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Treatment of Ewing sarcoma

Due to the difficulties associated with the organization of treatment in Turkey, Switzerland, South Korea and India, we are not currently processing requests to these regions.

If you are interested in treatment in Germany, please leave a request and our specialists will contact you as soon as possible.

 

Cost for treatment

Ewing sarcoma diagnosis
 from  2230
Chemotherapy and radiation therapy for Ewing sarcoma
 from  25574
Surgical treatment for Ewing sarcoma
 from  7045

MediClin Robert Janker Clinic

9.5/10
location_onGermany, Bonn

Department of Oncology and Palliative Care

The MediClin Robert Janker Clinic is a progressive medical facility, which has all the very latest diagnostic and treatment methods for the recovery of health of patients who suffer from cancers. The clinic was founded by renowned radiologist and surgeon Robert Janker. Today, its history has more than 80 years of successful clin
Ewing sarcoma diagnosis
6854

Medias Cancer Clinic Burghausen

10/10
location_onGermany, Burghausen

Department of Oncology and Surgical Oncology

The Medias Cancer Clinic Burghausen positions itself as a private highly specialised medical facility with international leadership in cancer treatment. The key areas of specialization of the clinic include regional chemotherapy, surgical oncology, hyperthermia, immunotherapy and pain therapy. The ultimate value of each emp
Ewing sarcoma diagnosis
7133

University Hospital Ulm

8.7/10
location_onGermany, Ulm

Department of Hematology, Oncology, Palliative Care, Rheumatology and Infectology

The University Hospital Ulm started its activities 35 years ago and during this time it has become one of the most prestigious medical institutions in Europe. The hospital is famous for its numerous discoveries and the world-class achievements in medicine and pharmaceuticals. The medical facility has 29 specialized departments a
Ewing sarcoma diagnosis
6854
Chemotherapy and radiation therapy for Ewing sarcoma
43646
Surgical treatment for Ewing sarcoma
20238

University Hospital Freiburg

9.7/10
location_onGermany, Freibung

Department of Hematology and Oncology

The University Hospital Freiburg is famous for its rich history and is one of the oldest and most prestigious medical facilities in Germany (one of the three best medical institutions in the country). The hospital was based on the Faculty of Medicine of the Albert Ludwig University of Freiburg, which celebrated its 550th anniver
Ewing sarcoma diagnosis
7140
Chemotherapy and radiation therapy for Ewing sarcoma
46138
Surgical treatment for Ewing sarcoma
21290

University Hospital Frankfurt am Main

10/10
location_onGermany, Frankfurt am Main

Cancer Center

According to the reputable Focus magazine, the University Hospital Frankfurt am Main ranks among the top German medical facilities! The hospital was founded in 1914 and today is a well-known German medical facility, which combines rich traditions and scientific innovations. A medical team of more than 6,500 employees cares about
Ewing sarcoma diagnosis
6558
Chemotherapy and radiation therapy for Ewing sarcoma
35577
Surgical treatment for Ewing sarcoma
19035

University Hospital Heidelberg

9.8/10
location_onGermany, Heidelberg

Department of Hematology, Oncology, Adult and Pediatric Rheumatology

According to the Focus magazine, the University Hospital Heidelberg ranks among the top five hospitals in Germany! The hospital is one of the most advanced and reputable medical institutions not only in Germany, but throughout Europe. There are more than 43 specialized departments and 13 medical institutes, which cover all field
Ewing sarcoma diagnosis
0
Chemotherapy and radiation therapy for Ewing sarcoma
0
Surgical treatment for Ewing sarcoma
0

University Hospital RWTH Aachen

8.7/10
location_onGermany, Aachen

Department of Oncology and Hematology

According to the prestigious Focus magazine, the University Hospital RWTH Aachen ranks among the top German hospitals! As a maximum care university medical facility, the hospital guarantees patients first-class medical services combined with a respectful and human attitude. The hospital integrates all the modern options for the
Ewing sarcoma diagnosis
7101
Chemotherapy and radiation therapy for Ewing sarcoma
45818
Surgical treatment for Ewing sarcoma
21286

University Hospital Würzburg

9.2/10
location_onGermany, Würzburg

Department of Gastroenterology, Hematology, Oncology, Hepatology, Infectology, Rheumatology and Clinical Immunology

According to the Focus magazine in 2019, the University Hospital Würzburg ranks among the top national German hospitals! The hospital is one of the oldest medical facilities in Germany. The centuries-old traditions of first-class treatment are combined with the very latest achievements of modern evidence-based medicine and
Ewing sarcoma diagnosis
6111
Chemotherapy and radiation therapy for Ewing sarcoma
35670
Surgical treatment for Ewing sarcoma
18966

University Hospital Carl Gustav Carus Dresden

9.1/10
location_onGermany, Dresden

Department of Oncology

According to the prestigious Focus magazine, the University Hospital Carl Gustav Carus Dresden is among the top three hospitals in Germany! The hospital is the embodiment of the standards of modern high-quality medicine. Since the hospital positions itself as a maximum care medical facility, it represents all medical fields. The
Ewing sarcoma diagnosis
8405
Chemotherapy and radiation therapy for Ewing sarcoma
35508
Surgical treatment for Ewing sarcoma
25423

University Hospital Erlangen

9.1/10
location_onGermany, Erlangen

Department of Hematology and Oncology

According to the Focus magazine, the University Hospital Erlangen ranks among the top German medical facilities! The hospital is one of the leading medical facilities in Bavaria and offers the highest level of medical care, which is characterized by the close intertwining of clinical activities with research and training of medi
Ewing sarcoma diagnosis
6839
Chemotherapy and radiation therapy for Ewing sarcoma
43301
Surgical treatment for Ewing sarcoma
20331

University Hospital Halle (Saale)

9.6/10
location_onGermany, Halle

Department of Hematology and Oncology

According to the prestigious Focus magazine, the University Hospital Halle (Saale) ranks among the top German medical facilities! The history of the hospital has more than 300 years, and during this time it managed to earn an excellent reputation not only in Germany, but throughout the world. The hospital positions itself as a s
Ewing sarcoma diagnosis
6073
Chemotherapy and radiation therapy for Ewing sarcoma
35971
Surgical treatment for Ewing sarcoma
19454

University Hospital Hamburg-Eppendorf

9.2/10
location_onGermany, Hamburg

Department of Hematology, Oncology and Pulmonology

According to the Focus magazine, the University Hospital Hamburg-Eppendorf ranks among the top ten hospitals in Germany! Since its foundation in 1889, the hospital has taken a leading position in the European medical arena and still occupies it until today. A highly competent medical team of more than 11,000 employees takes care
Ewing sarcoma diagnosis
6192
Chemotherapy and radiation therapy for Ewing sarcoma
35907
Surgical treatment for Ewing sarcoma
25376

Charite University Hospital Berlin

9/10
location_onGermany, Berlin

Charité Comprehensive Cancer Center

According to the authoritative Focus magazine, the Charite University Hospital Berlin occupies the first place in the rating of the top German medical facilities! The hospital is one of the largest and leading university medical complexes in Europe. The hospital in Germany provides modern diagnostics and treatment of patients, a
Ewing sarcoma diagnosis
6197
Chemotherapy and radiation therapy for Ewing sarcoma
46251
Surgical treatment for Ewing sarcoma
28574

University Hospital Bonn

9.2/10
location_onGermany, Bonn

Department of Oncology, Hematology, Rheumatology and Immunoncology

According to the authoritative Focus magazine, the University Hospital Bonn ranks among the top ten medical facilities in Germany! The hospital was opened on January 1, 2001, although in fact it inherits the medical facility, which operated at the Faculty of Medicine of the University of Bonn. The hospital in Germany combin
Ewing sarcoma diagnosis
7159
Chemotherapy and radiation therapy for Ewing sarcoma
36038
Surgical treatment for Ewing sarcoma
21541

University Hospital Giessen UKGM

9.5/10
location_onGermany, Giessen

Department of Oncology, Hematology and Palliative Care

The University Hospital Giessen UKGM positions itself as an ultramodern medical facility with outstanding quality of medical care. The hospital presents almost all areas of medicine, ranging from ophthalmology to traumatology and dentistry. The priorities of the hospital’s activities include surgery, neurosurgery, oncology
Ewing sarcoma diagnosis
6165
Surgical treatment for Ewing sarcoma
18078

University Hospital Marburg UKGM

8.6/10
location_onGermany, Marburg

Department of Hematology, Oncology and Immunology

The University Hospital Marburg UKGM offers patients modern diagnostics and comprehensive therapy at the international level. As a maximum care hospital, the medical facility specializes in all fields of modern medicine ranging from ophthalmology to traumatology and dentistry. The main areas of specialization of the hospital are
Ewing sarcoma diagnosis
6147
Chemotherapy and radiation therapy for Ewing sarcoma
43322
Surgical treatment for Ewing sarcoma
17982
| from Booking Health GmbH

Content

  1. What you should know about Ewing sarcoma
  2. When considering diagnostics for Ewing sarcoma?
  3. Diagnostics
  4. Treatment options
  5. Prognosis
  6. Where to undergo diagnostics and treatment of Ewing sarcoma?
  7. What`s the cost of treatment for Ewing sarcoma?
  8. How to go for diagnostics and treatment of Ewing sarcoma abroad?

 

Ewing sarcoma is a malignant neoplasm that develops from bone tissue. It most often occurs in adolescence. It affects short (feet and hands) and long (extremities) tubular bones. It is one of the most aggressive metastasis-prone tumors.

What you should know about Ewing sarcoma

 

Ewing sarcoma is a form of bone cancer that is characterized by rapid growth and early formation of metastases. It usually develops in children, adolescents, and young adults.

Ewing sarcoma is the second most common form of bone cancer that occurs in childhood, accounting for 10 to 15% of the total number of bone cancer cases. It is rare in adults because the developing bone tissue is a favorable environment for Ewing sarcoma onset.

In some cases, the primary neoplasm in this disease occurs in soft tissues, and not in bones. This form of bone cancer is called extraosseous Ewing sarcoma. Also, there are aggressive malignant tumors that are similar in nature and structure and belong to the Ewing sarcoma group of bone cancer. This group, in addition to extraosseous and bone sarcoma, includes PNET (peripheral primitive neuroectodermal tumors). Extraosseous forms and PNET together account for about 15% of the total number of cases of Ewing sarcoma.

When considering diagnostics for Ewing sarcoma?

 

The first and earliest clinical sign is the specific pain in the affected area, mostly bone pain. At first, there’s a minor pain that disappears spontaneously, and then appears again. Unlike pain that is common for other types of cancer, pain in Ewing sarcoma does not diminish at rest or at night. Moreover, Ewing's sarcoma is characterized by pain that is worse at night.

As the pain progresses, it becomes more intense, deprives patients of sleep, and limits daily activities. There are symptoms like a local increase in the blood flow and enlargement of veins of the affected area.

Local clinical signs are combined with increasing symptoms of general tumor intoxication. Patients complain of general weakness or fatigue and loss of appetite. There is a decrease in body mass, up to exhaustion. Regional enlargement of one or several lymph nodes also belongs to the symptoms of Ewing sarcoma.

Some symptoms depend on the location of this type of bone cancer. So, when Ewing sarcoma occurs in the lower extremities, the impaired functioning of the bones of the lower extremities occurs. With damage to the vertebrae, development of myelopathy (compression of the spinal cord) with dysfunction of the pelvic organs and the impaired functioning of the lower extremities occurs. With neoplasms in the chest bones, respiratory failure, the presence of excess fluid in the lungs, and coughing up blood may occur.

The tumor grows rapidly (usually several months after the onset of the first symptoms) and becomes so large that it can be easily felt. At the later stages, a pathological fracture often occurs in the area of bone cancer.

Diagnostics

 

The first-line clinical examination for Ewing sarcoma is an X-ray of the area of concern. When clinical signs of Ewing's sarcoma are detected on X-ray, the patient is referred to the oncology department, where a comprehensive examination is carried out to assess type, and the process of development of bone cancer. In the course of such an examination, CT scan and MRI of bones and soft tissues affected by bone cancer are performed. These clinical studies make it possible to determine the size of the Ewing sarcoma, its spread to the bone marrow, and its connection with the neurovascular bundle and surrounding tissues.

To detect metastases in the lungs, computed tomography and radiography of the lungs are used. To detect metastases in the bones, bone marrow, and internal organs, positron emission tomography, and ultrasound scan are performed. Also, some additional medical studies are indicated to determine the type of bone cancer.

A biopsy is also performed. The material is harvested from a site of bone near the bone marrow, or, if this is not possible, from the soft tissue component of the tumor. Since Ewing sarcoma is characterized by local and distant damage to the bone marrow, a bone marrow aspiration is performed, during which bone marrow tissue is harvested. To assess the nature of the process, immunohistochemical analysis and molecular genetic studies can also be carried out.

Treatment options

 

The treatment options for Ewing sarcoma include surgery, preoperative and postoperative chemotherapy, radiation therapy, and bone marrow transplantation.

However, since this tumor belongs to the category of highly aggressive neoplasms, and is characterized by early metastasizing, treatments should be systemic, even in cases of absence of the metastases. The fact is that there is a very high probability of the early appearance of micrometastases, which cannot be detected at the time of diagnosis making.

Surgical treatment of Ewing sarcoma

The choice of the method of surgery depends on the location of bone cancer and the prognosis of the functioning of the affected part of the body after surgery.

If bone cancer is located in the chest, it is removed along with several ribs, which are replaced with synthetic material. Cancer cells in the lungs are removed during the surgical intervention as well. After the operation, such patients undergo radiation therapy. In patients with Ewing sarcoma with damage to the vascular system, radiation therapy could be used as an alternative to surgery.

In many cases, the affected bone or soft tissue can be completely removed by surgery without affecting organ function. In other cases, the preservation of organ function after the complete removal of the tumor tissue is impossible.

If surgical treatment for bone cancer is carried out at the advanced stages, poor wound healing and infectious complications can develop. This is due to the previously performed chemotherapy and radiation therapy. After the surgical treatment, many patients with Ewing sarcoma require rehabilitation treatments.

Radiation therapy

Ewing sarcoma is highly sensitive to radiation and most patients can be treated with a combination of chemotherapy and radiation therapy.

However, radiation therapy can have specific side effects.

Bone growth disorder is a serious complication of radiation therapy. Irradiation of the pelvic area may damage the bladder and colon. When applied to the spinal cord and brain, radiation therapy may cause the worsening of the health condition that manifests itself with headaches. Moreover, the younger the patient is, the more pronounced the side effects and complications are.

In 20% of cases, high doses of radiation lead to the development of a secondary malignant tumor. So, radiation therapy in Ewing sarcoma treatment is usually reserved for very serious cases.

Chemotherapy

Chemotherapy in patients with Ewing sarcoma is carried out with the help of anti-cancer drugs that are usually administered intravenously.

This method of treatment is indicated for all patients, regardless of the degree of bone cancer progression. This is because patients with a localized process may have micrometastases that are detected only by microscopic examination. Therefore, refusal of chemotherapy in patients with Ewing sarcoma will eventually lead to the growth of these micrometastases.

Chemotherapy can cause various side effects, including nausea, vomiting, loss of appetite, increased susceptibility to infections, menstrual irregularities, and damage to the heart muscle.

Bone marrow transplantation

Recently, patients with a poor prognosis, in particular those with bone cancer metastases, with a survival rate of less than 10%, have been receiving more intensive treatments consisting of high-dose chemotherapy and radiotherapy, and transplantation of bone marrow. This approach allows curing more than 30% of patients with metastatic processes.

Prognosis

 

The prognosis for Ewing sarcoma depends on many factors. If metastases are found, the prognosis worsens significantly. However, the complex therapy can successfully treat patients with advanced forms of bone cancer in 30% cases.

After recovery, all patients should undergo regular check-ups for early detection of relapses and control of side effects. It should be borne in mind that some side effects can occur not only during treatment, but also long after its completion. However, many patients treated for Ewing sarcoma can live full lives.

Where to undergo diagnostics and treatment of Ewing sarcoma?

 

Here’s the list of hospitals specialized in the diagnostics and treatment of Ewing sarcoma:

  1. MediClin Robert Janker Clinic, Germany
  2. Medias Cancer Clinic Burghausen, Germany
  3. HELIOS Clinic Krefeld, Germany
  4. Medicana International Ankara Hospital, Turkey
  5. Memorial Bahcelievler Hospital Istanbul, Turkey

If you consider any of the listed hospitals for treatment, leave the request on the Booking Health website.

What’s the cost of treatment for Ewing sarcoma?

 

The cost of treatment depends on the country patients undergo therapy for bone cancer in, on the pricing policy of the hospitals, and the medical procedures in each particular case.

Generally, the cost of treatment of Ewing sarcoma with chemotherapy and radiotherapy in Germany starts at 32,181 EUR, and in Turkey it starts at 25,574 EUR.

The cost of treatment with surgical intervention in Germany starts at 16,533 EUR, and in Turkey – at 11,899 EUR.

The price for diagnostics alone in Germany starts at 5,714 EUR, and in Turkey – at 3,813 EUR.

There’s more information about treatment prices on the Booking Health website.

How to go for diagnostics and treatment of Ewing sarcoma abroad?

 

Unfortunately, hospitals in some countries are not able to provide proper cancer care, especially when it comes to such rare and complex health conditions as Ewing sarcoma. Besides, the treatment methods and technologies usually lag behind the foreign ones.

Recently, more and more people are thinking about traveling to other countries to treat various types of cancer and receive qualified health care, diagnostics, as well as having a second opinion. Often, it is the right thing to confirm the diagnosis and treatment correctness in foreign hospitals.

So, treatment abroad is clearly a good option for many cancer patients, but how can one go for treatment abroad? Well, instead of going through countless sources on the topic, you can contact the medical tourism agency Booking Health.

Booking Health will help you select a specialized medical facility for your diagnosis among the best hospitals in the world, will take upon all the organizational issues, and will assist you throughout your journey for treatment.

For what it's worth, it is much more comforting not to do it alone. To find out how to start your treatment, leave the request on the Booking Health website.

Authors: Dr. Nadezhda IvanisovaDr. Farrukh Ahmed




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