Treatment of Prostate Cancer With Metastasis by Lutetium 177-PSMA (LU-177)

University Hospital of Ludwig Maximilian University of Munich

location_onGermany, Munich

Department of Nuclear Medicine

The Department of Nuclear Medicine offers the full range of diagnostic and therapeutic services in modern nuclear medicine for both outpatients and inpatients. The focus is on the detection and treatment of oncological, neurological and cardiac diseases. The department is the largest institution of this kind in Germany. The international recognition is approved by ISO 9001: 2015 certification.

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Hospital directly17505
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Helios Hospital Berlin-Buch

location_onGermany, Berlin

Department of Nuclear Medicine

The Department of Nuclear Medicine offers the full range of diagnostic and therapeutic procedures using modern radioactive substances. The diagnostic options include scintigraphic studies of the lungs, heart, brain, kidneys, lymph nodes, bones, including in small patients. In the field of therapy, one of the priority focuses is the use of radioiodine therapy for thyroid pathologies. Medical care and patient care are provided by highly qualified doctors and nursing staff who believe that the health and wellbeing of their patients is a top priority.

Hospital directly16231
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University Hospital Frankfurt am Main

location_onGermany, Frankfurt am Main

Department of Nuclear Medicine

The Department of Nuclear Medicine offers the full range of modern diagnostics and therapy using various radioisotopes. The department is equipped with the advanced systems for carrying out such high-precision and informative examinations as SPECT, PET, etc. The department carries out more than 8,000 outpatient examinations annually. The key focus in the field of diagnostics is on the detection of neurological, cardiac and oncological diseases. The department's therapeutic options include the treatment of benign and malignant diseases of the thyroid gland, pain therapy in bone metastases, treatment of malignant tumors in children (for example, neuroblastomas). The spectrum is also complemented by such innovative techniques as radiosynoviorthesis, selective internal radiation therapy and radioimmunotherapy.

University Hospital Carl Gustav Carus Dresden

location_onGermany, Dresden

Department of Nuclear Medicine

The Department of Nuclear Medicine offers the full range of diagnostics and treatment with therapeutic radionuclides. The department has been successful in conducting clinical activities for more than 60 years, and therefore has an extensive experience and outstanding achievements. The department is equipped with the state-of-the-art medical equipment, which allows its specialists to provide the optimal medical services in accordance with the highest international standards. Special focus is on treatment of benign and malignant thyroid diseases.

University Hospital Erlangen

location_onGermany, Erlangen

Department of Nuclear Medicine

The Department of Nuclear Medicine offers the full range of diagnostic and therapeutic services in its specialization. Of particular interest are PET/CT, SPECT/CT, as well as innovative therapeutic methods of nuclear medicine, such as peptide radioreceptor therapy for neuroendocrine tumors, radioembolization of liver tumors and treatment of prostate cancer with radioligands targeting a prostate specific membrane antigen (PSMA therapy). The highly qualified world-renowned doctors take care of the patients.

University Hospital Bonn

location_onGermany, Bonn

Department of Nuclear Medicine

The Department of Nuclear Medicine offers the full range of radioisotope diagnostics and treatment of various diseases. The department began its work in 1951 and today it is one of the leading and most reputable medical facilities of this kind in Germany. The clinical activities mainly focus on detection and treatment of pathologies of the thyroid gland, heart, lung cancer, breast cancer, prostate gland, liver cancer and metastases, neuroendocrine tumors, malignant melanoma, and brain tumors. The doctors use only reliable, the most effective innovative methods of examination and therapy, which guarantee an optimal result.

University Hospital Duesseldorf

location_onGermany, Duesseldorf

Department of Nuclear Medicine

The Department of Nuclear Medicine offers the full range of diagnostics and treatment with radioactive substances. It conducts many scintigraphic examinations, ranging from the diagnostics of the thyroid gland and skeleton to amino acid metabolism studies in brain tumors and metabolic studies in other malignant tumors. The department has at its disposal a specialized outpatient clinic for the diagnostics and treatment of thyroid diseases.

University Hospital Halle (Saale)

location_onGermany, Halle

Department of Nuclear Medicine

The Department of Nuclear Medicine offers the full range of services in this ​​medical field. It carries out all common and proven types of scintigraphic diagnostics and treatment. A unique offer of the department is SPECT-CT and PET-CT using various tracers and modern targeted radiopharmaceuticals. The department has an in-house Section of Radiochemistry, in which all the necessary radiopharmaceuticals for the diagnostics and therapy are synthesized. Thus, the department has all the resources to provide excellent medical service.

University Hospital Jena

location_onGermany, Jena

Department of Nuclear Medicine

The Department of Nuclear Medicine offers the full range of radioisotope diagnostics and treatment using the state-of-art gamma cameras and PET-CT systems. The main therapeutic facilities of the department include radioiodine therapy, selective internal radiotherapy, peptide-receptor radionuclide therapy. All medical services comply with the guidelines of national and international professional societies, which ensures an accurate diagnostics and optimal treatment outcome.

University Hospital Würzburg

location_onGermany, Würzburg

Department of Nuclear Medicine

The Department of Nuclear Medicine offers all modern diagnostic and therapeutic procedures using radioactive substances. In addition to the classical methods of nuclear diagnostics, for example, thyroid scintigraphy, special attention is paid to the functional and molecular imaging using the state-of-art PET-CT and SPECT-CT techniques. A special feature of the department is also the Section of Radiochemistry, which produces its own radiopharmaceutical medicines for the targeted therapy of oncopathology (including prostate cancer, neuroendocrine tumors or lymphomas), diseases of the cardiovascular system, and neurological disorders.

University Hospital Muenster

location_onGermany, Muenster

Department of Adult and Pediatric Nuclear Medicine

The Department of Adult and Pediatric Nuclear Medicine offers the full range of radioisotope diagnostics and therapy at the highest technical level. The department specializes in the detection and treatment of benign and malignant thyroid diseases, oncopathology of other organs and anatomical structures of the human body. The department's feature is the radioisotope examinations in children, for example, PET-CT, PET-MRI, kidney, bone scintigraphy, etc. The high-quality medical care is provided thanks to the availability of advanced medical technologies and experienced medical personnel who regularly undergo advanced training courses to keep abreast of medical innovations.

University Hospital Tuebingen

location_onGermany, Tuebingen

Department of Nuclear Medicine and Clinical Imaging Diagnostics

The Department of Nuclear Medicine and Clinical Imaging Diagnostics offers the full range of radioisotope diagnostics and treatment of various diseases. Both classical diagnostic methods, for example, scintigraphy, SPECT and innovative hybrid techniques, for example, PET-CT, PET-MRT, SPECT-CT are available in the department, which allow to detect metabolic changes at the early stages of various diseases, as well as their localization in the human body. In addition, the department's doctors specialize in radiotherapy for the treatment of oncopathologies.

University Hospital Heidelberg

location_onGermany, Heidelberg

Department of Nuclear Medicine

The Department of Nuclear Medicine offers the full range of radioisotope diagnostics and treatment of various diseases. The department is equipped with the advanced medical equipment, which provides the most accurate scanning of all anatomical structures and organs of the human body. In the field of treatment, the focus is on oncological, cardiological and neurological diseases. The department's doctors work in accordance with the international standards, therefore, each patient receives high-quality, individualized medical care.

University Hospital Essen

location_onGermany, Essen

Department of Nuclear Medicine

The Department of Nuclear Medicine offers the full range of radioisotope diagnostics and treatment. Of particular interest is the detection and treatment of thyroid diseases, endocrine tumors. The department also specializes in radioiodine therapy for the treatment of thyroid diseases, radionuclide therapy for bone metastases, MIBG therapy for the treatment of neuroblastomas, malignant pheochromocytes and many other therapies. In addition, the department operates its own Radiopharmaceutical Section, which produces radiopharmaceuticals for two positron emission tomography (PET) scanners.

HELIOS University Hospital Wuppertal

location_onGermany, Wuppertal

Department of Nuclear Medicine

The Department of Nuclear Medicine offers the full range in this medical focus. The main activities of the department include PET-CT diagnostics of oncological diseases, neurological and cardiological diseases, scintigraphy of bones, thyroid gland, kidneys, myocardium, radioimmunotherapy, pain therapy and radioiodine therapy.

University Hospital Saarland Homburg

location_onGermany, Homburg

Department of Nuclear Medicine

The Department of Nuclear Medicine annually provides treatment to more than 620 patients with metastatic prostate cancer. During the therapy a high-quality radioactive lutetium isotope (Lu-177) preparation is used. Lu-177 specifically bounds to the PSMA-containing tumor cells and metastases and kills them. Doctors of the department under the guidance of Prof. Dr. med. S. Ezziddin offer effective treatment with a minimal complications rate.

The most effective among the metastatic prostate cancer treatments is the Lutetium-177 PSMA therapy.

Cancer treatment with Lu-177 affects primary tumor and distant metastases regardless of their localization in the body.

It irradiates cells that have PSMA (specific marker of prostate cancer) on the surface.

The price of therapy in the best hospitals starts from 16,381 €. It is performed in a limited number of hospitals worldwide.


There are many treatment options for metastatic prostate cancer. These include chemotherapy, radiation therapy and hormone therapy, but when all these techniques become ineffective, PSMA therapy comes to the rescue. Administration of Lutetium 177 for prostate cancer treatment is a radionuclide technique, in which a radiopharmaceutical administered intravenously selectively accumulates in cancer cells and destroys them.

The essence of this technique

The radionuclide Lu177 (Lutetium) is used for the targeted treatment of metastatic prostate cancer. Lutetium PSMA therapy for lymph nodes involvement also demonstrates good results. Unlike irradiation with alpha particles, Lutetium treatment in Germany implies using beta emitters. This agent is related to prostate specific membrane antigen. It affects cancer cells. Since PSMA is marked by radioactive Lutetium, tumor tissues become irradiated and die.

The advantages of the technique:

  • It can be used both for the diagnostics and treatment of tumors
  • It binds to malignant cells, wherever they are in the body, so the doctors can achieve good results in the treatment of advanced prostate cancer
  • High safety of the technique and its good tolerability

The role of Lutetium in cancer therapy is not limited to Lutetium PSMA study performing and administration of Lutetium for prostate cancer. The radionuclide in the form of Lutetium dotatate (labeled with Lu somatostatin analogue) is successfully used in the diagnostics and treatment of neuroendocrine tumors. This radioligand is perfectly visible during nuclear imaging and may carry radiotherapeutic payload. One more field of administering Lutetium is peptide receptor therapy of neuroblastoma cancer.

The performance of the procedure

A person undergoes the diagnostics. It involves not only the assessment of the clinical symptoms of prostate cancer, but also CT or MRI, scintigraphy, laboratory tests. One more important test that defines expected efficacy of Lutetium for cancer treatment is Lutetium PSMA PET CT. It is forbidden to eat fatty foods and alcohol a few days before the procedure.

During PSMA therapy, the drug is injected to men intravenously. It is done at the hospital, under the supervision of a physician. The procedure can be performed several times. Before the injection of Lutetium-177 PSMA, the salivary glands and kidneys are cooled. It is due to the fact that these organs can accumulate radiopharmaceuticals.

The duration of the course depends on the stage of prostate cancer, the number of metastases, the size of the main tumor and metastatic foci, their interactions with other anatomical structures, histological tumor type, the severity of the symptoms of prostate cancer and body's response to the treatment. Lutetium therapy for prostate cancer is usually performed several times, after which the doctors carry out a control scintigraphy. After the diagnostics, the doctor decides whether the prostate cancer treatment should be continued or it may be completed.

Treatment safety

Prior to the treatment, the patients are always interested in whether there will be serious side effects, whether the prostate cancer symptoms will worsen.

PSMA therapy is not a 100% safe method. However, radionuclide treatment is usually better tolerated by patients than chemotherapy or radiation therapy. Sometimes, it gives side effects, but all undesirable effects are not severe and irreversible. It is possible to compensate Lutetium 177 treatment side effects by the administration of additional drugs.

In order to avoid the severe treatment effects, all patients are carefully examined prior to the treatment. They undergo kidney ultrasound examination and biochemical blood test. During the treatment, the doctors perform the necessary measures in order to minimize the risks of negative effects of Lutetium 177 for cancer treatment. They carry out the following procedures:

  • Cool the kidneys and salivary glands
  • Fdminister drugs in order to prevent or relieve side effects
  • Intravenously inject crystalloid solutions
  • In the case of liver metastases, the patient will undergo stenting in order to prevent cholestasis

If the doctors suspect that the procedure will significantly harm the patient, may cause symptoms of renal or hepatic failure, the injection of the radiopharmaceutical agent will be canceled.

Medical treatment abroad

Most countries cannot provide the treatment of metastatic prostate cancer with Lutetium-177, since it is a new technique available only in developed countries. Therefore, many people have to undergo treatment abroad in order to take an advantage of this therapy.

The cost of treatment abroad is often higher but medical services are provided with better quality. Therefore, despite the higher cost of treatment, the patients from other countries very often visit such countries as Germany in order to undergo Lutetium treatment for cancer. This country provides the following benefits when treating this disease:

  • Availability of the very latest techniques
  • Highly qualified oncologists and urologists
  • High-quality surgical interventions
  • Modern radiation therapy techniques
  • Conventional therapy in combination with novel treatment methods in order to achieve the best results
  • Low risk of complications
  • Low perioperative and postoperative mortality

Organization of treatment 

The high costs of medical treatment abroad do not stop those people who want to take an advantage of achievements of modern medicine and oncology. They still visit Germany or other developed countries to undergo prostate cancer treatment. The Booking Health company can organize a trip for you. We offer medical treatment abroad in the best German hospitals. PSMA therapy is used in the following medical facilities:

  • University Hospital Cologne
  • University Hospital Saarland Homburg
  • University Hospital Würzburg
  • University Hospital RWTH Aachen

The employees of the Booking Health company will select the best hospital for you based on the annual qualification profile. While choosing the medical facility, we take into account specialization, treatment effectiveness, risk of complications, prices and other factors.

You will receive the following benefits:

  • Reduced treatment costs – we will agree on the absence of coefficients for foreign patients
  • Establishment of communication with the hospital
  • Preparation of the treatment program taking into account previous examinations
  • Booking the appointment on the convenient date for you, reduction of waiting time for the treatment
  • Full control of the program at all its stages
  • Help in forwarding of medicines
  • Communication with the hospital after program completion
  • Organization of additional diagnostic procedures
  • Control of invoices and return of unspent funds

Our high-level service includes the provision of an interpreter, assistance in the preparation of documents, meeting at the German airport and transfer to the hospital. Upon the treatment completion, we will provide a return transfer.

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