The Department of Internal Medicine at the Hospital zum Heiligen Geist in Frankfurt am Main annually diagnoses and treats over 4,500 inpatients with diseases of the entire spectrum of internal medicine.  In addition, the Department receives a large number of patients before and after hospitalization, provides emergency medical care, as well as performs outpatient surgery (colonoscopy). The Department closely collaborates with the Department of Psychosomatics. 

The Department of General and Abdominal Surgery at the Hospital zum Heiligen Geist in Frankfurt am Main treats a wide array of surgical diseases in the field of general and abdominal surgery. A special focus is placed on hernia repair and coloproctology. The Department has the best diagnostic and therapeutic capabilities, including the most advanced treatments.

The Hospital zum Heiligen Geist in Frankfurt am Main with its Department of Gynecology and Obstetrics offers patients the best diagnostic and therapeutic options involving the use the cutting-edge methods. The Department specializes in the treatment of gynecologic cancers, special gynecological surgery and minimally invasive surgical techniques. 

The Department of Vascular and Endovascular Surgery at the Hospital zum Heiligen Geist in Frankfurt am Main has a long experience in the treatment of patients with acute and chronic arterial and venous diseases. The Department specializes in the treatment of carotid stenosis, aortic dilatation (aortic aneurysm), obliteration of the vessels in the pelvic and legs (arterial occlusive disease), implantation of atrioventricular shunts for dialysis patients, as well as the surgical treatment of varicose veins.

The Department of Orthopedics, Trauma and Spinal Column Surgery at the Hospital zum Heiligen Geist am Main offers all current conservative and operative treatment options of the musculoskeletal system at the highest medical level. Main focuses are orthopedics, spinal column surgery (operative interventions on the spinal column and multimodal pain treatment of back pain) and trauma surgery. The Department is certified as the Center for Endoprosthetics (EndoProthetikzentrum, EPZ) in accordance with EndoCert.