Mitral Valve Insufficiency (prolapse) | Annuloplasty With Carillon Mitral Contour System Treatment. Hospital Prices, Ranking, Reviews - Bookinghealth

Annuloplasty With Carillon Mitral Contour System for Mitral Valve Insufficiency (prolapse) treatment

➤Surgical treatment of mitral valve insufficiency with Carillon Mitral Contour System (minimally invasive) ★ Direct prices from the best hospitals in the world $ We will help you save money on treatment ✔ Patient support 24/7

Treatment prices are regulated by national law of the corresponding countries, but can also include additional hospital coefficients. In order to receive the individual cost calculation, please send us the request and medical records.

University Hospital RWTH Aachen
Specialized hospital

Department of Cardiothoracic Surgery

According to the Focus magazine, the Department of Cardiothoracic Surgery ranks among the top medical facilities in the field of its ​​specialization! The department offers all options of modern surgery for the treatment of diseases of the cardiovascular system and thoracic organs. The department widely uses modern minimally invasive techniques, which are considered the gold standard of surgery. Since its founding in 1976, the department has performed more than 40,000 open heart interventions. The department's surgeons also have vast experience in the field of implantation of the artificial heart and mechanical heart support systems. All operations are carried out in strict accordance with the protocols of professional societies.

Rüdiger Autschbach
Prof. Dr. med.Rüdiger Autschbach
Price from: 31882.99
University Hospital Halle (Saale)
Specialized hospital

Department of Cardiothoracic Surgery

The Department of Cardiothoracic Surgery covers the entire range of top-class medical services in this field. Special attention is paid to minimally invasive operations, which, along with the optimal functional result, ensure minimal traumatization, fast recovery and the absence of a cosmetic defect. The optimal type of therapy is selected in collaboration with the specialists from all the necessary related disciplines and adapts to the specific clinical indications of the patient.

Britt Hofmann
PD Dr. med.Britt Hofmann
Price from: 28412.74

Department of Adult and Pediatric Cardiac Surgery, Heart Transplantation, Vascular Surgery

The Department of Adult and Pediatric Cardiac Surgery, Heart Transplantation, Vascular Surgery offers the full range of surgical interventions for the treatment of diseases of the cardiovascular system, including donor and artificial heart transplantation. The department's priority clinical focuses include coronary artery bypass grafting, heart valve surgery, thoracic aortic surgery, heart transplantation, as well as the treatment of diseases of the blood vessels, arteries and veins. The department also provides treatment to children with congenital heart diseases. The medical facility has an excellent technical base for performing high-complexity surgery in order to restore the normal functioning of the heart. Whenever possible, the doctors use sparing minimally invasive techniques, which ensure a short hospital stay after surgery. The skills and professionalism of the department's cardiac surgeons are known far beyond Turkey. They have performed over 126 heart transplantations and thousands of successful heart surgical procedures that have saved the lives of many patients from Turkey and abroad.

Deniz Suha Kucukaksu
Prof. Dr. med.Deniz Suha Kucukaksu
Price from: 34388.32
Hospital Kassel

Hospital Kassel

Overall rating 9.9 / 10

Department of Adult and Pediatric Cardiac Surgery

The Department of Adult and Pediatric Cardiac Surgery offers the full range of open and minimally invasive heart and coronary artery surgical procedures. The department mostly performs coronary artery bypass grafting, heart valve repair and replacement, surgery to correct congenital heart defects in adults, interventions to implant left and right ventricular assist devices in the case of advanced types of heart failure, as well as combined interventions. In addition, the department successfully performs extracorporeal membrane oxygenation, which involves the use of an artificial heart and lung to temporarily maintain the patient's life and the functioning of his body when a person's own heart and/or lungs cannot function normally due to the pathological changes. The procedure is performed in both adults and children from 1 year old with severe respiratory failure. Both state-of-the-art medical equipment and long experience of the department's cardiac surgeons enable them to perform most heart operations using minimally invasive techniques, without a thoracotomy and a heart-lung machine. Such an approach guarantees the patient a minimum risk of complications during or after surgery, reduced hospitalization period and speedy recovery after surgery. The treatment success rates demonstrated by the department are registered by the Federal Office of Quality Assurance (BQS). With a low mortality rate and postoperative complications, the medical facility ranks third among Heart Surgery Clinics in Germany.

Ali Asghar Peivandi
PD Dr. med.Ali Asghar Peivandi
Price from: 28185.14
Helios Hospital Siegburg

Helios Hospital Siegburg

Overall rating 9.4 / 10

Department of Cardiac Surgery

The Department of Cardiac Surgery offers the full range of surgical treatment for heart disease, with the exception of chest organ transplants. The medical facility successfully performs operations for mitral, aortic, and tricuspid valve replacement and repair, operations for the implantation of pacemakers, implantable cardioverter-defibrillators, and devices for cardiac resynchronization therapy, operations for thoracic aortic aneurysms and dissection, coronary artery bypass grafting, and operations for the implantation of ventricular assist devices and artificial hearts (VAD and TAH). Most surgical procedures are performed using minimally invasive techniques without opening the chest. The department is part of the Heart Center Siegburg, where cardiac surgeons, cardiologists, and vascular surgeons work together for the benefit of patients. Complex clinical cases are considered by medical boards. This allows physicians to develop the most effective course of treatment for each patient. The Heart Center Siegburg treats over 7,000 patients annually, many of whom undergo cardiac surgery. Along with the use of the latest technologies and treatment methods, the department's cardiac surgeons attach importance to a humane attitude towards patients.

Mirko Doss
Prof. Dr. med.Mirko Doss
Price from: 27828
German Heart Center Munich

German Heart Center Munich

Overall rating 9 / 10

Department of Cardiac Surgery

The Department of Cardiac Surgery offers the full range of modern surgical treatments for cardiovascular diseases. The department enjoys a reputation as a leading medical facility specializing in treating acquired heart defects. The department's surgeons perform about 2,800 cardiac surgical interventions every year, including especially complex ones. Cardiac surgeons most often perform operations for heart defects and pathologies of the coronary arteries, heart valves, and aorta. All operations are performed in state-of-the-art operating rooms with advanced equipment and high-precision monitoring systems, which make surgical treatment not only the most effective but also the safest for a patient. Sparing, minimally invasive techniques are widely used in clinical practice, and some operations are performed without the use of a heart-lung machine. After the operation, the patient receives proper care for a rapid recovery.

Rüdiger Lange
Prof. Dr. med.Rüdiger Lange
Price from: 30497.6

Mitral valve insufficiency is one of the two most common heart defects, along with aortic stenosis. The condition is usually treated with an open heart operation. But if you receive medical care abroad, doctors can eliminate the defect or reduce its severity using a minimally invasive procedure that is performed through the blood vessels. Doctors from Heart Centers abroad use the Carillon system to reduce valve area and eliminate regurgitation. You can go abroad for this safe and minimally invasive treatment of mitral valve insufficiency. On the Booking Health website, you can find the cost of treatment and choose the most suitable medical care program for yourself.


  1. What is mitral valve insufficiency and how can it be treated?
  2. What is the Carillon system?
  3. Advantages of Carillon over MitraClip
  4. Treatment results
  5. Where to undergo treatment?

What is mitral valve insufficiency and how can it be treated?


The mitral valve closes the opening between the left ventricle and the atrium. It allows blood to flow in one direction. But if the valve cannot close the hole completely, when the heart contracts, part of the blood, instead of getting into the aorta, returns back to the atrium. This phenomenon is called mitral valve regurgitation or insufficiency.

Insufficiency can be organic and functional. In the case of organic insufficiency, doctors replace the valve when, for example, its leaflets are damaged or torn off as a result of a bacterial infection or a rheumatic disease. Functional insufficiency, however, is more common. In this case, the valve itself remains normal, but the opening that it must close increases due to the expansion of the cavity of the left ventricle.

The disease affects 2% of the population. The risk also increases with age.

The Carillon system can be used to treat functional (secondary) mitral valve regurgitation, so we will focus on this form of the disease. The condition develops due to impaired blood supply to the heart muscle in coronary artery disease and impaired contractility of the heart area, as well as due to dilated cardiomyopathy (a condition in which the heart ventricles become enlarged). As a result, the pathology leads to mitral annular dilation or papillary muscle displacement, causing retrograde blood flow due to improperly closed mitral valve leaflets. Secondary mitral insufficiency often develops in patients with heart failure, atrial fibrillation, and hypertrophic cardiomyopathy. Approximately 1% of cases are associated with papillary muscle rupture as a result of myocardial infarction.

Mild regurgitation causes no symptoms. Grade 1 insufficiency does not even require any treatment. As the pathology progresses, shortness of breath occurs, exercise tolerance decreases, the jugular veins swell, and edema develops. In advanced cases, presyncope, fainting, and bluish skin tone may occur. Right ventricular heart failure gradually develops. Fluid accumulation in the abdominal cavity and pericardium, liver and spleen enlargement may develop.

The standard treatment for mitral valve insufficiency is an open operation. In a functional type of insufficiency, doctors perform an annuloplasty. This procedure can be sutural or performed using support rings. In any case, the goal of the surgical intervention is to narrow the orifice so that the mitral valve can close it completely.

Another option to eliminate mitral insufficiency is prosthetics. However, this treatment can be used in extreme cases only, when the problem cannot be solved without prosthetics. Healthcare professionals usually strive to repair the valve since the results of such operations are longer-term and the hemodynamic parameters are better compared to prosthetics.

The use of the Carillon system is a minimally invasive treatment option that helps avoid an open heart operation. The procedure is minimally traumatic. The intervention is performed through the coronary sinus and does not require a transseptal puncture (puncture of the septum of the heart).

What is the Carillon system?


Carillon is a system for an indirect annuloplasty. The device consists of two self-expanding nitinol anchors, which are connected to each other by a curved segment. The Carillon system is implanted without operation, through the jugular vein into the coronary sinus, along the posterior surface of the annulus fibrosus. It is located outside the heart in the mitral valve.

The Carillon system has been used in Europe since 2011. The TITAN study showed that after the procedure, the area of ​​the valve is halved in patients, namely on average from 0.23 to 0.12 square centimeters. The scope of regurgitation (reverse blood flow) also decreased by 2 times from the initial 34 ml to 17 ml. A decrease in the severity of mitral valve insufficiency was recorded by at least one grade, and in some patients, by two grades. The improvement in the quality of life was maintained for at least 2 years, during which the monitoring of patients continued.

The main advantages of the Carillon system are as follows:

  • implantation that is technically simple;
  • general anesthesia is not required;
  • a very low risk of complications;
  • there is virtually no risk of conversion to heart surgery. 

The disadvantage of the system is that the device cannot be implanted in about one in six patients due to the threat of circumflex branch compression in the left coronary artery. The technique is ineffective or limitedly effective in people with a significant dilation of the cavities of the heart. In this case, the location of the coronary sinus relative to the mitral valve structures changes, so the annulus fibrosus compression may be insufficient. In the first Carillon models, breakdowns of the part of the device that connects the two anchors were fixed, but in the new models, this defect has been corrected.

Advantages of Carillon over MitraClip


The first minimally invasive treatment of mitral valve regurgitation approved in developed countries was the MitraClip system. It has been used for over 20 years and has been implanted in tens of thousands of patients. This is a "clothespin" that is attached to the valve leaflets and pulls them together, thus narrowing the valve opening.

However, the REDUCE FMR study showed a number of benefits of the Carillon system. The authors came to the conclusion that Carillon should be more widely used. The following are the advantages of this system:

  • implantation of the device through the coronary sinus so the functioning of the mitral apparatus is not disturbed;
  • an easy approach as the Carillon system does not require a transseptal puncture;
  • the Carillon system may be the best option for patients with a small annulus;
  • the treatment method is suitable for patients in whom other types of interventional procedures can cause mitral valve stenosis;
  • the device is safer.

New models of the Carillon system have made this treatment more versatile. According to the REDUCE FMR study, in only 8 cases out of 87, physicians concluded that the device could not be implanted for anatomical reasons.

Treatment results


Minimally invasive treatment of insufficiency using the Carillon system avoids open heart operations. The treatment technique allows doctors to reduce the grade of mitral valve regurgitation safely, improving the quality of life as well as potentially increasing its duration.

The Carillon mitral contour system can be used for grade 2, 3, or 4 mitral valve regurgitation. This device lowers the severity of the disease by 1-2 degrees.

The success of therapy can be determined not only with an ultrasound scan, according to the REDUCE FMR, the first blinded placebo-controlled trial to test the new device. There was a subjective improvement in the person's quality of life, an increase in exercise tolerance, symptom relief, and changes in the heart associated with an increase in life expectancy.

The authors recorded the following improvements 12 months after the device was implanted:

  • improved results from a six-minute walk test;
  • lowering the grade of heart failure;
  • reduced number of hospitalizations;
  • reduced risk of sudden cardiac death.

An improvement in quality of life was recorded using the KCCQ (Kansas City Cardiomyopathy Questionnaire).

After implanting the device, doctors observed left ventricular remodeling. It is associated with an increase in the life expectancy of patients.

After the publication of the REDUCE FMR study results, the Carillon system has been approved in most developed countries. Now this is a real alternative to operations to repair mitral valve disease. The treatment can be completed without any operation, without any pain, without the risk of complications, and without any long-term rehabilitation. Even high-risk surgical patients, for whom conventional open heart surgery is unsafe, can receive medical care.

Where to undergo treatment?


You can go abroad to undergo minimally invasive treatment of mitral valve insufficiency without any operations but with the use of the Carillon system. The procedure is performed in most developed countries. Doctors at specialized centers have vast experience in its implantation. The system has already been implanted in thousands of patients with good results.

There are a few reasons for you to undergo your treatment abroad:

  • the Carillon system belongs to new treatment methods, and perhaps this methodology is not yet applied in your native country or is not actively used;
  • as specialists abroad have been using the Carillon system to repair mitral valve function for several years, they have great experience in this field;
  • accurate diagnostics: even before the procedure, doctors will be able to determine whether you are suitable for the implantation of the device, considering the anatomical features of your heart and blood vessels;
  • it is a safe procedure because if you are undergoing your treatment abroad, the risk of complications is close to zero;
  • in more than 90% of cases, the technical success of the procedure at specialized centers abroad is achieved;
  • physicians use the latest Carillon systems, which are more effective in treating mitral valve insufficiency and help to further reduce the risk of complications as compared to previous models.

You are welcome to use the Booking Health website to undergo your treatment of mitral valve disease without any operation in one of the developed countries. On our website, you can find the cost of treatment and choose a medical care program at the best price. Please leave your request on our website, and our specialists will contact you within a few hours. The specialists from the Booking Health company will help you to select a hospital and arrange your trip. The cost of treatment when choosing a medical care program through the Booking Health website will be lower due to the lack of additional fees for foreign patients.



The article was edited by medical experts, board-certified doctors Dr. Nadezhda Ivanisova and Dr. Vadim Zhiliuk. For the treatment of the conditions referred to in the article, you must consult a doctor; the information in the article is not intended for self-medication!



European Society of Cardiology

American Heart Association