ALS or amyotrophic lateral sclerosis (Lou Gehrig's disease) is a pathology that causes the death of motor neurons. Although ALS is often considered to be a muscular disease, it is actually not. In fact, this is a neurological disease. Only recently scientists began to understand how ALS develops. Since the causes of ALS had been unknown for a long time, ALS treatment was reduced to symptomatic therapy.
The main cause of ALS is a dysfunction of the protein metabolism of the central nervous system. In excess these proteins accumulate in the neurons of the brain, which are responsible for coordination of movements and muscle tone. This accumulation provokes the destruction of neurons, and as a result, symptoms of ALS appear.
Thanks to the modern equipment and highly qualified doctors, the leading positions in the diagnostics and comprehensive treatment of amyotrophic lateral sclerosis are held by the following clinics:
- University Hospital Frankfurt am Main, Department of Neurology
- University Hospital Rechts der Isar Munich, Department of Neurology
- Charite University Hospital Berlin, Department of Neurology.
- Bundeswehr Academic Hospital Berlin, Department of Neurology.
- Beta Klinik Bonn, Department of Neurology and Epileptology.
- University Hospital Ulm, Department of Neurology.
The cost of the medical program depends on the required preliminary examination and treatment tactics. Average prices for diagnostics and treatment of amyotrophic lateral sclerosis are listed below:
- Diagnostics
- Diagnostics and conservative treatment
Like all diseases of an autoimmune nature, amyotrophic sclerosis is constantly progressing and it is difficult to treat. Nevertheless, there are ongoing studies aimed at finding new therapeutic approaches. The main goal of new types of treatment is still focused on the improvement of the patient's quality of life and increasing one’s life span. It is still too early to talk about a complete cure at this stage of the medical development. However, the latest achievements of scientists inspire hope. In this article we will talk about modern methods of treating ALS syndrome.
Modern methods of ALS treatment
New drugs
The US and some European countries use a tyrosine kinase inhibitor to treat ALS. This is a drug aimed at blocking a protein that accumulates in motor neurons. It has been used since 2008 with other neurological diseases. However, only in 2016 it was approved for the treatment of amyotrophic lateral sclerosis, when the next phase of trials was completed.
In 2017, another step was taken in the treatment of ALS. In Japan, an innovative ALS drug was developed - an antioxidant that can slow the progression of amyotrophic sclerosis. Over the past two decades, it is the first ALS drug approved by the Sanitary Commission for the Supervision of Food and Drug Administration (FDA).
It is likely that some of the conservative treatment methods will help prolong the life of patients with ALS or prolong the period of work capacity.
In ALS, the functional window during which a patient can benefit most from any intervention — whether drug therapy, HAL-therapy, or stem cell treatment — narrows continuously as motor neuron loss progresses. A patient who delays treatment organization by several months while navigating hospital selection, document preparation, and visa processing independently may arrive at a German clinic at a meaningfully different stage than if that process had been compressed.
Booking Health runs all administrative steps simultaneously — hospital selection, document translation, visa support, accommodation, and scheduling — so that the time between the decision to seek treatment in Germany and the first appointment is as short as the patient's condition allows.
CHECK IF A BETTER SOLUTION EXISTS FOR YOUHAL-Therapy
This method employs a special suit - an exoskeleton. It perceives signals from nerves and strengthens them, forcing muscles to contract. This suit helps a person talk and perform all the necessary actions for self-service.
It is used in the hospitals of Germany and Japan. The method is aimed at fighting the symptoms of amyotrophic lateral sclerosis, in order to improve the patient's mobility. The therapy slows muscle atrophy, but does not affect the rate of death of motor neurons and the life expectancy of the patient.
«NurOwn» technology
This method uses stem cells for ALS treatment. According to preliminary studies, the introduction of stem cells into the spinal cord enables partial restoration of its structure and slow the development of the disease. Stem cells replace the dead motoneurons. With a single injection of stem cells into the subarachnoid space, improvement in the patient's condition was noted in 88% of cases with observation of 3 months and in 73% in a 6-month follow-up. With intramuscular injection of stem cells, they form and restore connections of denervated muscles, which slows the death of neurons, and also develop factors that support nerve cells.
Studies have shown that ALS treatment with stem cells decreased the rate of reduction in forced vital capacity from 5.1% to 1.2%. The main cause of death of patients with ALS is respiratory failure, which develops as a result of paralysis of the respiratory muscles. Therefore, such test results inspire optimism and give doctors hope that the life expectancy of patients with ALS will be increased.
The forced vital capacity data above is what makes stem cell therapy in ALS most clinically significant: respiratory muscle function is the primary survival determinant, and slowing its decline from 5.1% to 1.2% per period is not a marginal improvement.
The 88% response rate at three months applies to patients treated at that functional stage — which means current FVC measurement and respiratory function assessment are the data points the German neurological team needs before the treatment program can be designed.
Booking Health identifies whether current pulmonary function testing is present in the patient's record and arranges any missing assessment before the first consultation.
Folk remedies in the treatment of ALS
Treatment of ALS with folk remedies can not replace a fully-fledged treatment. Folk medicine can be used only with the approval of your doctor and only together with the main therapy, not instead of it.
Prognosis
Is it possible to cure ALS? Despite all the modern innovations in the treatment of ALS, the prognosis remains unfavorable. Patients with ALS diagnosis live from 2 to 6 years. Stem cell therapy can prolong this period by 9-18 months. However, not a single confirmed case of cure for ALS has been registered to date. Nevertheless, medicine knows the cases when the patient managed to live much longer than 6 years. A striking example of this is one of the most famous scientists in the world, Stephen Hawking. He is chained to a wheelchair, but he lives with amyotrophic lateral sclerosis for more than 70 years.
Where ALS is treated?
Over the past decade, Japan, Germany and the United States have made a big leap in the study of amyotrophic lateral sclerosis. Scientific institutes actively search for a cure for this neurodegenerative disease. Treatment of ALS in Russia and other countries on the territory of the former CIS do not yet have the opportunities that are available in foreign clinics.
Every Patient Has a Story: Booking Health Treatment Journeys that Inspire
Services of Booking Health
Booking Health helps patients with ALS to receive the most modern treatment in German hospitals. To benefit from our services, you need to leave a request on our website. Our managers will select a treatment program for you and organize your trip to Germany.
Organizational services of Booking Health include:
- Selection and booking of the hospital
- Appointment with a neurologist
- Translation of your medical extracts into German and an accompanying interpreter during consultations with a doctor
- Assistance in obtaining a visa, hotel reservation and air tickets
- Meeting at the airport and transfer to the medical center
Once care begins, a personal medical case manager — a qualified physician — oversees your case and remains in contact for up to 12 months. This person does not disappear after the booking is confirmed. They monitor the treatment process, protect your interests if anything does not go according to plan, and are there throughout every stage.
THE PRACTICAL SUPPORT IS COMPREHENSIVE:
- Full handling of medical documentation and translations
- Clinic appointments, treatment scheduling, flights, hotels, transfers, and interpreters - all organized
- Transparent treatment budget with no hidden costs - you know the full cost in advance
- Complication insurance up to €200,000, covering potential medical costs if complications arise after treatment
- Decision-making support when several treatment options are available, with clear explanation of benefits and risks
Booking Health holds ISO 9001 quality certification, reflecting well-established processes and strict quality control at every stage of the treatment journey — not just at the initial consultation, but throughout.
Choose treatment abroad and you will for sure get the best results!
Source:
01. Ze Wang, Jiajun Huang, Di Yun. Current and emerging therapeutic strategies for amyotrophic lateral sclerosis: from pharmacological approaches to gene and stem cell therapies. Front Neurol. 2026 Jan 22;17:1729302. doi: 10.3389/fneur.2026.1729302. [DOI] [PMC free article]
02. Andrea Barp, Francesca Gerardi, Andrea Lizio, Valeria Ada Sansone, Christian Lunetta. Emerging Drugs for the Treatment of Amyotrophic Lateral Sclerosis: A Focus on Recent Phase 2 Trials. Expert Opin Emerg Drugs. 2020 Jun;25(2):145-164. doi: 10.1080/14728214.2020.1769067. Epub 2020 May 27. [DOI] [PubMed]
03. Paola Ruffo, Bryan J Traynor, Francesca Luisa Conforti. Advancements in genetic research and RNA therapy strategies for amyotrophic lateral sclerosis (ALS): current progress and future prospects. J Neurol. 2025 Feb 26;272(3):233. doi: 10.1007/s00415-025-12975-8. [DOI] [PMC free article]
Read:
01. Stem Cell Treatment for ALS in Germany: Pioneering Protocols and Breakthrough Technologies
02. Inside the Science: How Stem Cells Are Revolutionizing ALS Treatment
