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Treatment of Neuroendocrine Tumors (NETs) in Germany

Due to the difficulties associated with the organization of treatment in Turkey, Switzerland, South Korea and India, we are not currently processing requests to these regions.

If you are interested in treatment in Germany, please leave a request and our specialists will contact you as soon as possible.

 

Cost for treatment

Diagnosis of neuroendocrine tumors (NETs)
1010
Chemotherapy in neuroendocrine tumors (NETs)
2383
Neuroendocrine Tumors (NETs) Treatment with Lutetium-177-DOTATATE
13965

University Hospital Duesseldorf

8.5/10
location_onGermany, Duesseldorf

Department of Gastroenterology, Hepatology and Infectology

According to the authoritative Focus magazine, the University Hospital Duesseldorf ranks among the top Germany hospitals! The hospital is an excellent example of a combination of high-quality health care, research and teaching activities. With more than 50,000 inpatients and about 300,000 outpatients every year, the hospital is
Diagnosis of neuroendocrine tumors (NETs)
3846
Chemotherapy in neuroendocrine tumors (NETs)
7348
Neuroendocrine Tumors (NETs) Treatment with Lutetium-177-DOTATATE
16518

University Hospital of Ludwig Maximilian University of Munich

10/10
location_onGermany, Munich

Department of Gastroenterology and Hepatology

According to the Focus magazine, the University Hospital of Ludwig Maximilian University of Munich is regularly ranked among the best medical institutions in Germany! The hospital is the largest multidisciplinary medical facility, as well as a leading research and training center in Germany and Europe. The hospital is proud of i
Diagnosis of neuroendocrine tumors (NETs)
3871
Chemotherapy in neuroendocrine tumors (NETs)
8535
Neuroendocrine Tumors (NETs) Treatment with Lutetium-177-DOTATATE
16736

University Hospital Ulm

8.7/10
location_onGermany, Ulm

Department of Gastroenterology and Hepatology

The University Hospital Ulm started its activities 35 years ago and during this time it has become one of the most prestigious medical institutions in Europe. The hospital is famous for its numerous discoveries and the world-class achievements in medicine and pharmaceuticals. The medical facility has 29 specialized departments a
Diagnosis of neuroendocrine tumors (NETs)
3790
Chemotherapy in neuroendocrine tumors (NETs)
8276
Neuroendocrine Tumors (NETs) Treatment with Lutetium-177-DOTATATE
15763

PAN Clinic Cologne

9/10
location_onGermany, Cologne

Department of Proctology and Endoscopy

The PAN Clinic Cologne is a multidisciplinary medical facility that combines advanced medicine, excellent quality of patient care and a high level of comfort. Founded in 1999, the clinic is located in the very heart of Cologne. During this time, the medical complex has gained long clinical experience, but at the same time it has
Diagnosis of neuroendocrine tumors (NETs)
3807

University Hospital Frankfurt am Main

10/10
location_onGermany, Frankfurt am Main

Department of Gastroenterology, Hepatology, Pulmonology, Allergology, Endocrinology and Diabetology

According to the reputable Focus magazine, the University Hospital Frankfurt am Main ranks among the top German medical facilities! The hospital was founded in 1914 and today is a well-known German medical facility, which combines rich traditions and scientific innovations. A medical team of more than 6,500 employees cares about
Diagnosis of neuroendocrine tumors (NETs)
3485
Chemotherapy in neuroendocrine tumors (NETs)
7733
Neuroendocrine Tumors (NETs) Treatment with Lutetium-177-DOTATATE
15203

University Hospital Heidelberg

9.8/10
location_onGermany, Heidelberg

Department of Gastroenterology, Hepatology and Infectology

According to Focus magazine, the University Hospital Heidelberg ranks among the top five hospitals in Germany! The hospital is one of the most advanced and reputable medical institutions not only in Germany, but throughout Europe. There are more than 43 specialized departments and 13 medical institutes, which cover all fields of
Diagnosis of neuroendocrine tumors (NETs)
0
Chemotherapy in neuroendocrine tumors (NETs)
0
Neuroendocrine Tumors (NETs) Treatment with Lutetium-177-DOTATATE
0

University Hospital Würzburg

9.2/10
location_onGermany, Würzburg

Department of Gastroenterology, Hematology, Oncology, Hepatology, Infectology, Rheumatology and Clinical Immunology

According to the Focus magazine in 2019, the University Hospital Würzburg ranks among the top national German hospitals! The hospital is one of the oldest medical facilities in Germany. The centuries-old traditions of first-class treatment are combined with the very latest achievements of modern evidence-based medicine and
Diagnosis of neuroendocrine tumors (NETs)
3355
Chemotherapy in neuroendocrine tumors (NETs)
7491
Neuroendocrine Tumors (NETs) Treatment with Lutetium-177-DOTATATE
14882

University Hospital Bonn

9.2/10
location_onGermany, Bonn

Department of Gastroenterology, Hepatology, Nephrology, Infectology, Endocrinology and Diabetology

According to the authoritative Focus magazine, the University Hospital Bonn ranks among the top ten medical facilities in Germany! The hospital was opened on January 1, 2001, although in fact it inherits the medical facility, which operated at the Faculty of Medicine of the University of Bonn. The hospital in Germany combin
Diagnosis of neuroendocrine tumors (NETs)
3929
Chemotherapy in neuroendocrine tumors (NETs)
8442
Neuroendocrine Tumors (NETs) Treatment with Lutetium-177-DOTATATE
16911

University Hospital Carl Gustav Carus Dresden

9.1/10
location_onGermany, Dresden

Department of Gastroenterology and Hepatology

According to the reputable Focus magazine, the University Hospital Carl Gustav Carus Dresden ranks among the top five German hospitals! The hospital is the benchmark for modern high-quality medicine. Positioning itself as a maximum care medical facility, the hospital represents all medical fields. There are 26 specialized depart
Diagnosis of neuroendocrine tumors (NETs)
4383
Chemotherapy in neuroendocrine tumors (NETs)
9649
Neuroendocrine Tumors (NETs) Treatment with Lutetium-177-DOTATATE
19327

University Hospital Hamburg-Eppendorf

9.2/10
location_onGermany, Hamburg

Department of Gastroenterology, Hepatology and Infectology

According to the Focus magazine, the University Hospital Hamburg-Eppendorf ranks among the top ten hospitals in Germany! Since its foundation in 1889, the hospital has taken a leading position in the European medical arena and still occupies it until today. A highly competent medical team of more than 11,000 employees takes care
Diagnosis of neuroendocrine tumors (NETs)
4560
Chemotherapy in neuroendocrine tumors (NETs)
7407
Treatment of neuroendocrine tumor (NET) of the appendix with chemotherapy
7400

Charite University Hospital Berlin

9/10
location_onGermany, Berlin

Department of Hepatology and Gastroenterology

According to the authoritative Focus magazine, the Charite University Hospital Berlin occupies the first place in the rating of the top German medical facilities! The hospital is one of the largest and leading university medical complexes in Europe. The hospital in Germany provides modern diagnostics and treatment of patients, a
Diagnosis of neuroendocrine tumors (NETs)
5097
Chemotherapy in neuroendocrine tumors (NETs)
7353
Neuroendocrine Tumors (NETs) Treatment with Lutetium-177-DOTATATE
21700

University Hospital RWTH Aachen

8.7/10
location_onGermany, Aachen

Department of Gastroenterology, Metabolic Disorders and Internal Intensive Care

According to the prestigious Focus magazine, the University Hospital RWTH Aachen ranks among the top German hospitals! As a maximum care university medical facility, the hospital guarantees patients first-class medical services combined with a respectful and human attitude. The hospital integrates all the modern options for the
Diagnosis of neuroendocrine tumors (NETs)
3870
Chemotherapy in neuroendocrine tumors (NETs)
8683
Neuroendocrine Tumors (NETs) Treatment with Lutetium-177-DOTATATE
16953

University Hospital Marburg UKGM

8.6/10
location_onGermany, Marburg

Department of Gastroenterology, Endocrinology, Metabolism and Clinical Infectology

The University Hospital Marburg UKGM offers patients modern diagnostics and comprehensive therapy at the international level. As a maximum care hospital, the medical facility specializes in all fields of modern medicine ranging from ophthalmology to traumatology and dentistry. The main areas of specialization of the hospital are
Diagnosis of neuroendocrine tumors (NETs)
3352
Chemotherapy in neuroendocrine tumors (NETs)
7509
Neuroendocrine Tumors (NETs) Treatment with Lutetium-177-DOTATATE
15978

University Hospital Jena

8.9/10
location_onGermany, Jena

Department of Gastroenterology, Hepatology and Infectology

According to the prestigious Focus magazine, the University Hospital Jena regularly ranks among the top German medical facilities! The hospital has positioned itself as a multidisciplinary medical facility with a long history of more than 200 years. Since its foundation, the hospital has been constantly developing and modernizin
Diagnosis of neuroendocrine tumors (NETs)
3904
Chemotherapy in neuroendocrine tumors (NETs)
7519
Neuroendocrine Tumors (NETs) Treatment with Lutetium-177-DOTATATE
16594

University Hospital Halle (Saale)

9.6/10
location_onGermany, Halle

Department of Gastroenterology, Hepatology and Pulmonology

According to the prestigious Focus magazine, the University Hospital Halle (Saale) ranks among the top German medical facilities! The history of the hospital has more than 300 years, and during this time it managed to earn an excellent reputation not only in Germany, but throughout the world. The hospital positions itself as a s
Diagnosis of neuroendocrine tumors (NETs)
3629
Chemotherapy in neuroendocrine tumors (NETs)
7519
Neuroendocrine Tumors (NETs) Treatment with Lutetium-177-DOTATATE
14684

University Hospital Rechts der Isar Munich

9.8/10
location_onGermany, Munich

Department of Gastroenterology, Hepatology, Endocrinology and Infectology

The University Hospital Rechts der Isar Munich was founded in 1834. It combines long traditions with the very latest advances in modern medicine. The medical facility includes 33 specialized departments and 20 interdisciplinary centers, where patients can receive top-class medical care in all medical fields. The hospital annuall
Diagnosis of neuroendocrine tumors (NETs)
3905
Chemotherapy in neuroendocrine tumors (NETs)
8722
Neuroendocrine Tumors (NETs) Treatment with Lutetium-177-DOTATATE
16768
| from Booking Health GmbH

Content

  1. Overview
  2. Symptoms
  3. Diagnostics
  4. Treatment
  5. Where can I undergo treatment of neuroendocrine tumors in Germany?
  6. The cost of treatment in Germany
  7. How can I undergo treatment of neuroendocrine tumors in Germany?

 

Neuroendocrine tumors (NET) are pathological formations originating from cells of the endocrine or nervous system. NETs most often develop in the intestines, but it can also affect the pancreas, lungs, and other parts of the body. Malignant NETs are rare and are usually diagnosed at an advanced stage of the disease.

Overview

 

Neuroendocrine tumors (NETs) are the common term for a diverse group of tumors that develop from neuroendocrine cells. Neuroendocrine tumors (NETs) are a heterogeneous group of neoplasms with biologically active properties. Neuroendocrine cells have certain secretory characteristics that cause the development of syndromes of overproduction of regulatory peptides, which can lead to the development of the corresponding clinical manifestations.

A neuroendocrine tumor is a formation from neuroendocrine cells located in epithelial tissues. Neuroendocrine cells produce bioactive substances that have various regulatory functions. Since these cells are located in so many body regions, neuroendocrine tumors have a variety of localizations, different growth patterns, clinical manifestations, etc. NETs can be both benign and malignant. The most common of them are insulinoma, gastrinoma, glucagonoma, and neurinoma.

These single cells are located in different organs and are part of humoral regulation, while simultaneously participating in the work of the nervous and hormonal systems. They can absorb amino acids and convert them into substances that transmit nerve impulses (neurotransmitters). Additionally, the same cells produce the following peptide hormones from amino acids.

These hormones bind to special receptors on the surface of cells and stimulate internal biochemical processes. Thus, hormone-like substances produced by the tumor affect all systems of the body. This causes a carcinoid syndrome, i.e. a pathological condition that involves all organs and systems.

The independent degeneration of such elements is very rare; therefore neuroendocrine tumors are rare and poorly studied. The main causes of their development are stress, hormonal abnormalities, exposure to carcinogenic factors (radiation, heavy metals). The most likely locations are the respiratory (25% of cases) and digestive systems (60% of cases). The tumor usually grows slowly and causes various endocrine disorders, depending on the hormones and neurotransmitters produced.

In medicine, neuroendocrine tumors are divided into groups according to their location and the main substances produced. Neuroendocrine tumors are characterized by two main features that also determine the treatment tactics. The first factor is the organ in which the tumor has formed. The second factor is the rate of cell division.

Carcinoids are most commonly found in the lungs and small intestine. The term carcinoid tumor is best used to describe NETs that develop from aerodigestive tissues and are well- or moderately differentiated. NETs with a moderately differentiated grade are also called atypical carcinoids, while poorly differentiated NETs are sometimes considered small cell carcinomas. If the cells of the tumor and the structure of the tumor’s tissue resemble normal cells and tissues, the tumor is called well-differentiated. Carcinoids are always malignant. The most aggressive form of the carcinoid is the large cell carcinoid. It produces serotonin and histamine.

Most neuroendocrine tumors originate in the gastrointestinal tract. These neoplasms are divided into two types depending on the source of the tumor process – whether they start in the intestine or the pancreas. In some patients, the development of the disease is associated with gene mutations.

The most frequent localization of NETs (66% of cases) is the gastrointestinal tract. The predominant locations are the cecum (17.1% of cases) and the rectum (16.3% of cases). About 30% of NETs are found in the bronchopulmonary system.

Neuroendocrine tumors are a rare type of cancer. Now, due to the improvement of diagnostic methods, the number of cases of neuroendocrine tumors detected annually is increasing. The symptoms of the disease are nonspecific, which makes it difficult to diagnose it at the early stage. Therefore, healthcare professionals recommend undergoing preventative examinations, whether symptoms manifest or don’t.

Symptoms

 

The main symptoms that patients with neuroendocrine tumors may experience are:

  • Face blushes
  • Losing weight
  • Heartburn
  • Hypoglycemia
  • Violation of food passing
  • Diarrhea
  • Cholelithiasis
  • Erythema
  • Hypotension
  • Disturbances of the heart rhythm
  • Cushing's syndrome

Depending on the localization of NETs, one or another symptom predominates.

With hormonally active neuroendocrine tumors patients may experience:

  • Hot flashes, low blood pressure, stool disturbances, abdominal pain
  • Loss of appetite, nausea, and diarrhea, weight loss with swelling of the face and limbs
  • Increased sweating, trembling of the limbs, blurred vision, confused consciousness, convulsions
  • Single and multiple small ulcers in various parts of the gastrointestinal tract
  • Diabetes mellitus, stomatitis, glossitis, depression

With hormonally inactive tumors, there are no specific clinical manifestations and complaints, but the risk of malignancy remains.

Neuroendocrine tumors are neoplasms that produce hormones and have features of nervous cells at the same time.

NETs are diagnosed with hormone tests, US scan, CT scan and MRI, biopsy with molecular testing.

NETs include neoplasms of gastrointestinal tract, adrenal glands, lungs, genitourinary tract, and skin.

University Hospital Duesseldorf, University Hospital of Ludwig Maximilian University of Munich, University Hospital Ulm, PAN Clinic Cologne, University Hospital Frankfurt am Main.

Approximate costs are as follows:

Medical program

Price in Germany

Diagnostics

from 1,010 EUR

Surgery

from 12,579 EUR

Chemotherapy

from 2,252 EUR

Treatment with Lutetium-177 PSMA

from 13,310 EUR

Diagnostics

 

Since NETs can involve different types of cells that perform different functions in the body of patients, symptoms can be very different. In addition to non-specific symptoms such as abdominal pain, constipation, and anemia, specific symptoms such as acromegaly (marked enlargement of the hands, feet, skull, or protruding body parts), Cushing's syndrome, or gastrointestinal ulcers may occur.

In the descending by frequency order, NETs are detected in the appendix (cecum), small intestine, rectum, and bronchi. In the presence of metastases in the liver, the already mentioned carcinoid syndrome often develops. The signs of carcinoid syndrome are redness of the face, diarrhea, narrowing of the bronchi, low blood pressure, etc.

During a visit, a doctor collects anamnesis of patients and conducts examination. After that, various laboratory parameters and the level of hormones in the patients’ blood will be determined. Then imaging methods will be applied, which include X-ray examination, ultrasound scanning, computed or magnetic resonance imaging (CT / MRI), bone scintigraphy, and especially – positron emission tomography (PET).

Often, a tissue sample is taken from the affected organ for further histological and immunohistochemical research during the endoscopic examination.

Laboratory identification of bioactive substances produced by neuroendocrine cells in blood/urine is very important for the diagnosis of neuroendocrine tumors.

Treatment

 

Recently, oncologists have been increasingly using drugs that destroy neuroendocrine tumor cells by delivering a targeted dose of radiation to them. It is a safe method of treatment of cancer patients, which has proven effectiveness in the treatment of thyroid cancer, neuroendocrine tumors, some brain tumors (meningiomas), and prostate cancer. Such treatment is currently possible with the use of a drug labeled with the isotope Lutetium-177.

Peptide receptor radionuclide therapy is a molecularly targeted procedure for the treatment of patients with neuroendocrine tumors (NETs). In the last decade, this type of therapy has been used in Europe to improve the prognosis in patients with NETs.

Drugs for peptide receptor radionuclide therapy are solutions that are administered intravenously for 10-20 minutes. After that, the doctors monitor patients’ condition for at least 48 hours. Usually, for each injection of the drug, patients are hospitalized for 4-5 days. A total of 3 to 5 treatment cycles are needed, with intervals of 8 weeks. The effectiveness of the drug is checked using scintigraphy combined with computed tomography. During treatment, blood tests are performed; kidney and liver function is monitored.

NET cells usually express receptors for the hormone somatostatin. Peptide receptor radionuclide therapy uses radiopharmaceuticals, in which a radioactive isotope is bound to a tumor-targeting protein (peptide) – an analogue of somatostatin. When radiopharmaceuticals enter the bloodstream via intravenous injection, they bind to somatostatin receptors on the surface of NET cells. Tumor cells absorb the radioactive substance and die.

This therapy is called targeted, since the drug targets tumor cells without causing harm to healthy tissues of the body. Despite the use of radioactive substances, radiation exposure to healthy cells is minimal.

Peptide receptor radionuclide therapy is used to treat NETs that develop in the intestines, lungs, or pancreas, otherwise known as carcinoids or islet cell carcinomas. Peptide receptor radionuclide therapy is indicated for patients with advanced metastatic NETs who are not candidates for surgery and who do not respond well to other treatments.

Currently, peptide receptor radionuclide therapy is not prescribed for children and patients with chronic kidney disease, since there is not enough data on the possible effects of treatment of such patients.

Where can I undergo treatment of neuroendocrine tumors in Germany?

 

Health tourism is becoming more and more popular these days, as a treatment in Germany often ensures a much better quality of neuroendocrine tumors treatment.

The following hospitals show the best success rates in the treatment of neuroendocrine tumors:

  1. University Hospital Duesseldorf
  2. University Hospital of Ludwig Maximilian University of Munich
  3. University Hospital Ulm
  4. PAN Clinic Cologne
  5. University Hospital Frankfurt am Main

You can find more information about the hospitals on the Booking Health website.

The cost of treatment in Germany

 

The prices in hospitals listed on the Booking Health website are relatively low. With Booking Health, you can undergo neuroendocrine tumors treatment in Germany at an affordable price.

The cost of treatment varies, as the price depends on the hospital, the specifics of the disease, and the complexity of its treatment.

The cost of treatment of neuroendocrine tumors with peptide receptor radionuclide therapy is 13,310-20,790 EUR.

You might want to consider the cost of additional procedures and follow-up care. Therefore, the ultimate cost of treatment in Germany may differ from the initial price.

To make sure that the overall cost of treatment in Germany is suitable for you, contact us by leaving the request on the Booking Health website.

How can I undergo treatment of neuroendocrine tumors in Germany?

 

It is not easy to self-organize any treatment abroad. It requires certain knowledge and expertise. Thus, it is safer, easier, and less stressful to use the services of a medical tourism agency.

As the largest and most transparent medical tourism agency in the world, Booking Health has up-to-date information about the treatment of neuroendocrine tumors in the best hospitals in Germany. We will help you select the right clinic taking into account your wishes for treatment.

We want to help you and take on all the troubles. You can be free of unnecessary stress, while Booking Health takes care of all organizational issues regarding the treatment. Our services are aimed at undergoing treatment of neuroendocrine tumors safely and successfully.

Medical tourism can be easy! All you need to do is to leave a request on the Booking Health website, and our manager will contact you shortly.

Authors: Dr. Nadezhda Ivanisova, Dr. Sergey Pashchenko




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