Diagnostic of Prostate Cancer with PSMA-PET

Helios Hospital Berlin-Buch

location_onGermany, Berlin

Department of Nuclear Medicine

The Department of Nuclear Medicine offers the full range of diagnostic and therapeutic procedures using modern radioactive substances. The diagnostic options include scintigraphic studies of the lungs, heart, brain, kidneys, lymph nodes, bones, including in small patients. In the field of therapy, one of the priority focuses is the use of radioiodine therapy for thyroid pathologies. Medical care and patient care are provided by highly qualified doctors and nursing staff who believe that the health and wellbeing of their patients is a top priority.

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University Hospital Frankfurt am Main

location_onGermany, Frankfurt am Main

Department of Nuclear Medicine

The Department of Nuclear Medicine offers the full range of modern diagnostics and therapy using various radioisotopes. The department is equipped with the advanced systems for carrying out such high-precision and informative examinations as SPECT, PET, etc. The department carries out more than 8,000 outpatient examinations annually. The key focus in the field of diagnostics is on the detection of neurological, cardiac and oncological diseases. The department's therapeutic options include the treatment of benign and malignant diseases of the thyroid gland, pain therapy in bone metastases, treatment of malignant tumors in children (for example, neuroblastomas). The spectrum is also complemented by such innovative techniques as radiosynoviorthesis, selective internal radiation therapy and radioimmunotherapy.

University Hospital Carl Gustav Carus Dresden

location_onGermany, Dresden

Department of Nuclear Medicine

The Department of Nuclear Medicine offers the full range of diagnostics and treatment with therapeutic radionuclides. The department has been carrying out successful clinical activities for over 60 years, and therefore it has vast experience and outstanding achievements. The department has state-of-the-art medical equipment, thereby providing each patient with optimal medical care that meets the highest international standards. A special focus is placed on the treatment of benign and malignant thyroid diseases. The department cooperates closely with the specialized centers for breast cancer, prostate cancer, lung cancer and skin cancer. The specialists in the field of nuclear medicine also actively cooperate with doctors from the Comprehensive Cancer Center Dresden. Most diagnostic examinations are carried out on an outpatient basis, and therapeutic interventions most often take place in an 18-bed inpatient medical facility – one of the largest of this kind in Germany.

University Hospital Erlangen

location_onGermany, Erlangen

Department of Nuclear Medicine

The Department of Nuclear Medicine offers the full range of diagnostic and therapeutic services in the area of ​​its specialization. Of particular interest are PET/CT, PET/MRI, SPECT/CT, as well as innovative therapeutic methods of nuclear medicine, such as peptide radioreceptor therapy for neuroendocrine tumors, liver tumor radioembolization, and treatment of prostate cancer using radioligands to prostate-specific membrane antigen (PSMA therapy). The department's doctors most often admit patients suffering from cancers, diseases of the nervous and cardiovascular system. The patients receive medical care from the highly qualified internationally renowned specialists with profound clinical training and rich experience. The department's doctors use only reliable radioisotopes, which do not have a harmful effect on the human body and do not cause any side effects. The patients are admitted both on an inpatient and outpatient basis.

University Hospital Bonn

location_onGermany, Bonn

Department of Nuclear Medicine

The Department of Nuclear Medicine offers the full range of radioisotope diagnostics and treatment of various diseases. The department began its work in 1951 and today it is one of the leading and most reputable medical facilities of this kind in Germany. The clinical activities mainly focus on detection and treatment of pathologies of the thyroid gland, heart, lung cancer, breast cancer, prostate gland, liver cancer and metastases, neuroendocrine tumors, malignant melanoma, and brain tumors. The doctors use only reliable, the most effective innovative methods of examination and therapy, which guarantee an optimal result.

University Hospital Duesseldorf

location_onGermany, Duesseldorf

Department of Nuclear Medicine

The Department of Nuclear Medicine offers the full range of diagnostics and treatment with radioactive substances. It conducts many scintigraphic examinations, ranging from the diagnostics of the thyroid gland and skeleton to amino acid metabolism studies in brain tumors and metabolic studies in other malignant tumors. The department has at its disposal a specialized outpatient clinic for the diagnostics and treatment of thyroid diseases.

University Hospital of Ludwig Maximilian University of Munich

location_onGermany, Munich

Department of Nuclear Medicine

The Department of Nuclear Medicine offers the full range of modern methods of radioisotope-based diagnostics and treatment. The department provides outpatient and inpatient medical care. In the field of diagnostics, special attention is paid to positron emission tomography (PET), including in combination with computed tomography (PET/CT), scintigraphy, single photon emission computed tomography (SPECT), and SPECT/CT. These examinations are most often performed for suspected cancers, neurological disorders, and heart disease. Radioisotope-based therapies can be used to treat benign and malignant thyroid diseases, benign joint lesions, prostate cancer, neuroendocrine tumors, primary and secondary liver tumors, and bone metastases. The department is the largest facility of this kind in Germany and is deservedly proud of its prestigious international ISO 9001:2015 certification.

University Hospital Halle (Saale)

location_onGermany, Halle

Department of Nuclear Medicine

The Department of Nuclear Medicine offers the full range of services in this ​​medical field. It carries out all common and proven types of scintigraphic diagnostics and treatment. A unique offer of the department is SPECT-CT and PET-CT using various tracers and modern targeted radiopharmaceuticals. The department has an in-house Section of Radiochemistry, in which all the necessary radiopharmaceuticals for the diagnostics and therapy are synthesized. Thus, the department has all the resources to provide excellent medical service.

University Hospital Jena

location_onGermany, Jena

Department of Nuclear Medicine

The Department of Nuclear Medicine offers the full range of radioisotope diagnostics and treatment using the state-of-art gamma cameras and PET-CT systems. The main therapeutic facilities of the department include radioiodine therapy, selective internal radiotherapy, peptide-receptor radionuclide therapy. All medical services comply with the guidelines of national and international professional societies, which ensures an accurate diagnostics and optimal treatment outcome.

University Hospital Rechts der Isar Munich

location_onGermany, Munich

Department of Nuclear Medicine

The Department of Nuclear Medicine offers the full range of services in this area. Key clinical areas include the diagnostics and treatment of tumors, diseases of the thyroid gland, kidneys, brain and heart. For this purpose, doctors have at their disposal the necessary medical equipment of the latest generation: devices for PET, PET/CT, SPECT/CT, etc. After comprehensive diagnostics, doctors of the medical facility assess the advisability of radioisotope therapy. In 2020, there was founded the Section for Theranostics – an innovative approach in medicine, providing for the creation of medications that can be simultaneously used for both diagnostic and therapeutic purposes. The department was one of the first specialized medical institutions of its kind in Germany and has been providing patients with high-quality medical care for many years.

University Hospital Würzburg

location_onGermany, Würzburg

Department of Nuclear Medicine

The Department of Nuclear Medicine offers all modern diagnostic and therapeutic procedures using radioactive substances. In addition to the classical methods of nuclear diagnostics, for example, thyroid scintigraphy, special attention is paid to the functional and molecular imaging using the state-of-art PET-CT and SPECT-CT techniques. A special feature of the department is also the Section of Radiochemistry, which produces its own radiopharmaceutical medicines for the targeted therapy of oncopathology (including prostate cancer, neuroendocrine tumors or lymphomas), diseases of the cardiovascular system, and neurological disorders.

University Hospital Muenster

location_onGermany, Muenster

Department of Adult and Pediatric Nuclear Medicine

The Department of Adult and Pediatric Nuclear Medicine offers the full range of radioisotope diagnostics and therapy at the highest technical level. The department specializes in the detection and treatment of benign and malignant thyroid diseases, oncopathology of other organs and anatomical structures of the human body. The department's feature is the radioisotope examinations in children, for example, PET-CT, PET-MRI, kidney, bone scintigraphy, etc. The high-quality medical care is provided thanks to the availability of advanced medical technologies and experienced medical personnel who regularly undergo advanced training courses to keep abreast of medical innovations.

University Hospital Tuebingen

location_onGermany, Tuebingen

Department of Nuclear Medicine and Clinical Imaging Diagnostics

The Department of Nuclear Medicine and Clinical Imaging Diagnostics offers the full range of radioisotope diagnostics and treatment of various diseases. Both classical diagnostic methods, for example, scintigraphy, SPECT and innovative hybrid techniques, for example, PET-CT, PET-MRT, SPECT-CT are available in the department, which allow to detect metabolic changes at the early stages of various diseases, as well as their localization in the human body. In addition, the department's doctors specialize in radiotherapy for the treatment of oncopathologies.

University Hospital Heidelberg

location_onGermany, Heidelberg

Department of Nuclear Medicine

The Department of Nuclear Medicine offers the full range of radioisotope diagnostics and treatment of various diseases. The department is equipped with the advanced medical equipment, which provides the most accurate scanning of all anatomical structures and organs of the human body. In the field of treatment, the focus is on oncological, cardiological and neurological diseases. The department's doctors work in accordance with the international standards, therefore, each patient receives high-quality, individualized medical care.

University Hospital Essen

location_onGermany, Essen

Department of Nuclear Medicine

The Department of Nuclear Medicine offers the full range of radioisotope diagnostics and treatment. Of particular interest is the detection and treatment of thyroid diseases, endocrine tumors. The department also specializes in radioiodine therapy for the treatment of thyroid diseases, radionuclide therapy for bone metastases, MIBG therapy for the treatment of neuroblastomas, malignant pheochromocytes and many other therapies. In addition, the department operates its own Radiopharmaceutical Section, which produces radiopharmaceuticals for two positron emission tomography (PET) scanners.

University Hospital Saarland Homburg

location_onGermany, Homburg

Department of Nuclear Medicine

The Department of Nuclear Medicine annually examines more than 760 patients with suspected prostate cancer. PSMA PET-CT is the most precise technique for revealing tumors at the initial stages. In addition, PSMA PET-CT detects metastases and is used in case of the disease recurrence. Based on the result of examination, doctors of the department under the guidance of Prof. Dr. med. S. Ezziddin elaborate the most effective treatment scheme.

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PSMA PET scan is the diagnostic imaging technique that combines CT scan, PET scan and intravenous introduction of the radioactive tracer with PSMA.

PSMA PET diagnostics is performed during prostate cancer treatment planning, for the distant metastases detection.

The best hospitals that offer PSMA PET in prostate cancer are Helios Hospital Berlin-Buch, University Hospital Frankfurt-am-Main, and University Hospital Carl Gustav Carus Dresden.

Price of the examination starts from 2,337 €.


To diagnose prostate cancer, the best hospitals in developed countries often use PET. This examination is not used to detect new cases of the disease, but to clarify the stage, detect signs of relapse and metastases. PET is also used in the process of radionuclide treatment of metastatic prostate cancer.  

What is PSMA-PET?

PET is a scan of body areas with the primary cancer and its metastatic foci. Prior to that, a radiopharmaceutical is injected into the body. It accumulates in the tumor cells and "highlights" them. Thus, the doctor can see them.  

Although fluorodeoxyglucose is used as a biomarker in most countries, it is not very informative for diagnosing prostate cancer. In particular, this biomarker cannot reliably distinguish a local recurrence from a postoperative scar. It effectively accumulates in metastases, but at the same time it penetrates the organs of the gastrointestinal tract and liver, which can have no metastatic foci.

Other markers also have certain disadvantages. Therefore, in modern medicine, they are supplanted by substances capable of binding to the prostate-specific membrane antigen (PSMA). This is a membrane glycoprotein formed in the epithelium of the prostate of all people: both completely healthy men and prostate cancer patients. Other organs almost do not contain it. In benign prostatic hyperplasia, the amount of PSMA does not increase significantly.

PSMA expression in prostate cancer cells is 100-1000 times higher than in any other tissues of the body, including in healthy prostate cells. Moreover, the intensity of expression may also increase in case of:

  • advanced cancer;
  • metastatic cancer;
  • hormone-dependent cancer.

PSA may be detected in the blood, whereas PSMA may not be found there. Thus, it is an ideal marker of prostate cancer cells, which provides both high sensitivity and specificity of PET. The increased sensitivity means that if there is a metastatic focus, it necessarily contains PSMA. The high specificity is the ability of the radiopharmaceutical to accumulate only in cancer cells, but not in healthy tissues.

Various clinics use various radionuclides as a radiopharmaceutical. This may be radioactive iodine, lutetium, actinium and other substances. To conduct PSMA-PET, the German Hospital Heidelberg started to use small peptide molecules modified with urea. They have high affinity for PSMA, good pharmacokinetics, high long-term accumulation, and rapid elimination from the body. This radiopharmaceutical has a very high coefficient of differential accumulation (minimal number of nuclides in the healthy tissues) and it is able to image even the smallest metastatic foci.

When do patients need PSMA-PET?

The cancer clinics use PSMA-PET not to initially diagnose oncological diseases, but to plan cancer treatment. Positron emission tomography helps to identify metastases, so with its application the doctor can understand the following things:

  • is it possible to perform surgery;
  • if it has already been performed, whether the cancer has developed after surgery again;
  • if the applied cancer treatment is effective (radiation therapy, chemotherapy, hormone therapy);
  • is it possible to use radionuclide cancer treatment.

PSMA-PET should be necessarily used before the prescription of radionuclide therapy and in the process of its implementation. This is a treatment option for prostate cancer, in which radionuclides capable of binding to PSMA are introduced into the body. They bind to the antigen, accumulate in cancer cells and destroy them. At the same time, the radiation is so short that the healthy tissues remain almost unaffected.

PSMA-PET is carried out prior to this procedure to determine whether the radiopharmaceutical will accumulate in the sufficient quantity. In the case of its sufficient accumulation, the doctor prescribes radionuclide therapy. PSMA-PET is then performed after each radionuclide therapy procedure in order to evaluate the results and understand how many more sessions are required to ensure the desired effect.

Where can the patient undergo PSMA-PET?

Thanks to Booking Health, every person, regardless of his place of residence, has the opportunity to contact the best cancer clinics for a full-fledged diagnostics. Here are some examples of reputable German medical facilities:

University Hospital Carl Gustav Carus Dresden. The diagnostics is provided in the Department of Radionuclide Medicine. There are available both PET-CT and PET-MRT. The latter does not cause any radiation exposure, therefore, it is safer for the patient. The department has been working for 60 years. Consequently, the treatment options offered here are among the most effective in the world.

University Hospital of Ludwig Maximilian University of Munich. The hospital has at its disposal the largest Department of Nuclear Medicine in Germany, which doctors conduct PSMA-PET for patients.  Since August 2013, the department has launched a new center for the production of radiopharmaceuticals. The department conducts PSMA therapy for the patients who cannot undergo surgical treatment, in case if chemotherapy is not effective or is not indicated for them.  

University Hospital Frankfurt am Main. The Department of Nuclear Medicine examines about 8,000 patients every year. Many of them undergo PSMA-PET. The department widely uses lutetium PSMA therapy for prostate cancer as a more effective and safe alternative to chemotherapy. Even in the case of advanced metastatic cancer, it allows for a long-term remission of the disease.

Organization of treatment abroad

If you want to restore your health, undergo examination and treatment in the best cancer clinics of the planet, the best option will be to contact the specialists from Booking Health. Below you can see our services and benefits:

  • Selection of the best cancer clinic with a modern Department of Nuclear Medicine for diagnosing, treating or rehabilitating prostate cancer patients.
  • Since we agree on the lack of extra charges and coefficients for foreign patients, you will benefit from a more affordable cost of treatment.  
  • Preparation of the examination and treatment program without repeating previously performed diagnostic procedures.
  • Reduced waiting time for an appointment with the doctor and provision of both diagnostics and treatment in the cancer clinic at the most suitable dates for the patient.
  • Provision of communication with the doctor.
  • Program control at all its stages.
  • Control of the cost of treatment, the cost of various procedures, the return of unused funds upon the program completion.
  • Communication with the clinic after examination and treatment abroad.
  • Assistance in buying and forwarding medicines.
  • The possibility of organizing additional procedures, such as chemotherapy, rehabilitation and other methods aimed at the improvement of the health of cancer patients.

Booking Health will provide you with all the necessary services. We will fully arrange your treatment abroad, help you to draw up documents, book a hotel and airline tickets, provide you with the interpreting service, meet you at the airport and take you to the clinic by car.

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