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Treatment of Neuroendocrine Tumors (NETs)

Due to the difficulties associated with the organization of treatment in Turkey, Switzerland, South Korea and India, we are not currently processing requests to these regions.

If you are interested in treatment in Germany, please leave a request and our specialists will contact you as soon as possible.

 

Cost for treatment

Diagnosis of neuroendocrine tumors (NETs)
 from  1010
Chemotherapy in neuroendocrine tumors (NETs)
 from  2383
Neuroendocrine Tumors (NETs) Treatment with Lutetium-177-DOTATATE
 from  13965

University Hospital Duesseldorf

8.5/10
location_onGermany, Duesseldorf

Department of Gastroenterology, Hepatology and Infectology

According to the authoritative Focus magazine, the University Hospital Duesseldorf ranks among the top Germany hospitals! The hospital is an excellent example of a combination of high-quality health care, research and teaching activities. With more than 50,000 inpatients and about 300,000 outpatients every year, the hospital is
Diagnosis of neuroendocrine tumors (NETs)
3846
Chemotherapy in neuroendocrine tumors (NETs)
7348
Neuroendocrine Tumors (NETs) Treatment with Lutetium-177-DOTATATE
16518

University Hospital of Ludwig Maximilian University of Munich

10/10
location_onGermany, Munich

Department of Gastroenterology and Hepatology

According to the Focus magazine, the University Hospital of Ludwig Maximilian University of Munich is regularly ranked among the best medical institutions in Germany! The hospital is the largest multidisciplinary medical facility, as well as a leading research and training center in Germany and Europe. The hospital is proud of i
Diagnosis of neuroendocrine tumors (NETs)
3871
Chemotherapy in neuroendocrine tumors (NETs)
8535
Neuroendocrine Tumors (NETs) Treatment with Lutetium-177-DOTATATE
16736

University Hospital Ulm

8.7/10
location_onGermany, Ulm

Department of Gastroenterology and Hepatology

The University Hospital Ulm started its activities 35 years ago and during this time it has become one of the most prestigious medical institutions in Europe. The hospital is famous for its numerous discoveries and the world-class achievements in medicine and pharmaceuticals. The medical facility has 29 specialized departments a
Diagnosis of neuroendocrine tumors (NETs)
3790
Chemotherapy in neuroendocrine tumors (NETs)
8276
Neuroendocrine Tumors (NETs) Treatment with Lutetium-177-DOTATATE
15763

PAN Clinic Cologne

9/10
location_onGermany, Cologne

Department of Proctology and Endoscopy

The PAN Clinic Cologne is a multidisciplinary medical facility that combines advanced medicine, excellent quality of patient care and a high level of comfort. Founded in 1999, the clinic is located in the very heart of Cologne. During this time, the medical complex has gained long clinical experience, but at the same time it has
Diagnosis of neuroendocrine tumors (NETs)
3807

University Hospital Frankfurt am Main

10/10
location_onGermany, Frankfurt am Main

Department of Gastroenterology, Hepatology, Pulmonology, Allergology, Endocrinology and Diabetology

According to the reputable Focus magazine, the University Hospital Frankfurt am Main ranks among the top German medical facilities! The hospital was founded in 1914 and today is a well-known German medical facility, which combines rich traditions and scientific innovations. A medical team of more than 6,500 employees cares about
Diagnosis of neuroendocrine tumors (NETs)
3485
Chemotherapy in neuroendocrine tumors (NETs)
7733
Neuroendocrine Tumors (NETs) Treatment with Lutetium-177-DOTATATE
15203

University Hospital Heidelberg

9.8/10
location_onGermany, Heidelberg

Department of Gastroenterology, Hepatology and Infectology

According to the Focus magazine, the University Hospital Heidelberg ranks among the top five hospitals in Germany! The hospital is one of the most advanced and reputable medical institutions not only in Germany, but throughout Europe. There are more than 43 specialized departments and 13 medical institutes, which cover all field
Diagnosis of neuroendocrine tumors (NETs)
0
Chemotherapy in neuroendocrine tumors (NETs)
0
Neuroendocrine Tumors (NETs) Treatment with Lutetium-177-DOTATATE
0

University Hospital Würzburg

9.2/10
location_onGermany, Würzburg

Department of Gastroenterology, Hematology, Oncology, Hepatology, Infectology, Rheumatology and Clinical Immunology

According to the Focus magazine in 2019, the University Hospital Würzburg ranks among the top national German hospitals! The hospital is one of the oldest medical facilities in Germany. The centuries-old traditions of first-class treatment are combined with the very latest achievements of modern evidence-based medicine and
Diagnosis of neuroendocrine tumors (NETs)
3355
Chemotherapy in neuroendocrine tumors (NETs)
7491
Neuroendocrine Tumors (NETs) Treatment with Lutetium-177-DOTATATE
14882

University Hospital Bonn

9.2/10
location_onGermany, Bonn

Department of Gastroenterology, Hepatology, Nephrology, Infectology, Endocrinology and Diabetology

According to the authoritative Focus magazine, the University Hospital Bonn ranks among the top ten medical facilities in Germany! The hospital was opened on January 1, 2001, although in fact it inherits the medical facility, which operated at the Faculty of Medicine of the University of Bonn. The hospital in Germany combin
Diagnosis of neuroendocrine tumors (NETs)
3929
Chemotherapy in neuroendocrine tumors (NETs)
8442
Neuroendocrine Tumors (NETs) Treatment with Lutetium-177-DOTATATE
16911

University Hospital Carl Gustav Carus Dresden

9.1/10
location_onGermany, Dresden

Department of Gastroenterology and Hepatology

According to the prestigious Focus magazine, the University Hospital Carl Gustav Carus Dresden is among the top three hospitals in Germany! The hospital is the embodiment of the standards of modern high-quality medicine. Since the hospital positions itself as a maximum care medical facility, it represents all medical fields. The
Diagnosis of neuroendocrine tumors (NETs)
4383
Chemotherapy in neuroendocrine tumors (NETs)
9649
Neuroendocrine Tumors (NETs) Treatment with Lutetium-177-DOTATATE
19327

University Hospital Hamburg-Eppendorf

9.2/10
location_onGermany, Hamburg

Department of Gastroenterology, Hepatology and Infectology

According to the Focus magazine, the University Hospital Hamburg-Eppendorf ranks among the top ten hospitals in Germany! Since its foundation in 1889, the hospital has taken a leading position in the European medical arena and still occupies it until today. A highly competent medical team of more than 11,000 employees takes care
Diagnosis of neuroendocrine tumors (NETs)
4560
Chemotherapy in neuroendocrine tumors (NETs)
7407
Treatment of neuroendocrine tumor (NET) of the appendix with chemotherapy
7400

Charite University Hospital Berlin

9/10
location_onGermany, Berlin

Department of Hepatology and Gastroenterology

According to the authoritative Focus magazine, the Charite University Hospital Berlin occupies the first place in the rating of the top German medical facilities! The hospital is one of the largest and leading university medical complexes in Europe. The hospital in Germany provides modern diagnostics and treatment of patients, a
Diagnosis of neuroendocrine tumors (NETs)
5097
Chemotherapy in neuroendocrine tumors (NETs)
7353
Neuroendocrine Tumors (NETs) Treatment with Lutetium-177-DOTATATE
21700

University Hospital RWTH Aachen

8.7/10
location_onGermany, Aachen

Department of Gastroenterology, Metabolic Disorders and Internal Intensive Care

According to the prestigious Focus magazine, the University Hospital RWTH Aachen ranks among the top German hospitals! As a maximum care university medical facility, the hospital guarantees patients first-class medical services combined with a respectful and human attitude. The hospital integrates all the modern options for the
Diagnosis of neuroendocrine tumors (NETs)
3870
Chemotherapy in neuroendocrine tumors (NETs)
8683
Neuroendocrine Tumors (NETs) Treatment with Lutetium-177-DOTATATE
16953

University Hospital Marburg UKGM

8.6/10
location_onGermany, Marburg

Department of Gastroenterology, Endocrinology, Metabolism and Clinical Infectology

The University Hospital Marburg UKGM offers patients modern diagnostics and comprehensive therapy at the international level. As a maximum care hospital, the medical facility specializes in all fields of modern medicine ranging from ophthalmology to traumatology and dentistry. The main areas of specialization of the hospital are
Diagnosis of neuroendocrine tumors (NETs)
3352
Chemotherapy in neuroendocrine tumors (NETs)
7509
Neuroendocrine Tumors (NETs) Treatment with Lutetium-177-DOTATATE
15978

University Hospital Jena

8.9/10
location_onGermany, Jena

Department of Gastroenterology, Hepatology and Infectology

According to the prestigious Focus magazine, the University Hospital Jena regularly ranks among the top German medical facilities! The hospital has positioned itself as a multidisciplinary medical facility with a long history of more than 200 years. Since its foundation, the hospital has been constantly developing and modernizin
Diagnosis of neuroendocrine tumors (NETs)
3904
Chemotherapy in neuroendocrine tumors (NETs)
7519
Neuroendocrine Tumors (NETs) Treatment with Lutetium-177-DOTATATE
16594

University Hospital Halle (Saale)

9.6/10
location_onGermany, Halle

Department of Gastroenterology, Hepatology and Pulmonology

According to the prestigious Focus magazine, the University Hospital Halle (Saale) ranks among the top German medical facilities! The history of the hospital has more than 300 years, and during this time it managed to earn an excellent reputation not only in Germany, but throughout the world. The hospital positions itself as a s
Diagnosis of neuroendocrine tumors (NETs)
3629
Chemotherapy in neuroendocrine tumors (NETs)
7519
Neuroendocrine Tumors (NETs) Treatment with Lutetium-177-DOTATATE
14684

University Hospital Rechts der Isar Munich

9.8/10
location_onGermany, Munich

Department of Gastroenterology, Hepatology, Endocrinology, Diabetology and Infectology

According to the prestigious FOCUS magazine, the University Hospital Rechts der Isar Munich ranks among the Germany's top medical institutions! Founded in 1834, the hospital combines long traditions and the very latest achievements of modern medicine. The medical facility includes 33 specialized departments, 20 interdiscipli
Diagnosis of neuroendocrine tumors (NETs)
3905
Chemotherapy in neuroendocrine tumors (NETs)
8722
Neuroendocrine Tumors (NETs) Treatment with Lutetium-177-DOTATATE
16768
| from Booking Health GmbH

Content

  1. Peculiarities of neuroendocrine tumors
  2. Symptoms of neuroendocrine cancer
  3. Stages of neuroendocrine cancer
  4. Diagnosis and treatment of neuroendocrine tumors
  5. Surgery for the treatment of neuroendocrine tumors
  6. Stereotactic radiosurgery
  7. Radiation therapy
  8. Chemotherapy
  9. Targeted therapy
  10. Lutetium-177 PSMA therapy
  11. Where can I undergo treatment of neuroendocrine tumors?
  12. The cost of treatment of neuroendocrine tumors
  13. How can I undergo treatment of neuroendocrine tumors?

 

Neuroendocrine tumors are a group of cancers that can be located in different parts of the body. Neuroendocrine tumors develop from neuroendocrine cells present in various organs and systems. The cells produce the hormones and biologically active peptides. Most neuroendocrine cancers develop slowly and do not cause clinical symptoms for a long time. Nevertheless, there are also aggressive NET types with significant hormonal activity. These types of neoplasms are more likely to metastasize.

Peculiarities of neuroendocrine tumors

 

Neuroendocrine cancer usually develops slowly. It may be asymptomatic or cause various endocrine disorders, depending on the hormones and mediators produced. The main peculiarity of NETs is the secreted compounds (hormones and other biologically active substances) and their amount.

Many neuroendocrine tumors (NETs) are diagnosed only posthumously, which is connected with the difficulty of diagnosis making. According to statistics, neuroendocrine cancer is found in 2-3 patients per 100 thousand population. After death, tumors are found twice as often.

Symptoms of neuroendocrine cancer

 

Patients with neuroendocrine tumors in the gastrointestinal tract or pancreas experience:

  • Disturbances of food passage
  • Intestinal disorders
  • Gallstones formation

Patients with neuroendocrine tumors in the respiratory system experience:

  • Respiratory disorders
  • Reduced blood pressure
  • Interruptions in the work of the heart

Almost all patients with neuroendocrine tumors experience weight loss, skin rashes, circulatory disorders, pathologies of blood clotting, and panic attacks. Neuroendocrine cancer patients also often complain of headaches.

Osteoarthritis is a gradual joint destruction, cartilage degeneration and bone tissue lesion. The disease develops gradually, progresses slowly, but steadily. As a result, it leads to complete joint destruction, its immobility and chronic pains. Such cases require joint replacement surgery.

Neuroendocrine tumors are endocrinally active neoplasms that develop in different body parts.

NETs arise from specialized cells, so this cancer can imitate endocrine disorders.

NETs are treated with surgeries, chemotherapy and radionuclide therapy with Lutetium-177 PSMA.

The best hospitals are University Hospital of Ludwig Maximilian University of Munich, University Hospital Duesseldorf, University Hospital Ulm, University Hospital Frankfurt am Main, and PAN Clinic Cologne.

Estimated costs are represented in the table below.

Medical program

Prices in Europe

Diagnostics

from 1,010 EUR

Chemotherapy

from 2,252 EUR

Treatment with Lutetium-177 PSMA

from 13,310 EUR

Surgery

from 12,579 EUR

 

Stages of neuroendocrine cancer

 

To date, there is no clear staging of neuroendocrine cancer. It is known that the formations grow slowly and go through the few stages of development that are common for all cancers.

At the first stage of development, the neuroendocrine tumors are small. In the future, they grow into nearby tissues and metastasize actively to the distant organs, mainly to the liver and bones. As a result, a large number of formations grow in the body.

Patients often die due to a malfunction of the organs in which secondary tumors develop. About 80% of patients already have metastases at the moment of the diagnosis making.

If the tumor is single and has no metastases, then surgical removal is possible. In the presence of multiple metastases, substances that suppress the production of hormones are used, which significantly improves the health condition of patients. In the future, doctors prescribe chemotherapy, which destroys neuroendocrine tumors, and targeted therapy. Targeted therapy acts only on pathological cells, causing their death.

Diagnosis and treatment of neuroendocrine tumors

 

At the first stage of diagnosis making, the following examinations are often required:

  • Tumor marker blood tests
  • Hormonal blood and urine tests
  • Ultrasound scanning or endoscopy
  • Computed tomography or MRI
  • Biopsy of the affected organ

Based on the results of the diagnostic procedures, individual therapy is prescribed.

Since neuroendocrine cancer can develop in any organ, the method of treatment is selected taking into account its localization. The spreading of the cancer process is also considered.

In general, the survival rate of patients with neuroendocrine tumors (NETs) is rather high, if the treatment takes place in specialized medical centers with high-precision equipment and professional personnel with the relevant experience.

Surgery for the treatment of neuroendocrine tumors

 

Radical removal of the tumor is the most preferred method of neuroendocrine cancer treatment. Further it may be complemented by other methods, for a more stable effect of therapy.

The location of the neuroendocrine tumors (NETs) and their size determine primarily how the surgery is carried out. As a rule, surgeons choose the endoscopic method as the most sparing one. The endoscopic method does not require making surgical incisions, as the access to the pathological focus is provided through small, several centimeters wide, tissue incisions.

In case of neuroendocrine tumors (NETs) in the abdominal cavity, laparoscopic surgery can be performed, with making punctures in the peritoneal region. In case of neuroendocrine cancer of the lungs punctures are made near the ribs. This method reduces blood loss, the risk of infection, and postoperative recovery time.

If the lesion is located in a hard-to-reach region and its removal is connected with the high risk of damaging nearby tissues, the da Vinci robotic surgical system can be used. Since the device's components can reach even the areas that are physically impossible to operate on with a conventional scalpel, the tumor is removed as precisely as possible, without damaging healthy tissues.

Stereotactic radiosurgery

 

The removal of neuroendocrine tumors can be carried out using stereotactic radiosurgery.

This method is usually preferred when conventional surgery cannot provide a positive treatment result or when there are contraindications for traditional surgery. Stereotactic radiosurgery can be used for the treatment of neuroendocrine cancer of the pancreas, pituitary gland, and lungs.

The pathological focus is treated with a high dose of radiation, which allows destroying cancer cells in one or two sessions. Despite the high irradiation dose, the healthy tissues are affected minimally. Only the pathological focus receives a high radiation dose. This can significantly reduce the influence of radiation therapy on the body.

Radiation therapy

 

Radiation therapy is prescribed for neuroendocrine cancer treatment when it is not possible to remove the tumor.

In patients with neuroendocrine cancer, brachytherapy is used. In brachytherapy a radioactive substance is placed directly near the tumor. Being released gradually, ionizing radiation affects cancer cells much more effectively. Radioactive substances can be placed in microcapsules, which are delivered to the tumor tissue with a special catheter, or injected with a special needle.

Chemotherapy

 

Chemotherapy can be used as a separate method, as well as in combination with radiation therapy or surgical treatment. Chemotherapy can effectively fight metastases throughout the body.

With the spread of the cancer process in the abdominal cavity, intraoperative chemotherapy can be applied. This allows doctors to make the remission period longer and to make sure that all cancer cells are destroyed.

Modern medical centers use new-generation drugs, so the toxic effect on the patient’s organism is reduced.

Targeted therapy

 

Targeted therapy in the treatment of neuroendocrine tumors has already demonstrated good results.

Drugs used in targeted therapy affect only cancer cells. However, different drugs have different "targeted" strategies. For example, some of them affect the metabolic processes of cancer cells, i.e. they block the process of intracellular metabolism. Other drugs can deliver chemotherapy or radioactive substances to cancer cells, and also help the immune system recognize atypical cells and destroy them.

A distinctive feature of targeted therapy is the absence of a negative influence on healthy organs and tissues.

Lutetium-177 PSMA therapy

 

Cells of neuroendocrine tumors often have somatostatin receptors on the surface of their membranes. Somatostatin is a hormone that is produced naturally in the pancreas, hypothalamus, tissues of the digestive tract, as well as in various parts of the CNS. A radioactive isotope Lutetium-177 is considered to be a somatostatin analog.

After the Lutetium-177 is administered to patients, it binds to the receptors on the surface of NETs, and the tumor cells absorb the radioactive substance. Thus, the high dose of radiation goes directly to the cancer cells.

Since the drugs are infused into the patient's bloodstream, Lutetium-177 PSMA therapy is a systemic therapy that reaches all areas of the body. Nevertheless, since these substances are able to identify the specific surface membrane antigens on cells of the neuroendocrine tumors, the effect of radiation on healthy tissues is limited. The intravenous administration of the drug takes about 4-5 hours, after which patients stay in the hospital for about two days to monitor the health condition and undergo follow-up diagnostic tests.

Where can I undergo treatment of neuroendocrine tumors?

 

Health tourism is becoming more and more popular these days, as medicine abroad often ensures a much better quality of neuroendocrine cancer treatment.

Where you go for treatment matters! The following hospitals show the best success rates in the treatment of neuroendocrine tumors:

  1. Memorial Bahcelievler Hospital Istanbul, Turkey
  2. University Hospital Duesseldorf, Germany
  3. University Hospital of Ludwig Maximilian University of Munich, Germany
  4. University Hospital Ulm, Germany
  5. Primus Super Speciality Hospital New Delhi, India

You can find more information about the hospitals on the Booking Health website.

The cost of treatment of neuroendocrine tumors

 

The prices in hospitals on the Booking Health website are relatively low.

The cost of treatment varies, as the prices depend on the hospitals, the specifics of the disease, and the complexity of its treatment.

The cost of treatment of neuroendocrine tumors with chemotherapy in Turkey is 3,766-3,896 EUR.

The cost of treatment of neuroendocrine tumors with chemotherapy in Germany is 6,949-9,893 EUR.

The average cost of treatment of neuroendocrine tumors with chemotherapy in India is 2,330 EUR.

You might want to consider the cost of possible additional procedures and follow-up care. Therefore, the ultimate cost of treatment may differ from the initial price.

To make sure that the overall cost of treatment is suitable for you, you may contact us by leaving the request on the Booking Health website.

How can I undergo treatment of neuroendocrine tumors?

 

It is not easy to self-organize any treatment abroad. It requires certain knowledge and expertise. Thus, it is safer, easier, and less stressful to use the services of a medical tourism agency.

As the largest and most transparent medical tourism agency in the world, Booking Health has up-to-date information about the treatment of neuroendocrine tumors in the world’s best hospitals. We will help you select the right medical center taking into account your wishes for treatment.

We want to help you and take on all the troubles. You can be free of unnecessary stress, while Booking Health takes care of all organizational issues regarding the treatment.

Medical tourism can be easy! All you need to do is to leave a request on the Booking Health website, and our manager will contact you shortly.

Authors: Dr. Nadezhda Ivanisova, Dr. Sergey Pashchenko




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