Treatment of Rectal cancer with CRS and HIPEC - hyperthermic intraperitoneal chemotherapy
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University Hospital of Ludwig Maximilian University of Munich
Department of General, Abdominal, Transplant, Hepatopancreatobiliary, Colorectal, Endocrine, Bariatric Surgery and Hernia Surgery
The Department of General, Abdominal, Transplant, Hepatopancreatobiliary, Colorectal, Endocrine, Bariatric Surgery and Hernia Surgery provides the full range of services in the areas of its specialization and holds a leading position at the national and international levels in terms of the number of surgical interventions performed and their success. Of particular interest are operations for treating diseases of the bowel, stomach, esophagus, pancreas, liver, gallbladder, and bile ducts, and endocrine glands. The department's doctors have excellent skills in the surgical treatment of cancer, surgery for liver, kidney, pancreas, and small intestine transplants, and operations for morbid obesity. The department's operating rooms are the pride of the medical facility, since they have all the necessary technical options for performing operations with the da Vinci surgical system, image-guided interventions, and endoscopic surgical procedures, which are characterized by minimal trauma rates.
Department of General, Abdominal and Vascular Surgery
According to the Focus magazine, the Department of General, Abdominal and Vascular Surgery ranks among the top German medical facilities specializing in the treatment of bowel and lung cancer! The department offers all the modern surgical options for the treatment of diseases of the abdominal cavity and blood vessels. The department's doctors have expert knowledge and vast experience in the treatment of colorectal cancer, stomach, esophageal, pancreatic cancers, liver metastases, inflammatory bowel diseases (diverticular disease, Crohn's disease, ulcerative colitis). Also, they specialize in the surgical treatment of vascular pathologies and thyroid diseases.
Department of General and Abdominal Surgery, Hepatopancreatobiliary Surgery, Colorectal Surgery, Endocrine Surgery, Hernia Surgery and Bariatric Surgery
The Department of General and Abdominal Surgery, Hepatopancreatobiliary Surgery, Colorectal Surgery, Endocrine Surgery, Hernia Surgery and Bariatric Surgery offers the full range of effective surgical treatments in accordance with modern medical standards. Operations of varying complexity are performed on the stomach, colon, pancreas, liver, gallbladder, bile ducts, rectum, thyroid gland, and parathyroid glands in the department's operating rooms every day. The department's primary focus is the surgical treatment of malignant gastrointestinal tumors. The medical facility is certified in this area by the German Cancer Society (DKG). The team of endocrine surgeons specializes in the treatment of diseases of the thyroid gland, parathyroid glands, and adrenal glands. Patients with morbid obesity are also successfully operated on here. In their work, the department’s specialists primarily use minimally invasive surgical techniques, which virtually eliminate trauma to healthy tissue during the intervention. The department's operating suite is equipped with an innovative da Vinci Surgical System, which allows the doctors to perform sparing and high-precision surgical interventions. The specialists of the medical facility strictly adhere to hygiene and safety standards and create the most comfortable conditions for each patient during their hospital stays.
Department of Abdominal and Colorectal Surgery, Hepatobiliary Surgery, Hernia Surgery, Bariatric Surgery, Endocrine Surgery, Thoracic and Vascular Surgery
The Department of Abdominal and Colorectal Surgery, Hepatobiliary Surgery, Hernia Surgery, Bariatric Surgery, Endocrine Surgery, Thoracic and Vascular Surgery offers the full range of services in these medical fields. It provides surgical treatment of diseases of the gastrointestinal tract, thyroid and parathyroid glands, thoracic organs, vascular system, rectum, anus and colon. In addition, the department performs bariatric interventions for the treatment of morbid obesity. A special focus is made on the treatment of gastrointestinal cancer. Minimally invasive surgical techniques are always preferred, if clinically indicated. The team of the department's surgeons has 8 progressive operating rooms equipped with everything necessary for successful treatment. The department also has the da Vinci Xi surgical system for high-precision minimally invasive robot-assisted interventions. The patient's health is in the safe hands of the best German surgeons who have gone through a rigorous selection and have vast clinical experience.
Department of General and Abdominal Surgery
According to the Focus magazine, the Department of General and Abdominal Surgery ranks among the top German departments specializing in bowel cancer treatment! The department offers the full range of classical and minimally invasive methods for the treatment of common surgical diseases, cancer pathologies, diseases of the endocrine organs, proctological problems. The specialization also covers transplant surgery (liver, kidney and pancreas transplantation). The department is certified by the German Cancer Society for its outstanding results in the treatment of bowel, pancreatic, stomach and liver cancers.
Department of Adult and Pediatric General, Abdominal, Transplant Surgery
According to Focus magazine, the Department of Adult and Pediatric General, Abdominal, Transplant Surgery ranks among the top German medical facilities specializing in bowel cancer treatment! The department performs surgical treatment of general surgical diseases, abdominal pathologies, and also specializes in organ transplantation. Of particular interest are surgical oncology of the abdominal organs, as well as pancreatic and liver surgery. The department annually performs more than 3,000 surgical interventions, which contributes to its credibility at the national level.
Department of Abdominal, Thoracic and Vascular Surgery
The Department of Abdominal, Thoracic and Vascular Surgery offers all modern surgical interventions in these fields. Specialization covers the treatment of diseases of the abdominal organs, endocrine glands, pathologies of the lungs and chest wall, pathological vascular lesions of all parts of the body. In addition, kidney transplantation and pancreas transplantation are part of the surgeons' tasks. Whenever possible, operations are performed using minimally invasive techniques that have several advantages over classical interventions.
Department of General, Abdominal and Vascular Surgery
According to the Focus magazine, the Department of General, Abdominal and Vascular Surgery ranks among the top German medical facilities specializing in the treatment of bowel cancer! The department offers the full range of surgical treatment of diseases of the abdominal organs and blood vessels, including the transplantation of abdominal organs. The sparing minimally invasive surgical techniques are widely used in the clinical practice, which allow to provide treatment in simple and complex clinical cases by making small incisions and using special tiny surgical instruments. The exceptional experience and profound knowledge of the department's doctors are also an integral part of the high treatment success rates.
Department of General, Abdominal, Vascular and Endocrine Surgery
The Department of General, Abdominal, Vascular and Endocrine Surgery offers the full range of medical services in these fields. The department specializes in the surgical treatment of gastrointestinal cancers (surgical treatment of pancreatic, liver, stomach, esophageal and colon malignancies), hernia repair, treatment of gastrointestinal inflammatory diseases, endocrine surgery and surgical correction of vascular diseases and defects. The treatment of patients is carried out in close cooperation with the experts from related fields, particularly, with oncologists, gastroenterologists, radiologists, angiologists, etc.
Department of General, Abdominal and Transplant Surgery
According to the Focus magazine, the Department of General, Abdominal and Transplant Surgery ranks among the top German departments specializing in bowel cancer treatment! The department offers the full range of services in these medical fields and guarantees the first-class medical care at the university level. The department specializes in the treatment of diseases of the abdominal cavity, esophagus and thyroid gland, transplantation of liver, kidney and pancreas. The medical facility has won the reputation of one of the three largest and most successful Transplant Centers in Germany. Also, within the clinical practice, doctors hold highly-specialized consultations on rare diseases and provide 24-hour emergency care.
Department of General, Abdominal and Thoracic Surgery
According to the Focus magazine, the Department of General, Abdominal and Thoracic Surgery ranks among the top German departments specializing in bowel cancer treatment! The department offers the full range of surgical treatment of diseases of the thorax and abdomen, endocrine glands, blood vessels and morbid obesity. If possible, the preference is always given to sparing minimally invasive surgical techniques. The department performs more than 3,000 outpatient and about 2,600 inpatient interventions every year. The department has one of the largest interdisciplinary Obesity Centers, as well as one of three supraregional Centers for Pancreatic, Stomach and Esophageal Surgery.
Department of General, Abdominal, Transplant, Vascular and Pediatric Surgery
The Department of General, Abdominal, Transplant, Vascular and Pediatric Surgery covers the whole range of services in these fields. The department specializes in the treatment of diseases of the upper and lower gastrointestinal tract, liver, gallbladder, pancreas, thyroid and parathyroid glands, adrenal glands, as well as overweight. In addition, the department is a recognized Center for Vascular and Pediatric Surgery.
Department of General, Abdominal, Adult and Pediatric Transplant Surgery
According to the Focus magazine, the Department of General, Abdominal, Adult and Pediatric Transplant Surgery ranks among the top German departments specializing in the treatment of bowel cancer! The department specializes in the treatment of tumors of the gastrointestinal tract, pancreas, liver, and retroperitoneal space (peritoneal carcinomatosis), liver, kidney, pancreas, bowel transplantations in children and adults, as well as the surgical treatment of obesity and general surgical interventions.
Department of Adult and Pediatric General, Abdominal, Hepatobiliary, Endocrine, Thoracic and Hernia Surgery
The Department of Adult and Pediatric General, Abdominal, Hepatobiliary, Endocrine, Thoracic and Hernia Surgery offers the full range of services in these fields. The team of the department's surgeons is rightfully proud of their high professionalism and successfully performs operations of varying degrees of complexity for diseases of the thyroid and parathyroid glands, stomach, esophagus, intestines, pancreas, liver, biliary tract, lungs. The medical facility also performs surgery for inguinal, umbilical and incisional hernias. The department has four high-tech operating rooms equipped with advanced surgical instruments, computer systems, devices for intraoperative ultrasound scanning, radiography, etc. Whenever possible, the department's surgeons perform low-traumatic laparoscopic procedures, after which patients need to spend only a few days in the hospital. The department has 100 beds for patient hospitalization.
Department of General, Abdominal and Transplant Surgery
According to the Focus magazine, the Department of General, Abdominal and Transplant Surgery is ranked among the top German medical facilities specializing in the bowel cancer treatment! The department offers the full range of services in these medical fields. The main clinical focuses include the surgical treatment of abdominal oncopathology, robotic surgery, minimally invasive surgery, endoscopy, organ transplantation and intensive care after surgical treatment. The department's doctors have special competence in the treatment of intestinal, pancreatic, stomach and liver cancers (certification of the German Cancer Society).
Department of General, Abdominal and Pediatric Surgery
The Department of General, Abdominal and Pediatric Surgery offers the full range of surgical treatment of diseases of the organs of abdominal cavity, thorax, emergency surgical care in polytrauma, as well as many surgical interventions in children. Of particular interest is cancer surgery on the liver, gallbladder, and pancreas. In addition, the department's specialists masterfully manage all the methods of bariatric surgery. Many operations are performed using minimally invasive techniques, which facilitate the quickest possible recovery of the patient.
Rectal cancer is a malignancy that begins in the rectum and can have a profound impact on quality of life. Over 1.9 million new cases of colorectal cancer (which includes both colon and rectal tumors) were diagnosed worldwide in 2020, according to the World Cancer Research Fund. A subset of rectal cancer cases can lead to peritoneal metastasis, a severe condition with a poor survival prognosis. Treating such advanced stages demands specialized techniques and expertise. Among the most promising methods of rectal cancer treatment are cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC).
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CRS, cytoreductive surgery, is the removal of the rectal tumor, as well as the involved lymph nodes and neighboring organs.
HIPEC, hyperthermic intraperitoneal chemotherapy, involves flushing the abdomen with a solution heated to 42-43 degrees Celsius containing high doses of chemotherapy. The procedure is done immediately after CRS.
Specialized clinics for the treatment of rectal cancer are the University Hospital of Ludwig Maximilian University of Munich, the Charite University Hospital Berlin, and the University Hospital Ulm.
The cost of treatment ranges from €52,000 to €92,000. On the Booking Health website you will find a list of specialized medical centers with current prices for the treatment.
For information and preliminary consultation with a doctor, leave your contacts in the "Treatment Request" form on the Booking Health website. A consultant will contact you the same day.
What are CRS and HIPEC?
Cytoreductive surgery for rectal cancer involves the surgical removal of tumors, with a goal to leave no visible disease loci. This way, surgeons reduce the cancerous load and create an environment where subsequent treatments are more effective. CRS is often combined with HIPEC, an innovative procedure that's gaining popularity in the medical community for its promising results.
HIPEC for rectal cancer involves the administration of heated chemotherapy agents directly into the abdominal cavity, right after the CRS procedure. According to the research data published in the World Journal of Surgical Oncology in 2022, the combination of CRS and HIPEC noticeably improves patients’ survival rates. The study's results revealed that the overall survival in the CRS and HIPEC group was significantly higher than in the control group.
How is it performed?
The HIPEC procedure includes several steps:
- The abdominal cavity is infused with heated chemotherapy drugs following CRS.
- These drugs circulate within the abdomen for 60-90 minutes, a duration shown to maximize effectiveness.
- After this, the solution is removed, and the abdominal cavity is rinsed.
During HIPEC, the temperature of the chemotherapeutic solution is calibrated between 40°C and 42°C. This specific temperature range is crucial because it allows the therapeutic agents to selectively target and destroy cancer cells, while largely sparing healthy tissues. This is why the procedure is not only suitable for rectal cancer, you can also check other cancer treatments using CRS and HIPEC.
Why choose CRS and HIPEC?
There are multiple advantages to using CRS and HIPEC in rectal cancer treatment:
- Direct delivery of chemotherapy into the abdomen allows for higher drug concentrations at the cancer site.
- Enhanced survival rates, which is proven by robust scientific research.
- Lower risk of cancer recurrence post-surgery.
- Less pronounced side effects compared to traditional intravenous chemotherapy due to localized drug administration.
You can also check other cancer treatments using CRS and HIPEC.
Quality treatment in Germany
Germany has a strong reputation in cancer treatment, and specifically in the use of CRS and hyperthermic intraperitoneal chemoperfusion. Leading German centers using this technique are:
- Charité University Hospital. It is widely known for its specialized Department of general, abdominal, and vascular surgery.
- Ludwig Maximilian University Hospital in Munich. This hospital specializes in abdominal tumor treatments.
- Helios Clinic in Krefeld. Doctors here specialize in abdominal and minimally invasive surgery, including CRS and HIPEC procedures.
Experienced specialists and high-tech equipment in these hospitals ensure the best results in treating multiple forms of malignant tumors, including rectal cancer. However, organizing a complex treatment process can be challenging, especially for someone already battling an oncological disease. For those considering advanced rectal cancer treatments like CRS and HIPEC, Booking Health can make the experience more accessible and less stressful. The cost of HIPEC ranges from €52,123 to €91,955 and depends on the type of cancer, the extent to which it has spread and the level of the hospital. The platform provides a number of tailored services to help patients with their recovery:
- Booking Health's network includes world's most prestigious clinics specializing in innovative cancer treatments like CRS and HIPEC.
- The platform offers transparent prices, explaining every cost associated with treatment, from surgical expenses to hospital stays.
- Navigating visa requirements can be difficult for international patients. Booking Health assists in fast-tracking the process.
- The company’s representatives manage the patients’ medical schedule.
- Booking Health can help you find a comfortable, affordable place to stay, close to your treatment center.
- All your medical records are translated and securely transferred.
- The company arranges distant follow-up appointments after you undergo the treatment.
By using these services, patients can focus more on their recovery and less on the logistical challenges that often come with complex medical treatment options like CRS and HIPEC. With Booking Health as a partner, you can make your path towards recovery simpler and less stressful.
Authors:
The article was edited by medical experts, board-certified doctors Dr. Nadezhda Ivanisova and Dr. Vadim Zhiliuk. For the treatment of the conditions referred to in the article, you must consult a doctor; the information in the article is not intended for self-medication!
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