Active immune system at any age: rejuvenation of immunity with dendritic cells
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Aging affects not only a person's appearance and physical activity but also the state of the immune system. One of the manifestations of age-related changes in immunity is inflammatory aging (inflammaging). Chronic inflammation leads to the development of atherosclerosis, heart attacks, strokes, Parkinson's disease, Alzheimer's disease, diabetes mellitus, and other conditions. In addition, immunosenescence is a risk factor for the development of cancer. Rejuvenation of the immune system with dendritic cells reduces the likelihood of developing incurable chronic diseases and allows a person to lead an active life for longer.
Content
- How is a significant anti-aging effect achieved with dendritic cell therapy?
- How is anti-senescence therapy carried out?
- Results of anti-senescence therapies with dendritic cells
- Body rejuvenation with dendritic cells abroad
How is a significant anti-aging effect achieved with dendritic cell therapy?
Immunosenescence is the inevitable age-related change in innate and acquired immunity. With the help of anti-aging therapy with dendritic cells, doctors can restore the normal functioning of the immune system and prevent the development of many diseases. This happens through three unique mechanisms. These are the following:
- Blocking inflammatory processes. Older people secrete more proinflammatory cytokines. Cytokines are small protein molecules that signal cells to respond with inflammation to an invading virus, bacterium, or other pathogen. At the same time, anti-inflammatory and immunoregulatory cytokine levels decrease, making the inflammatory process more active and uncontrolled. As a result, people suffer from chronic gastritis, chronic pancreatitis, vasculitis, and other diseases. Renewed dendritic cells block uncontrolled inflammation.
- Blocking harmful autoimmune reactions. Normally, the immune system does not react to a person's own antigens, defining them as "self-antigens". Senescent cells of the immune system lose this ability. The result is the development of autoimmune diseases, in which the immune system's attacks are directed at blood vessels, the brain and spinal cord, joints, and other tissues and organs. Due to the injection into the blood of young fractions of dendritic cells, the differences between self-antigens and non-self-antigens again become apparent for immunity.
The best presentation of non-self-antigens to T cells. Young dendritic cells injected from the outside allow a person of any age to respond quickly and effectively to infections and malignant processes, suppressing them at an early stage. The main role of dendritic cells is to help natural killer cells. Dendritic cells help killer cells recognize bacteria, viruses, cancers, and other pathogens. Without the help of dendritic cells, T cells are not able to do their functions effectively, as a result of which a person develops infectious diseases and oncology.
How is anti-senescence therapy carried out?
The renewed dendritic cells of the patients themselves are used for the rejuvenation of the immune system. Before starting a program against aging, a doctor assesses a person's general health condition. The specialist assesses heart function and blood pressure, kidney and liver function, the presence of active inflammatory processes or autoimmune diseases, and the need for constant medication.
When doctors are convinced that there are no contraindications to the procedure, they take 120-200 ml of blood from the patient's vein. This is a small volume that will restore itself on its own within a few weeks. If it is undesirable for a person to lose even a minimal amount of blood, leukapheresis will be performed. This is a procedure for automatic blood filtration with the selection of the necessary cells. In this case, these are monocytes.
Obtained during leukapheresis or from whole blood, monocytes are the precursors of young, immature dendritic cells. They are cultured in the laboratory for several days to increase the number of active dendritic cells that can replace dendritic cells in human aging.
When the number of renewed dendritic cells reaches several million, they are mixed with the patient's T cells. So T cells again learn to distinguish the body's self-antigens from non-self ones, not reacting to the former and actively attacking the latter. This process takes about 7-10 days, after which the resulting drug is administered intravenously in a day hospital. A patient spends several hours under the supervision of a doctor, after which they go home.
Results of anti-senescence therapies with dendritic cells
By increasing the levels of young and active dendritic cells, doctors achieve several results. These are the following:
- Suppression of the activity of autoimmune processes and long-term remission of autoimmune diseases
- Elimination of chronic inflammation and restoration of the function of the affected internal organs against this background
- Increasing the effectiveness of vaccination, including vaccination against cancer and COVID-19
- Prevention and treatment of cancer
- Prevention of infectious diseases
- Prevention of recurrence of previous diseases due to the restoration or formation of immunological memory
Doctors also suggest that certain types of dendritic cells (conventional dendritic cells, cDCs) are involved in the regulation of fat metabolism and, through it, are associated with age-related weight gain, fatty liver degeneration, impaired tissue sensitivity to insulin, the development of diabetes mellitus, and dyslipidemias. This further expands the potential indications for the use of dendritic cells.
Depending on the specific clinical situation, medical specialists elaborate individual regimens for the injection of dendritic cells. This may be a drug to suppress a specific autoimmune reaction or a vaccine to treat cancer.
Body rejuvenation with dendritic cells abroad
Dendritic cell therapy is a modern technique that is not available in all hospitals. In addition to experienced specialists, hospitals should have their own laboratories for the cultivation of dendritic cells and the manufacture of individual preparations with them. If such treatment is not yet available in your native country, you can get it abroad by using Booking Health services. Booking Health is an expert in the field of medical tourism that provides information about hospitals, healthcare professionals and average cost of treatment.
The company has been organizing the treatment of patients from 75 countries in the world's leading hospitals for more than 12 years. Booking Health operates in accordance with strict international standards. The specialists at the Booking Health company will help you:
- Select a hospital with high success rates for rejuvenation and treatment with dendritic cells
- Get a preliminary remote consultation with a doctor from a foreign hospital
- Undergo your treatment quickly and on your preferred dates
- Look at a preliminary treatment program and understand the essence of medical procedures
- Get medical care at a lower price by eliminating high taxes for foreign patients (save up to 50%)
- Control the cost of medical and related services
- Buy medicines to continue your treatment at home
- Maintain contact with the clinic after the completion of your treatment
- Have additional diagnostic procedures or treatment if needed
You will also receive top-class organizational service, including booking hotels, airline tickets, and transfers. You will be accompanied by an interpreter at the hospital. Your personal medical coordinator will control the treatment process together with the Booking Health doctors.
Choose treatment abroad and you will for sure get the best results!
See the interview for more information:
INNOVATIVE DENDRITIC CELL TREATMENT IN GERMANY – interview with Prof. Dr. med. Frank Gansauge
Authors:
The article was edited by medical experts, board certified doctors Dr. Nadezhda Ivanisova and Dr. Vadim Zhiliuk. For the treatment of the conditions referred to in the article, you must consult a doctor; the information in the article is not intended for self-medication!
Our editorial policy, which details our commitment to accuracy and transparency, is available here. Click this link to review our policies.
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