemotherapy. Doctors prefer to prescribe less toxic treatment regimens to such patients, so as not to aggravate their existing immune deficiency.

The results of cancer treatment on patients with recurrent tumors are usually worse than in the primary treatment of a newly diagnosed lymphoma. Nonetheless, the specialists in Germany select effective schemes, even for such patients, to achieve remission. The doctors use rescue schemes, such as R-IVAC, R-GDP, R-ICE, or DHAP. For young patients who are in good health, the specialists resort to stem cell transplants.

Toxicity and side effects

 

The big problem with lymphoma treatment is its toxicity. It is associated with tumor lysis syndrome, high doses of chemotherapy drugs, and worsening immunodeficiency. As a result, the risk of developing complications increases.

Due to the toxicity, the treatment options for Burkitt lymphoma are limited in immunocompromised individuals and elderly debilitated patients. In elderly patients, it is often impossible to apply standard chemotherapy regimens, and the treatment is palliative in its nature: it slows down the development of the disease, but does not cure it and does not bring it into remission. In cases of immunodeficiency, the drug doses also have to be reduced in order to avoid infectious complications, but most patients still manage to achieve the remission of their Burkitt lymphoma. German doctors use antiretroviral therapy to suppress HIV, additional treatment to boost the immune system defenses, and antibiotics to suppress developing infections.

Tumor lysis syndrome is a problem that develops due to the destruction of a large tumor mass at the start of treatment. The contents of the cancer cells poison the body and have a particularly strong effect on the kidneys. As a result, water and electrolyte metabolism is disturbed, and kidney failure can develop, which is associated with increased calcium concentration in the blood. The release of large amounts of calcium, phosphate, and potassium can also lead to arrhythmias and lesions of the central nervous system. This complication is more common in the following groups of patients:

  • male patients;
  • patients with kidney diseases; 
  • patients with elevated lactate dehydrogenase (LDH) levels;
  • patients with elevated uric acid levels; 
  • patients with an enlarged spleen. 

The doctors in Germany use additional drugs to prevent tumor lysis syndrome, without waiting for its development. If the syndrome has already developed, the patients receive adequate medical care, primarily to normalize their blood pH, compensate for water and electrolyte imbalance, and improve kidney function. Some patients may need hemodialysis (cleansing the blood with an "artificial kidney").

Why is it worth undergoing treatment in Germany?

 

Burkitt lymphoma is a deadly disease that, if left untreated, leads to a patient's death within a few months. However, doctors in Germany can successfully treat most cases of the disease. In Germany, you can count on receiving effective treatment, even if you have an advanced stage of cancer. You are welcome to use our Booking Health service to book your Burkitt lymphoma treatment program in Germany at an affordable price. The cost of treatment in Germany may differ depending on the hospital. On the Booking Health website, you have the opportunity to compare prices and choose the treatment program that suits you best. Our experts will help you to choose the best option in terms of both price and the quality of treatment.

There are a few reasons for you to undergo your treatment in Germany: 

  • more than 90% of children are cured of Burkitt lymphoma, and at stages 1-2 this indicator reaches 98%;
  • successful treatment of adult patients;
  • the use of the very latest drugs for chemotherapy, targeted therapy, and immunotherapy;
  • if an operation is required, then it will be performed using small incisions, whilst maintaining the function of the organs, and with minimal health risks;
  • good results in patients who are infected with HIV: simultaneous antiretroviral therapy, immune system boosting, and infection suppression;
  • prevention of tumor lysis syndrome and other complications;
  • in severe cases and in a relapse of lymphoma, a stem cell transplant is performed;
  • the opportunity to participate in clinical trials to take advantage of the very latest advances in medicine.

If you make an appointment for your treatment through the Booking Health website, then the cost of your treatment in Germany will be final. Even if additional procedures are required, all extra costs will be covered by your insurance, up to the amount of up to 200,000 EUR, so the quoted price for your treatment will not change.

 

Authors: 

The article was edited by medical experts, board certified doctors Dr. Vadim Zhiliuk and Dr. Sergey Pashchenko. For the treatment of the conditions referred to in the article, you must consult a doctor; the information in the article is not intended for self-medication!

 

Sources:

Cancer Research Institute

Cancer. Net

Verywell Health




Feedback of our customers from other resources

Need Help?

Thank you!

We received your treatment application in the best Europe clinics. Our manager will contact you within the next 24 hours.