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Hyperthermic Intraperitoneal Chemotherapy (HIPEC)

Due to the difficulties associated with the organization of treatment in Turkey, Switzerland and South Korea, we have currently suspended the processing of requests to these regions.

If you are interested in treatment in Germany, please leave a request and our specialists will contact you as soon as possible.

 

Cost for treatment

Multimodality treatment of appendix cancer with cytoreductive surgery and HIPEC
 from  38050
Multimodality treatment of colon cancer with cytoreductive surgery and HIPEC
 from  38154
Multimodality treatment of duodenal cancer with cytoreductive surgery and HIPEC
 from  38446

HELIOS Clinic Krefeld

9.7/10
location_onGermany, Krefeld

Department of General, Abdominal and Minimally Invasive Surgery

Founded in 2014, the HELIOS Clinic Krefeld is one of the most modern medical facilities in Germany today. A team of highly qualified specialists, innovative medical equipment and comfortable accommodation conditions – the clinic has everything to make the treatment run smoothly and efficiently. Having crossed the threshold
Multimodality treatment of appendix cancer with cytoreductive surgery and HIPEC
44139
Multimodality treatment of colon cancer with cytoreductive surgery and HIPEC
44004
Multimodality treatment of duodenal cancer with cytoreductive surgery and HIPEC
44377

University Hospital of Ludwig Maximilian University of Munich

10/10
location_onGermany, Munich

Department of General, Abdominal and Transplant Surgery

According to the Focus magazine, the University Hospital of Ludwig Maximilian University of Munich is regularly ranked among the best medical institutions in Germany! The hospital is the largest multidisciplinary medical facility, as well as a leading research and training center in Germany and Europe. The hospital is proud of i
Multimodality treatment of appendix cancer with cytoreductive surgery and HIPEC
50144
Multimodality treatment of colon cancer with cytoreductive surgery and HIPEC
50181
Multimodality treatment of duodenal cancer with cytoreductive surgery and HIPEC
50280

Charite University Hospital Berlin

9/10
location_onGermany, Berlin

Department of General, Abdominal and Vascular Surgery

According to the authoritative Focus magazine, the Charite University Hospital Berlin occupies the first place in the rating of the top German medical facilities! The hospital is one of the largest and leading university medical complexes in Europe. The hospital in Germany provides modern diagnostics and treatment of patients, a
Multimodality treatment of appendix cancer with cytoreductive surgery and HIPEC
67555
Multimodality treatment of colon cancer with cytoreductive surgery and HIPEC
67436
Multimodality treatment of duodenal cancer with cytoreductive surgery and HIPEC
67692

University Hospital Ulm

8.7/10
location_onGermany, Ulm

Department of General and Abdominal Surgery

The University Hospital Ulm started its activities 35 years ago and during this time it has become one of the most prestigious medical institutions in Europe. The hospital is famous for its numerous discoveries and the world-class achievements in medicine and pharmaceuticals. The medical facility has 29 specialized departments a
Multimodality treatment of appendix cancer with cytoreductive surgery and HIPEC
46896
Multimodality treatment of colon cancer with cytoreductive surgery and HIPEC
47281
Multimodality treatment of duodenal cancer with cytoreductive surgery and HIPEC
47237

University Hospital Carl Gustav Carus Dresden

9.1/10
location_onGermany, Dresden

Department of Abdominal, Thoracic and Vascular Surgery

According to the prestigious Focus magazine, the University Hospital Carl Gustav Carus Dresden is among the top three hospitals in Germany! The hospital is the embodiment of the standards of modern high-quality medicine. Since the hospital positions itself as a maximum care medical facility, it represents all medical fields. The
Multimodality treatment of appendix cancer with cytoreductive surgery and HIPEC
58981
Multimodality treatment of colon cancer with cytoreductive surgery and HIPEC
58927
Multimodality treatment of duodenal cancer with cytoreductive surgery and HIPEC
58685

University Hospital Frankfurt am Main

10/10
location_onGermany, Frankfurt am Main

Department of General and Abdominal Surgery

According to the reputable Focus magazine, the University Hospital Frankfurt am Main ranks among the top German medical facilities! The hospital was founded in 1914 and today is a well-known German medical facility, which combines rich traditions and scientific innovations. A medical team of more than 6,500 employees cares about
Multimodality treatment of appendix cancer with cytoreductive surgery and HIPEC
44037
Multimodality treatment of colon cancer with cytoreductive surgery and HIPEC
44134
Multimodality treatment of duodenal cancer with cytoreductive surgery and HIPEC
44469

University Hospital RWTH Aachen

9.2/10
location_onGermany, Aachen

Department of Adult and Pediatric General, Abdominal, Transplant Surgery

According to the prestigious Focus magazine, the University Hospital RWTH Aachen ranks among the top German hospitals! As a maximum care university medical facility, the hospital guarantees patients first-class medical services combined with a respectful and human attitude. The hospital integrates all the modern options for the
Multimodality treatment of appendix cancer with cytoreductive surgery and HIPEC
50237
Multimodality treatment of colon cancer with cytoreductive surgery and HIPEC
50005
Multimodality treatment of duodenal cancer with cytoreductive surgery and HIPEC
50363

University Hospital Marburg UKGM

8.6/10
location_onGermany, Marburg

Department of Abdominal, Thoracic and Vascular Surgery

The University Hospital Marburg UKGM offers patients modern diagnostics and comprehensive therapy at the international level. As a maximum care hospital, the medical facility specializes in all fields of modern medicine ranging from ophthalmology to traumatology and dentistry. The main areas of specialization of the hospital are
Multimodality treatment of appendix cancer with cytoreductive surgery and HIPEC
41295
Multimodality treatment of colon cancer with cytoreductive surgery and HIPEC
41052
Multimodality treatment of duodenal cancer with cytoreductive surgery and HIPEC
41524

University Hospital Halle (Saale)

9.6/10
location_onGermany, Halle

Department of General, Abdominal, Vascular and Endocrine Surgery

According to the prestigious Focus magazine, the University Hospital Halle (Saale) ranks among the top German medical facilities! The history of the hospital has more than 300 years, and during this time it managed to earn an excellent reputation not only in Germany, but throughout the world. The hospital positions itself as a s
Multimodality treatment of appendix cancer with cytoreductive surgery and HIPEC
44258
Multimodality treatment of colon cancer with cytoreductive surgery and HIPEC
44280
Multimodality treatment of duodenal cancer with cytoreductive surgery and HIPEC
44154

University Hospital Jena

8.9/10
location_onGermany, Jena

Department of General, Abdominal and Vascular Surgery

According to the prestigious Focus magazine, the University Hospital Jena regularly ranks among the top German medical facilities! The hospital has positioned itself as a multidisciplinary medical facility with a long history of more than 200 years. Since its foundation, the hospital has been constantly developing and modernizin
Multimodality treatment of appendix cancer with cytoreductive surgery and HIPEC
38050
Multimodality treatment of colon cancer with cytoreductive surgery and HIPEC
38154
Multimodality treatment of duodenal cancer with cytoreductive surgery and HIPEC
38446

University Hospital Heidelberg

9.8/10
location_onGermany, Heidelberg

Department of General, Abdominal and Transplant Surgery

According to the Focus magazine, the University Hospital Heidelberg ranks among the top five hospitals in Germany! The hospital is one of the most advanced and reputable medical institutions not only in Germany, but throughout Europe. There are more than 43 specialized departments and 13 medical institutes, which cover all field
Multimodality treatment of appendix cancer with cytoreductive surgery and HIPEC
0
Multimodality treatment of colon cancer with cytoreductive surgery and HIPEC
0
Multimodality treatment of duodenal cancer with cytoreductive surgery and HIPEC
0

University Hospital Hamburg-Eppendorf

9.2/10
location_onGermany, Hamburg

Department of General, Abdominal and Thoracic Surgery

According to the Focus magazine, the University Hospital Hamburg-Eppendorf ranks among the top ten hospitals in Germany! Since its foundation in 1889, the hospital has taken a leading position in the European medical arena and still occupies it until today. A highly competent medical team of more than 11,000 employees takes care
Multimodality treatment of appendix cancer with cytoreductive surgery and HIPEC
58754
Multimodality treatment of colon cancer with cytoreductive surgery and HIPEC
59010
Multimodality treatment of duodenal cancer with cytoreductive surgery and HIPEC
58713

University Hospital Würzburg

9.2/10
location_onGermany, Würzburg

Department of General, Abdominal, Transplant, Vascular and Pediatric Surgery

According to the Focus magazine in 2019, the University Hospital Würzburg ranks among the top national German hospitals! The hospital is one of the oldest medical facilities in Germany. The centuries-old traditions of first-class treatment are combined with the very latest achievements of modern evidence-based medicine and
Multimodality treatment of appendix cancer with cytoreductive surgery and HIPEC
44445
Multimodality treatment of colon cancer with cytoreductive surgery and HIPEC
44278
Multimodality treatment of duodenal cancer with cytoreductive surgery and HIPEC
44191

University Hospital Tuebingen

9.2/10
location_onGermany, Tuebingen

Department of General, Abdominal, Adult and Pediatric Transplant Surgery

According to the prestigious medical publication Focus, the University Hospital Tuebingen ranks among the top five German hospitals! The hospital was founded in 1805, therefore it is proud of its long history, unique experience, and outstanding achievements in the field of medical care, as well as research and teaching activitie
Multimodality treatment of appendix cancer with cytoreductive surgery and HIPEC
47240
Multimodality treatment of colon cancer with cytoreductive surgery and HIPEC
47069
Multimodality treatment of duodenal cancer with cytoreductive surgery and HIPEC
47403

University Hospital Rechts der Isar Munich

9.8/10
location_onGermany, Munich

Department of Surgery

According to the prestigious FOCUS magazine, the University Hospital Rechts der Isar Munich ranks among the Germany's top medical institutions! Founded in 1834, the hospital combines long traditions and the very latest achievements of modern medicine. The medical facility includes 33 specialized departments, 20 interdiscipli
Multimodality treatment of appendix cancer with cytoreductive surgery and HIPEC
50047
Multimodality treatment of colon cancer with cytoreductive surgery and HIPEC
50100
Multimodality treatment of duodenal cancer with cytoreductive surgery and HIPEC
50365

University Hospital Muenster

9.8/10
location_onGermany, Muenster

Department of General, Abdominal and Transplant Surgery

According to the Focus magazine, the University Hospital Muenster ranks among the top German hospitals! The hospital belongs to the most prestigious medical institutions in Germany. The hospital is distinguished by a high professionalism of its doctors, state-of-the-art technological equipment and the availability of the most ad
Multimodality treatment of appendix cancer with cytoreductive surgery and HIPEC
44108
Multimodality treatment of colon cancer with cytoreductive surgery and HIPEC
43908
Multimodality treatment of duodenal cancer with cytoreductive surgery and HIPEC
44259
| from Booking Health GmbH

Peritoneal cancer, which affects the membrane lining the abdominal cavity, causes multiple foci of malignant neoplasms. Doctors do not always manage to find and remove them all. Therefore, the risk of relapse after surgical treatment will remain high. To reduce it, doctors use HIPEC – hyperthermic intraperitoneal chemotherapy.

What is peritoneal cancer?

Peritoneal cancer (peritoneal carcinomatosis) is a variant of the progression of malignant abdominal tumors, which causes multiple metastases on the serous membrane of the abdominal cavity. It develops in every third patient with tumors of the pancreas, stomach and appendix. This complication develops in 10% of patients suffering from colorectal cancer. Other localizations of the primary tumor that lead to peritoneal cancer include:

  • ovaries;
  • endometrium;
  • fallopian tubes;
  • liver;
  • gallbladder;
  • peritoneum (peritoneal mesothelioma).

There are four stages of the disease. The first stage is characterized by small metastases up to 5 mm in size. All of them are located in one area. In the second stage, the tumors are located diffusely throughout the abdomen. At the third stage, they are from 5 to 20 mm in size, while at the fourth stage the size of foci may reach over 20 mm.

What is HIPEC surgery?

Surgery remains the main method of treating patients with abdominal neoplasms. The main tumor is removed. In case of peritoneal carcinomatosis and the spread of metastases to other organs, there may be performed cytoreductive surgery. It involves the removal of all visible tumor nodes.  For this purpose, doctors resect several organs at once.

Nonetheless, the doctor cannot always detect all metastatic foci. In addition, many of them have microscopic dimensions. Therefore, the probability of cancer recurrence after cytoreductive surgery remains high. HIPEC (hyperthermic intraperitoneal chemotherapy) serves to reduce it.  It is made directly during the surgical intervention.

HIPEC surgery allows for the destruction of the remaining foci of tumor cells. The procedure aims to completely eradicate the tumor. If successful, complete recovery of the patient is possible. But even if cancer cannot be cured, HIPEC can significantly increase the life expectancy. Approximately two thirds of patients after using HIPEC surgery live 5 years or longer. The procedure also significantly decreases the severity of symptoms of the disease.

How is the procedure performed?

HIPEC is conducted immediately after cytoreduction, that is, after the resection of organs and the destruction of all visible tumor foci.

The doctors place drainage to provide outflow and inflow. Thermal sensors are used to monitor the intra-abdominal temperature. They are located in different parts of the peritoneal cavity. The abdominal skin is sutured with a temporary suture.

The next step is the abdominal irrigation with a chemotherapy solution heated to 42.5 degrees. The total perfusion is about 5 liters. The average flow rate is 700 ml per minute. The perfusion is performed using a special apparatus. The average duration of the procedure is an hour and a half. Then the doctors make a revision of the abdominal cavity. It drains and the surgical wound is sutured.

When treating peritoneal cancer, HIPEC has significant advantages over systemic chemotherapy when drugs are taken orally or administered intravenously. The advantages are as follows:

  • pharmacokinetics – intracavitary administration of drugs can significantly increase the dose;
  • hyperthermia – heating of the drug makes it possible to increase the selective antitumor effect, increase the ablastic effect and increase the depth of penetration of the drug into the tumor tissues.

Where can one get treatment?

To treat cancer, patients often go to Germany.  This country achieves phenomenal success in the fight against malignant tumors.  It successfully performs cytoreductive surgical procedures, uses intraperitoneal chemotherapy. Here is a list of the best clinics abroad where patients can undergo treatment:

Helios Clinic Krefeld. The Department of Abdominal and Minimally Invasive Surgery is responsible for performing cytoreductive surgery with intraperitoneal chemotherapy here. The department shows excellent results in the treatment of abdominal cancers. The cost of treatment is about 40 thousand euros.

Charite University Hospital. It is one of the most reputable medical institutions in Europe. The surgery combined with hyperthermic chemotherapy is performed in the Department of General, Abdominal and Vascular Surgery. Cytoreductive surgery for oncological diseases remains one of the main department’s work focuses. The cost of treatment here reaches 60 thousand euros.

University Hospital of Ludwig Maximilian University.  It is included in the ranking of the top medical facilities specializing in the treatment of abdominal cancers. The cytoreductive surgical procedures with hyperthermic chemotherapy are performed in the Department of General, Abdominal and Transplant Surgery. The treatment cost is 45 thousand euros.

Treatment organization

If you have symptoms of cancer, you can become a patient of one of German clinics. Booking Health will help you in organizing treatment in the best clinics abroad. Our services and benefits:

  • Selection of the best clinic specializing in cytoreductive surgery with hyperthermic intraperitoneal chemotherapy.
  • Treatment cost reduction up to 50% by eliminating coefficients for foreign patients.
  • Possibility to undergo treatment at the dates convenient for you.
  • Establishment of communication with doctors and administration before the start of treatment and after the end of the program.
  • Preparation of a treatment program without repeating previously completed examinations.
  • Monitoring of the program at all its stages.
  • Funds management and return of unspent funds.
  • Organization of additional examinations.
  • Assistance in purchasing and transmission of medicines.

Booking Health will provide you with high level of service. We will book a hotel and airline tickets for you, help you complete the necessary paperwork, meet you at the airport and take to the clinic by car.

Authors: Dr. Nadezhda Ivanisova, Dr. Sergey Pashchenko




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