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Treatment of Ovarian Polyembryoma

Cost for treatment

Diagnostics of polyembryoma ovarian
1265.33
Chemotherapy of polyembryoma ovarian (1 course)
1698.59
Surgery treatment of polyembryoma ovarian
2288.45

University Hospital Rechts der Isar Munich

9.8/10
location_onGermany, Munich

Department of Gynecology, Mammology and Obstetrics

The University Hospital Rechts der Isar Munich was founded in 1834. It combines long traditions with the very latest advances in modern medicine. The medical facility includes 33 specialized departments and 20 interdisciplinary centers, where patients can receive top-class medical care in all medical fields. The hospital annuall
Diagnostics of polyembryoma ovarian
4039.23
Chemotherapy of polyembryoma ovarian (1 course)
7171.38
Surgery treatment of polyembryoma ovarian
8015.97

University Hospital Tuebingen

9.2/10
location_onGermany, Tuebingen

Department of Adult and Pediatric Gynecology, Mammology, Obstetrics

According to the prestigious medical publication Focus, the University Hospital Tuebingen ranks among the top five German hospitals! The hospital was founded in 1805, therefore it is proud of its long history, unique experience, and outstanding achievements in the field of medical care, as well as research and teaching activitie
Diagnostics of polyembryoma ovarian
3666.52
Chemotherapy of polyembryoma ovarian (1 course)
7045.05
Surgery treatment of polyembryoma ovarian
8085.92

University Hospital Ulm

8.7/10
location_onGermany, Ulm

Department of Obstetrics, Adult and Pediatric Gynecology

The University Hospital Ulm started its activities 35 years ago and during this time it has become one of the most prestigious medical institutions in Europe. The hospital is famous for its numerous discoveries and the world-class achievements in medicine and pharmaceuticals. The medical facility has 29 specialized departments a
Diagnostics of polyembryoma ovarian
3518.28
Chemotherapy of polyembryoma ovarian (1 course)
6893.67
Surgery treatment of polyembryoma ovarian
7995.09

University Hospital Carl Gustav Carus Dresden

9.1/10
location_onGermany, Dresden

Department of Adult and Pediatric Gynecology, Mammology, Obstetrics and Reproductive Medicine

According to the reputable Focus magazine, the University Hospital Carl Gustav Carus Dresden ranks among the top five German hospitals! The hospital is the benchmark for modern high-quality medicine. Positioning itself as a maximum care medical facility, the hospital represents all medical fields. There are 26 specialized depart
Diagnostics of polyembryoma ovarian
4785.69
Chemotherapy of polyembryoma ovarian (1 course)
8165.26
Surgery treatment of polyembryoma ovarian
9381.52

University Hospital Heidelberg

9.8/10
location_onGermany, Heidelberg

Department of Obstetrics, Adult and Pediatric Gynecology

According to Focus magazine, the University Hospital Heidelberg ranks among the top five hospitals in Germany! The hospital is one of the most advanced and reputable medical institutions not only in Germany, but throughout Europe. There are more than 43 specialized departments and 13 medical institutes, which cover all fields of
Diagnostics of polyembryoma ovarian
0
Chemotherapy of polyembryoma ovarian (1 course)
0
Surgery treatment of polyembryoma ovarian
0

University Hospital Frankfurt am Main

10/10

Department of Adult and Pediatric Gynecology, Obstetrics and Mammology

According to the reputable Focus magazine, the University Hospital Frankfurt am Main ranks among the top German medical facilities! The hospital was founded in 1914 and today is a well-known German medical facility, which combines rich traditions and scientific innovations. A medical team of more than 6,500 employees cares about
Diagnostics of polyembryoma ovarian
3741.69
Chemotherapy of polyembryoma ovarian (1 course)
6695.31
Surgery treatment of polyembryoma ovarian
7801.95

Charite University Hospital Berlin

9/10
location_onGermany, Berlin

Department of Adult and Pediatric Gynecology, Mammology

According to the authoritative Focus magazine, the Charite University Hospital Berlin occupies the first place in the rating of the top German medical facilities! The hospital is one of the largest and leading university medical complexes in Europe. The hospital in Germany provides modern diagnostics and treatment of patients, a
Diagnostics of polyembryoma ovarian
5468.47
Chemotherapy of polyembryoma ovarian (1 course)
6279.8
Surgery treatment of polyembryoma ovarian
10502.78

University Hospital of Ludwig Maximilian University of Munich

10/10
location_onGermany, Munich

Department of Obstetrics, Adult and Pediatric Gynecology

According to the Focus magazine, the University Hospital of Ludwig Maximilian University of Munich is regularly ranked among the best medical institutions in Germany! The hospital is the largest multidisciplinary medical facility, as well as a leading research and training center in Germany and Europe. The hospital is proud of i
Diagnostics of polyembryoma ovarian
3750.04
Chemotherapy of polyembryoma ovarian (1 course)
7282.04
Surgery treatment of polyembryoma ovarian
8627.76

University Hospital Erlangen

9.1/10
location_onGermany, Erlangen

Department of Adult and Pediatric Gynecology, Mammology, Obstetrics

According to the Focus magazine, University Hospital Erlangen ranks among the best medical facilities in Germany! The hospital is one of the leading healthcare facilities in Bavaria and offers top-class medical care distinguished by the close intertwining of clinical activities with research and training of medical students. The
Diagnostics of polyembryoma ovarian
3483.82
Chemotherapy of polyembryoma ovarian (1 course)
6945.87
Surgery treatment of polyembryoma ovarian
8100.54

University Hospital Halle (Saale)

9.6/10
location_onGermany, Halle

Department of Gynecology and Mammology

According to the prestigious Focus magazine, the University Hospital Halle (Saale) ranks among the top German medical facilities! The history of the hospital has more than 300 years, and during this time it managed to earn an excellent reputation not only in Germany, but throughout the world. The hospital positions itself as a s
Diagnostics of polyembryoma ovarian
3853.4
Chemotherapy of polyembryoma ovarian (1 course)
6293.37
Surgery treatment of polyembryoma ovarian
7662.06

University Hospital Hamburg-Eppendorf

9.2/10
location_onGermany, Hamburg

Department of Gynecology and Mammology

According to the Focus magazine, the University Hospital Hamburg-Eppendorf ranks among the top ten hospitals in Germany! Since its foundation in 1889, the hospital has taken a leading position in the European medical arena and still occupies it until today. A highly competent medical team of more than 11,000 employees takes care
Diagnostics of polyembryoma ovarian
4713.66
Chemotherapy of polyembryoma ovarian (1 course)
6317.38
Surgery treatment of polyembryoma ovarian
9752.14

University Hospital Würzburg

9.2/10
location_onGermany, Würzburg

Department of Adult and Pediatric Gynecology, Mammology and Obstetrics

According to the Focus magazine in 2019, the University Hospital Würzburg ranks among the top national German hospitals! The hospital is one of the oldest medical facilities in Germany. The centuries-old traditions of first-class treatment are combined with the very latest achievements of modern evidence-based medicine and
Diagnostics of polyembryoma ovarian
3852.36
Chemotherapy of polyembryoma ovarian (1 course)
6344.53
Surgery treatment of polyembryoma ovarian
7725.74

University Hospital RWTH Aachen

8.9/10
location_onGermany, Aachen

Department of Gynecology, Mammology and Obstetrics

According to the prestigious Focus magazine, the University Hospital RWTH Aachen ranks among the top German hospitals! As a maximum care university medical facility, the hospital guarantees patients first-class medical services combined with a respectful and human attitude. The hospital integrates all the modern options for the
Diagnostics of polyembryoma ovarian
4222.98
Chemotherapy of polyembryoma ovarian (1 course)
7142.14
Surgery treatment of polyembryoma ovarian
8644.46

University Hospital Duesseldorf

9.5/10
location_onGermany, Duesseldorf

Department of Adult and Pediatric Gynecology, Obstetrics and Mammology

According to the authoritative Focus magazine, the University Hospital Duesseldorf ranks among the top Germany hospitals! The hospital is an excellent example of a combination of high-quality health care, research and teaching activities. With more than 50,000 inpatients and about 300,000 outpatients every year, the hospital is
Diagnostics of polyembryoma ovarian
4113.36
Chemotherapy of polyembryoma ovarian (1 course)
6467.72
Surgery treatment of polyembryoma ovarian
8482.64

University Hospital Muenster

9.8/10
location_onGermany, Muenster

Department of Adult and Pediatric Gynecology, Obstetrics

According to the Focus magazine, the University Hospital Muenster ranks among the top German hospitals! The hospital belongs to the most prestigious medical institutions in Germany. The hospital is distinguished by a high professionalism of its doctors, state-of-the-art technological equipment and the availability of the most ad
Diagnostics of polyembryoma ovarian
3771.97
Chemotherapy of polyembryoma ovarian (1 course)
6278.76
Surgery treatment of polyembryoma ovarian
7685.02

University Hospital Bonn

9.2/10
location_onGermany, Bonn

Department of Gynecology and Gynecologic Oncology

According to the authoritative Focus magazine, the University Hospital Bonn ranks among the top ten medical facilities in Germany! The hospital was opened on January 1, 2001, although in fact it inherits the medical facility, which operated at the Faculty of Medicine of the University of Bonn. The hospital in Germany combin
Diagnostics of polyembryoma ovarian
4304.41
Chemotherapy of polyembryoma ovarian (1 course)
7156.76
Surgery treatment of polyembryoma ovarian
8309.34
| from Booking Health GmbH

An ovarian polyembryoma is a rare germ cell tumor. The neoplasm is diagnosed predominantly in young women. Ovarian polyembryomas practically do not occur in their pure form. The elements of a polyembryoma are usually part of mixed tumors. The larger its proportion, the worse the prognosis, since this type of tumor is more aggressive than most types of cancer. It is a complex task to treat this cancer, and it also recurs more often. This cancer is resistant to irradiation and to many chemotherapy agents. Despite all the difficulties, doctors in German Oncology Centers successfully cope with ovarian polyembryomas.

Content

  1. Treatment principles
  2. Surgical treatment
  3. Chemotherapy
  4. Other treatment methods
  5. Why is it worth undergoing polyembryoma treatment in Germany?

Treatment principles

 

The main treatment options for patients with a newly diagnosed ovarian polyembryoma are:

  • surgery and follow-up monitoring (early stage only);
  • surgery followed by chemotherapy (the most common treatment option);
  • chemotherapy followed by surgery (if a tumor has reached a large size at the time of its detection and this needs to be reduced in order to try to remove it completely);
  • only chemotherapy (if a surgical intervention is contraindicated or the patient refuses it).

Radiation therapy is usually not used. A polyembryoma is highly resistant to radiation. Radiation therapy can sometimes be carried out in the advanced stages of the disease to relieve symptoms and reduce the risk of complications.

Surgical treatment

 

Treatment usually begins with tumor removal. Operations can be performed at any stage of an oncological disease, from the early stages to the advanced ones. However, the extent of surgical interventions and the goals of treatment differ significantly. The disease can be cured completely in the early stages, but as the tumor process progresses, the cure becomes less and less likely, since cancer spreads through the abdominal cavity. It is almost impossible to destroy all cancer cells. Nonetheless, even in such a case, good results can be obtained: the disease can be controlled for many years by reducing the tumor mass with cytoreductive surgery and destroying the remaining cancer cells with chemotherapy agents.

There are several types of surgical interventions for patients with an ovarian polyembryoma:

Bilateral adnexectomy is the removal of the ovaries with fallopian tubes. This is the main operation at the initial stage. It is performed on all women who do not plan to conceive a baby. As a rule, surgical interventions are performed via an open rather than a laparoscopic approach. This is necessary for performing surgical staging procedures. When both ovaries are removed, a woman cannot become pregnant unless she has frozen her eggs beforehand. However, the uterus is preserved, so pregnancy is possible with the help of IVF. Embryos are transferred into the uterus from a woman's own frozen or donated oocytes.

Unilateral adnexectomy is another surgical opinion. The removal of two ovaries is more effective, since in this case the risk that the tumor recurs is reduced. However, such an operation entails two problems: infertility and premature menopause. Since the majority of patients are children and young women, the removal of both ovaries should be avoided whenever possible. Doctors can only remove the uterine appendages on one side. As the risk of oncology recurrence increases in this case, women need more accurate monitoring: regular tumor marker blood tests, gynecological examinations, and instrumental tests of the pelvic organs. Should any signs of recurrence be detected, a second operation can be performed to cure the cancer.

Surgical staging is a number of procedures that are performed during the operation. If surgical intervention is performed at an early stage, the goal of treatment is the complete elimination of the ovarian polyembryoma. Therefore, doctors have to make sure that they are really dealing with the early stage and that the tumor has not spread to other organs. As part of surgical staging, suspicious lymph nodes are also removed and examined. Doctors accurately examine the entire abdominal cavity, take a biopsy, smears and swabs from suspicious areas of the peritoneum.

Cytoreductive surgery is performed at an advanced stage of cancer. The aim of this intervention is to reduce the tumor mass as much as possible. Doctors remove the uterus, appendages, omentum, as well as all tumor foci detected in the abdominal cavity. Sometimes there are quite a few of them, so doctors have to partially remove the intestine, bladder, and sometimes other organs as well. After the removal of the tumors, a reconstructive stage of the operation is performed to restore the damaged organs.

Depending on the extent, cytoreduction can be:

  • complete cytoreduction that involves the removal of all visible tumors;
  • optimal cytoreduction that involves the removal of all tumors larger than 1 cm;
  • suboptimal cytoreduction, after which at least one tumor larger than 1 cm remains.

Suboptimal cytoreduction is actually an unsuccessful operation, since if tumor foci larger than 1 cm remain, the survival rates of patients are approximately the same as in the case of chemotherapy alone, without any surgical intervention. Optimal cytoreduction significantly increases life expectancy as it is more effective than drug therapy. The best results can be achieved with complete cytoreduction.

Chemotherapy

 

The second most important treatment method for an ovarian polyembryoma is chemotherapy. This is prescribed to most patients with a polyembryoma, except at a very early stage of the disease. Doctors use different chemotherapy regimens, such as PEP, PEI, TIP, and VeIP. The choice of the regimen is determined by the goal of therapy, the stage of the disease, the response to previous treatment, and the health status of a woman.

Chemotherapy can be used in the following cases:

  • chemotherapy after surgery is the most common option, as the use of drugs allows doctors to destroy the remaining cancer cells in the body and lower the likelihood of recurrence;
  • chemotherapy before surgery can be used for advanced polyembryomas, as doctors can shrink the tumors to improve the chances of achieving a complete cytoreduction with follow-up surgery;
  • chemotherapy can be used as the main treatment method for those for whom surgery is contraindicated (but if there are no medical contraindications, it is advisable to perform surgical treatment even at the advanced stage, since it increases the survival rate of patients);
  • chemotherapy can be used to treat recurrence if it is impossible to perform a second operation to remove the tumor.

Most women respond to initial treatment. However, in the future, the tumor may return, in which case the therapy must be repeated. The further treatment regimen depends on the timing of the onset of recurrence. If the tumor has recurred in a year or more, doctors may use the same chemotherapy regimen that has been successfully tried before. However, in the early recurrence that occurs less than 6 months later, the chances of success with the same drugs are low. Therefore, doctors use second-line therapy. They use drugs from other pharmacological groups. If there is no response to treatment, third-line therapy and so on may be used until the result is achieved.

Other treatment methods

 

If other treatment methods do not work, doctors may try non-standard methods to control oncological diseases:

High-dose chemotherapy with a stem cell transplant. This technique is currently being studied in clinical trials. Doctors use high doses of drugs to destroy all cancer cells in the body. This is followed by a donor stem cell transplant, which restores impaired hematopoiesis and activates a "graft-versus-tumor" effect.

Targeted therapy and immunotherapy. Drugs from different pharmacological groups are still being tested in clinical trials and are not part of a standard treatment. Patients who are not responding to conventional chemotherapy may be eligible to participate in these trials.

Radiation therapy. This treatment option has low efficiency for a polyembryoma, but doctors in developed countries use innovative options of radiation therapy, which are more accurate and sparing for surrounding tissues. They help to deliver more radiation to the tumor to overcome radioresistance. Doctors often use radiation therapy not to destroy the primary tumor, but to control metastases, for example, in the brain.

Chemoembolization. This therapeutic procedure can be used for metastatic liver lesions. This is a minimally invasive procedure that is performed from the inside of the blood vessels. Doctors use tiny microspheres containing chemotherapy agents to block the arteries that supply the tumor. As a result, the metastatic tumor dies due to the lack of blood supply, and the remaining cancer cells in the liver are destroyed by drugs that are released from the microspheres over several weeks.

Why is it worth undergoing polyembryoma treatment in Germany?

 

German hospitals offer modern equipment, innovative methods, and drugs. The high level of qualification of German doctors is beyond doubt. When you get medical services in this country, you can count on the best results with minimal health risks.

There are several reasons for you to undergo your ovarian polyembryoma treatment in a German hospital:

  • the possibility of a complete cure of cancer at an early stage;
  • preservation of the reproductive function for young women;
  • highly accurate intraoperative diagnostics to determine the exact stage of an ovarian polyembryoma and choose the best treatment tactics;
  • successful cytoreductive operations even at the advanced stages of the ovarian polyembryoma;
  • when performing cytoreductive operations, doctors mostly manage to achieve a complete cytoreduction, which significantly improves the prognosis for patients;
  • cancer can be cured or controlled with drugs for many years if the tumor is detected at the advanced stage;
  • doctors use the most effective combinations of chemotherapy drugs that have proven themselves in clinical trials.

You are welcome to use the Booking Health service to go to Germany to undergo your ovarian polyembryoma treatment in one of the best clinics in the world. On our website, you can find the cost of treatment in Germany, compare prices in different hospitals, and book your treatment at the best price. The Booking Health staff will help you to find the best German hospital and take care of all travel arrangements. The cost of treatment in Germany will be lower for you due to the lack of additional taxes for foreign patients. If you make your treatment appointment through our service, the initial price will be final: this will not increase even if additional medical procedures are required, as their cost will be covered by insurance.

 

Authors: 

The article was edited by medical experts, board-certified doctors Dr. Nadezhda Ivanisova and Dr. Sergey Pashchenko. For the treatment of the conditions referred to in the article, you must consult a doctor; the information in the article is not intended for self-medication!

 

Sources:

MedlinePlus

Verywell Health

Science Direct




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