google_counter
background_img

Ovarian Cancer — CRS and HIPEC - Hyperthermic Intraperitoneal Chemoperfusion: treatment in the Best Hospitals in the World

University Hospital Tuebingen

9.2/10
location_onGermany, Tuebingen

Department of Adult and Pediatric Gynecology, Mammology, Obstetrics

According to the Focus magazine, the Department of Adult and Pediatric Gynecology, Mammology, Obstetrics is included in the ranking of the top German departments specializing in obstetrics and breast cancer treatment! The department offers the full range of diagnostics and treatment of diseases of the female reproductive system, breast pathologies. Also, the specialists of the department provide a comprehensive management of pregnancy, childbirth and postpartum care for both mother and child. Key attention is paid to the treatment of female genital cancers, as well as breast cancer treatment. For this purpose, the department has all the modern therapeutic techniques, as well as its our own innovative developments by the department doctors.

Include:
people Interpreter up to 20 hours
list Translation up to 10 pages
card_membership Visa support

Leverkusen Clinic

10/10
location_onGermany, Leverkusen

Department of Gynecology, Urogynecology, Mammology and Obstetrics

The Department of Gynecology, Urogynecology, Mammology and Obstetrics offers the full range of high quality diagnostic and therapeutic services for patients with diseases of the mammary glands, internal and external genitalia. The department's specialists are distinguished by their special competence in the treatment of oncological diseases of the female genital organs and breast cancer. The department has high-tech operating rooms for sparing surgical treatment, namely laparoscopic interventions and da Vinci robot-assisted surgery. The department is a Level I Perinatal Center, so it provides an integrated management of pregnancy, including high-risk pregnancies and multiple pregnancies, as well as a safe delivery and a postpartum care. The department delivers more than 1,800 babies every year.

University Hospital Ulm

8.7/10
location_onGermany, Ulm

Department of Obstetrics, Adult and Pediatric Gynecology

The Department of Obstetrics, Adult and Pediatric Gynecology offers the full range of services in these fields and specializes in the diagnostics and treatment of general gynecological diseases, oncological diseases of the female reproductive system, breast, endometrial pathologies and urinary incontinence. In the clinical practice, only proven accurate diagnostic methods and effective therapeutic measures are used. In addition, the department is the Level I Perinatal Center, in which about 3,000 babies are born annually.

University Hospital Carl Gustav Carus Dresden

9.1/10
location_onGermany, Dresden

Department of Adult and Pediatric Gynecology, Mammology and Obstetrics

According to the Focus magazine, the Department of Adult and Pediatric Gynecology, Mammology and Obstetrics is included in the ranking of the top German departments specializing in obstetrics and breast cancer treatment! The department offers the full range of surgical and conservative treatment of the pathologies of the female reproductive system, breast, as well as first-class obstetric services, including pregnancy management and postnatal care for both mother and child. The excellent technical equipment of the department, highly qualified medical personnel and the availability of advanced treatments ensure optimal, tailored treatment at the highest level.

University Hospital Frankfurt am Main

10/10
location_onGermany, Frankfurt am Main

Department of Adult and Pediatric Gynecology, Obstetrics and Mammology

According to the Focus magazine, the Department of Adult and Pediatric Gynecology, Obstetrics and Mammology ranks among the top German departments specializing in the provision of obstetric services and breast cancer treatment! The department offers all diagnostic and therapeutic options for patients of all ages with diseases of the female reproductive system, mammary gland, as well as provides the comprehensive pregnancy management, childbirth and postpartum care in accordance with the highest standards of modern obstetrics. One of the priority focuses of the department’s work is the treatment of oncopathology in women. All specialists have excellent qualifications and tremendous experience, and therefore they achieve successful results even in extremely difficult clinical cases.

Charite University Hospital Berlin

9/10
location_onGermany, Berlin

Department of Adult and Pediatric Gynecology, Mammology

According to the Focus magazine, the Department of Adult and Pediatric Gynecology, Mammology ranks among the top German medical facilities in the fields of its specialization! The department offers all options of modern medicine for the diagnostics and treatment of diseases of the female reproductive organs and breast. Of particular interest is the treatment of cancers of the female reproductive organs and breast (certification of the German Cancer Society). In addition, the department's doctors have exceptional competence in the treatment of gynecological problems in children of all age groups, including surgical correction of congenital malformations of the reproductive organs. The department is proud of its outstanding treatment results achieved thanks to the professional skills of doctors and excellent technical base.

University Hospital Heidelberg

9.8/10
location_onGermany, Heidelberg

Department of Obstetrics, Adult and Pediatric Gynecology

According to the Focus magazine, the Department of Obstetrics, Adult and Pediatric Gynecology ranks among the top departments in Germany specializing in obstetrics and breast cancer treatment! The department offers the full range of diagnostics and treatment of diseases of the female genital organs, as well as provides first-class obstetric services, prenatal diagnostics and comprehensive management of pregnancy, including high-risk pregnancy. As part of the National Cancer Center (NCT), the department ensures an individualized, interdisciplinary treatment of female oncopathology. All the therapeutic measures carried out by the doctors of the department meet the highest international standards. 

University Hospital of Ludwig Maximilian University of Munich

10/10
location_onGermany, Munich

Department of Obstetrics, Adult and Pediatric Gynecology

According to the Focus magazine rating, the Department of Obstetrics, Adult and Pediatric Gynecology ranks among the top German clinics specializing in obstetrics and breast cancer treatment! The department offers the full range of diagnostics and treatment of diseases of the female reproductive system, urinary system, hormonal disorders, problems with conceiving a child, and first-class obstetric services. In addition, the department provides comprehensive consultations, diagnostics and treatment of puberty disorders and problems of the gynecological spectrum in girls and young girls.

University Hospital Erlangen

9.1/10
location_onGermany, Erlangen

Department of Gynecology, Obstetrics and Mammology

According to the Focus magazine, the Department of Gynecology, Obstetrics and Mammology ranks among the top German departments specializing in obstetrics and breast cancer treatment! The department offers the full range of services in its areas of specialization and is one of the largest medical facilities of this kind in Germany. Of particular interest is the treatment of oncopathology of the female reproductive system, including breast cancer, first-class obstetric care and comprehensive pregnancy management, gynecologic endocrinology and reproductive medicine. A highly competent team of doctors, who has tremendous experience and keeps abreast of the cutting-edge medical innovations, cares about the health of patients.

University Hospital Halle (Saale)

9.6/10
location_onGermany, Halle

Department of Gynecology and Mammology

According to the Focus magazine, the Department of Gynecology and Mammology ranks among the top German departments specializing in breast cancer treatment! The department offers the full range of accurate diagnostics, conservative and surgical treatment of diseases of the female reproductive system, breast. The department’s state-of-art infrastructure, advanced diagnostic equipment and the highest professionalism of doctors allow for the achievement of excellent treatment results.

University Hospital Hamburg-Eppendorf

9.2/10
location_onGermany, Hamburg

Department of Gynecology and Mammology

According to the Focus magazine, the Department of Gynecology and Mammology ranks among the top German departments specializing in breast cancer treatment! The department offers the full range of diagnostic and therapeutic services in its areas of specialization. Due to its successful clinical activities, the department has the status of a supraregional Competence Center for Surgical and Conservative Gynecologic Oncology, as well as of the leading Breast Cancer Center. All therapeutic measures meet the modern standards of both national and international specialized societies.

University Hospital Würzburg

9.2/10
location_onGermany, Würzburg

Department of Adult and Pediatric Gynecology, Mammology and Obstetrics

The Department of Adult and Pediatric Gynecology, Mammology and Obstetrics offers the diagnostics and treatment of all gynecological diseases. The department specializes in the treatment of breast cancer and cancer of the female reproductive organs. All traditional and modern conservative and surgical methods are used for this purpose. The department also provides reliable and individual obstetric services at the Center for Mother and Child and offers all methods of prenatal diagnostics.

University Hospital Duesseldorf

9.5/10
location_onGermany, Duesseldorf

Department of Adult and Pediatric Gynecology, Obstetrics and Mammology

According to the Focus magazine rating, the Department of Adult and Pediatric Gynecology, Obstetrics and Mammology ranks among the top German departments specializing in breast cancer treatment! The department offers the full range of services in these medical fields. In the field of gynecology, it provides the diagnostics and treatment of all pathologies of the female reproductive system, including the gynecological problems in girls aged from 0 to 18 years. The department's obstetricians provide quality care for expectant mothers before, during and after pregnancy. The department's scope of activities also includes the management of high-risk pregnancies. The key focus of clinical activities is the treatment of oncological diseases of the female genital organs, including breast cancer.

University Hospital RWTH Aachen

8.9/10
location_onGermany, Aachen

Department of Gynecology, Mammology and Obstetrics

According to the Focus magazine, the Department of Gynecology, Mammology and Obstetrics ranks among the top German medical facilities specializing in breast cancer treatment and provision of obstetric services! The department provides all modern medical services in the fields of its specialization. The gynecologists treat both general and oncological diseases of the female reproductive sphere. Should surgical treatment be required, minimally invasive techniques will be used. The department's mammologists specialize in the treatment of breast cancer using all the classic and innovative therapeutic options. The department is also the Level I Perinatal Center, in which the patient receives the highest quality pregnancy management, comfortable childbirth and postpartum care.

University Hospital Rechts der Isar Munich

9.8/10
location_onGermany, Munich

Department of Gynecology, Mammology, Obstetrics and Perinatal Medicine

As the center of advanced medicine, the Department of Gynecology, Mammology, Obstetrics and Perinatal Medicine offers the full range of services in these fields, providing patients with optimal treatment based on the latest scientific achievements and innovative technologies. The scope of the department's tasks includes the diagnosis and treatment of all gynecological diseases, breast pathologies, as well as the management of pregnancy, childbirth, postpartum care for the mother and baby, elimination of fertility problems.

University Hospital Muenster

9.8/10
location_onGermany, Muenster

Department of Adult and Pediatric Gynecology, Obstetrics

According to the Focus magazine, the Department of Adult and Pediatric Gynecology, Obstetrics ranks among the top German departments specializing in obstetrics! The department offers the full range of diagnostics and treatment of all gynecologic diseases in women and girls. The specialization includes surgical gynecology and gynecologic oncology, obstetrics and perinatal medicine, gynecological endocrinology and reproductive medicine. A special focus is made on the treatment of malignant tumors of the female reproductive organs, which is carried out within the Comprehensive Cancer Center Muenster. All the very latest and most effective treatment methods are available here.

Ovarian cancer can occur at any period of life, but it is often diagnosed in patients of 40-50 years of age. In terms of incidence, ovarian cancer ranks second in gynecologic oncology with a significant prevalence of advanced forms (75-80%).

Overview

The problem of an ovarian cancer diagnosis is one of the most urgent in modern medicine. Its relevance is due to the undoubted increase in mortality from this pathology, that was noted in recent decades in many countries of the world.

The majority (75-87%) of ovarian cancer patients are admitted for treatment at advanced stages of the disease, at which the 5-year survival rate does not exceed 10%. Poor prognosis of ovarian cancer is due to both the absence of specific signs of the disease and the late treatment of patients.

Symptoms

In most cases, even with advanced forms of the pathology when the cancer process spreads through the body, medical signs may include loss of appetite, weakness, nausea, and an increase in the volume of the abdomen. Clinical manifestations of the advanced forms of the disease are more pronounced than ones of the early forms. In such cases, there is abdominal bloating, especially in the upper section of the abdomen, and satiety from small portions of food, which is due to the large volume of the tumor which creates difficulties in food passing. As the tumor grows, the volume of the abdomen increases, shortness of breath develops, and a feeling of fullness arises.

With advanced forms of ovarian cancer, the menstrual cycle is disrupted, dysfunctional uterine bleeding occurs, the amount of urine decreases, and constipation occurs.

Diagnosis

The asymptomatic development of ovarian cancer at the early stages of the disease forces clinicians to develop more advanced methods of cancer detection and to single out a group of patients with increased risks. Judgments about the significance of anamnestic data in patients with ovarian cancer are heterogeneous, but summarizing them, one can find medical signs preceding the development of a tumor in the form of endocrine hormonal disorders that can manifest as:

  • Later onset of menstruation
  • Infertility
  • Diabetes mellitus
  • Early or late menopause
  • Obesity
  • Myoma
  • Endometriosis

It should be emphasized that the risk of ovarian cancer development increases if patients have a combination of 2 or 3 signs. Therefore, in presence of risk factors, every woman should have preventive examinations at least 2 times a year. This allows detecting ovarian cancer at an early stage of the disease.

The information about a history of chronic inflammation of the uterine appendages or surgery for a benign ovarian tumor is particularly important. It is known that with unilateral removal of a benign ovarian tumor, the appearance of ovarian cancer in another ovary is very likely. Information about tumor diseases in the family is also important. All of these details should be clarified in order to recognize ovarian cancer early.

To make the diagnosis, the patients are examined using ultrasound scanning of the pelvis. The advantage of the ultrasound method in the diagnosis of ovarian cancer is its high information content, simplicity, speed, harmlessness, painlessness, the possibility of repeated carrying out, and objective documentation.

The search for tumor markers is of great importance in the diagnosis of ovarian cancer. These are specific biological substances that are produced by the tumor and can be determined by biochemical or immunological methods. Concerning ovarian cancer, the most important is the associated antigen CA-125. The level of CA-125 above 35 U/ml is found in almost 80% of patients with ovarian cancer.

Treatment

For ovarian cancer, surgery is necessary. It allows establishing the stage of the disease and removal of the tumor. And not only the tumor that has grown in the ovary or fallopian tube in the lower abdomen, but also any cancer cells that have spread outside the pelvic region are subject to removal. Surgeons try to remove as much of the affected tissue as possible so that by the beginning of the chemotherapy course the patient has only a small number of pathological cells.

With ovarian cancer, the goal of any surgery is to remove affected tissues from the abdomen and any other areas where cancer has spread. Another purpose of the surgery is to find the organs and structures affected by cancer. It is on this basis that doctors determine the stage of the disease.

Patients often hear the term "staging surgery". It indicates the surgery required to obtain information. The doctor performs a surgery, which usually removes both ovaries along with the fallopian tubes, and also performs a hysterectomy (removal of the uterus and cervix).

Cytoreductive surgery (CRS) is surgery performed to remove the maximum volume of affected tissues. Additionally, the lymph nodes are excised, which is called lymphadenectomy. It is necessary to remove the lymph nodes of the abdominal cavity, which are located near the large blood vessels that carry blood to the heart and back. The lymph nodes along these blood vessels are most often at risk in metastatic ovarian cancer, so doctors remove them during surgery. If, as a result, tumor cells are found in the removed lymph nodes, doctors can establish the stage of development of the pathology.

When doctors perform such surgery as a part of the therapy in young women, they make every possible effort to preserve ovarian function and fertility. For example, only one fallopian tube and one ovary can be removed, while the other ovary along with the fallopian tube remains in place (if it is healthy at the time of the surgery).

CRS in combination with HIPEC therapy has shown the greatest effectiveness in the treatment of ovarian cancer.

Hyperthermic intraperitoneal chemotherapy is one of the most innovative methods of treatment of advanced cancer, which is also known as HIPEC or hot chemotherapy. Today, chemotherapy HIPEC is the only type of therapy in medicine that can extend the life of patients with ovarian cancer by 20-50% when other methods are ineffective.

Many types of oncology that develop in the intra-abdominal organs can affect the peritoneal cavity. This indicates that cancer has progressed significantly. In this case, intravenous chemotherapy is usually not effective enough because the drugs simply do not reach the peritoneal cavity. The only efficient treatment in this case is intraperitoneal chemotherapy which allows drugs to target tumor lesions directly.

Hyperthermic intraperitoneal chemotherapy is a three-step treatment. First of all, a cytoreductive surgery is performed, during which doctors remove all affected tissues and organs (colon, ovaries, gallbladder, part of the stomach). After that, while the patients are still under the action of general anesthesia in the operating room, it is the turn of hyperthermic intraperitoneal chemotherapy.

Cytoreductive surgery takes 6-10 hours. It is performed by experienced surgeons, and, if necessary, also by gynecologists-oncologists. At the same time, HIPEC requires long and thorough preparation, extensive experience, and well-coordinated work of a whole team of medical specialists. Radiologists, medical oncologists, pathologists, nuclear medicine specialists, nutritional experts, anesthesiologists, and nurses are also involved in patient care.

About 3.5 liters of chemotherapy drugs are injected into the peritoneal area. Their temperature is 41-43 degrees. The solution circulates for 1.5 hours, penetrating all areas and affecting the tumor cells remaining after a patient is treated surgically. The fluid is then pumped out and the abdominal cavity is closed. Cytoreductive surgery and HIPEC may also be complemented by systemic chemotherapy.

However, in some cases, hyperthermic intraperitoneal chemotherapy (HIPEC) can be performed without surgery. Drugs can be injected into the abdominal cavity laparoscopically, through catheters.

Positive effects of HIPEC for ovarian cancer treatment include:

  • The drug’s even distribution over the entire inner surface of the abdominal cavity, delivering high doses of the drug directly to malignant neoplasms
  • The therapeutic effect of chemotherapy drugs increases due to heating
  • Better penetration of the medical substances into the affected tissues and their ability to destroy the malignant cells left after surgery
  • The drug does not affect healthy organs located outside the abdominal cavity, which reduces the risk of side effects development (those noticed after a patient is treated with conventional chemotherapy)

Besides, HIPEC can be used to treat ascites (fluid accumulation in the abdominal cavity), which often develops in patients with advanced cancer. This pathological process causes bloating and leads to the spread of cancer cells in the peritoneum up to the diaphragm.

Cytoreductive surgery with HIPEC, however, is not used in patients with metastases outside the abdominal cavity (cranial, pulmonary, and bone metastases). Also, HIPEC is not used in patients with multiple, inoperable liver metastases.

HIPEC is a very complex treatment that carries higher risks compared to side effects after a tumor is treated with standard surgical procedures. Most often, patients experience temporary deterioration of gastrointestinal function. During the surgery, there is also a risk of hemorrhage, kidney failure, clots in the lungs or brain, and bone marrow damage. In this case, the mortality risk is about 0-7%.

However, given the complexity of the disease and the high mortality risks of this pathology, the surgery is more preferable. Cytoreductive surgery in combination with HIPEC and systemic chemotherapy is currently the only treatment that can prolong the patient's life and improve its quality.

Where can I undergo CRS and HIPEC treatment abroad?

Health tourism is becoming more and more popular these days, as medicine abroad often ensures a much better quality of ovarian cancer treatment.

The following hospitals show the best success rates in ovarian cancer treatment with CRS and HIPEC:

  1. University Hospital Tuebingen, Germany
  2. Memorial Sisli Hospital Istanbul, Turkey
  3. Medicana International Istanbul Hospital, Turkey
  4. University Hospital Ulm, Germany
  5. Rambam Health Care Campus Haifa, Israel

You can find more information about the hospitals on the Booking Health website.

The cost of treatment abroad

The prices in hospitals listed on the Booking Health website are relatively low. With Booking Health, you can undergo ovarian cancer treatment with CRS and HIPEC abroad at an affordable price.

The cost of treatment varies, as the price depends on the hospital, specifics of the disease, and the complexity of its treatment.

The cost of treatment with HIPEC and CRS in Germany is 38,009-67,767 EUR.

The cost of treatment with HIPEC and CRS in Turkey is approximately 29,705 EUR.

The cost of treatment with HIPEC and CRS in Israel is approximately 40,967 EUR.

You also need to consider the cost of possible additional procedures and follow-up care. Therefore, the ultimate cost of treatment may differ from the initial price.

To make sure that the overall cost of treatment is suitable for you, contact us by leaving the request on the Booking Health website.

How can I undergo CRS and HIPEC treatment abroad?

It is not easy to self-organize any treatment abroad. It requires certain knowledge and expertise. Thus, it is safer, easier, and less stressful to shift some responsibility onto a medical tourism agency.

As the largest and most transparent medical tourism agency in the world, Booking Health has up-to-date information about ovarian cancer treatment with CRS and HIPEC in the best hospitals in the world. Therefore, we will help you select the right clinic taking into account your wishes for treatment.

We want to help you and take on all the troubles. You can be free of unnecessary stress, while Booking Health takes care of all organizational issues regarding the treatment. Our services aimed at undergoing ovarian cancer treatment with CRS and HIPEC safely and successfully.

Medical tourism can be easy! All you need to do is to leave a request on the Booking Health website and our manager will contact you shortly.




Feedback of our customers from other resources

Need Help?

Thank you!

We received your treatment application in the best Europe clinics. Our manager will contact you within the next 24 hours.