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HIPEC - Hyperthermic Intraperitoneal Chemoperfusion for ovarian cancer treatment in the Best Hospitals in the World

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The selection of doctors and clinics is carried out on the basis of annual qualification reports. The main selection criterion is the number of operations or procedures performed. It takes into account experience, reputation in the medical society, the availability of quality certificates and high specialization in a certain field.

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Academic Hospital Asklepios Barmbek Hamburg

9.5/10
location_onGermany, Hamburg

Department of General, Abdominal Surgery and Surgical Oncology

The Department of General, Abdominal Surgery and Surgical Oncology offers the full range of services in these medical focuses. The department provides high-quality surgical treatment of all abdominal diseases. The surgeons of the department have a huge experience in performing open and laparoscopic interventions.

Include:
Chief physician
One-bed patient room
Transfer
people Interpreter up to 20 hours
list Translation up to 10 pages
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University Hospital of Ludwig Maximilian University of Munich

10/10
location_onGermany, Munich

Department of General, Abdominal and Transplant Surgery

According to the Focus magazine, the Department of General, Abdominal and Transplant Surgery ranks among the best departments in Germany specializing in bowel cancer treatment! The department covers the full range of services in these medical fields and holds the leading position at the national and international level in terms of the number of surgical interventions performed and their success rate. Of particular interest are operations to treat cancer, organ transplants, as well as minimally invasive surgery.

Charite University Hospital Berlin

9/10
location_onGermany, Berlin

Department of General, Abdominal and Vascular Surgery

According to the Focus magazine, the Department of General, Abdominal and Vascular Surgery ranks among the top German medical facilities specializing in the treatment of bowel and lung cancer! The department offers all the modern surgical options for the treatment of diseases of the abdominal cavity and blood vessels. The department's doctors have expert knowledge and vast experience in the treatment of colorectal cancer, stomach, esophageal, pancreatic cancers, liver metastases, inflammatory bowel diseases (diverticular disease, Crohn's disease, ulcerative colitis). Also, they specialize in the surgical treatment of vascular pathologies and thyroid diseases.

University Hospital Ulm

8.7/10
location_onGermany, Ulm

Department of General and Abdominal Surgery

The Department of General and Abdominal Surgery offers the full range of surgical treatment of diseases of the esophagus and abdominal organs, thyroid and parathyroid glands, as well as the interventions in bariatric surgery. The surgeons of the department have a deep knowledge in all open and minimally invasive surgical techniques, perform extensive operations of high complexity with maximum safety for the patient.

University Hospital Marburg UKGM

8.6/10
location_onGermany, Marburg

Department of Abdominal, Thoracic and Vascular Surgery

The Department of Abdominal, Thoracic and Vascular Surgery offers all modern surgical interventions in these fields. Specialization covers the treatment of diseases of the abdominal organs, endocrine glands, pathologies of the lungs and chest wall, pathological vascular lesions of all parts of the body. In addition, kidney transplantation and pancreas transplantation are part of the surgeons' tasks. Whenever possible, operations are performed using minimally invasive techniques that have several advantages over classical interventions.

University Hospital RWTH Aachen

9.2/10
location_onGermany, Aachen

Department of Adult and Pediatric General, Abdominal, Transplant Surgery

According to Focus magazine, the Department of Adult and Pediatric General, Abdominal, Transplant Surgery ranks among the top German medical facilities specializing in bowel cancer treatment! The department performs surgical treatment of general surgical diseases, abdominal pathologies, and also specializes in organ transplantation. Of particular interest are surgical oncology of the abdominal organs, as well as pancreatic and liver surgery. The department annually performs more than 3,000 surgical interventions, which contributes to its credibility at the national level.

University Hospital Carl Gustav Carus Dresden

9.1/10
location_onGermany, Dresden

Department of Abdominal, Thoracic and Vascular Surgery

According to the Focus magazine, the Department of Abdominal, Thoracic and Vascular Surgery is included in the ranking of the top German departments specializing in colon cancer treatment! The department offers the full range of services in these medical fields. It provides the surgical treatment of diseases of the gastrointestinal tract, thyroid and parathyroid glands, thoracic organs and blood vessels. Special focus is on the treatment of gastrointestinal cancer. With appropriate clinical indications, preference is always given to minimally invasive surgical techniques.

University Hospital Frankfurt am Main

10/10
location_onGermany, Frankfurt am Main

Department of General and Abdominal Surgery

According to the Focus magazine, the Department of General and Abdominal Surgery ranks among the top German departments specializing in bowel cancer treatment! The department offers the full range of classical and minimally invasive methods for the treatment of common surgical diseases, cancer pathologies, diseases of the endocrine organs, proctological problems. The specialization also covers transplant surgery (liver, kidney and pancreas transplantation). The department is certified by the German Cancer Society for its outstanding results in the treatment of bowel, pancreatic, stomach and liver cancers.

University Hospital Halle (Saale)

9.6/10
location_onGermany, Halle

Department of General, Abdominal, Vascular and Endocrine Surgery

The Department of General, Abdominal, Vascular and Endocrine Surgery offers the full range of medical services in these fields. The department specializes in the surgical treatment of gastrointestinal cancers (surgical treatment of pancreatic, liver, stomach, esophageal and colon malignancies), hernia repair, treatment of gastrointestinal inflammatory diseases, endocrine surgery and surgical correction of vascular diseases and defects. The treatment of patients is carried out in close cooperation with the experts from related fields, particularly, with oncologists, gastroenterologists, radiologists, angiologists, etc.

University Hospital Jena

8.9/10
location_onGermany, Jena

Department of General, Abdominal and Vascular Surgery

According to the Focus magazine, the Department of General, Abdominal and Vascular Surgery ranks among the top German medical facilities specializing in the treatment of bowel cancer! The department offers the full range of surgical treatment of diseases of the abdominal organs and blood vessels, including the transplantation of abdominal organs. The sparing minimally invasive surgical techniques are widely used in the clinical practice, which allow to provide treatment in simple and complex clinical cases by making small incisions and using special tiny surgical instruments. The exceptional experience and profound knowledge of the department's doctors are also an integral part of the high treatment success rates.

University Hospital Heidelberg

9.8/10
location_onGermany, Heidelberg

Department of General, Abdominal and Transplant Surgery

According to the Focus magazine, the Department of General, Abdominal and Transplant Surgery ranks among the top German departments specializing in bowel cancer treatment! The department offers the full range of services in these medical fields and guarantees the first-class medical care at the university level. The department specializes in the treatment of diseases of the abdominal cavity, esophagus and thyroid gland, transplantation of liver, kidney and pancreas. The medical facility has won the reputation of one of the three largest and most successful Transplant Centers in Germany. Also, within the clinical practice, doctors hold highly-specialized consultations on rare diseases and provide 24-hour emergency care. 

University Hospital Würzburg

9.2/10
location_onGermany, Würzburg

Department of General, Abdominal, Transplant, Vascular and Pediatric Surgery

The Department of General, Abdominal, Transplant, Vascular and Pediatric Surgery covers the whole range of services in these fields. The department specializes in the treatment of diseases of the upper and lower gastrointestinal tract, liver, gallbladder, pancreas, thyroid and parathyroid glands, adrenal glands, as well as overweight. In addition, the department is a recognized Center for Vascular and Pediatric Surgery.

University Hospital Hamburg-Eppendorf

9.2/10
location_onGermany, Hamburg

Department of General, Abdominal and Thoracic Surgery

According to the Focus magazine, the Department of General, Abdominal and Thoracic Surgery ranks among the top German departments specializing in bowel cancer treatment! The department offers the full range of surgical treatment of diseases of the thorax and abdomen, endocrine glands, blood vessels and morbid obesity. If possible, the preference is always given to sparing minimally invasive surgical techniques. The department performs more than 3,000 outpatient and about 2,600 inpatient interventions every year. The department has one of the largest interdisciplinary Obesity Centers, as well as one of three supraregional Centers for Pancreatic, Stomach and Esophageal Surgery.

University Hospital Tuebingen

9.2/10
location_onGermany, Tuebingen

Department of General, Abdominal, Adult and Pediatric Transplant Surgery

According to the Focus magazine, the Department of General, Abdominal, Adult and Pediatric Transplant Surgery ranks among the top German departments specializing in the treatment of bowel cancer! The department specializes in the treatment of tumors of the gastrointestinal tract, pancreas, liver, and retroperitoneal space (peritoneal carcinomatosis), liver, kidney, pancreas, bowel transplantations in children and adults, as well as the surgical treatment of obesity and general surgical interventions.

University Hospital Rechts der Isar Munich

9.8/10
location_onGermany, Munich

Department of Surgery

The Department of Surgery offers the full range of services in this field and specializes in general, abdominal, thoracic, transplant surgery. The medical team of the department, consisting of 10 specialized senior physicians, 30 medical specialists and assistant physicians, as well as highly motivated nursing staff, provides first-class treatment of tumors, inflammatory and degenerative diseases of the esophagus, stomach, intestines, pancreas, liver, gallbladder, spleen, lungs, thyroid and parathyroid glands. The department is headed by Prof. Dr. med. Helmut Friess.

University Hospital Duesseldorf

9.5/10
location_onGermany, Duesseldorf

Department of General, Abdominal and Pediatric Surgery

The Department of General, Abdominal and Pediatric Surgery offers the full range of surgical treatment of diseases of the organs of abdominal cavity, thorax, emergency surgical care in polytrauma, as well as many surgical interventions in children. Of particular interest is cancer surgery on the liver, gallbladder, and pancreas. In addition, the department's specialists masterfully manage all the methods of bariatric surgery. Many operations are performed using minimally invasive techniques, which facilitate the quickest possible recovery of the patient.

Peritoneal carcinomatosis is an affection of the peritoneum by cancer metastases. It most often occurs in colorectal cancer and cancer of the stomach.

Overview

Carcinomatosis is one of the most unfavorable types of colorectal cancer metastasizing. However, it is very common.

Generally, carcinomatosis is a process of the malignant cells spreading, which subsequently leads to damage of the various organs in the human body. Such a process is often observed at the last stages of colorectal cancer. It manifests itself in the form of damage to organs such as the abdominal cavity organs and pleura.

Peritoneal carcinomatosis isn’t considered an independent pathological process. It is rather a complication of previous cancerous formations.

The malignant cells move inside the body through the blood. Moving along the abdominal cavity, the altered cells penetrate its structures, which leads to damaging other organs, regardless of where they are located.

In most cases, doctors find out that patients with carcinomatosis have a severe form of cancer, which is very difficult to cure.

Symptoms of peritoneal carcinomatosis

Since peritoneal carcinomatosis is not an independent disease, its clinical picture is determined by both the clinical manifestations of the primary tumor and the signs of the secondary malignant lesions.

The most common symptom is the presence of the fluid in the abdominal cavity, the so-called ascites. Ascites is often the only symptom in patients with peritoneal carcinomatosis. Also, there may be some non-specific signs, such as significant weight loss, nausea, vomiting, severe fatigue, and weakness.

The main signs indicating the development of a malignant lesion of the peritoneum include:

  • Dull, aching pain in the abdomen. It can be either permanent or disturb the patient for periods of several hours or days.
  • Abdominal enlargement with rapid weight loss. An enlarging abdomen is formed due to the accumulation of fluid in the abdominal cavity (ascites).
  • Severe indigestion. Patients have nausea and pain in the abdomen; vomiting is also possible. Difficulties arise with defecation; often constipation is interchanged with diarrhea.
  • Increasing symptoms of intoxication. Severe weakness, sweating, fever, pain in muscles, and headaches. Patients feel exhausted.
  • Presence of a tumor that is palpable through the anterior abdominal wall.

The diagnosis is established taking into account the medical history of patients, clinical manifestations, laboratory and instrumental research data.

Diagnostics

Modern oncology centers have all the resources for accurate diagnostics of peritoneal carcinomatosis.

On the day of arrival at the oncology center, a consultation with the attending physician takes place. Doctors examine patients and study the anamnesis.

Further, all diagnostic measures are taken. The standard examination plan for peritoneal carcinomatosis includes the following procedures:

  • CT. CT is conducted to obtain layer-by-layer images of the affected organ.
  • Blood tests.
  • Abdominal ultrasound examination. Modern ultrasound equipment detects even small loci of colorectal cancer.
  • MRI.
  • Biopsy. A biopsy is conducted to obtain material for histological examination.
  • Diagnostic laparoscopy.

After receiving the results, doctors elaborate the therapeutic scheme for patients.

Treatment of patients with diagnosed peritoneal carcinomatosis is rather complicated. Currently, there are no standard methods of radical treatment of this cancerous process, so the colorectal cancer treatment is strictly individual.

Treatment of peritoneal carcinomatosis

For almost the entire history of oncology, it was believed that peritoneal carcinomatosis in patients with colorectal cancer did not respond to any of the existing treatments.

For a long time, patients with peritoneal carcinomatosis were considered incurable. And to this day, many doctors hold the same opinion. Patients with colorectal cancer are often "discharged" from the hospital because "there are no oncologists in hospitals treating carcinomatosis." When they come to modern oncology centers and find information about the possibility of colorectal cancer treatment with HIPEC, it turns out that this is the first time they hear about such a technique.

In most hospitals treating patients with colorectal cancer radiation therapy is not used due to its inefficiency in the treatment of peritoneal carcinomatosis. High doses of radiation are dangerous for patients with colorectal cancer and this treatment is usually connected with severe complications.

Conventional surgical treatment is also ineffective as metastases on the surface of the peritoneum can be very small, or located in inaccessible places, and the doctor simply does not see them during the surgery.

Systemic chemotherapy has almost no effect on peritoneal carcinomatosis as cancer cells of this type practically do not contact the system of blood vessels, and therefore are not available for systemic intravenous chemotherapy.

Treatment of peritoneal carcinomatosis is now possible by combining surgical intervention with the use of hyperthermic intraperitoneal chemotherapy.

The goal of the procedure is to destroy the maximum amount of cancer cells that remain even after the most thorough surgical removal of the lesions and cause colorectal cancer recurrence.

The essence of the HIPEC technique is that immediately after the cytoreductive (that is, aimed at removing tumor cells) surgery on the abdominal organs, patients are perfused for 60-90 minute with a concentrated chemotherapy drug, heated up to 42-43°C.

Both adjectives are important in the name "hyperthermic intraperitoneal chemotherapy"."Hyperthermic" stands for the rise of temperature.

The high temperature itself is capable of causing damage or death of cancer cells. Besides, it makes them more vulnerable to chemotherapy drugs.

Another important feature of hyperthermic intraperitoneal chemotherapy (HIPEC) is that it promotes more active penetration of the drugs into the tissues. This is enough to destroy most metastases remaining after surgery.

Hyperthermic intraperitoneal chemotherapy (HIPEC) acts directly on cancer cells. Moreover, drugs practically do not "leak" into the general bloodstream through the peritoneum.

This makes it possible to use the concentration of chemotherapy drugs in HIPEC that are 20, 50, and sometimes 100 times higher than the ones used in systemic chemotherapy. Cancer cells inside the abdominal cavity receive lethal doses, and the whole body practically does not suffer from side effects.

One of the main advantages of HIPEC is that sometimes it can be the only way to prolong the life of a person at the last stages of colorectal cancer.

Indications for HIPEC

For surgery followed by HIPEC to be effective, several conditions must be met:

  1. Patients must be able to undergo both surgery and chemotherapy at the same time. Health conditions of patients should allow the treatment. Before the procedure, patients are examined thoroughly.
  2. The spread of metastases should be limited to the abdominal cavity only.

How HIPEC is carried out

Surgical intervention with the use of hyperthermic intraperitoneal chemotherapy is carried out in two stages: first, surgical removal is conducted, and then the chemotherapy drugs are introduced.

Surgical intervention and hyperthermic intraperitoneal chemotherapy are separate but equally important steps in a single therapeutic regimen. For maximum cancer treatment efficacy, both stages should be carried out one after the other.

The HIPEC procedure is the second half of a whole range of measures. Without the cytoreductive surgery, HIPEC can be performed in a few cases with specific indications. Typically, the HIPEC is a continuation of the surgical procedure, which significantly improves the prognosis of survival.

Together with the surgical removal of the cancerous tumor, the entire intervention takes from 6 to 18 hours. The process can be divided into 4 stages.

  1. Additional examination of the abdominal cavity.

It is carried out to understand whether treatment with HIPEC is indicated for patients and whether it will increase the life expectancy. The examination is performed intraoperatively, just before the main surgical intervention.

  1. Cytoreductive surgery.

Some sections of the peritoneum, where the primary tumor originates from, adjacent internal organs, or their parts, are removed if they are also affected by metastases. Often these are areas of the intestines, spleen, and gallbladder.

  1. Hyperthermic intraperitoneal chemotherapy.

The actual HIPEC. Catheters and temperature sensors are inserted into the abdominal cavity, connected to a special device, and a container with a chemotherapy drug. After the procedure, the drug is removed from the abdominal cavity, it is washed with saline solution, and the sensors and catheters are removed.

  1. Reconstructive surgery.

If parts of the intestine are removed, the surgeon restores the functioning of the intestine with the help of a colostomy (brings the end of the intestine to the surface of the abdomen for defecation restoring).

On average, patients spend 2-4 weeks in the oncology center. A control examination is performed in 2-3 weeks after the surgical intervention. It must be repeated in 3 months, and after that the frequency of examinations is reduced to one per year.

Postoperative period

The postoperative period is a separate stage, but it is no less important. We understand how difficult the recovery period can be for patients with extremely serious conditions. Therefore, immediately after the surgery patients are transferred to the intensive care unit and stay under the constant medical supervision.

Complications can be the same as after any surgical intervention on the abdominal cavity organs, therefore, the patient is closely monitored in order to notice signs of bleeding or inflammation of the postoperative wound timely.

Side effects of chemotherapy drugs with intraperitoneal hyperthermic chemotherapy are even less pronounced and the antitumor effect is ten times higher in comparison with the intravenous chemotherapy administration.

Where can I undergo HIPEC for colorectal cancer treatment abroad?

The best success rates in hyperthermic intraperitoneal chemotherapy (HIPEC) are demonstrated by:

  1. Academic Hospital Asklepios Barmbek Hamburg, Germany
  2. University Hospital of Ludwig Maximilian University Munich, Germany
  3. Charite University Hospital, Germany
  4. University Hospital Ulm, Germany
  5. University Hospital Marburg UKGM, Germany

You can check out the full list of hospitals on the Booking Health website.

The cost of colorectal cancer treatment with HIPEC

The prices in hospitals listed on the Booking Health website are relatively low. With Booking Health, you can undergo cancer treatment in the best hospitals in the world at an affordable price.

The cost varies, as the price for treatment depends on the hospital, the diagnosis, and the complexity of treatment:

  1. The price for treatment in Germany is from 35,633 EUR to 62,794 EUR
  2. The price for treatment in Israel is approximately 45,200 EUR
  3. The price for treatment in Turkey is approximately 27,700 EUR

The final cost may differ from the prices mentioned above. To make sure that the price for treatment is suitable for you, contact us by leaving the request on the Booking Health website.

Hyperthermic intraperitoneal chemotherapy (HIPEC) meets the definition of medical necessity and should be covered by insurance. Contact your insurance company to find out the details.

How can I undergo HIPEC abroad?

It is not easy to choose the right hospital that ensures a successful HIPEC procedure. It is vital to have accurate information on the success rates of the hospital in colorectal cancer treatment.

We have up-to-date information on colorectal cancer treatment in the best hospitals in the world. Booking Health will help you select a hospital, taking into account your wishes and the indications for colorectal cancer treatment.

We want to help you during this difficult period and take on all the issues. You can be free of unnecessary stress, while Booking Health takes care of all organizational issues. Our goal is to find the best facility for colorectal cancer treatment for you.

Cancer can be treated! The earlier you start the treatment, the higher the chances of returning to your day-to-day life. All you need to do is to leave the request on the Booking Health website and our manager will contact you shortly.




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