Glioblastoma is a malignant neoplasm that arises from glial cells of the brain. The tumor is heterogeneous and requires a differentiated therapeutic approach. When elaborating a treatment regimen, German oncologists take into account the molecular and genetic composition of the tumor and its location in relation to vital parts of the brain. The clinics in Germany offer innovative medical devices and drugs, thanks to which the doctors make maximum use of all therapeutic options. These include surgical resection and irradiation, chemotherapy, immunotherapy, therapy with tumor treatment fields, and experimental gene techniques.
Surgery and radiation therapy are the treatment basis
A surgical procedure is the first step in the comprehensive brain tumor treatment in Germany. The completeness of tumor removal largely determines the success of subsequent therapeutic stages. Glioblastoma can rarely be removed totally since it has infiltrative growth and affects vital regions of the brain.
It is difficult to distinguish the tumor from healthy brain tissue with a naked eye, and therefore fluorescence-guided navigation with 5-ALA is used during surgery. 5-ALA selectively accumulates in cancer cells and provides clear imaging of the glioblastoma growth boundary.
The doctors use a stereotactic technique to increase the accuracy of neurosurgical procedures, which allows for determining the tumor location in a 3D coordinate system using MRI. The surgery can be performed using an open method or minimally invasive catheter techniques (for example, laser ablation with the Visualase system).
Due to the elimination of the remaining cancer cells in the brain, radiation therapy consolidates the result of surgical treatment. The safest irradiation technique is proton therapy.
Proton therapy for brain cancer
Proton therapy is one of the most precise and advanced forms of radiation treatment available for brain tumors. The key advantage of proton therapy for brain cancer in Germany lies in its ability to deliver highly targeted radiation doses. The unique physical properties of protons allow for what's known as the Bragg peak effect – where the maximum dose of radiation is deposited directly in the tumor, with minimal exit dose beyond the target. This translates to significantly reduced radiation exposure to healthy brain tissue, critical structures like the brain stem, and sensitive organs such as the eyes, ears, and pituitary gland.
Clinical studies have demonstrated that proton therapy can achieve excellent local tumor control while maintaining a favorable safety profile. Patients typically experience fewer side effects compared to traditional radiation therapy, which is particularly important for quality of life during and after treatment. The reduced risk of long-term cognitive complications makes proton therapy an especially valuable option for treating brain tumors in sensitive locations or in cases where preserving cognitive function is crucial.
Supportive chemotherapy
As a rule, chemotherapy for brain cancer is not administered as a first-line option since tumor cells mutate rapidly and become resistant to drugs. The indications for chemotherapy include:
- Surgical removal of more than 90% of the tumor volume
- Risk of relapse after the initial intervention
- Relapse of the disease (for slowing the disease progression)
Also, the doctors can administer chemotherapy drugs, if the surgical intervention is contraindicated. In this situation, the drug is administered orally. When chemotherapy complements surgery, the implant with the active substance is placed in the brain, near the tumor. This method of administration can improve the accuracy of the chemotherapy drug delivery, thereby allowing it to penetrate the blood-brain barrier.
Therapy with the tumor treating fields
In 2012, phase III of a randomized clinical trial was completed. This trial studied a fundamentally new method of treating brain cancer, namely the effect of tumor treating fields (TTF). The TTFs have been used in patients with recurrent glioblastoma who have not tolerated supportive chemotherapy. The study showed the same efficacy of TTF and chemotherapy, while TTF had a significant advantage due to the absence of toxicity and a higher quality of life.
In 2015, scientists received additional data on the increase in survival rates when using TTF, after which FDA, the reputable American organization, approved the use of the "Optune" device. The "Optune" and its analogs create an electric field around the neoplasm that suppresses the multiplication of cancer cells. At the same time, the TTF technique guarantees the absence of negative effects on healthy tissues.
Immunotherapy transforms glioblastoma treatment
Glioblastoma has traditionally been considered a "cold tumor," a type of brain cancer in which immunotherapy is ineffective. However, the results of the 2019 studies showed an extension of the period of remission and the life expectancy of patients with neoadjuvant immunotherapy. The studies used monoclonal antibody preparations.
With neoadjuvant administration, monoclonal antibodies form antitumor immunity during the active stage of treatment, when the tumor cannot "mask" and suppress the immune system. As a result, the patient's T-lymphocytes can subsequently recognize and destroy cancer cells.
Prescription of immunotherapy is preceded by mandatory genetic testing since monoclonal antibodies have the best possible effect on the neoplasms with changed MAPK signaling pathways. At the same time, the tumors with PTEN mutations are more resistant.
Dendritic cell therapy for brain cancer
Dendritic cell therapy represents a groundbreaking approach in brain cancer immunotherapy, dramatically improving patient outcomes. While standard treatments alone result in an average life expectancy of 15-17 months after diagnosis, with a 5-year survival rate of only 3-5%, dendritic cell therapy shows remarkable promise. Clinical studies demonstrate that after vaccination with dendritic cells, 60% of patients lived 2 years longer than the average expected time period, and approximately one-third of patients achieved complete remission.
The therapy offers several key advantages:
Treatment efficacy:
- Proven effectiveness at all cancer stages
- Particularly valuable for advanced-stage brain tumors
- Can be effective when conventional treatments fail
Safety and tolerability:
- Minimal side effects due to using the patient's own immune cells
- Patients maintain normal daily activities during treatment
- Excellent safety profile compared to traditional therapies
Long-term benefits:
- Creates persistent immune response against cancer cells
- Significantly reduces relapse risks
- Continues working long after treatment completion
Flexible treatment options:
- Uses tumor tissue from surgery when available
- Modern liquid biopsy allows treatment without tumor tissue
- Can be combined with other therapeutic approaches
As a cutting-edge treatment continuously refined through clinical trials, dendritic cell therapy represents the latest advancement in German brain cancer care. This innovative approach provides new hope for patients across different stages of brain cancer, particularly those seeking safe and effective long-term treatment solutions.
Advanced Cancer Treatment: Patient Success Stories with Booking Health
Patient Testimonials and Success Stories
The effectiveness of brain cancer treatment in Germany is best illustrated through real patient experiences. While each case is unique, numerous patients have reported positive outcomes, particularly when combining traditional treatments with innovative approaches like dendritic cell therapy.
Success stories often highlight the importance of early intervention and comprehensive treatment approaches. Patients frequently note improved tolerance to standard therapies when combined with immunotherapy, enhanced quality of life during treatment, and in many cases, promising scan results during follow-up examinations.
In one recent interview, a patient diagnosed with stage 4 glioblastoma in early 2024 shared her experience of receiving treatment in Germany. The interview details her journey from initial diagnosis through successful treatment combining traditional therapies with dendritic cell immunotherapy. Her story offers insight into the practical aspects of seeking treatment in Germany and the potential benefits of advanced treatment options.
You can watch the interview with Daria Rogers and her husband Morris, recorded in late 2024, to learn more about their personal experience with brain cancer treatment in Germany.
"I Wouldn't Be Here Without This Treatment": Daria Rogers (Ireland) on Beating Brain Cancer in Germany
Experimental gene therapies
Glioblastoma can be different in its histological structure and molecular genetic status. The large University Hospitals and Research Centers carry out genetic testing aimed at finding genes unique to all tumor types.
Such studies resulted in the creation of an MKNK2 hybrid gene. Normally, this gene provides the synthesis of two types of tumor proteins – MKNK2a, which inhibits tumor growth, and MKNK2b, which stimulates tumor growth. The MKNK2 hybrid gene shifts this balance towards the MKNK2a protein. As a result, glioblastoma either becomes smaller in size or disappears completely.
At the moment, the safety and effectiveness of the MKNK2 molecule are being studied in the laboratory on a mouse model. Given the high rates in both parameters, one can hope that people will soon use the technique.
Leading Hospitals and Specialists in Germany
When seeking treatment for brain cancer in Germany, patients have access to world-class medical facilities equipped with cutting-edge technology and staffed by experienced specialists. Here are the leading institutions specializing in brain cancer treatment:
- LDG Laboratories Dr. Gansauge Berg. LDG Laboratories has established itself through pioneering LANEX-DC® dendritic cell immunotherapy. While the clinic is known for treating various types of cancer, their dendritic cell-based immunotherapy shows promise for brain cancer patients, particularly those who haven't responded well to conventional treatments. This innovative therapy activates the patient's immune system through individually created vaccines, offering minimal side effects and convenient outpatient treatment options.
- University Hospital Frankfurt am Main. The hospital's Department of Adult and Pediatric Neurosurgery stands among Germany's premier facilities for brain tumor treatment. Their neuro-oncological expertise is particularly evident in their comprehensive approach to brain cancer care. The center utilizes cutting-edge technologies including functional imaging, image-guided neuronavigation, and intraoperative mapping. Their interdisciplinary tumor boards ensure each brain cancer patient receives optimally coordinated care combining multiple therapeutic approaches, including advanced surgical techniques, targeted chemotherapy, and innovative immunotherapy.
- Asklepios Hospital Barmbek Hamburg. As an academic hospital of the University of Hamburg, Asklepios Barmbek combines modern infrastructure with innovative neuro-oncological approaches. Their neurosurgery department is equipped with state-of-the-art technology for brain tumor treatment, including advanced imaging systems and surgical navigation tools. The facility's expertise in treating brain cancers is supported by their DKG (German Cancer Society) certification and comprehensive care approach, serving both inpatient and outpatient needs with a staff of 1,600 medical professionals.
- Clinic of Advanced Biological Medicine Frankfurt am Main. This specialized facility offers an integrative approach to brain cancer treatment, combining traditional oncology with advanced biological therapies. For brain tumor patients, they develop personalized protocols that integrate conventional treatments with complementary methods. Their approach focuses on strengthening the immune system while managing treatment side effects, particularly important for brain cancer patients. The clinic's treatment plans are customized based on detailed diagnostics and individual clinical indicators specific to neuro-oncological conditions.
- Hyperthermia Center Hannover. The center specializes in alternative cancer treatments, offering various hyperthermia methods that can be particularly beneficial for brain cancer patients. Their approach combines local hyperthermia specifically targeted for brain tumors with holistic medicine. The facility's integrated approach includes both innovative therapies and psychological support, crucial for brain cancer patients. Their outpatient treatment model allows for comprehensive care without extended hospitalization.
Costs for Brain Cancer Treatment in Germany
The cost of brain cancer treatment in Germany varies significantly based on multiple factors. As not all treatments are covered by insurance policies, particularly innovative and experimental therapies, it's crucial for patients to have a clear understanding of potential expenses before beginning treatment. The final price is calculated individually for each patient, taking into account:
- Duration of the treatment course
- Combination of required therapies
- Patient's current health status
- Hospital's level and reputation
- Attending physician's qualification (from ordinator to professor)
- Additional medical procedures and diagnostics needed
| Treatment Type | Price Range (EUR) |
|---|---|
| Surgical tumor removal | 9,600 - 50,200 |
| Proton beam therapy | 46,900 - 86,500 |
| MRI-guided laser ablation | 58,600 - 75,200 |
| CAR T-cell therapy | 450,000 - 550,000 |
| Dendritic cell therapy | 20,000 - 38,000 |
| Monoclonal antibodies therapy | 375,000 - 420,000 |
| Chemotherapy and radiotherapy | 21,100 - 58,400 |
Through established partnerships with Germany's leading medical facilities, Booking Health provides access to these advanced treatments at the most favorable rates. Direct cooperation with top clinics allows Booking Health to secure optimal pricing. The final cost will be calculated based on your individual treatment plan, which is developed after a thorough evaluation of your medical case.
Step-by-Step Guide to Brain Cancer Treatment in Germany
The Process of Getting Started
The journey toward brain cancer treatment in Germany begins with a careful evaluation of your medical case. The first step is to prepare and submit your current medical records, including MRI scans, biopsy results, and previous treatment history. Our medical team reviews these documents within 24-48 hours to determine the most appropriate treatment approach.
Once your case is evaluated, you'll receive a preliminary treatment plan and cost estimate. This includes recommendations from German specialists and potential treatment options. We then help coordinate direct consultations with appropriate specialists, either online or in person, to refine the treatment strategy.
Before arrival, we assist in obtaining necessary medical visas and handling administrative procedures. Our team ensures all required medical documents are properly translated and prepared according to German healthcare standards.
Travel and Accommodation Tips for International Patients
When planning your stay in Germany for medical treatment, consider these practical tips:
- Most major German cities have excellent public transportation systems, but patients should stay within comfortable distance of their treatment facility. Many hotels near hospitals offer special rates for medical patients and their families. Long-term apartment rentals might be more suitable for extended treatment periods.
- The best time to arrive is 2-3 days before your scheduled treatment to account for jet lag and allow time for initial consultations. Major German cities have mild winters and moderate summers, but pack accordingly for the season of your visit.
- Consider practical aspects like having a working mobile phone, downloading translation apps, and familiarizing yourself with basic German medical terms. Many German medical staff speak English, but having key medical phrases in German can be helpful.
- For extended stays, investigate local support groups or patient communities. This network can be invaluable for practical advice and emotional support during your treatment journey.
Booking Health – complete arrangement of glioblastoma treatment in Germany
Glioblastoma treatment in Germany is available to both German citizens and patients from other countries. The foreign patients seek the medical help of German oncologists via the Booking Health international portal.
Booking Health is a medical tourism operator with an established system of cooperation with German clinics. This allows offering patients modern treatment in a short time. The Booking Health specialists will also help you with the following organizational and medical aspects:
- Selection of the clinic, which specializes in glioblastoma treatment
- Direct communication with your attending physician
- Preliminary elaboration of an individual treatment program, without repeating previous examinations
- Provision of the favorable cost of surgery or other types of therapy, without overpricing and additional coefficients for foreign patients (saving up to 50%)
- Making an appointment with a doctor or hospitalization on the desired date
- Independent monitoring of the medical program at all its stages
- Assistance in buying and forwarding medicines
- Communication with the clinic after the medical program completion
- Control of invoices and return of unspent funds
- Organization of additional diagnostic examinations and rehabilitation measures
- Top-class service: booking hotels, airplane tickets, transfer
Please, describe your medical problem in the "Send a request" form on the company’s website, and a competent medical advisor or patient case manager will contact you the same day.
Choose treatment abroad and you will for sure get the best results!
Authors:
The article was edited by medical experts, board certified doctors Dr. Vadim Zhiliuk, Dr. Nadezhda Ivanisova. For the treatment of the conditions referred to in the article, you must consult a doctor; the information in the article is not intended for self-medication!
Our editorial policy, which details our commitment to accuracy and transparency, is available here. Click this link to review our policies.
Sources:
Read:
Article menu:
- Surgery and radiation therapy are the treatment basis
- Supportive chemotherapy
- Therapy with the tumor treating fields
- Immunotherapy transforms glioblastoma treatment
- Patient Testimonials and Success Stories
- Experimental gene therapies
- Leading Hospitals and Specialists in Germany
- Costs for Brain Cancer Treatment in Germany
- Step-by-Step Guide to Brain Cancer Treatment in Germany
- Booking Health – complete arrangement of glioblastoma treatment in GermanyBooking Health – complete arrangement of glioblastoma treatment in Germany
Don't know where to start?
Contact Booking Health
