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Treatment of Myelofibrosis

Due to the difficulties associated with the organization of treatment in Turkey, Switzerland, South Korea and India, we are not currently processing requests to these regions.

If you are interested in treatment in Germany, please leave a request and our specialists will contact you as soon as possible.

 

Cost for treatment

Myelofibrosis Diagnosis
 from  1638
Allogeneic bone marrow transplantation in myelofibrosis
 from  97328
Cancer rehabilitation
 from  951

University Hospital Mannheim

9.8/10
location_onGermany, Mannheim

Department of Hematology and Oncology

According to the reputable Focus magazine, the University Hospital Mannheim ranks among the top medical institutions of Germany, which is an undeniable confirmation of the impeccable medical care and excellent reputation of the hospital! The hospital is a high-tech modern medical institution, which provides accurate diagnosis an
Myelofibrosis Diagnosis
3115
Allogeneic bone marrow transplantation in myelofibrosis
212370

University Hospital Ulm

8.7/10
location_onGermany, Ulm

Department of Hematology, Oncology, Palliative Care, Rheumatology and Infectology

The University Hospital Ulm started its activities 35 years ago and during this time it has become one of the most prestigious medical institutions in Europe. The hospital is famous for its numerous discoveries and the world-class achievements in medicine and pharmaceuticals. The medical facility has 29 specialized departments a
Myelofibrosis Diagnosis
3485
Allogeneic bone marrow transplantation in myelofibrosis
271581

University Hospital Freiburg

9.7/10
location_onGermany, Freibung

Department of Hematology and Oncology

The University Hospital Freiburg is famous for its rich history and is one of the oldest and most prestigious medical facilities in Germany (one of the three best medical institutions in the country). The hospital was based on the Faculty of Medicine of the Albert Ludwig University of Freiburg, which celebrated its 550th anniver
Myelofibrosis Diagnosis
3593
Allogeneic bone marrow transplantation in myelofibrosis
291419

University Hospital Heidelberg

9.8/10
location_onGermany, Heidelberg

Department of Hematology, Oncology, Adult and Pediatric Rheumatology

According to the Focus magazine, the University Hospital Heidelberg ranks among the top five hospitals in Germany! The hospital is one of the most advanced and reputable medical institutions not only in Germany, but throughout Europe. There are more than 43 specialized departments and 13 medical institutes, which cover all field
Myelofibrosis Diagnosis
0
Allogeneic bone marrow transplantation in myelofibrosis
0

University Hospital Frankfurt am Main

10/10
location_onGermany, Frankfurt am Main

Department of Hematology, Oncology, Hemostaseology, Rheumatology and Infectology

According to the reputable Focus magazine, the University Hospital Frankfurt am Main ranks among the top German medical facilities! The hospital was founded in 1914 and today is a well-known German medical facility, which combines rich traditions and scientific innovations. A medical team of more than 6,500 employees cares about
Myelofibrosis Diagnosis
3393
Allogeneic bone marrow transplantation in myelofibrosis
251480

University Hospital RWTH Aachen

8.7/10
location_onGermany, Aachen

Department of Oncology and Hematology

According to the prestigious Focus magazine, the University Hospital RWTH Aachen ranks among the top German hospitals! As a maximum care university medical facility, the hospital guarantees patients first-class medical services combined with a respectful and human attitude. The hospital integrates all the modern options for the
Myelofibrosis Diagnosis
3638
Allogeneic bone marrow transplantation in myelofibrosis
291388

University Hospital Würzburg

9.2/10
location_onGermany, Würzburg

Department of Gastroenterology, Hematology, Oncology, Hepatology, Infectology, Rheumatology and Clinical Immunology

According to the Focus magazine in 2019, the University Hospital Würzburg ranks among the top national German hospitals! The hospital is one of the oldest medical facilities in Germany. The centuries-old traditions of first-class treatment are combined with the very latest achievements of modern evidence-based medicine and
Myelofibrosis Diagnosis
3204
Allogeneic bone marrow transplantation in myelofibrosis
232324

University Hospital Erlangen

9.1/10
location_onGermany, Erlangen

Department of Hematology and Oncology

According to the Focus magazine, the University Hospital Erlangen ranks among the top German medical facilities! The hospital is one of the leading medical facilities in Bavaria and offers the highest level of medical care, which is characterized by the close intertwining of clinical activities with research and training of medi
Myelofibrosis Diagnosis
3588
Allogeneic bone marrow transplantation in myelofibrosis
271503

University Hospital Halle (Saale)

9.6/10
location_onGermany, Halle

Department of Hematology and Oncology

According to the prestigious Focus magazine, the University Hospital Halle (Saale) ranks among the top German medical facilities! The history of the hospital has more than 300 years, and during this time it managed to earn an excellent reputation not only in Germany, but throughout the world. The hospital positions itself as a s
Myelofibrosis Diagnosis
3202
Allogeneic bone marrow transplantation in myelofibrosis
231869

University Hospital Hamburg-Eppendorf

9.2/10
location_onGermany, Hamburg

Department of Hematology, Oncology and Pulmonology

According to the Focus magazine, the University Hospital Hamburg-Eppendorf ranks among the top ten hospitals in Germany! Since its foundation in 1889, the hospital has taken a leading position in the European medical arena and still occupies it until today. A highly competent medical team of more than 11,000 employees takes care
Myelofibrosis Diagnosis
3184
Allogeneic bone marrow transplantation in myelofibrosis
232096

Charite University Hospital Berlin

9/10
location_onGermany, Berlin

Charité Comprehensive Cancer Center

According to the authoritative Focus magazine, the Charite University Hospital Berlin occupies the first place in the rating of the top German medical facilities! The hospital is one of the largest and leading university medical complexes in Europe. The hospital in Germany provides modern diagnostics and treatment of patients, a
Myelofibrosis Diagnosis
3135
Allogeneic bone marrow transplantation in myelofibrosis
232159

University Hospital Bonn

9.2/10
location_onGermany, Bonn

Department of Oncology, Hematology, Rheumatology and Immunoncology

According to the authoritative Focus magazine, the University Hospital Bonn ranks among the top ten medical facilities in Germany! The hospital was opened on January 1, 2001, although in fact it inherits the medical facility, which operated at the Faculty of Medicine of the University of Bonn. The hospital in Germany combin
Myelofibrosis Diagnosis
3648
Allogeneic bone marrow transplantation in myelofibrosis
290975

University Hospital Giessen UKGM

9.5/10
location_onGermany, Giessen

Department of Oncology, Hematology and Palliative Care

The University Hospital Giessen UKGM positions itself as an ultramodern medical facility with outstanding quality of medical care. The hospital presents almost all areas of medicine, ranging from ophthalmology to traumatology and dentistry. The priorities of the hospital’s activities include surgery, neurosurgery, oncology
Myelofibrosis Diagnosis
3273
Allogeneic bone marrow transplantation in myelofibrosis
231898

University Hospital of Ludwig Maximilian University of Munich

10/10
location_onGermany, Munich

Department of Oncology and Hematology

According to the Focus magazine, the University Hospital of Ludwig Maximilian University of Munich is regularly ranked among the best medical institutions in Germany! The hospital is the largest multidisciplinary medical facility, as well as a leading research and training center in Germany and Europe. The hospital is proud of i
Myelofibrosis Diagnosis
3764
Allogeneic bone marrow transplantation in myelofibrosis
291151

University Hospital Marburg UKGM

8.6/10
location_onGermany, Marburg

Department of Hematology, Oncology and Immunology

The University Hospital Marburg UKGM offers patients modern diagnostics and comprehensive therapy at the international level. As a maximum care hospital, the medical facility specializes in all fields of modern medicine ranging from ophthalmology to traumatology and dentistry. The main areas of specialization of the hospital are
Myelofibrosis Diagnosis
3223
Allogeneic bone marrow transplantation in myelofibrosis
231799

University Hospital Muenster

9.8/10
location_onGermany, Muenster

Department of Hematology, Hemostaseology, Oncology and Pulmonology

According to the Focus magazine, the University Hospital Muenster ranks among the top German hospitals! The hospital belongs to the most prestigious medical institutions in Germany. The hospital is distinguished by a high professionalism of its doctors, state-of-the-art technological equipment and the availability of the most ad
Myelofibrosis Diagnosis
3175
Allogeneic bone marrow transplantation in myelofibrosis
232101
| from Booking Health GmbH

Content

  1. Symptoms and clinical course
  2. Diagnostics
  3. Treatment in Germany
  4. Organization of treatment abroad

 

Myelofibrosis is a condition of unknown origin characterized by red bone marrow fibrosis and impaired blood formation. The pathology is characterized by the formation of extramedullary (located outside the red bone marrow) foci of blood formation. Nevertheless, the produced cells are inferior. As a result, the person develops anemia, blood clotting disorders.

Symptoms and clinical course

 

According to the 2008 WHO classification, myelofibrosis belongs to myeloproliferative neoplasms. It is associated with the transformation of the pluripotent hematopoietic stem cell, enhanced with the production of myeloid and stromal cells. This condition is characterized by both early and rapid progression of bone marrow fibrosis with the development of extramedullary foci of pathological hematopoiesis.  

In 90% of cases, the disease develops after 40 years. At the time of diagnostics of this pathology, most patients are between 50 and 70 years of age. Myelofibrosis is diagnosed in young patients only in single cases. The average life expectancy of patients after the diagnosis is 5 years.

The symptoms develop gradually. The patient does not immediately seek help, and therefore myelofibrosis can be diagnosed only 1-2 years later after the onset of the disease. The size of the spleen helps approximately determine disease duration. In myelofibrosis, it increases by an average of 1 cm per year.

Initial symptoms:

  • pallor;
  • fatigue;
  • loss of appetite;
  • weight loss;
  • fever;
  • jaundice.

5% of patients do not have any symptoms. Their disease is diagnosed by chance, after the detection of an enlarged spleen. It can be quite impressive in size and often squeezes adjacent organs.

30% of patients are diagnosed with enlarged lymph nodes. The patients often complain of spontaneous bone pain. It may aggravate with palpation.

Diagnostics

 

There are various options of the course of the disease. The clinical form of myelofibrosis determines the changes that will be detected in the blood.  The prevailing symptoms are also determined by them.

In total, there are 6 clinical forms:

  • classic;
  • thrombocythemic;
  • anemic with and without reticulocytosis;
  • erythemic;
  • thrombocytopenic.

The classic form of myelofibrosis is characterized by moderate blood leukocytosis, increased number of neurophils, decreased levels of hemoglobin with a change in the form of erythrocytes. Platelet count is normal or slightly increased, while the appearance of platelets changes. There are often found giant forms of platelets.

Features of other clinical forms:

  • The thrombocythemic form is characterized by the increased number of platelets due to their enhanced production. There also develops hypercoagulation and tendency to thrombosis.
  • On the contrary, the thrombocytopenic form is characterized by the very low levels of platelets. There is a tendency to bleed. 
  • The anemic form may develop due to the bone marrow dysfunction. In this case, there is no reticulocytosis. If the mechanism of anemia development becomes the destruction of red blood cells (hemolysis), it results in the increased number of reticulocytes (young forms of cells) in the blood.
  • The erythemic form is characterized by the increased levels of erythrocytes and hemoglobin, impaired microcirculation.

The diagnostics primarily involves the use of complete blood count, which may be a means to suspect the presence of oncohematological disease, as well as cytological bone marrow examination. To conduct it, the doctors make a biopsy. The bone marrow examination allows for the differential diagnostics with other myeloproliferative tumors.  

Treatment in Germany

 

Conservative therapy does not allow cure myelofibrosis. The drugs that are currently used can only improve the quality of human life, reduce symptoms and increase life expectancy. Nonetheless, the disease will still progress and eventually lead to death.

The conservative therapy may involve the use of:

  • cytostatic drugs (chemotherapy) in the myeloproliferative stage of the disease;
  • glucocorticoids;
  • transfusion of platelet and red blood cells at the stage of bone marrow failure;
  • interferons;
  • irradiation or removal of the spleen.

Complete cure of myelofibrosis can be achieved only with the help of allogeneic stem cell transplantation. This procedure is also called a bone marrow transplant from a donor.

The donor may be a close relative of the patient, if he has sufficient compatibility. The brothers and sisters are checked first of all. The probability of compatibility is about 25%. If not, one can use the donor base to search for suitable stem cells.

The transplantation is performed after preliminary preparation. As a rule, donor’s stem cells are obtained from blood. Then they are cultivated to obtain the required amount.

A patient with myelofibrosis undergoes high-dose chemotherapy. This therapy allows for a complete destruction of the remaining stem cells in the body. To reduce side effects, the patient undergoes symptomatic therapy, which is followed by stem cell transplantation performed under general anesthesia.

During the entire period of treatment, a person stays in the sterile isolation, as his immunity is completely destroyed and cannot resist infections for some time. However, the transplanted stem cells gradually begin to divide and produce the formed elements of the blood. Thus, the patient restores his immunity.

The treatment of myelofibrosis with stem cells has both advantages and disadvantages. The disadvantages are as follows: 

  • The high treatment costs (it costs about 200 thousand euros in Germany).
  • The procedure is unsafe, since the mortality rate for patients under 35 years old is 5-10%, whereas for the elderly it reaches 30%.
  • There is a risk of developing a graft-versus-host-disease in case of insufficient histocompatibility with the donor.  
  • There is a risk of developing infectious complications in the early postoperative period.  

But all these disadvantages are outweighed by one significant advantage. Stem cell transplantation remains the only way to cure myelofibrosis. All other methods of therapy can only delay the approach of death.

Organization of treatment abroad

 

You can visit the best clinics abroad to get an adequate therapy for myelofibrosis. Booking Health can arrange a trip to Germany for you. German clinics perform stem cell transplantation. This country has a huge base of donors, and therefore each person can receive the best option in terms of histocompatibility.

Our services and benefits:

  • We will choose for you the best clinic abroad, which shows good statistics in the treatment of myelofibrosis.
  • The treatment costs will be significantly lower due to the absence of extra charges for foreign patients.
  • We will establish communication with the doctors of the clinic and its administration.
  • We will help control the treatment program.
  • We will plan the program taking into account the previous examinations without their repeated conduction.
  • We will ensure invoice verification with the return of unspent funds after the end of the program.
  • We will help you purchase and send medicines.
  • We will organize additional examination and treatment, if necessary.

Booking Health will also provide services, such as booking of the airline tickets and hotels, transfer from the airport to the clinic and back.

Authors: Dr. Nadezhda Ivanisova, Dr. Sergey Pashchenko




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