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Ovarian Cancer — CRS and HIPEC - Hyperthermic Intraperitoneal Chemoperfusion: treatment in the Best Hospitals of Germany

University Hospital Tuebingen

9.2/10
location_onGermany, Tuebingen

Department of Adult and Pediatric Gynecology, Mammology, Obstetrics

According to the Focus magazine, the Department of Adult and Pediatric Gynecology, Mammology, Obstetrics is included in the ranking of the top German departments specializing in obstetrics and breast cancer treatment! The department offers the full range of diagnostics and treatment of diseases of the female reproductive system, breast pathologies. Also, the specialists of the department provide a comprehensive management of pregnancy, childbirth and postpartum care for both mother and child. Key attention is paid to the treatment of female genital cancers, as well as breast cancer treatment. For this purpose, the department has all the modern therapeutic techniques, as well as its our own innovative developments by the department doctors.

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Leverkusen Clinic

10/10
location_onGermany, Leverkusen

Department of Gynecology, Urogynecology, Mammology and Obstetrics

The Department of Gynecology, Urogynecology, Mammology and Obstetrics offers the full range of high quality diagnostic and therapeutic services for patients with diseases of the mammary glands, internal and external genitalia. The department's specialists are distinguished by their special competence in the treatment of oncological diseases of the female genital organs and breast cancer. The department has high-tech operating rooms for sparing surgical treatment, namely laparoscopic interventions and da Vinci robot-assisted surgery. The department is a Level I Perinatal Center, so it provides an integrated management of pregnancy, including high-risk pregnancies and multiple pregnancies, as well as a safe delivery and a postpartum care. The department delivers more than 1,800 babies every year.

University Hospital Ulm

8.7/10
location_onGermany, Ulm

Department of Obstetrics, Adult and Pediatric Gynecology

The Department of Obstetrics, Adult and Pediatric Gynecology offers the full range of services in these fields and specializes in the diagnostics and treatment of general gynecological diseases, oncological diseases of the female reproductive system, breast, endometrial pathologies and urinary incontinence. In the clinical practice, only proven accurate diagnostic methods and effective therapeutic measures are used. In addition, the department is the Level I Perinatal Center, in which about 3,000 babies are born annually.

University Hospital Carl Gustav Carus Dresden

9.1/10
location_onGermany, Dresden

Department of Adult and Pediatric Gynecology, Mammology and Obstetrics

According to the Focus magazine, the Department of Adult and Pediatric Gynecology, Mammology and Obstetrics is included in the ranking of the top German departments specializing in obstetrics and breast cancer treatment! The department offers the full range of surgical and conservative treatment of the pathologies of the female reproductive system, breast, as well as first-class obstetric services, including pregnancy management and postnatal care for both mother and child. The excellent technical equipment of the department, highly qualified medical personnel and the availability of advanced treatments ensure optimal, tailored treatment at the highest level.

University Hospital Frankfurt am Main

10/10
location_onGermany, Frankfurt am Main

Department of Adult and Pediatric Gynecology, Obstetrics and Mammology

According to the Focus magazine, the Department of Adult and Pediatric Gynecology, Obstetrics and Mammology ranks among the top German departments specializing in the provision of obstetric services and breast cancer treatment! The department offers all diagnostic and therapeutic options for patients of all ages with diseases of the female reproductive system, mammary gland, as well as provides the comprehensive pregnancy management, childbirth and postpartum care in accordance with the highest standards of modern obstetrics. One of the priority focuses of the department’s work is the treatment of oncopathology in women. All specialists have excellent qualifications and tremendous experience, and therefore they achieve successful results even in extremely difficult clinical cases.

Charite University Hospital Berlin

9/10
location_onGermany, Berlin

Department of Adult and Pediatric Gynecology, Mammology

According to the Focus magazine, the Department of Adult and Pediatric Gynecology, Mammology ranks among the top German medical facilities in the fields of its specialization! The department offers all options of modern medicine for the diagnostics and treatment of diseases of the female reproductive organs and breast. Of particular interest is the treatment of cancers of the female reproductive organs and breast (certification of the German Cancer Society). In addition, the department's doctors have exceptional competence in the treatment of gynecological problems in children of all age groups, including surgical correction of congenital malformations of the reproductive organs. The department is proud of its outstanding treatment results achieved thanks to the professional skills of doctors and excellent technical base.

University Hospital Heidelberg

9.8/10
location_onGermany, Heidelberg

Department of Obstetrics, Adult and Pediatric Gynecology

According to the Focus magazine, the Department of Obstetrics, Adult and Pediatric Gynecology ranks among the top departments in Germany specializing in obstetrics and breast cancer treatment! The department offers the full range of diagnostics and treatment of diseases of the female genital organs, as well as provides first-class obstetric services, prenatal diagnostics and comprehensive management of pregnancy, including high-risk pregnancy. As part of the National Cancer Center (NCT), the department ensures an individualized, interdisciplinary treatment of female oncopathology. All the therapeutic measures carried out by the doctors of the department meet the highest international standards. 

University Hospital of Ludwig Maximilian University of Munich

10/10
location_onGermany, Munich

Department of Obstetrics, Adult and Pediatric Gynecology

According to the Focus magazine rating, the Department of Obstetrics, Adult and Pediatric Gynecology ranks among the top German clinics specializing in obstetrics and breast cancer treatment! The department offers the full range of diagnostics and treatment of diseases of the female reproductive system, urinary system, hormonal disorders, problems with conceiving a child, and first-class obstetric services. In addition, the department provides comprehensive consultations, diagnostics and treatment of puberty disorders and problems of the gynecological spectrum in girls and young girls.

University Hospital Erlangen

9.1/10
location_onGermany, Erlangen

Department of Adult and Pediatric Gynecology, Mammology, Obstetrics

According to the Focus magazine, the Department of Adult and Pediatric Gynecology, Mammology, Obstetrics ranks among the top German departments specializing in obstetrics and breast cancer treatment! The department offers the full range of services in the areas of its specialization and is one of the largest medical facilities of this kind in Germany. Of particular interest is the treatment of cancers of the female reproductive system, including breast cancer, medical care for hormonal imbalance of gynecological genesis, treatment of urinary incontinence and pelvic organ prolapse in women, top-class obstetric care and integrated pregnancy management. In addition, the department's gynecologists admit women suffering from infertility. They can undergo comprehensive diagnostics of the reproductive system and the further required therapeutic manipulations, such as uterine fibroid removal, treatment of endometriosis and other pathologies, which prevent the conception of a child. The department also specializes in the treatment of congenital malformations and acquired gynecological diseases in children. The highly qualified team of doctors with colossal experience, who keep pace with advanced innovations in medicine, take care of the patients' health. The specialists do everything possible to restore the health of patients, taking into account their needs and wishes.

University Hospital Halle (Saale)

9.6/10
location_onGermany, Halle

Department of Gynecology and Mammology

According to the Focus magazine, the Department of Gynecology and Mammology ranks among the top German departments specializing in breast cancer treatment! The department offers the full range of accurate diagnostics, conservative and surgical treatment of diseases of the female reproductive system, breast. The department’s state-of-art infrastructure, advanced diagnostic equipment and the highest professionalism of doctors allow for the achievement of excellent treatment results.

University Hospital Hamburg-Eppendorf

9.2/10
location_onGermany, Hamburg

Department of Gynecology and Mammology

According to the Focus magazine, the Department of Gynecology and Mammology ranks among the top German departments specializing in breast cancer treatment! The department offers the full range of diagnostic and therapeutic services in its areas of specialization. Due to its successful clinical activities, the department has the status of a supraregional Competence Center for Surgical and Conservative Gynecologic Oncology, as well as of the leading Breast Cancer Center. All therapeutic measures meet the modern standards of both national and international specialized societies.

University Hospital Würzburg

9.2/10
location_onGermany, Würzburg

Department of Adult and Pediatric Gynecology, Mammology and Obstetrics

The Department of Adult and Pediatric Gynecology, Mammology and Obstetrics offers the diagnostics and treatment of all gynecological diseases. The department specializes in the treatment of breast cancer and cancer of the female reproductive organs. All traditional and modern conservative and surgical methods are used for this purpose. The department also provides reliable and individual obstetric services at the Center for Mother and Child and offers all methods of prenatal diagnostics.

University Hospital Duesseldorf

9.5/10
location_onGermany, Duesseldorf

Department of Adult and Pediatric Gynecology, Obstetrics and Mammology

According to the Focus magazine rating, the Department of Adult and Pediatric Gynecology, Obstetrics and Mammology ranks among the top German departments specializing in breast cancer treatment! The department offers the full range of services in these medical fields. In the field of gynecology, it provides the diagnostics and treatment of all pathologies of the female reproductive system, including the gynecological problems in girls aged from 0 to 18 years. The department's obstetricians provide quality care for expectant mothers before, during and after pregnancy. The department's scope of activities also includes the management of high-risk pregnancies. The key focus of clinical activities is the treatment of oncological diseases of the female genital organs, including breast cancer.

University Hospital RWTH Aachen

8.9/10
location_onGermany, Aachen

Department of Gynecology, Mammology and Obstetrics

According to the Focus magazine, the Department of Gynecology, Mammology and Obstetrics ranks among the top German medical facilities specializing in breast cancer treatment and provision of obstetric services! The department provides all modern medical services in the fields of its specialization. The gynecologists treat both general and oncological diseases of the female reproductive sphere. Should surgical treatment be required, minimally invasive techniques will be used. The department's mammologists specialize in the treatment of breast cancer using all the classic and innovative therapeutic options. The department is also the Level I Perinatal Center, in which the patient receives the highest quality pregnancy management, comfortable childbirth and postpartum care.

University Hospital Rechts der Isar Munich

9.8/10
location_onGermany, Munich

Department of Gynecology, Mammology, Obstetrics and Perinatal Medicine

As the center of advanced medicine, the Department of Gynecology, Mammology, Obstetrics and Perinatal Medicine offers the full range of services in these fields, providing patients with optimal treatment based on the latest scientific achievements and innovative technologies. The scope of the department's tasks includes the diagnosis and treatment of all gynecological diseases, breast pathologies, as well as the management of pregnancy, childbirth, postpartum care for the mother and baby, elimination of fertility problems.

University Hospital Muenster

9.8/10
location_onGermany, Muenster

Department of Adult and Pediatric Gynecology, Obstetrics

According to the Focus magazine, the Department of Adult and Pediatric Gynecology, Obstetrics ranks among the top German departments specializing in obstetrics! The department offers the full range of diagnostics and treatment of all gynecologic diseases in women and girls. The specialization includes surgical gynecology and gynecologic oncology, obstetrics and perinatal medicine, gynecological endocrinology and reproductive medicine. A special focus is made on the treatment of malignant tumors of the female reproductive organs, which is carried out within the Comprehensive Cancer Center Muenster. All the very latest and most effective treatment methods are available here.

Ovarian cancer is a dangerous disease. At its early stages, it is asymptomatic. In many patients the malignant process has spread throughout the body at the time of diagnosis, and then the disease becomes difficult to treat. But if ovarian cancer is detected at the beginning of its development, the chance of recovery and even preservation of reproductive function is high.

Overview

Ovarian cancer is a malignant disease that usually affects women over the age of 50, but also can develop at an early age. However, in patients of older age groups, ovarian cancer is diagnosed more often. Ovarian cancer is very widespread and ranks second after cervical cancer in the structure of oncological diseases in women.

The presence of a pelvic tumor in combination with ascites usually indicates ovarian cancer, but in some cases, it may be Meigs syndrome (benign ovarian fibroma with ascites and right-sided hydrothorax). Benign functional cysts in young women can also simulate malignant tumors.

Symptoms

Symptoms of ovarian cancer at the early stages are not distinctive, so they can be easily confused with the clinical manifestations of another disease. Ovarian cancer is characterized by latent development, which leads to late diagnosis and high mortality rates.

The group of patients at risk includes:

  • Patients with a genetic predisposition or family history of ovarian and breast cancer
  • Patients who have not had pregnancies
  • Older patients (the risk of developing ovarian cancer increases with age)
  • Overweight patients
  • Patients that have been taking fertility medicine for a long time

It has been proven that the risk of ovarian cancer is increased significantly in taking fertility drugs that stimulate ovulation. The risk increases even more if patients do not become pregnant while taking the drug.

Most women with advanced ovarian cancer have nonspecific symptoms (e.g., indigestion, bloating, early satiety, gas pain, and back pain). Then, as a rule, there are pelvic pain, anemia, cachexia, and an enlarged abdomen due to an increase of the ovary or ascites development.

 Ovarian cancer may manifest itself in the form of:

  • Tumors of unknown etiology in the pelvic area 
  • Bloating
  • Bowel changes
  • Unintentional weight loss
  • Sudden abdominal pain

Some women report severe abdominal pain associated with the torsion of the ovarian tumor.

Diagnostics

At the early stages, ovarian cancer is usually asymptomatic. Tumors of the uterine appendages, that are often solid and heterogeneous, can be discovered by chance. They are usually detected during vaginal and rectal examinations.

Instrumental diagnostics of ovarian cancer includes:

  • Vaginal examination, which clarifies the condition of the uterus and the condition of the uterine appendages
  • Ultrasound scanning of the pelvic organs and retroperitoneal space
  • Computed tomography (CT) of the pelvic organs with intravenous contrast enhancement

With the help of the CT technique and the use of a contrast agent, images of the body are taken in different projections, thus helping to obtain detailed information about organs and systems of the patient’s body. This study allows identifying the presence of a tumor, as well as estimating the stage of the process.

  • CA-125 tumor marker test
  • Complete blood count, biochemical blood tests, coagulation test, urinalysis
  • Blood tests for hepatitis B, C, as well as the test for syphilis (if a surgery is scheduled)
  • ECG (electrocardiogram)
  • Diagnostic laparotomy

Laparotomy allows for a thorough revision of the abdominal and retroperitoneal organs, contributes to the morphological verification of the diagnosis, determination of the features of the tumor, and, most importantly, allows performing surgery for the tumor complete or partial removal.

Treatment

Ovarian cancer is a widespread oncogynecological disease, ranking second in the frequency of occurrence and first in mortality. Among all oncological pathologies in women, ovarian cancer is in fourth place in mortality.

The main methods of ovarian cancer treatment are surgery, drug therapy, and radiation therapy.

At present, surgery is of paramount importance as an independent method and as the stage of the complex treatment protocols.

The standard of primary treatment for advanced ovarian cancer is cytoreductive surgery followed by hyperthermic intraperitoneal chemotherapy (HIPEC). Most patients achieve initial clinical remission using such a combination of surgery and chemotherapy.

Cytoreductive surgery in combination with HIPEC represents a comprehensive treatment approach aimed at the destruction of the tumor, which is considered the most effective method in the treatment of ovarian cancer. This treatment includes the surgical removal of visible tumor and the HIPEC chemotherapy procedure to destroy the microscopic residual malignant cells.

Cytoreductive surgery with hyperthermic intraperitoneal chemoperfusion (HIPEC) provides promising results for patients with advanced primary or recurrent ovarian cancer. For many patients, combination therapy strategy is more beneficial than standard cytoreductive surgery without hyperthermic intraperitoneal chemotherapy.

The essence of the HIPEC technique includes the following. Immediately after a cytoreductive surgery on the peritoneum and abdominal organs, the patient is perfused with a chemotherapeutic solution for 60-90 minutes. The abdominal cavity is washed with a concentrated solution of a chemotherapy drug, heated additionally up to 42-43°C.

The goal of HIPEC is to destroy the maximum of tumor cells that would inevitably remain even after the most careful surgical removal of the malignant lesions.

There is a certain amount of skepticism about HIPEC chemotherapy based on technical difficulties and the potential risk of complications. However, hyperthermic intraperitoneal chemoperfusion (HIPEC) combines advantages of intracavitary administration of a chemotherapy drug (local dose increase), as well as hyperthermia (selective antitumor effect of the method, increased drugs effect, and penetration depth).

The properties that make HIPEC the truly unique technique include:

  • Postoperative adhesions in the abdominal cavity do not interfere with drug penetration
  • During the procedure, intra-abdominal chemotherapy is carried out following strictly standardized rules, and the surgeon can optimally control the time of the chemotherapy
  • The hyperthermic component of the HIPEC increases the cytotoxic effect of chemotherapeutic agents

It is obvious that today, in order to improve long-term results in patients with ovarian cancer, the treatment strategy should be modified.

Cytoreductive surgery can significantly improve outcomes and should be recommended in the treatment of ovarian cancer. The advantage of HIPEC chemotherapy in comparison with the systemic administration of chemotherapy has been proven by numerous studies in medicine.

According to the studies, cytoreductive surgery is the most significant measure for survival in patients with ovarian cancer. HIPEC chemotherapy improves survival and quality of life. HIPEC chemotherapy after the surgery is another treatment approach that has shown long-term improvement in clinical trials.

Where can I undergo CRS and HIPEC treatment in Germany?

Health tourism is becoming more and more popular these days, as medicine in Germany often ensures a much better quality of ovarian cancer treatment.

The following hospitals show the best success rates in ovarian cancer treatment with CRS and HIPEC in Germany:

  1. University Hospital Tuebingen
  2. University Hospital Ulm
  3. University Hospital Carl Gustav Carus Dresden
  4. University Hospital Frankfurt am Main
  5. Charite University Hospital Berlin

You can find more information about the hospitals in Germany on the Booking Health website.

The cost of treatment in Germany

The prices in hospitals listed on the Booking Health website are relatively low. With Booking Health, you can undergo ovarian cancer treatment with CRS and HIPEC abroad at an affordable price.

The cost of treatment varies, as the price depends on the hospital, specifics of the disease, and the complexity of its treatment.

The cost of treatment with HIPEC and CRS in Germany is 38,009-67,767 EUR.

You also need to consider the cost of possible additional procedures and follow-up care. Therefore, the ultimate cost of treatment may differ from the initial price.

To make sure that the overall cost of treatment is suitable for you, contact us by leaving the request on the Booking Health website.

How can I undergo CRS and HIPEC treatment in Germany?

It is not easy to self-organize any treatment abroad. It requires certain knowledge and expertise. Thus, it is safer, easier, and less stressful to shift some responsibility onto a medical tourism agency.

As the largest and most transparent medical tourism agency in the world, Booking Health has up-to-date information about ovarian cancer treatment with CRS and HIPEC in the best hospitals in Germany. Therefore, we will help you select the right clinic taking into account your wishes for treatment in Germany.

We want to help you and take on all the troubles. You can be free of unnecessary stress, while Booking Health takes care of all organizational issues regarding the treatment. Our services aimed at you safely and successfully undergoing ovarian cancer treatment in Germany with CRS and HIPEC.

Medical tourism can be easy! All you need to do is to leave a request on the Booking Health website, and our manager will contact you shortly.




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